Preparation of 2-alkyl-3-(4,5-dihydroisoxazol-3-yl) halobenzenes
    9.
    发明授权
    Preparation of 2-alkyl-3-(4,5-dihydroisoxazol-3-yl) halobenzenes 有权
    2-烷基-3-(4,5-二氢异恶唑-3-基)卤代苯的制备

    公开(公告)号:US06603017B2

    公开(公告)日:2003-08-05

    申请号:US10141236

    申请日:2002-05-09

    IPC分类号: C07D26118

    CPC分类号: C07D261/04

    摘要: A novel process for preparing the compounds of the formula I where: n is 0, 1 or 2; R1, R2 are C1-C6-alkyl; R3, R4, R5 are hydrogen or C1-C6-alkyl, or R4 and R5 together form a bond; R6 is Cl, Br, which comprises a synthesis sequence starting from 1,2-dialkylbenzenes of the formula II with subsequent halogenation to give 3,6-dihalo-1,2-dialkylbenzenes, haloalkylation to give benzyl bromides, oxidation to give benzaldehydes, oximation, reaction with alkenes to give isoxazoles, conversion into thioethers and, if appropriate, oxidation to give sulfenyl or sulfonyl derivatives of the formula I.

    摘要翻译: 一种制备式I化合物的新方法,其中n为0,1或2; R 1,R 2为C 1 -C 6 - 烷基; R 3,R 4,R 5为氢或C 1 -C 6烷基,或者R 4和R 5一起形成 R 6是Cl,Br,其包含从式II的1,2-二烷基苯开始的合成序列,随后卤化以得到3,6-二卤代-1,2-二烷基苯,卤代烷基化得到苄基溴,氧化得到 苯甲醛,肟化,与烯烃的反应得到异恶唑,转化成硫醚,如果合适,氧化得到式I的磺酰基或磺酰基衍生物。