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公开(公告)号：US5690944A
公开(公告)日：1997-11-25
申请号：US359975
申请日：1994-12-20
IPC分类号： A61K8/30 , A61K8/00 , A61K8/06 , A61K8/36 , A61K8/362 , A61K8/365 , A61K8/42 , A61K8/44 , A61K8/46 , A61K8/49 , A61K8/60 , A61K8/68 , A61K31/185 , A61K31/19 , A61K31/195 , A61K31/197 , A61K31/198 , A61K31/44 , A61K31/47 , A61K31/485 , A61K45/06 , A61P17/00 , A61P43/00 , A61Q3/02 , A61Q5/00 , A61Q5/12 , A61Q19/00 , A61Q19/08 , A61K6/00
CPC分类号： A61Q19/08 , A61K31/19 , A61K31/197 , A61K45/06 , A61K8/365 , A61K8/44 , A61K8/46 , A61K8/494 , A61K8/606 , A61K8/68 , A61Q5/00 , A61K2800/782
摘要： Inhibitors of lactate dehydrogenase stimulate keratinocyte proliferation and collagen synthesis in cutaneous tissues. The inhibitors are used preferably with certain co-active ingredients such as pyruvic acid, acetic acid, acetoacetic acid, .beta.-hydroxybutyric acid, a Krebs cycle pathway metabolite, an aliphatic saturated or an unsaturated fatty acid containing from 8 to 26 carbon atoms, an .omega.-hydroxy acid containing from 22 to 34 carbon atoms, glutamic acid, glutamine, valine, alanine, leucine, and mixtures thereof.
摘要翻译： 乳酸脱氢酶抑制剂刺激皮肤组织中的角质形成细胞增殖和胶原合成。 抑制剂优选与某些共活性成分例如丙酮酸，乙酸，乙酰乙酸，β-羟基丁酸，克雷伯循环途径代谢物，含有8至26个碳原子的脂族饱和或不饱和脂肪酸， 含有22至34个碳原子的ω-羟基酸，谷氨酸，谷氨酰胺，缬氨酸，丙氨酸，亮氨酸及其混合物。
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公开(公告)号：US5853742A
公开(公告)日：1998-12-29
申请号：US790409
申请日：1997-01-29
IPC分类号： A61K8/30 , A61K8/00 , A61K8/06 , A61K8/36 , A61K8/362 , A61K8/365 , A61K8/42 , A61K8/44 , A61K8/46 , A61K8/49 , A61K8/60 , A61K8/68 , A61K31/185 , A61K31/19 , A61K31/195 , A61K31/197 , A61K31/198 , A61K31/44 , A61K31/47 , A61K31/485 , A61K45/06 , A61P17/00 , A61P43/00 , A61Q3/02 , A61Q5/00 , A61Q5/12 , A61Q19/00 , A61Q19/08 , A61K7/48
CPC分类号： A61Q19/08 , A61K31/19 , A61K31/197 , A61K45/06 , A61K8/365 , A61K8/44 , A61K8/46 , A61K8/494 , A61K8/606 , A61K8/68 , A61Q5/00 , A61K2800/782
摘要： Inhibitors of lactate dehydrogenase stimulate keratinocyte proliferation and collagen synthesis in cutaneous tissues. The inhibitors are used preferably with certain co-active ingredients such as pyruvic acid, acetic acid, acetoacetic acid, .beta.-hydroxybutyric acid, a Krebs cycle pathway metabolite, an aliphatic saturated or an unsaturated fatty acid containing from 8 to 26 carbon atoms, an .omega.-hydroxy acid containing from 22 to 34 carbon atoms, glutamic acid, glutamine, valine, alanine, leucine, and mixtures thereof.
摘要翻译： 乳酸脱氢酶抑制剂刺激皮肤组织中的角质形成细胞增殖和胶原合成。 抑制剂优选与某些共活性成分例如丙酮酸，乙酸，乙酰乙酸，β-羟基丁酸，克雷伯循环途径代谢物，含有8至26个碳原子的脂族饱和或不饱和脂肪酸， 含有22至34个碳原子的ω-羟基酸，谷氨酸，谷氨酰胺，缬氨酸，丙氨酸，亮氨酸及其混合物。
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公开(公告)号：US10195136B2
公开(公告)日：2019-02-05
申请号：US13216626
申请日：2011-08-24
摘要： Methods and compositions for preventing, ameliorating, or reducing dermatological signs of aging are provided which employ a botanical extract of Justicia ventricosa, Archidendron clypearia, Abrus fruticulosus, or combinations thereof and a cosmetically acceptable vehicle.
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公开(公告)号：US20140065086A1
公开(公告)日：2014-03-06
申请号：US13599631
申请日：2012-08-30
申请人： Uma Santhanam , Qi Hong , Sunghan Yim
发明人： Uma Santhanam , Qi Hong , Sunghan Yim
IPC分类号： A61K8/99 , A61Q7/02 , A61Q19/00 , A61Q19/02 , A61P29/00 , A61P17/02 , A61Q19/08 , A61P25/00 , A61P17/10 , A61K36/06 , A61P17/00
CPC分类号： A61K8/99 , A61K36/06 , A61K36/896 , A61K2236/19 , A61Q7/02 , A61Q19/02 , A61Q19/08 , A61K2300/00
摘要： The present invention relates generally to compositions for topical application to the skin which comprise at least one DICKKOPF-1 expression modulator and the use of such compositions to provide benefits to the skin, including but not limited to lightening or darkening skin; treating hyper or hypopigmented skin; increasing or decreasing skin thickness; reducing or increasing skin hirsuteness; and/or changing skin phenotype from non-palmoplantar to palmoplantar.
摘要翻译： 本发明一般涉及用于局部施用于皮肤的组合物，其包含至少一种DICKKOPF-1表达调节剂以及使用这些组合物来为皮肤提供益处，包括但不限于减轻或变暗的皮肤; 治疗皮肤过度或色素沉着; 增加或减少皮肤厚度; 减少或增加皮肤多毛性; 和/或改变皮肤表型从非掌跖到掌跖。
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公开(公告)号：US20130052288A1
公开(公告)日：2013-02-28
申请号：US13216626
申请日：2011-08-24
CPC分类号： A61K8/97 , A61K36/19 , A61K36/48 , A61Q19/08 , A61K2300/00
摘要： Methods and compositions for preventing, ameliorating, or reducing dermatological signs of aging are provided which employ a botanical extract of Justicia ventricosa, Archidendron clypearia, Abrus fruticulosus, or combinations thereof and a cosmetically acceptable vehicle.
摘要翻译： 提供了用于预防，改善或减少老化皮肤病学症状的方法和组合物，其采用了法蒂西娅（Petricia ventricosa）的植物提取物，西葫芦（Archidendron clypearia）或其组合以及美容上可接受的载体。
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公开(公告)号：US20120003168A1
公开(公告)日：2012-01-05
申请号：US12975415
申请日：2010-12-22
申请人： John W. Lyga , Uma Santhanam , William J. Welsh
发明人： John W. Lyga , Uma Santhanam , William J. Welsh
摘要： The disclosure relates to novel topical lightening compositions a skin depigmenting agent and a vehicle. There is provided a topical lightening composition comprising a substituted-4-oxobutanoic acid, ester, or amide tyrosinase inhibitor, and a vehicle. The depigmenting agents of this disclosure can be used as such or as a pharmaceutically acceptable salt including conventional non-toxic salts which include a metal salt or an alkaline earth metal salt, an ammonium salt, or an organic base salt. The depigmenting agents of this disclosure can be incorporated into any cosmetically-, dermatologically-, or cosmeticatically-acceptable vehicle or carrier normally used for topical application. The compositions and methods of the disclosure are effective to lighten skin, hair, lips, and/or nails.
摘要翻译： 本公开涉及新颖的局部减光组合物皮肤色素沉着剂和载体。 提供了包含取代的-4-氧代丁酸，酯或酰胺酪氨酸酶抑制剂和载体的局部减轻组合物。 本公开的脱色剂可以原样使用或作为药学上可接受的盐使用，包括常规无毒盐，包括金属盐或碱土金属盐，铵盐或有机碱盐。 本公开的脱色剂可以并入通常用于局部应用的美容，皮肤病学或化妆品可接受的载体或载体中。 本公开的组合物和方法有效地减轻皮肤，头发，嘴唇和/或指甲。
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公开(公告)号：US6007829A
公开(公告)日：1999-12-28
申请号：US213496
申请日：1998-12-17
申请人： Ronni Weinkauf , Uma Santhanam , Laura Rose Palanker , Allan Robert Burger , Anthony Vincent Rawlings
发明人： Ronni Weinkauf , Uma Santhanam , Laura Rose Palanker , Allan Robert Burger , Anthony Vincent Rawlings
IPC分类号： A61K8/00 , A61K20060101 , A61K8/30 , A61K8/362 , A61K8/46 , A61K31/194 , A61P17/00 , A61Q17/04 , A61Q19/00 , A61Q19/08 , A61K7/02
CPC分类号： A61Q19/00 , A61K8/362 , A61Q19/004 , A61Q19/007 , A61Q19/08 , A61Q17/04 , Y10S514/937 , Y10S514/938
摘要： Cosmetic skin care compositions containing succinate compounds and cosmetic method of improving the appearance of wrinkled, lined, dry, flaky, aged or photodamaged skin and improving skin thickness, elasticity, flexibility, radiance, glow and plumpness.
摘要翻译： 含有琥珀酸酯化合物的化妆品护肤组合物和改善皱纹，衬里，干燥，片状，老化或光损伤皮肤外观的美容方法，并改善皮肤厚度，弹性，柔韧性，光泽度，发光和丰满度。
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8.发明授权Compositions and methods for stimulation MAGP-1 to improve the appearance of skin 有权用于刺激MAGP-1以改善皮肤外观的组合物和方法公开(公告)号：US09132294B2
公开(公告)日：2015-09-15
申请号：US13158947
申请日：2011-06-13
申请人： Qian Zheng , Siming W. Chen , Uma Santhanam , John W. Lyga
发明人： Qian Zheng , Siming W. Chen , Uma Santhanam , John W. Lyga
CPC分类号： A61K8/97 , A61K8/466 , A61K8/49 , A61K31/5377 , A61K36/185 , A61K36/39 , A61K36/53 , A61K36/74 , A61K45/06 , A61K2800/20 , A61Q19/00 , A61Q19/08
摘要： The present disclosure relates to methods for treating, preventing and improving the condition and aesthetic appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating fine lines and/or wrinkles of skin, by application of one or a combination of natural compounds or extracts that stimulate MAGP-1 expression and which improves the appearance of aged and/or photodamaged skin. The compositions of the invention are topically applied to the skin, or are delivered by directed means to a site in need thereof in an amount effective to improve the condition and aesthetic appearance of skin.
摘要翻译： 本公开内容涉及用于治疗，预防和改善皮肤的状况和美学外观的方法，特别是通过施用一种或其组合来治疗，预防，改善，减少和/或消除皮肤细纹和/或皱纹 刺激MAGP-1表达的天然化合物或提取物，并改善老化和/或光损伤皮肤的外观。 本发明的组合物局部施用于皮肤，或通过定向方式递送至有效改善皮肤状况和美观外观的量的有需要的部位。
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公开(公告)号：US20130224269A1
公开(公告)日：2013-08-29
申请号：US13817570
申请日：2011-11-03
CPC分类号： A61K8/0245 , A61K8/0241 , A61K8/19 , A61K8/64 , A61K2800/412 , A61K2800/624 , A61Q1/02 , A61Q3/02 , A61Q5/00 , A61Q5/065 , A61Q19/00
摘要： An extended wear cosmetic composition for application to a keratinous surface comprising a cosmetic particle coated with a biofunctional polymer wherein said coated particle adheres to the keratinous surface for an extended time period. A delivery system for conjugating a biofunctional polymer and cosmetic particle to specific cells on a keratinous surface such that the particle adheres to the keratinous surface for an extended time period.
摘要翻译： 一种用于角质表面的延长耐磨化妆品组合物，其包含涂覆有生物功能性聚合物的化妆品颗粒，其中所述涂覆的颗粒在角质表面附着较长时间。 用于将生物官能聚合物和化妆品颗粒与角质表面上的特定细胞缀合的递送系统，使得颗粒粘附至角质表面延长时间。
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10.发明申请Use of Eclipta Prostrata and Other PPAR-GAMMA Inhibitors in Cosmetics and Compositions Thereof 有权Eclipta Prostrata和其他PPAR-GAMMA抑制剂在化妆品及其组合物中的应用公开(公告)号：US20110305781A1
公开(公告)日：2011-12-15
申请号：US13115395
申请日：2011-05-25
申请人： Cheng S. Hwang , Uma Santhanam , Manpreet Randhawa
发明人： Cheng S. Hwang , Uma Santhanam , Manpreet Randhawa
IPC分类号： A61K36/28 , A61P3/04 , A61K36/535 , A61Q19/06 , A61K36/734 , A61K36/16
摘要： The present invention describes compositions and methods for improving the appearance of skin, particularly, treating, ameliorating, preventing, delaying, and/or improving one or more signs of excess accumulation and/or production of subcutaneous fat, such as cellulite, and conditions related thereto, by topically applying compositions comprising Eclipta prostrata extracts or other anti-lipid agents.
摘要翻译： 本发明描述了用于改善皮肤外观的组合物和方法，特别是治疗，改善，预防，延迟和/或改善皮肤脂肪过量积聚和/或产生的一种或多种迹象，例如脂肪团和相关条件 通过局部施用包含Eclipta prostrata提取物或其它抗脂质剂的组合物。
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