摘要:
The present application describes novel barbituric acid derivatives of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, L, R1, R2, R3, R4, R5, n, W, U, X, Y, Z, Ua, Xa, Ya, and Za are defined in the present specification, which are useful as TNF-α converting enzyme (TACE) and matrix metalloproteinases (MMP) inhibitors.
摘要翻译:本申请描述了式I的新型巴比妥酸衍生物或其药学上可接受的盐或前药形式,其中A,B,L,R 1,R 2, R 4,R 4,R 5,n,W,U,X,Y,Z,U a, 在本说明书中定义,其可用作TNF-α转化酶(TACE)和/或 基质金属蛋白酶(MMP)抑制剂。
摘要:
The present application describes novel barbituric acid derivatives of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, L, R1, R2, R3, R4, R5, n, W, U, X, Y, Z, Ua, Xa, Ya, and Za are defined in the present specification, which are useful as TNF-α converting enzyme (TACE) and matrix metalloproteinases (MMP) inhibitors.
摘要翻译:本申请描述了式I的新型巴比妥酸衍生物或其药学上可接受的盐或前药形式,其中A,B,L,R 1,R 2, R 4,R 4,R 5,n,W,U,X,Y,Z,U a, 在本说明书中定义,其可用作TNF-α转化酶(TACE)和/或 基质金属蛋白酶(MMP)抑制剂。
摘要:
The present application describes novel barbituric acid derivatives of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, L, R1, R2, R3, R4, R5, n, W, U, X, Y, Z, Ua, Xa, Ya, and Za are defined in the present specification, which are useful as TNF-α converting enzyme (TACE) and matrix metalloproteinases (MMP) inhibitors.
摘要:
Quinazoline and pyrido[2,3-d]pyrimidine phosphodiesterase 7 (PDE 7) inhibitors of the following formula wherein R1, R2, L, Y1, Y2, Y3 and Z are as described herein, are provided which are useful in treating T-cell mediated diseases.
摘要:
Fused heterocylic compounds of the following Formula wherein R1, R2, R5, Z, J1 and J2 are described herein, and analogs thereof are provided which are useful in treating leukocyte activation-associated disorders.
摘要:
This invention relates to methods of treating, managing and preventing body composition disorders, and to compounds and pharmaceutical compositions useful in such methods.
摘要:
This invention encompasses methods of improving cognitive performance and of treating, preventing and managing various diseases and disorders, such as Alzheimer's disease, autism, cognitive disorders, dementia, learning disorders, and short- and long-term memory loss.
摘要:
This invention relates to multicyclic compounds, pharmaceutical compositions comprising them, and methods of their use. Particular compounds of the invention are of formula I:
摘要:
This invention concerns novel thiazolopyrazole compounds and compositions comprising them. Methods of using these compounds for the treatment, prevention and management of various diseases and disorders are also encompassed by the invention.