公开(公告)号：US5979714A

公开(公告)日：1999-11-09

申请号：US905937

申请日：1997-08-05

申请人： Erwin Bleile ,  Andreas Geiger ,  Jochen Heinz ,  Reinhard Schluter ,  Michael Spallek ,  Michael Reinhard

发明人： Erwin Bleile ,  Andreas Geiger ,  Jochen Heinz ,  Reinhard Schluter ,  Michael Spallek ,  Michael Reinhard

IPC分类号： B29C45/14 ,  B65D23/08 ,  B65D83/00

CPC分类号： B65D23/0807 ,  B29C45/14778 ,  B29C2045/14163 ,  B29C2045/14877 ,  B29C45/14065 ,  B29K2709/08 ,  B29L2031/7158

摘要： A glass bottle (1) fitted with a narrowed neck (2) which can be filled under pressure with chiefly a medically active substance sprayable by aerosol and with a propellant and which exhibits an opening which may be closed using a dosage valve (5). This glass bottle (1) has a sprayed-on synthetic coating (4) to protect it against shattering and splintering, preventing the user from being injured by the broken bottle. To substantially enhance this safety, the neck (2) of the bottle (1) has been fitted with a bulge like edge (3) at the opening which is also coated with the synthetic material (4) and onto which the dosage valve (5) is mechanically attached by turning. Furthermore, the coating (4) consists of an elastic synthetic material with pronounced increased shrinkage properties used for the summoning of pre-stressing force on the glass body (1) and it exhibits several hole-like pressure relieving openings (7) permitting rapid pressure release in case of shattering.

摘要翻译： 玻璃瓶（1）装有狭窄的颈部（2），其可以在压力下被填充，主要是由气溶胶和推进剂喷射的医疗活性物质，并且其表现出可以使用剂量阀（5）封闭的开口。 该玻璃瓶（1）具有喷涂合成涂层（4），以防止其破碎和碎裂，从而防止使用者被破瓶损坏。 为了大大提高这种安全性，瓶（1）的颈部（2）在开口处已经装有类似凸起的边缘（3），该开口也涂覆有合成材料（4），并且向其上添加剂量阀 ）通过转动机械连接。 此外，涂层（4）由具有明显增加的收缩性质的弹性合成材料组成，用于召集玻璃体（1）上的预应力，并且其表现出几个孔状缓冲开口（7），允许快速压力 释放时发生破裂。

公开(公告)号：US06216922B1

公开(公告)日：2001-04-17

申请号：US09397119

申请日：1999-09-16

申请人： Erwin Bleile ,  Andreas Geiger ,  Jochen Heinz ,  Reinhard Schluter ,  Michael Spallek ,  Michael Reinhard

发明人： Erwin Bleile ,  Andreas Geiger ,  Jochen Heinz ,  Reinhard Schluter ,  Michael Spallek ,  Michael Reinhard

IPC分类号： B65D8300

CPC分类号： B65D23/0807 ,  B29C45/14065 ,  B29C45/14778 ,  B29C2045/14163 ,  B29C2045/14877 ,  B29K2709/08 ,  B29L2031/7158

摘要： The invention consists of a glass bottle (1) fitted with a narrowed neck (2) which can be filled under pressure with chiefly a medically active substance sprayable by aerosol and with a propellant and which exhibits an opening which may be closed using a dosage valve (5). This glass bottle (1) has a sprayed on synthetic coating (4) to protect it against shattering and splintering, preventing the user from being injured by the broken bottle. To substantially enhance this safety, the neck (2) of the bottle (1) has been fitted with a bulge like edge (3) at the opening which is also coated with the synthetic material (4) and onto which the dosage valve (5) is mechanically attached by turning. Furthermore, the coating (4) consists of an elastic synthetic material with pronounced increased shrinkage properties used for the summoning of pre-stressing force on the glass body (1) and it exhibits several hole like pressure relieving openings (7) permitting rapid pressure release in case of shattering.

摘要翻译： 本发明包括一个玻璃瓶（1），它装有一个狭窄的颈部（2），该瓶子可以在压力下被填充，主要是由气溶胶和推进剂喷射的医疗活性物质，并且其表现出可以使用剂量阀 （5）。 该玻璃瓶（1）喷洒在合成涂层（4）上，以防止其破碎和碎裂，从而防止使用者受到破碎的瓶子的伤害。为了大大提高安全性，瓶子（1）的颈部（2） ）在开口处已经装有凸起状的边缘（3），该开口也涂覆有合成材料（4），并且通过转动机械地附接剂量阀（5）。 此外，涂层（4）由弹性合成材料组成，具有明显增加的收缩性能，用于召集玻璃体（1）上的预应力，并且其具有几个孔状缓冲开口（7），允许快速释放压力 在破碎的情况下。

公开(公告)号：US5878917A

公开(公告)日：1999-03-09

申请号：US678857

申请日：1996-07-12

申请人： Michael Reinhard ,  Ralf Bouffleur ,  Michael Spallek ,  Andreas Geiger

发明人： Michael Reinhard ,  Ralf Bouffleur ,  Michael Spallek ,  Andreas Geiger

IPC分类号： B65D83/14 ,  A61M11/00 ,  A61M15/00 ,  B65D23/08 ,  B65D25/20 ,  B65D25/34 ,  B67D5/64

CPC分类号： A61M15/009

摘要： The invention relates to a device for administering substances at overpressure. The device includes a pressure vessel made of glass and containing a substance to be discharged from the pressure vessel and at least one propellent. The pressure vessel has an opening and an actuable discharge element mounted on the pressure vessel in the opening for releasing the substance from the pressure vessel. A self-supporting housing encloses the pressure vessel and at least a portion of the discharge element to prevent splinters of glass and the discharge element from being propelled away from the device in the event that the pressure vessel bursts. The self-supporting housing has a lower portion made of transparent plastic to facilitate viewing the substance in the pressure vessel.

摘要翻译： 本发明涉及一种用于在超压下给药物质的装置。 该装置包括由玻璃制成并包含要从压力容器排出的物质和至少一个推进剂的压力容器。 压力容器具有安装在开口中的压力容器上的开口和可致动的排放元件，用于将物质从压力容器释放。 在压力容器爆裂的情况下，自支撑壳体包围压力容器和排放元件的至少一部分，以防止玻璃碎片和排放元件被推离远离装置。 自支撑壳体具有由透明塑料制成的下部，以便于观察压力容器中的物质。

公开(公告)号：US5897532A

公开(公告)日：1999-04-27

申请号：US92287

申请日：1998-06-05

申请人： Michael Spallek ,  Andreas Geiger ,  John W. Pellow

发明人： Michael Spallek ,  Andreas Geiger ,  John W. Pellow

IPC分类号： A61M5/31 ,  A61M5/00

CPC分类号： A61M5/3135 ,  A61M2005/3139

摘要： A gripping strip for prefilled disposable syringes having a syringe cylinder. The gripping strip has a gripping strip element formed as a separate synthetic plastic part fixedly mountable on the syringe cylinder, a plate-shaped abutment provided on the gripping strip element and having a hollow cylindrical receptacle with an outer diameter which is adapted to be smaller than an inner diameter of the syringe cylinder, arresting elements provided in a region of an outer surface of the gripping strip element for mounting with the syringe cylinder in a complimentary inner undercut of the syringe cylinder, a safety ring insertable in an interior of the receptacle for maintaining a working connection, the safety ring being connected with the interior of the receptacle of one piece through locations of desired breakage in an unsecured position, so that during placing the syringe cylinder over the receptacle it is displaceable into a securing position. The receptacle has an outer surface which is formed of peripheral portions with gaps therebetween, the arresting elements being arranged in the gaps for a form-locking operative connection with the inner undercut of the syringe cylinder.

摘要翻译： 用于具有注射器筒的预填充一次性注射器的夹持条。 夹持条具有形成为可固定地安装在注射器筒上的单独的合成塑料部分的夹持条状元件，设置在抓持条形元件上的板状邻接件，并且具有中空圆柱形容器，其外径适于小于 注射器筒的内径，设置在夹持条元件的外表面区域中的止动元件，用于将注射器筒安装在注射器筒的互补的内切口中;安全环，可插入到容器的内部， 保持工作连接，安全环通过一个片段的容器的内部连接到处于不安全位置的期望的断裂的位置，使得在将注射器筒放置在容器上方时，其可移位到固定位置。 该容器具有外表面，该外表面由其间具有间隙的周边部分形成，止动元件布置在间隙中，用于与注射器筒的内底切割操作连接。

公开(公告)号：US06599594B1

公开(公告)日：2003-07-29

申请号：US09564758

申请日：2000-05-04

申请人： Marten Walther ,  Andreas Geiger ,  Petra Auchter-Krummel ,  Michael Spallek

发明人： Marten Walther ,  Andreas Geiger ,  Petra Auchter-Krummel ,  Michael Spallek

IPC分类号： B65D2302

CPC分类号： C23C16/045 ,  C03C17/22 ,  C03C17/30 ,  C03C2217/282 ,  C03C2218/153 ,  Y10S215/03 ,  Y10T428/1317 ,  Y10T428/1321

摘要： The glass container stores and preserves pharmaceutical or diagnostic solutions for medicinal purposes. So that the container is free of silicones and other residues, it is provided with an amorphous, transparent anti-adherent coating (4) over its entire interior surface from its bottom over the wall (3) to the closure device (2). This anti-adherent coating (4) is free of heavy metals, free of silicones, is stable after autoclaving at about 120° C. for about 20 min or hot air sterilization for 30 min at 300° C., has a contact angle for wetting with water of ≧80°, contains silicon, oxygen, carbon, fluorine and hydrogen and is deposited by a PECVD method, especially a PICVD method. If the coating contains less than 0.1% by weight fluorine, then it contains greater than or equal to 10% by weight carbon, but if it contains greater than or equal to 0.1% fluorine then it contains greater than or equal to 5% by weight carbon.

摘要翻译： 玻璃容器储存并保存用于药用目的的药物或诊断溶液。 为了使容器不含有机硅和其他残留物，在其整个内表面上从其底部（3）到封闭装置（2）的底部提供无定形透明的抗粘附涂层（4）。 这种抗粘附涂层（4）不含重金属，不含硅氧烷，在约120℃下高压灭菌约20分钟或在300℃热空气灭菌30分钟后是稳定的，具有接触角 用> = 80°的水润湿，含有硅，氧，碳，氟和氢，并通过PECVD法，特别是PICVD法沉积。 如果涂层含有少于0.1重量％的氟，则其含有大于或等于10重量％的碳，但如果其含有大于或等于0.1％的氟，则其含有大于或等于5重量％ 碳。

公开(公告)号：US6156399A

公开(公告)日：2000-12-05

申请号：US23283

申请日：1998-02-13

申请人： Michael Spallek ,  Marten Walther ,  Andreas Geiger

发明人： Michael Spallek ,  Marten Walther ,  Andreas Geiger

IPC分类号： G01N1/00 ,  A61J1/00 ,  A61J1/05 ,  B65D1/00 ,  B65D23/02 ,  C03C3/095 ,  C03C17/22 ,  C03C17/245 ,  B32B17/06 ,  A61B19/00

CPC分类号： B65D23/02 ,  C03C17/245 ,  C03C3/095 ,  A61J1/00 ,  Y10T428/1317

摘要： The invention is a glass container which can be sterilized for medical purposes, including the storage of pharmaceutical or diagnostic products, further including solutions. The container is made from glass containing a stabilizer which inhibits the deleterious effects of high energy radiation, wherein the surface which is in direct contact with the product or solution has a coating that has a thickness of less than 400 nm and is formed from oxides or nitrides of the elements Si, Ti, Ta, AI or a mixture thereof.

摘要翻译： 本发明是一种可以用于医疗目的的灭菌玻璃容器，包括药物或诊断产品的储存，还包括溶液。 容器由含有稳定剂的玻璃制成，该稳定剂抑制高能量辐射的有害影响，其中与产物或溶液直接接触的表面具有厚度小于400nm并由氧化物或 元素Si，Ti，Ta，AI或它们的混合物的氮化物。

公开(公告)号：US5980495A

公开(公告)日：1999-11-09

申请号：US064496

申请日：1998-04-22

申请人： Jochen Heinz ,  Michael Spallek

发明人： Jochen Heinz ,  Michael Spallek

IPC分类号： A61M5/31 ,  A61M5/32 ,  A61M5/00

CPC分类号： A61M5/3202 ,  A61M2005/3109 ,  Y10S128/919

摘要： The pre-filled single-use hypodermic devices must be provided with a needle cap device (1) during storage for protection of the injector needle (4) and the contents of the hypodermic device which is removed prior to use. The two-part needle cap device (1) includes a plastic outer casing (5) of hard elastic transparent material which is provided inside with a lining member (6) sealing the tip of the injector needle and made from a soft elastic material. The injector head (2) and the plastic outer casing (5) have a coupling device for making a mechanical stable form-fitting connection and/or a positive-locking connection with a reliable microbiological seal when the injector head (2) is inserted in the outer casing (5). This coupling device is formed by elements on or features of the injector head (2) and outer casing (5). The needle cap according to the invention permits a drop-free removal since the injector head and the form of the needle cap cooperate with and conform to each other so that the tip of the needle injector is released from the lining member (6) only when a pressure inside the outer casing corresponds to the external air pressure.

摘要翻译： 预先填充的一次性皮下注射装置在储存期间必须带有针头装置（1），用于保护注射针（4）和在使用前被移除的皮下注射装置的内容物。 两部分针头装置（1）包括硬质弹性透明材料的塑料外壳（5），其内部设置有密封注射针的尖端并由软弹性材料制成的衬里构件（6）。 注射头（2）和塑料外壳（5）具有联接装置，用于当注射器头（2）插入时，用于形成机械稳定的形状配合连接和/或具有可靠的微生物密封的正锁定连接 外壳（5）。 该联接装置由注射头（2）和外壳（5）上的元件或特征构成。 根据本发明的针帽允许无滴漏去除，因为注射头和针帽的形式彼此配合并相互一致，使得针注射器的尖端仅在 外壳内部的压力对应于外部空气压力。

公开(公告)号：US06960195B2

公开(公告)日：2005-11-01

申请号：US09918405

申请日：2001-07-30

申请人： Jochen Heinz ,  Michael Spallek

发明人： Jochen Heinz ,  Michael Spallek

IPC分类号： A61M5/31 ,  A61M5/315

CPC分类号： A61M5/31511 ,  A61M2005/3121 ,  A61M2005/3123

摘要： A metering receptacle has an elongate hollow body which at one end has a closable exit opening, and which at the other end is closable by way of a plastic plunger stopper. The plunger stopper is at the same time longitudinally displaceable in the hollow body by way of a plunger rod. The metering receptacle is configured such that the plunger stopper is formed of two parts, with a sealing stopper part of plastic which is rigidly positionable in the elongate hollow body and has a centric bore for the passage of the plunger rod, and with a longitudinally displaceable plunger part of lubricious plastic which is connected to the plunger rod.

摘要翻译： 计量插座具有细长的中空本体，其在一端具有可关闭的出口，并且在另一端可通过塑料柱塞止动器关闭。 柱塞止动器同时在中空体中通过柱塞杆纵向移位。 计量接收器构造成使得柱塞止动器由两部分组成，其中塑料的密封止动部分刚性地定位在细长的中空体中并具有用于柱塞杆通过的中心孔，并且具有纵向可移位的 与柱塞杆连接的润滑塑料的柱塞部分。

公开(公告)号：US06719141B2

公开(公告)日：2004-04-13

申请号：US09804438

申请日：2001-03-12

申请人： Jochen Heinz ,  Michael Spallek ,  Arthur Fabian

发明人： Jochen Heinz ,  Michael Spallek ,  Arthur Fabian

IPC分类号： B65D134

CPC分类号： A61M5/008 ,  B01L9/06

摘要： The device for transporting, filling and sterilizing medicinal containers (3) includes a rigid foamed plastic carrier plate (1) provided with a plurality of first openings (2) for receiving the respective containers (3). The first openings have respective open cross-sections adapted to corresponding cross-sections of the containers and the rigid carrier plate (1) has a predetermined thickness, so that the containers (3) are clamped and held fixed in position relative to the carrier plate and centered in the first openings (2) without rattling so that no scratch marks and/or no static charges are produced on the medicinal containers (3) during transport. The rigid foamed plastic carrier plate (1) is provided with a pore-free sealed surface that facilitates sterilization. Second openings (20), which are smaller than the first opening (2) and cannot receive the containers, are also provided in the carrier plate to facilitate sterilization in an autoclave.

摘要翻译： 用于运输，灌装和灭菌药物容器（3）的装置包括：一个刚性泡沫塑料托盘（1），设有多个用于容纳各个容器（3）的第一开口（2）。 第一开口具有适合于容器的相应横截面的相应的开口横截面，并且刚性承载板（1）具有预定厚度，使得容器（3）相对于承载板被夹紧并保持固定就位 并且在第一开口（2）中居中而不发出咔嗒声，使得在运输过程中在药物容器（3）上不产生划痕和/或不产生静电荷。 刚性泡沫塑料载体板（1）设有无孔密封表面，有助于灭菌。 第二开口（20）比第一开口（2）小并且不能容纳容器，也设置在承载板中，以便于高压灭菌器中的灭菌。

公开(公告)号：US06586039B2

公开(公告)日：2003-07-01

申请号：US09915424

申请日：2001-07-26

申请人： Jochen Heinz ,  Michael Spallek

发明人： Jochen Heinz ,  Michael Spallek

IPC分类号： B05D722

CPC分类号： C03C17/30 ,  A61M5/3129 ,  A61M2005/3131 ,  A61M2207/00 ,  B05B13/069 ,  B05C9/14 ,  B05C17/00576 ,  B05D3/067 ,  B05D3/147 ,  B05D5/08

摘要： The process for applying a thermally attached lubricating coating on an interior wall of a cylindrical medicinal container includes applying a thermally attachable lubricant to an interior wall of the container; uniformly spreading or homogenizing the applied lubricant on the wall to form a lubricating coating and thermally attaching the lubricating coating by irradiating the lubricating coating with infrared radiation selectively in a cylindrical region of the container at elevated temperatures above a maximum operating temperature of the container. The apparatus for performing the process includes an insertable spraying device for applying the thermally attachable lubricant (3) to the interior wall of the container (1) from a supply reservoir; a device for homogenizing the lubricant to form the lubricating coating (4) and a rod-shaped infrared radiation source (5) insertable into an interior space of the container. The radiation source has a radiation screen (5a, 6, 7) for keeping the radiation away from the container outlet.