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公开(公告)号：US20110135653A1
公开(公告)日：2011-06-09
申请号：US12961004
申请日：2010-12-06
申请人： Joaquin Arribas Lopez , Kim Pedersen , Pier-Davide Angellini , Josep Lluis Parra Palau , Jose Baselga Torres
发明人： Joaquin Arribas Lopez , Kim Pedersen , Pier-Davide Angellini , Josep Lluis Parra Palau , Jose Baselga Torres
CPC分类号： C07K16/32 , A61K2039/505 , C07K2317/34
摘要： The present invention relates to a method of diagnosis and therapy of cancers expressing the HER2 receptor.The invention provides antibodies or fragments thereof that recognise an epitope of the HER2 receptor truncated form CTF-611, said epitope being defined by a sequence included in SEQ ID NO: 2, and that are capable of discriminating between CTF-611 and CTF-616 (represented by SEQ ID NO:7), preferably additionally capable of discriminating between CTF-611 and CTF-613 (represented by SEQ ID NO:6).The invention also provides a method of cancer diagnosis using the disclosed antibodies, which comprises the detection of the presence of the HER2 receptor truncated form consisting of the amino acid sequence SEQ ID NO: 1 in a patient sample.
摘要翻译： 本发明涉及一种诊断和治疗表达HER2受体的癌症的方法。 本发明提供识别CTF-611截断的HER2受体的表位的抗体或其片段，所述表位由SEQ ID NO：2所包含的序列定义，并且能够区分CTF-611和CTF-616 （由SEQ ID NO：7表示），优选另外能够区分CTF-611和CTF-613（由SEQ ID NO：6表示）。 本发明还提供使用所公开抗体的癌症诊断方法，其包括检测患者样品中由氨基酸序列SEQ ID NO：1组成的HER2受体截短形式的存在。
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公开(公告)号：US08741586B2
公开(公告)日：2014-06-03
申请号：US12961004
申请日：2010-12-06
申请人： Joaquin Arribas Lopez , Kim Pedersen , Pier-Davide Angellini , Josep Lluis Parra Palau , Jose Baselga Torres
发明人： Joaquin Arribas Lopez , Kim Pedersen , Pier-Davide Angellini , Josep Lluis Parra Palau , Jose Baselga Torres
IPC分类号： C12P21/08 , C07K16/30 , C07K16/28 , G01N33/574 , G01N33/573 , G01N33/567 , G01N33/50
CPC分类号： C07K16/32 , A61K2039/505 , C07K2317/34
摘要： The present invention relates to a method of diagnosis and therapy of cancers expressing the HER2 receptor.The invention provides antibodies or fragments thereof that recognise an epitope of the HER2 receptor truncated form CTF-611, said epitope being defined by a sequence included in SEQ ID NO: 2, and that are capable of discriminating between CTF-611 and CTF-616 (represented by SEQ ID NO:7), preferably additionally capable of discriminating between CTF-611 and CTF-613 (represented by SEQ ID NO:6).The invention also provides a method of cancer diagnosis using the disclosed antibodies, which comprises the detection of the presence of the HER2 receptor truncated form consisting of the amino acid sequence SEQ ID NO: 1 in a patient sample.
摘要翻译： 本发明涉及一种诊断和治疗表达HER2受体的癌症的方法。 本发明提供识别CTF-611截断的HER2受体的表位的抗体或其片段，所述表位由SEQ ID NO：2所包含的序列定义，并且能够区分CTF-611和CTF-616 （由SEQ ID NO：7表示），优选另外能够区分CTF-611和CTF-613（由SEQ ID NO：6表示）。 本发明还提供使用所公开抗体的癌症诊断方法，其包括检测患者样品中由氨基酸序列SEQ ID NO：1组成的HER2受体截短形式的存在。
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3.发明授权Method for diagnosing cancers expressing the HER2 receptor or its truncated variants 有权用于诊断表达HER2受体或其截短变体的癌症的方法公开(公告)号：US08389227B2
公开(公告)日：2013-03-05
申请号：US12479035
申请日：2009-06-05
申请人： Joaquin Arribas Lopez , Kim Pedersen , Pier-Davide Angellini , Josep Liuis Parra Palau , Sirle Laos , Jose Baselga Torres
发明人： Joaquin Arribas Lopez , Kim Pedersen , Pier-Davide Angellini , Josep Liuis Parra Palau , Sirle Laos , Jose Baselga Torres
IPC分类号： C12P21/08 , C07K16/30 , C07K16/28 , G01N33/574 , G01N33/573 , G01N33/567 , G01N33/50 , C07K17/16
CPC分类号： C07K16/32 , G01N33/57484 , G01N2333/71
摘要： The present invention relates to a method of diagnosis and therapy of cancers expressing the HER2 receptor.The invention provides antibodies or fragments thereof that recognizes an epitope of a HER2 receptor truncated form, said epitope being defined by a sequence included in SEQ ID NO: 2.The invention also provides a method of cancer diagnosis, which comprises the detection of the presence of the HER2 receptor truncated form consisting of the amino acid sequence SEQ ID NO: 1 in a patient sample.
摘要翻译： 本发明涉及一种诊断和治疗表达HER2受体的癌症的方法。 本发明提供识别HER2受体截短形式的表位的抗体或其片段，所述表位由SEQ ID NO：2所包含的序列定义。本发明还提供了一种癌症诊断方法，其包括检测存在 的由病人样品中的氨基酸序列SEQ ID NO：1组成的HER2受体截短形式。
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4.发明申请Method for Diagnosing Cancers Expressing the HER2 Receptor or its Truncated Variants 有权用于诊断表达HER2受体或其截短变体的癌症的方法公开(公告)号：US20090311262A1
公开(公告)日：2009-12-17
申请号：US12479035
申请日：2009-06-05
申请人： Joaquin Arribas Lopez , Kim Pedersen , Pier-Davide Angellini , Josep Liuis Parra Palau , Sirle Laos , Jose Baselga Torres
发明人： Joaquin Arribas Lopez , Kim Pedersen , Pier-Davide Angellini , Josep Liuis Parra Palau , Sirle Laos , Jose Baselga Torres
IPC分类号： A61K39/395 , C07K16/30 , C12N5/16 , C12P21/02 , C07K14/47 , G01N33/574 , A61P35/00
CPC分类号： C07K16/32 , G01N33/57484 , G01N2333/71
摘要： The present invention relates to a method of diagnosis and therapy of cancers expressing the HER2 receptor.The invention provides antibodies or fragments thereof that recognises an epitope of a HER2 receptor truncated form, said epitope being defined by a sequence included in SEQ ID NO: 2.The invention also provides a method of cancer diagnosis, which comprises the detection of the presence of the HER2 receptor truncated form consisting of the amino acid sequence SEQ ID NO: 1 in a patient sample.
摘要翻译： 本发明涉及一种诊断和治疗表达HER2受体的癌症的方法。 本发明提供识别HER2受体截短形式的表位的抗体或其片段，所述表位由SEQ ID NO：2所包含的序列定义。本发明还提供了一种癌症诊断方法，其包括检测存在 的由病人样品中的氨基酸序列SEQ ID NO：1组成的HER2受体截短形式。
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公开(公告)号：US20070085717A1
公开(公告)日：2007-04-19
申请号：US10573053
申请日：2004-09-22
IPC分类号： H03M3/00
摘要： The invention relates to at least one self-oscillating loop (SOL) comprising at least one forward path (FP), at least one feedback path (FBP) wherein said at least one forward path (FP) comprises amplitude quantizing means (AQM) combined with time quantizing means (TQM) and outputting at least one time and amplitude quantized signal (OS). According to the invention, a high-speed high-resolution A/D converter may be obtained.
摘要翻译： 本发明涉及包括至少一个正向路径（FP），至少一个反馈路径（FBP）的至少一个自振荡回路（SOL），其中所述至少一个前向路径（FP）包括组合的幅度量化装置（AQM） 具有时间量化装置（TQM）并且输出至少一个时间和幅度量化信号（OS）。 根据本发明，可以获得高速高分辨率A / D转换器。
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公开(公告)号：US07183097B1
公开(公告)日：2007-02-27
申请号：US09700130
申请日：1999-05-07
IPC分类号： C12N1/20
CPC分类号： C12N15/74 , C12N15/635 , C12N15/68
摘要： Method of conditionally controlling the survivability of a recombinant cell population and of containing such cells to an environment or containing replicons to a host cell is based on the use of proteic killer systems including the E. coli relBE locus and similar systems found in Gram-negative and Gram-positive bacteria and Archae. Such system are generally based on a cytotoxin polypeptide and an antitoxin or antidote polypeptide that in contrast to the cytotoxin is degradable by proteases. The recombinant cells are useful as vaccines, pollulant degrading organisms or as biogical pest control organisms e.g. expressing B. thuringiensis crystalline proteins.
摘要翻译： 有条件地控制重组细胞群的生存能力和将这些细胞包含在宿主细胞环境或含有复制子中的方法是基于使用包括大肠杆菌relBE基因座在内的蛋白质杀伤系统和在革兰氏阴性菌中发现的类似系统 和革兰氏阳性菌和古菌。 这种系统通常基于细胞毒素多肽和与细胞毒素相反的抗毒素或解毒剂多肽可被蛋白酶降解。 重组细胞可用作疫苗，污染物降解生物体或作为生物传播的有害生物控制生物体。 表达苏云金芽孢杆菌结晶蛋白。
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公开(公告)号：US20080182327A1
公开(公告)日：2008-07-31
申请号：US11558856
申请日：2006-11-10
CPC分类号： C12N15/74 , C12N15/635 , C12N15/68
摘要： Method of conditionally controlling the survivability of a recombinant cell population and of containing such cells to an environment or containing replicons to a host cell is based on the use of proteic killer systems including the E. coli relBE locus and similar systems found in Gram-negative and Gram-positive bacteria and Archae. Such system are generally based on a cytotoxin polypeptide and an antitoxin or antidote polypeptide that in contrast to the cytotoxin is degradable by proteases. The recombinant cells are useful as vaccines, pollutant degrading organisms or as biological pest control organisms e.g. expressing B. thuringiensis crystalline proteins.
摘要翻译： 有条件地控制重组细胞群的生存能力和将这些细胞包含在宿主细胞环境或含有复制子中的方法是基于使用包括大肠杆菌relBE基因座在内的蛋白质杀伤系统和在革兰氏阴性菌中发现的类似系统 和革兰氏阳性菌和古菌。 这种系统通常基于细胞毒素多肽和与细胞毒素相反的抗毒素或解毒剂多肽可被蛋白酶降解。 重组细胞可用作疫苗，污染物降解生物体或作为生物有害生物控制生物体，例如， 表达苏云金芽孢杆菌结晶蛋白。
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公开(公告)号：US20070200626A1
公开(公告)日：2007-08-30
申请号：US10575495
申请日：2004-10-11
申请人： Kim Pedersen , Lars Arknes-Pedersen
发明人： Kim Pedersen , Lars Arknes-Pedersen
IPC分类号： H03F3/217
CPC分类号： H03F3/217 , H03F1/0211 , H03F1/30 , H03F1/303 , H03F1/32 , H03F1/3247 , H03F3/2175
摘要： The invention relates to an amplifier comprising amplification means (AM) comprising an input and an output, said amplification means (AM) comprising a switching output stage delivering at least one output signal (OUS) via said output, said amplification means being fed by power supply means (PSM) said amplifier further comprising compensation means (CM) providing a compensation signal (CS) derived from the power supply voltage (PSV) of the power supply means (PSM), said compensation signal (CS) comprising a substantially inverse representation of said power supply voltage (PSV) and said compensation signal (CS) being fed to said amplification means (AM). According to the invention, an effective error compensation of the output switching stage may in practice be implemented by establishment of a compensation, which on a run-time basis is based on the voltage of the power supply currently applied in the output switching stage.
摘要翻译： 本发明涉及一种放大器，包括包括输入和输出的放大装置（AM），所述放大装置（AM）包括通过所述输出传送至少一个输出信号（OUS）的开关输出级，所述放大装置由功率 供应装置（PSM），所述放大器还包括提供从电源装置（PSM）的电源电压（PSV）导出的补偿信号（CS））的补偿装置（CM），所述补偿信号（CS）包括基本上相反的表示 的所述电源电压（PSV）和所述补偿信号（CS）被馈送到所述放大装置（AM）。 根据本发明，实际上可以通过建立补偿来实现输出开关级的有效误差补偿，该补偿在运行时基于当前在输出切换级中施加的电源的电压。
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公开(公告)号：US20060114979A1
公开(公告)日：2006-06-01
申请号：US10538593
申请日：2002-12-09
申请人： Kim Pedersen , Knud Christensen
发明人： Kim Pedersen , Knud Christensen
IPC分类号： H03H7/30
摘要： The invention relates to a parametric equalizer comprising filtering means (FM), user interface means (UIM), audio signal input means and audio signal output means, said filtering means comprising at least one filter block (FIB) said user interface means (UIM) facilitating adjustment of corner frequency (fc), Shape (Q) and gain (G), said user interface means (UIM) comprising a further adjustment parameter (SYM), said user interface means being mapped by means of coefficient adjustment algorithms (CAD) into filter coefficient settings (FCP) of the at least one filter block (FIB), which when established reflects the adjustment of the user interface means (UIM) said further adjustment parameter (SYM) providing a filter coefficient setting (FCS) comprising a combined adjustment of at least one zero frequency, pole frequency, zero Q and pole Q of at least one filter block.
摘要翻译： 本发明涉及包括滤波装置（FM），用户接口装置（UIM），音频信号输入装置和音频信号输出装置的参数均衡器，所述滤波装置包括至少一个滤波器块（FIB），所述用户接口装置（UIM） 所述用户接口装置（UIM）包括另外的调整参数（SYM），所述用户界面装置通过系数调整算法（CAD）进行映射， 至少一个滤波器块（FIB）的滤波器系数设置（FCP），其在建立时反映了用户接口装置（UIM）的调整，所述进一步调整参数（SYM）提供滤波器系数设置（FCS），其包括组合 调整至少一个滤波器块的至少一个零频率，极点频率，零Q和极点Q。
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公开(公告)号：US20080206840A1
公开(公告)日：2008-08-28
申请号：US11837456
申请日：2007-08-10
IPC分类号： C12N1/20
CPC分类号： C12N15/74 , C12N15/635 , C12N15/68
摘要： Method of conditionally controlling the survivability of a recombinant cell population and of containing such cells to an environment or containing replicons to a host cell is based on the use of proteic killer systems including E. coli relBE locus and similar systems found in Gram-negative and Gram-positive bacteria and Archae. Such systems are generally based on a cytotoxin polypeptide and an antitoxin or antidote polypeptide that in contrast to the cytotoxin is degradable by proteases. The recombinant cells are useful as vaccines, pollutant degrading organisms or as biological pest control organism e.g. expressing B. thuringiensis crystalline proteins.
摘要翻译： 有条件地控制重组细胞群的生存性和将这些细胞包含在宿主细胞的环境或含有复制子的方法是基于使用包括大肠杆菌relBE基因座在内的蛋白质杀伤系统和在革兰氏阴性和 革兰氏阳性菌和古菌。 这样的系统通常基于细胞毒素多肽和与细胞毒素相反的抗毒素或解毒剂多肽可被蛋白酶降解。 重组细胞可用作疫苗，污染物降解生物体或作为生物有害生物控制生物体。 表达苏云金芽孢杆菌结晶蛋白。
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