公开(公告)号：US5980495A

公开(公告)日：1999-11-09

申请号：US064496

申请日：1998-04-22

申请人： Jochen Heinz ,  Michael Spallek

发明人： Jochen Heinz ,  Michael Spallek

IPC分类号： A61M5/31 ,  A61M5/32 ,  A61M5/00

CPC分类号： A61M5/3202 ,  A61M2005/3109 ,  Y10S128/919

摘要： The pre-filled single-use hypodermic devices must be provided with a needle cap device (1) during storage for protection of the injector needle (4) and the contents of the hypodermic device which is removed prior to use. The two-part needle cap device (1) includes a plastic outer casing (5) of hard elastic transparent material which is provided inside with a lining member (6) sealing the tip of the injector needle and made from a soft elastic material. The injector head (2) and the plastic outer casing (5) have a coupling device for making a mechanical stable form-fitting connection and/or a positive-locking connection with a reliable microbiological seal when the injector head (2) is inserted in the outer casing (5). This coupling device is formed by elements on or features of the injector head (2) and outer casing (5). The needle cap according to the invention permits a drop-free removal since the injector head and the form of the needle cap cooperate with and conform to each other so that the tip of the needle injector is released from the lining member (6) only when a pressure inside the outer casing corresponds to the external air pressure.

摘要翻译： 预先填充的一次性皮下注射装置在储存期间必须带有针头装置（1），用于保护注射针（4）和在使用前被移除的皮下注射装置的内容物。 两部分针头装置（1）包括硬质弹性透明材料的塑料外壳（5），其内部设置有密封注射针的尖端并由软弹性材料制成的衬里构件（6）。 注射头（2）和塑料外壳（5）具有联接装置，用于当注射器头（2）插入时，用于形成机械稳定的形状配合连接和/或具有可靠的微生物密封的正锁定连接 外壳（5）。 该联接装置由注射头（2）和外壳（5）上的元件或特征构成。 根据本发明的针帽允许无滴漏去除，因为注射头和针帽的形式彼此配合并相互一致，使得针注射器的尖端仅在 外壳内部的压力对应于外部空气压力。

公开(公告)号：US06960195B2

公开(公告)日：2005-11-01

申请号：US09918405

申请日：2001-07-30

申请人： Jochen Heinz ,  Michael Spallek

发明人： Jochen Heinz ,  Michael Spallek

IPC分类号： A61M5/31 ,  A61M5/315

CPC分类号： A61M5/31511 ,  A61M2005/3121 ,  A61M2005/3123

摘要： A metering receptacle has an elongate hollow body which at one end has a closable exit opening, and which at the other end is closable by way of a plastic plunger stopper. The plunger stopper is at the same time longitudinally displaceable in the hollow body by way of a plunger rod. The metering receptacle is configured such that the plunger stopper is formed of two parts, with a sealing stopper part of plastic which is rigidly positionable in the elongate hollow body and has a centric bore for the passage of the plunger rod, and with a longitudinally displaceable plunger part of lubricious plastic which is connected to the plunger rod.

摘要翻译： 计量插座具有细长的中空本体，其在一端具有可关闭的出口，并且在另一端可通过塑料柱塞止动器关闭。 柱塞止动器同时在中空体中通过柱塞杆纵向移位。 计量接收器构造成使得柱塞止动器由两部分组成，其中塑料的密封止动部分刚性地定位在细长的中空体中并具有用于柱塞杆通过的中心孔，并且具有纵向可移位的 与柱塞杆连接的润滑塑料的柱塞部分。

公开(公告)号：US06719141B2

公开(公告)日：2004-04-13

申请号：US09804438

申请日：2001-03-12

申请人： Jochen Heinz ,  Michael Spallek ,  Arthur Fabian

发明人： Jochen Heinz ,  Michael Spallek ,  Arthur Fabian

IPC分类号： B65D134

CPC分类号： A61M5/008 ,  B01L9/06

摘要： The device for transporting, filling and sterilizing medicinal containers (3) includes a rigid foamed plastic carrier plate (1) provided with a plurality of first openings (2) for receiving the respective containers (3). The first openings have respective open cross-sections adapted to corresponding cross-sections of the containers and the rigid carrier plate (1) has a predetermined thickness, so that the containers (3) are clamped and held fixed in position relative to the carrier plate and centered in the first openings (2) without rattling so that no scratch marks and/or no static charges are produced on the medicinal containers (3) during transport. The rigid foamed plastic carrier plate (1) is provided with a pore-free sealed surface that facilitates sterilization. Second openings (20), which are smaller than the first opening (2) and cannot receive the containers, are also provided in the carrier plate to facilitate sterilization in an autoclave.

摘要翻译： 用于运输，灌装和灭菌药物容器（3）的装置包括：一个刚性泡沫塑料托盘（1），设有多个用于容纳各个容器（3）的第一开口（2）。 第一开口具有适合于容器的相应横截面的相应的开口横截面，并且刚性承载板（1）具有预定厚度，使得容器（3）相对于承载板被夹紧并保持固定就位 并且在第一开口（2）中居中而不发出咔嗒声，使得在运输过程中在药物容器（3）上不产生划痕和/或不产生静电荷。 刚性泡沫塑料载体板（1）设有无孔密封表面，有助于灭菌。 第二开口（20）比第一开口（2）小并且不能容纳容器，也设置在承载板中，以便于高压灭菌器中的灭菌。

公开(公告)号：US06586039B2

公开(公告)日：2003-07-01

申请号：US09915424

申请日：2001-07-26

申请人： Jochen Heinz ,  Michael Spallek

发明人： Jochen Heinz ,  Michael Spallek

IPC分类号： B05D722

CPC分类号： C03C17/30 ,  A61M5/3129 ,  A61M2005/3131 ,  A61M2207/00 ,  B05B13/069 ,  B05C9/14 ,  B05C17/00576 ,  B05D3/067 ,  B05D3/147 ,  B05D5/08

摘要： The process for applying a thermally attached lubricating coating on an interior wall of a cylindrical medicinal container includes applying a thermally attachable lubricant to an interior wall of the container; uniformly spreading or homogenizing the applied lubricant on the wall to form a lubricating coating and thermally attaching the lubricating coating by irradiating the lubricating coating with infrared radiation selectively in a cylindrical region of the container at elevated temperatures above a maximum operating temperature of the container. The apparatus for performing the process includes an insertable spraying device for applying the thermally attachable lubricant (3) to the interior wall of the container (1) from a supply reservoir; a device for homogenizing the lubricant to form the lubricating coating (4) and a rod-shaped infrared radiation source (5) insertable into an interior space of the container. The radiation source has a radiation screen (5a, 6, 7) for keeping the radiation away from the container outlet.

公开(公告)号：US5979714A

公开(公告)日：1999-11-09

申请号：US905937

申请日：1997-08-05

申请人： Erwin Bleile ,  Andreas Geiger ,  Jochen Heinz ,  Reinhard Schluter ,  Michael Spallek ,  Michael Reinhard

发明人： Erwin Bleile ,  Andreas Geiger ,  Jochen Heinz ,  Reinhard Schluter ,  Michael Spallek ,  Michael Reinhard

IPC分类号： B29C45/14 ,  B65D23/08 ,  B65D83/00

CPC分类号： B65D23/0807 ,  B29C45/14778 ,  B29C2045/14163 ,  B29C2045/14877 ,  B29C45/14065 ,  B29K2709/08 ,  B29L2031/7158

摘要： A glass bottle (1) fitted with a narrowed neck (2) which can be filled under pressure with chiefly a medically active substance sprayable by aerosol and with a propellant and which exhibits an opening which may be closed using a dosage valve (5). This glass bottle (1) has a sprayed-on synthetic coating (4) to protect it against shattering and splintering, preventing the user from being injured by the broken bottle. To substantially enhance this safety, the neck (2) of the bottle (1) has been fitted with a bulge like edge (3) at the opening which is also coated with the synthetic material (4) and onto which the dosage valve (5) is mechanically attached by turning. Furthermore, the coating (4) consists of an elastic synthetic material with pronounced increased shrinkage properties used for the summoning of pre-stressing force on the glass body (1) and it exhibits several hole-like pressure relieving openings (7) permitting rapid pressure release in case of shattering.

摘要翻译： 玻璃瓶（1）装有狭窄的颈部（2），其可以在压力下被填充，主要是由气溶胶和推进剂喷射的医疗活性物质，并且其表现出可以使用剂量阀（5）封闭的开口。 该玻璃瓶（1）具有喷涂合成涂层（4），以防止其破碎和碎裂，从而防止使用者被破瓶损坏。 为了大大提高这种安全性，瓶（1）的颈部（2）在开口处已经装有类似凸起的边缘（3），该开口也涂覆有合成材料（4），并且向其上添加剂量阀 ）通过转动机械连接。 此外，涂层（4）由具有明显增加的收缩性质的弹性合成材料组成，用于召集玻璃体（1）上的预应力，并且其表现出几个孔状缓冲开口（7），允许快速压力 释放时发生破裂。

公开(公告)号：US06296893B2

公开(公告)日：2001-10-02

申请号：US09205165

申请日：1998-12-04

申请人： Jochen Heinz ,  Michael Spallek ,  Gerhard Weber

发明人： Jochen Heinz ,  Michael Spallek ,  Gerhard Weber

IPC分类号： B05D300

CPC分类号： A61M5/315 ,  A61L29/085 ,  A61M5/3129 ,  A61M2005/3131 ,  A61M2005/31506 ,  C08L83/04

摘要： The pharmaceutical packing device has a hollow plastic body (1) of axial length (I) and a cylindrical portion (7) extending over at least a part of its axial length and an interior silicone lubricant layer (3) provided on an interior surface of the plastic body in the cylindrical portion (7). The lubricant layer (3) provides a sliding surface for a flexible piston (4) slidably mounted in the hollow plastic body, thus forming an injector device. The silicone lubricant layer (3) is made by a method including preparing a mixture of reactive silicone oil and non-reactive silicone oil, applying this mixture to the interior surface at a temperature of at least 40° C. in a single step without activation of the surface to form a preliminary layer and cross-linking the reactive silicone oil in the preliminary layer to form the silicone lubricant layer.

摘要翻译： 药物包装装置具有轴向长度（I）的中空塑料体（1）和在轴向长度的至少一部分上延伸的圆柱形部分（7）和设置在其内表面上的内部硅润滑剂层（3） 圆柱形部分（7）中的塑料体。 润滑剂层（3）为可滑动地安装在中空塑料体中的柔性活塞（4）提供滑动表面，从而形成喷射器装置。 硅氧烷润滑剂层（3）通过包括制备反应性硅油和非反应性硅油的混合物的方法制备，将该混合物在至少40℃的温度下在单个步骤中将该混合物施加到内表面而不激活 的表面以形成预备层并交联预备层中的反应性硅油以形成硅氧烷润滑剂层。

公开(公告)号：US6117480A

公开(公告)日：2000-09-12

申请号：US168113

申请日：1998-10-08

申请人： Michael Spallek ,  Jochen Heinz ,  Peter Kinast ,  Monika Loffler

发明人： Michael Spallek ,  Jochen Heinz ,  Peter Kinast ,  Monika Loffler

IPC分类号： A61L29/08 ,  A61L31/10 ,  A61M5/32 ,  B05C1/06 ,  A61L31/00 ,  B05D1/18

CPC分类号： A61M5/32 ,  A61L29/085 ,  A61L31/10

摘要： Medical cannulas are typically provided with a silicone coating to improve incision performance. In order to produce a thin, continuous and even coating layer, silicone oil is provided at one side of an elastic foil and the foil is penetrated by the uncoated cannula from an opposite side. During this operation the cannula is wetted by the silicone oil. During withdrawal of the cannula from the foil, excess silicone oil is removed from the cannula and an even, particle-free thin coating which has no bulge- or bead-forming tendency during incision is obtained. Subsequently, the silicone coating is dried.

摘要翻译： 医疗插管通常提供有硅酮涂层以改善切口性能。 为了生产薄而连续且均匀的涂层，在弹性箔的一侧设置有硅油，并且箔从相对侧的未涂覆的套管穿透。 在此操作过程中，套管被硅油润湿。 在将套管从箔中取出时，从插管中取出多余的硅油，并获得在切口期间没有凸起或珠形成倾向的均匀的无颗粒的薄涂层。 随后，将硅氧烷涂层干燥。

公开(公告)号：US06485474B1

公开(公告)日：2002-11-26

申请号：US09715135

申请日：2000-11-20

申请人： Jochen Heinz ,  Michael Spallek

发明人： Jochen Heinz ,  Michael Spallek

IPC分类号： A61M500

CPC分类号： A61M5/3202 ,  A61M5/5086 ,  A61M2005/3109 ,  A61M2005/3118 ,  Y10S128/919

摘要： A cap of a closure arrangement of a prefilled disposable syringe is only removed in advance of utilizing the syringe. The disposable syringe has a syringe body (2, 3) and an injection needle (4) integrated in this body. The closure arrangement includes a stiff plastic cap (5) pushed onto the syringe head (2) and includes a lining (6) in the interior thereof which seals the needle tip. In another syringe type without integrated needle, a connecting cone of a conical connection is formed on the syringe body. The closure arrangement includes an elastomeric closure cap (tip-cap) seated on the connecting cone. The closure cap is covered by a stiff plastic cap connected to the syringe body. In both types of disposable syringes, the plastic cap is welded or cemented while forming a desired break location (7) with the syringe body (2, 3).

摘要翻译： 仅使用注射器之前，仅取出预填充一次性注射器的封闭装置的盖子。 一次性注射器具有一体的注射器主体（2,3）和注射针（4）。 封闭装置包括推到注射器头部（2）上的刚性塑料盖（5），并且在其内部包括密封针尖的内衬（6）。 在没有集成针的另一注射器型中，在注射器主体上形成锥形连接件的连接锥体。 封闭装置包括安置在连接锥体上的弹性体闭合盖（尖端帽）。 封闭盖被连接到注射器主体的刚性塑料盖覆盖。 在两种类型的一次性注射器中，塑料盖被焊接或胶合，同时与注射器主体（2,3）形成期望的断裂位置（7）。

公开(公告)号：US06216922B1

公开(公告)日：2001-04-17

申请号：US09397119

申请日：1999-09-16

申请人： Erwin Bleile ,  Andreas Geiger ,  Jochen Heinz ,  Reinhard Schluter ,  Michael Spallek ,  Michael Reinhard

发明人： Erwin Bleile ,  Andreas Geiger ,  Jochen Heinz ,  Reinhard Schluter ,  Michael Spallek ,  Michael Reinhard

IPC分类号： B65D8300

CPC分类号： B65D23/0807 ,  B29C45/14065 ,  B29C45/14778 ,  B29C2045/14163 ,  B29C2045/14877 ,  B29K2709/08 ,  B29L2031/7158

摘要： The invention consists of a glass bottle (1) fitted with a narrowed neck (2) which can be filled under pressure with chiefly a medically active substance sprayable by aerosol and with a propellant and which exhibits an opening which may be closed using a dosage valve (5). This glass bottle (1) has a sprayed on synthetic coating (4) to protect it against shattering and splintering, preventing the user from being injured by the broken bottle. To substantially enhance this safety, the neck (2) of the bottle (1) has been fitted with a bulge like edge (3) at the opening which is also coated with the synthetic material (4) and onto which the dosage valve (5) is mechanically attached by turning. Furthermore, the coating (4) consists of an elastic synthetic material with pronounced increased shrinkage properties used for the summoning of pre-stressing force on the glass body (1) and it exhibits several hole like pressure relieving openings (7) permitting rapid pressure release in case of shattering.

摘要翻译： 本发明包括一个玻璃瓶（1），它装有一个狭窄的颈部（2），该瓶子可以在压力下被填充，主要是由气溶胶和推进剂喷射的医疗活性物质，并且其表现出可以使用剂量阀 （5）。 该玻璃瓶（1）喷洒在合成涂层（4）上，以防止其破碎和碎裂，从而防止使用者受到破碎的瓶子的伤害。为了大大提高安全性，瓶子（1）的颈部（2） ）在开口处已经装有凸起状的边缘（3），该开口也涂覆有合成材料（4），并且通过转动机械地附接剂量阀（5）。 此外，涂层（4）由弹性合成材料组成，具有明显增加的收缩性能，用于召集玻璃体（1）上的预应力，并且其具有几个孔状缓冲开口（7），允许快速释放压力 在破碎的情况下。

公开(公告)号：US06207112B1

公开(公告)日：2001-03-27

申请号：US09148593

申请日：1998-09-04

申请人： Michael Spallek ,  Jochen Heinz

发明人： Michael Spallek ,  Jochen Heinz

IPC分类号： B01L302

CPC分类号： B01L3/0206 ,  Y10T436/119163 ,  Y10T436/2575

摘要： The piston burette for storing and dispensing a reagent used in analytical or metering work includes a calibrated burette cylinder (11) and a piston (13) slidably mounted in it. The piston burette includes a burette cylinder (11) provided with an outlet opening (12) at one end thereof and made of a plastic material by high precision injection molding with close tolerances, wherein from 10 to 100% by weight of the plastic material is a cycloolefin copolymer (COC); an attachment device (15) for releasable attachment of the burette cylinder to or in a burette apparatus (10); a predetermined amount of the reagent pre-filled in the burette cylinder; a device for retaining the reagent in the burette cylinder (11) including a removable closing cap (18,23) closing the outlet opening (12) at the one end of the burette cylinder; a liquid conducting device for feeding of the reagent from the burette cylinder including a metering tube (19) provided with a connector (21) for connection of the metering tube with the outlet opening (12) of the burette cylinder, when the removable cap is removed, in order to conduct the liquid from the burette cylinder; and a piston (13) slidably mounted in the burette cylinder (11) to close another end of the burette cylinder remote from the one end closed by the closing cap (18).

摘要翻译： 用于存储和分配用于分析或计量工作中的试剂的活塞滴定管包括校准的滴定管筒（11）和可滑动地安装在其中的活塞（13）。 活塞滴定管包括在其一端设置有出口开口（12）并由塑料材料制成的滴定管圆筒（11），该塑料材料通过高精度注射成型具有良好的公差，其中10至100重量％的塑料材料为 环烯烃共聚物（COC）; 用于将滴定管圆筒可释放地连接到或在一个滴定管装置（10）中的连接装置（15）。 预定量的预先装入滴定管筒中的试剂; 用于将试剂保持在滴定管圆筒（11）中的装置，包括在滴定管圆筒的一端封闭出口开口（12）的可移除的封闭盖（18,23） 用于从所述滴定管筒供给试剂的液体传导装置，所述液体导管装置包括设置有连接器（21）的计量管（19），所述计量管（19）用于将所述计量管与所述滴定管圆筒的出口（12）连接， 去除，以便从滴定管筒中导出液体; 以及可滑动地安装在所述滴定管筒（11）中的活塞（13），以将所述滴定筒的另一端远离由所述封闭盖（18）封闭的所述一端。