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    Topical Lightening Composition and Uses Thereof
    1.
    发明申请
    Topical Lightening Composition and Uses Thereof 有权
    局部减光成分及用途

    公开(公告)号：US20120003168A1

    公开(公告)日：2012-01-05

    申请号：US12975415

    申请日：2010-12-22

    申请人： John W. Lyga ,  Uma Santhanam ,  William J. Welsh

    发明人： John W. Lyga ,  Uma Santhanam ,  William J. Welsh

    IPC分类号： A61K8/46 ,  A61Q19/02

    CPC分类号： A61K31/74 ,  A61K8/46 ,  A61Q19/02

    摘要： The disclosure relates to novel topical lightening compositions a skin depigmenting agent and a vehicle. There is provided a topical lightening composition comprising a substituted-4-oxobutanoic acid, ester, or amide tyrosinase inhibitor, and a vehicle. The depigmenting agents of this disclosure can be used as such or as a pharmaceutically acceptable salt including conventional non-toxic salts which include a metal salt or an alkaline earth metal salt, an ammonium salt, or an organic base salt. The depigmenting agents of this disclosure can be incorporated into any cosmetically-, dermatologically-, or cosmeticatically-acceptable vehicle or carrier normally used for topical application. The compositions and methods of the disclosure are effective to lighten skin, hair, lips, and/or nails.

    摘要翻译： 本公开涉及新颖的局部减光组合物皮肤色素沉着剂和载体。 提供了包含取代的-4-氧代丁酸，酯或酰胺酪氨酸酶抑制剂和载体的局部减轻组合物。 本公开的脱色剂可以原样使用或作为药学上可接受的盐使用，包括常规无毒盐，包括金属盐或碱土金属盐，铵盐或有机碱盐。 本公开的脱色剂可以并入通常用于局部应用的美容，皮肤病学或化妆品可接受的载体或载体中。 本公开的组合物和方法有效地减轻皮肤，头发，嘴唇和/或指甲。

    Topical lightening composition and uses thereof
    2.
    发明授权
    Topical lightening composition and uses thereof 有权
    局部减光组合物及其用途

    公开(公告)号：US08329149B2

    公开(公告)日：2012-12-11

    申请号：US12975415

    申请日：2010-12-22

    申请人： John W. Lyga ,  Uma Santhanam ,  William J. Welsh

    发明人： John W. Lyga ,  Uma Santhanam ,  William J. Welsh

    IPC分类号： A61K31/74 ,  A61K8/46

    CPC分类号： A61K31/74 ,  A61K8/46 ,  A61Q19/02

    摘要： The disclosure relates to novel topical lightening compositions a skin depigmenting agent and a vehicle. There is provided a topical lightening composition comprising a substituted-4-oxobutanoic acid, ester, or amide tyrosinase inhibitor, and a vehicle. The depigmenting agents of this disclosure can be used as such or as a pharmaceutically acceptable salt including conventional non-toxic salts which include a metal salt or an alkaline earth metal salt, an ammonium salt, or an organic base salt. The depigmenting agents of this disclosure can be incorporated into any cosmetically-, dermatologically-, or cosmeticatically-acceptable vehicle or carrier normally used for topical application. The compositions and methods of the disclosure are effective to lighten skin, hair, lips, and/or nails.

    摘要翻译： 本公开涉及新颖的局部减光组合物皮肤色素沉着剂和载体。 提供了包含取代的-4-氧代丁酸，酯或酰胺酪氨酸酶抑制剂和载体的局部减轻组合物。 本公开的脱色剂可以原样使用或作为药学上可接受的盐使用，包括常规无毒盐，包括金属盐或碱土金属盐，铵盐或有机碱盐。 本公开的脱色剂可以并入通常用于局部应用的美容，皮肤病学或化妆品可接受的载体或载体中。 本公开的组合物和方法有效地减轻皮肤，头发，嘴唇和/或指甲。