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    Assay platforms and detection methodology using surface enhanced Raman scattering (SERS) upon specific biochemical interactions
    1.
    发明申请
    Assay platforms and detection methodology using surface enhanced Raman scattering (SERS) upon specific biochemical interactions 审中-公开
    使用表面增强拉曼散射（SERS）进行特异性生化相互作用的测定平台和检测方法

    公开(公告)号：US20080003576A1

    公开(公告)日：2008-01-03

    申请号：US11477675

    申请日：2006-06-30

    申请人： Jingwu Zhang ,  Handong Li ,  Narayan Sundararajan ,  Xing Su ,  Lei Sun

    发明人： Jingwu Zhang ,  Handong Li ,  Narayan Sundararajan ,  Xing Su ,  Lei Sun

    IPC分类号： C12Q1/68 ,  G01N33/555

    CPC分类号： G01N33/585 ,  C12Q1/6816 ,  G01N21/658 ,  G01N33/54373 ,  C12Q2563/155 ,  C12Q2565/632

    摘要： The embodiments of the invention are directed to a SERS cluster comprising a capture particle that is at least partially surrounded by analyte molecules, wherein both the capture particle and the analyte molecules surrounding the capture particle are at least partially surrounded by enhancer particles, wherein a majority of the analyte molecules are either sandwiched between capture and enhancer particles or located between junctions of the enhancer particles. The embodiments of the invention also relate to methods of manufacturing and detecting the SERS cluster. The embodiments of the invention also relate to a SERS active particle comprising a tag molecule comprising a Raman active compound and a probe or a linker having a specific biochemical binding capability and to a method for detecting of a target molecule using a SERS active particle having a tag molecule comprising a Raman active compound and a probe or a linker.

    摘要翻译： 本发明的实施方案涉及包含被分析物分子至少部分包围的捕获颗粒的SERS簇，其中捕获颗粒和捕获颗粒周围的分析物分子至少部分地被增强子颗粒包围，其中多数 分析物分子被夹在捕获和增强剂颗粒之间或位于增强剂颗粒的结之间。 本发明的实施例还涉及制造和检测SERS簇的方法。 本发明的实施方案还涉及包含包含拉曼活性化合物的标签分子和具有特定生物化学结合能力的探针或接头的SERS活性颗粒以及使用具有下列化合物的SERS活性颗粒检测靶分子的方法： 标签分子，其包含拉曼活性化合物和探针或接头。

    Composite organic inorganic nanoclusters
    5.
    发明申请
    Composite organic inorganic nanoclusters 审中-公开
    复合有机无机纳米团簇

    公开(公告)号：US20060234248A1

    公开(公告)日：2006-10-19

    申请号：US11081772

    申请日：2005-03-15

    申请人： Lei Sun ,  Xing Su ,  Mineo Yamakawa ,  Zhang Jingwu ,  Narayan Sundararajan

    发明人： Lei Sun ,  Xing Su ,  Mineo Yamakawa ,  Zhang Jingwu ,  Narayan Sundararajan

    IPC分类号： C12Q1/68 ,  G01N33/53

    CPC分类号： G01N21/658 ,  B82Y30/00 ,  G01N2021/653 ,  G01N2021/655 ,  G01N2021/656

    摘要： Metallic nanoclusters capable of providing an enhanced Raman signal from an organic Raman-active molecule incorporated therein are provided. The nanoclusters may be further functionalized, for example, with coatings and layers, such as adsorption layers, metal coatings, silica coatings, probes, and organic layers. The nanoclusters are generally referred to as COINs (composite organic inorganic nanoparticles) and are capable of acting as sensitive reporters for analyte detection. A variety of organic Raman-active compounds and mixtures of compounds can be incorporated into the nanocluster.

    摘要翻译： 提供能够从其中并入的有机拉曼活性分子提供增强的拉曼信号的金属纳米团簇。 纳米团簇可以进一步官能化，例如具有涂层和层，例如吸附层，金属涂层，二氧化硅涂层，探针和有机层。 纳米团簇通常被称为COIN（复合有机无机纳米粒子），并且能够作为敏感的报告物进行分析物检测。 可以将多种有机拉曼活性化合物和化合物的混合物掺入纳米团簇中。

    Composite organic inorganic nanoclusters
    6.
    发明申请
    Composite organic inorganic nanoclusters 审中-公开
    复合有机无机纳米团簇

    公开(公告)号：US20080076119A9

    公开(公告)日：2008-03-27

    申请号：US11081772

    申请日：2005-03-15

    申请人： Lei Sun ,  Xing Su ,  Mineo Yamakawa ,  Zhang Jingwu ,  Narayan Sundararajan

    发明人： Lei Sun ,  Xing Su ,  Mineo Yamakawa ,  Zhang Jingwu ,  Narayan Sundararajan

    IPC分类号： C12Q1/68 ,  G01N33/53

    CPC分类号： G01N21/658 ,  B82Y30/00 ,  G01N2021/653 ,  G01N2021/655 ,  G01N2021/656

    摘要： Metallic nanoclusters capable of providing an enhanced Raman signal from an organic Raman-active molecule incorporated therein are provided. The nanoclusters may be further functionalized, for example, with coatings and layers, such as adsorption layers, metal coatings, silica coatings, probes, and organic layers. The nanoclusters are generally referred to as COINs (composite organic inorganic nanoparticles) and are capable of acting as sensitive reporters for analyte detection. A variety of organic Raman-active compounds and mixtures of compounds can be incorporated into the nanocluster.

    摘要翻译： 提供能够从其中并入的有机拉曼活性分子提供增强的拉曼信号的金属纳米团簇。 纳米团簇可以进一步官能化，例如具有涂层和层，例如吸附层，金属涂层，二氧化硅涂层，探针和有机层。 纳米团簇通常被称为COIN（复合有机无机纳米粒子），并且能够作为敏感的报告物进行分析物检测。 可以将多种有机拉曼活性化合物和化合物的混合物掺入纳米团簇中。

    Phosphopeptide detection and surface enhanced Raman spectroscopy
    10.
    发明申请
    Phosphopeptide detection and surface enhanced Raman spectroscopy 审中-公开
    磷酸肽检测和表面增强拉曼光谱

    公开(公告)号：US20080158558A1

    公开(公告)日：2008-07-03

    申请号：US11647690

    申请日：2006-12-28

    申请人： Handong Li ,  Narayan Sundararajan

    发明人： Handong Li ,  Narayan Sundararajan

    IPC分类号： G01J3/44

    CPC分类号： G01N21/658 ,  C12Q1/42 ,  C12Q1/485 ,  G01N33/573 ,  G01N33/587 ,  G01N33/6842

    摘要： Raman-active molecules having specific affinity for phosphorylated peptides and proteins are provided. The Raman-active affinity molecules contain a Raman active group capable of providing a detectable spectrum. The affinity molecules act as tags or reporter molecules and are useful, for example in detecting the presence of a phosphorylated residue in a peptide or protein through the use of SERS spectroscopy. The affinity molecules provide the ability to detect and quantify phosphatase and kinase activities.

    摘要翻译： 提供了对磷酸化肽和蛋白质具有特异性亲和力的拉曼活性分子。 拉曼活性亲和分子含有能够提供可检测光谱的拉曼活性基团。 亲和分子用作标签或报告分子，并且可用于例如通过使用SERS光谱法检测肽或蛋白质中磷酸化残基的存在。 亲和分子提供检测和定量磷酸酶和激酶活性的能力。