Optical reader system for substrates having an optically readable code
    3.
    发明授权
    Optical reader system for substrates having an optically readable code 有权
    具有光学可读代码的基板的光学读取器系统

    公开(公告)号:US08333325B2

    公开(公告)日:2012-12-18

    申请号:US13014298

    申请日:2011-01-26

    IPC分类号: G06K7/10

    摘要: An optical reader system including a source light assembly that has a code-reading beam and a fluorescence-excitation beam that are configured to illuminate encoded substrates. The substrates have optically readable codes that provide output signals when the code-reading beam is incident thereon. The output signals are indicative of the codes. The reader system also includes a fluorescence detector that is configured to detect fluorescent signals from the substrates and code pickup optics that are configured to project the output signals from the optically readable codes onto a Fourier plane. The reader system also includes a code detector that is positioned to detect the output signals in the Fourier plane.

    摘要翻译: 一种光学读取器系统,包括具有代码读取光束的源光组件和被配置为照亮编码的基板的荧光激发光束。 衬底具有光学可读代码,当代码读取光束入射时,其提供输出信号。 输出信号表示代码。 读取器系统还包括荧光检测器,其被配置为检测来自基板的荧光信号和被配置为将来自光学可读代码的输出信号投影到傅立叶平面上的代码拾取光学器件。 读取器系统还包括代码检测器,其被定位成检测傅立叶平面中的输出信号。

    Optical reader system for substrates having an optically readable code
    4.
    发明授权
    Optical reader system for substrates having an optically readable code 有权
    具有光学可读代码的基板的光学读取器系统

    公开(公告)号:US07900836B2

    公开(公告)日:2011-03-08

    申请号:US12174490

    申请日:2008-07-16

    IPC分类号: G06K7/10

    摘要: An optical reader system that includes a plurality of substrates. The substrates have an optically readable code disposed therein and a source light assembly that is configured to illuminate the substrates with a code-reading beam and another beam for detecting another optically readable property of the substrate. The code-reading beam and the other beam form beam spots on the substrates that have different shapes. The system also includes a reader that is configured to receive output signals from the code-reading beam and the other beam when the substrates are illuminated. The output signals from the code-reading beam are indicative of the code.

    摘要翻译: 一种包括多个基板的光学读取器系统。 基板具有设置在其中的光学可读代码,以及源光组件,其被配置为用代码读取光束照射基板,另一个光束用于检测基板的另一光学可读性。 代码读取光束和另一个光束在具有不同形状的基板上形成光束点。 该系统还包括读取器,其被配置为当基板被照亮时从代码读取光束和另一个光束接收输出信号。 代码读取波束的输出信号表示代码。

    Methods of identifying an analyte and nucleic acid analysis
    5.
    发明授权
    Methods of identifying an analyte and nucleic acid analysis 有权
    识别分析物和核酸分析的方法

    公开(公告)号:US07843567B2

    公开(公告)日:2010-11-30

    申请号:US12644255

    申请日:2009-12-22

    IPC分类号: G01N21/25

    摘要: A method of identifying an analyte. The method includes providing a plurality of microparticles. The microparticles have optically detectable codes extending along bodies of the corresponding microparticle. The microparticles have the chemical probes attached thereto. Each of the chemical probes is associated with a corresponding one of the codes. The method also includes selectively binding target analytes to the chemical probes on the microparticles to produce labeled microparticles and distributing the labeled microparticles to random locations of a substrate. The method also includes determining the codes for the labeled microparticles in the random array and code positions of the codes in the random array. The method further includes detecting the label on the labeled microparticles in the random array and label positions of the labels in the random array. The method also includes using the code positions and the label positions to analyze the target analyte.

    摘要翻译: 识别分析物的方法。 该方法包括提供多个微粒。 微粒具有沿相应微粒的主体延伸的光学检测码。 微粒具有附着于其上的化学探针。 每个化学探针与相应的一个代码相关联。 该方法还包括将目标分析物选择性地结合到微粒上的化学探针以产生标记的微粒并将标记的微粒分布到基底的随机位置。 该方法还包括确定随机阵列中的标记微粒的代码和随机阵列中代码的代码位置。 该方法还包括随机阵列中标记的微粒上的标记和随机阵列中的标记的标记位置的检测。 该方法还包括使用代码位置和标签位置来分析目标分析物。

    ENCODED MICROPARTICLES
    6.
    发明申请
    ENCODED MICROPARTICLES 有权
    编码麦克风

    公开(公告)号:US20110003394A1

    公开(公告)日:2011-01-06

    申请号:US12876927

    申请日:2010-09-07

    IPC分类号: G01N21/75 B32B5/16 G01N33/00

    摘要: An encoded microparticle including an optical substrate comprising a material that permits light to propagate therethrough. The optical substrate has an elongated body that extends in a direction along a central axis. The optical substrate includes an outer region that extends about the central axis. The encoded microparticle also includes an optically detectable code that is disposed within the optical substrate and extends along the central axis. The outer region surrounds the optically detectable code about the central axis. The optically detectable code is readable when the light propagates through the outer region and is at least one of reflected or filtered by the optically detectable code. Said at least one of reflected or filtered light propagates through the outer region to be detected for reading the optically detectable code.

    摘要翻译: 包含光学基片的编码微粒包括允许光从其中传播的材料。 光学基板具有沿着中心轴线的方向延伸的细长主体。 光学基板包括围绕中心轴线延伸的外部区域。 编码的微粒还包括光学可检测的代码,其设置在光学基底内并沿着中心轴线延伸。 外部区域围绕围绕中心轴的光学检测码。 当光传播通过外部区域并且是由光学可检测的代码反射或过滤的至少一个时,光学可检测的代码是可读的。 所述至少一个反射或滤波的光传播通过待检测的外部区域以读取光学可检测的代码。

    Elongated microparticles having an optically detectable code configured to at least one of reflect or filter light
    7.
    发明授权
    Elongated microparticles having an optically detectable code configured to at least one of reflect or filter light 有权
    具有配置成反射或过滤光中的至少一种的光学可检测代码的细长微粒

    公开(公告)号:US08614852B2

    公开(公告)日:2013-12-24

    申请号:US12876927

    申请日:2010-09-07

    IPC分类号: G02B5/18

    摘要: An encoded microparticle including an optical substrate including a material that permits light to propagate therethrough. The optical substrate has an elongated body that extends in a direction along a central axis. The optical substrate includes an outer region that extends about the central axis. The encoded microparticle also includes an optically detectable code that is disposed within the optical substrate and extends along the central axis. The outer region surrounds the optically detectable code about the central axis. The optically detectable code is readable when the light propagates through the outer region and is at least one of reflected or filtered by the optically detectable code. Said at least one of reflected or filtered light propagates through the outer region to be detected for reading the optically detectable code.

    摘要翻译: 一种编码的微粒,其包括含有允许光从其传播的材料的光学基底。 光学基板具有沿着中心轴线的方向延伸的细长主体。 光学基板包括围绕中心轴线延伸的外部区域。 编码的微粒还包括光学可检测的代码,其设置在光学基底内并沿着中心轴线延伸。 外部区域围绕围绕中心轴的光学检测码。 当光传播通过外部区域并且是由光学可检测的代码反射或过滤的至少一个时,光学可检测的代码是可读的。 所述至少一个反射或滤光的光传播通过待检测的外部区域以读取光学可检测的代码。

    Methods of identifying analytes and using encoded particles
    8.
    发明授权
    Methods of identifying analytes and using encoded particles 有权
    识别分析物和使用编码的粒子的方法

    公开(公告)号:US08049893B2

    公开(公告)日:2011-11-01

    申请号:US12941568

    申请日:2010-11-08

    IPC分类号: G01N21/25

    摘要: A method of identifying analytes that react with probes on encoded particles. The method includes providing a support substrate that has a plurality of the particles randomly distributed on the support substrate. The particles have elongated bodies with codes that extend along the corresponding bodies. The codes identify probes that are attached to the corresponding bodies, wherein at least some of the probes include fluorescent labels from reactions with the analytes. The method also includes detecting fluorescent signals that are emitted from the fluorescent labels. The fluorescent signals emit from random spatial locations along the support substrate. The method also includes detecting the codes of the particles at the random spatial locations along the support substrate and analyzing the codes and the fluorescent signals to identify the analytes that react with the probes on the particles.

    摘要翻译: 识别与编码粒子上的探针反应的分析物的方法。 该方法包括提供具有随机分布在支撑衬底上的多个颗粒的支撑衬底。 颗粒具有细长体,其具有沿相应体部延伸的代码。 代码识别附着于相应体的探针,其中至少一些探针包括与分析物反应的荧光标记。 该方法还包括检测从荧光标记物发射的荧光信号。 荧光信号沿着支撑衬底从随机空间位置发射。 该方法还包括沿着支撑衬底的随机空间位置检测颗粒的代码并分析代码和荧光信号以识别与颗粒上的探针反应的分析物。

    Encoded microparticles and a method for fabricating
    9.
    发明授权
    Encoded microparticles and a method for fabricating 有权
    编码微粒及其制造方法

    公开(公告)号:US07796333B2

    公开(公告)日:2010-09-14

    申请号:US12235834

    申请日:2008-09-23

    IPC分类号: G02B5/18

    摘要: A method for fabricating microparticles. The method includes providing a removable substrate that has a photosensitive material. The substrate has a plurality of inner regions. Each inner region surrounds a corresponding outer region. The method also includes providing at least one optically detectable code within at least one of the inner regions of the substrate and etching lines into the substrate to create a plurality of microparticles having at least one optically detectable code therein. The microparticles have elongated bodies that extend in an axial direction. The optically detectable codes extend in the axial direction within the microparticles.

    摘要翻译: 一种微粒制造方法。 该方法包括提供具有感光材料的可移除基底。 衬底具有多个内部区域。 每个内部区域围绕相应的外部区域。 该方法还包括在衬底的内部区域中的至少一个内部提供至少一个可光学检测的代码,并将蚀刻线蚀刻到衬底中以产生其中具有至少一个光学可检测代码的多个微粒。 微粒具有沿轴向延伸的细长体。 可光学检测的代码沿着微粒内的轴向延伸。