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19 条记录 (耗时 0.025 秒)

    Method for the Characterization of Microorganisms on Solid or Semi-Solid Media
    1.
    发明申请
    Method for the Characterization of Microorganisms on Solid or Semi-Solid Media 有权
    固体或半固体培养基上微生物表征的方法

    公开(公告)号：US20140335558A1

    公开(公告)日：2014-11-13

    申请号：US14444708

    申请日：2014-07-28

    申请人： Jones M. Hyman ,  John D. Walsh ,  Thurman C. Thorpe

    发明人： Jones M. Hyman ,  John D. Walsh ,  Thurman C. Thorpe

    IPC分类号： C12Q1/04

    CPC分类号： C12Q1/04

    摘要： The present invention relates to methods and systems for scanning, detecting, and monitoring microorganisms on solid or semi-solid media using intrinsic fluorescence (IF) measurements. The methods are further directed to detection, characterization and/or identification of microorganisms on a solid or semi-solid media using intrinsic fluorescence (IF) measurements that are characteristic of said microorganisms.

    摘要翻译： 本发明涉及使用固有荧光（IF）测量在固体或半固体培养基上扫描，检测和监测微生物的方法和系统。 所述方法进一步涉及使用所述微生物特征的固有荧光（IF）测量法在固体或半固体培养基上检测，表征和/或鉴定微生物。

    Methods for detecting bacterial pathogens
    2.
    发明授权
    Methods for detecting bacterial pathogens 有权
    检测细菌病原体的方法

    公开(公告)号：US07429464B2

    公开(公告)日：2008-09-30

    申请号：US11006025

    申请日：2004-12-07

    申请人： John D. Walsh ,  Jones M. Hyman

    发明人： John D. Walsh ,  Jones M. Hyman

    IPC分类号： C12Q1/14 ,  C12Q1/04

    CPC分类号： G01N33/56916 ,  C12Q1/04 ,  C12Q1/10 ,  C12Q1/14 ,  G01N33/56938

    摘要： The present invention provides for methods for detecting bacterial pathogens in a sample. A preferred method includes the steps of: suspending a sample comprising a medium and microorganisms, the microorganisms suspected of comprising bacterial pathogens; mixing the sample, an adsorbent and a first solution in a vessel; separating the adsorbent and the microorganisms from the medium and the bulk of the first solution and removing the medium and the bulk of the first solution from the vessel; adding a second solution to the vessel to resuspend the adsorbent and the microorganisms; and detecting agglutination of the adsorbent wherein the agglutination of the adsorbent signifies bacterial pathogens are present in the sample.

    摘要翻译： 本发明提供了检测样品中细菌病原体的方法。 优选的方法包括以下步骤：将包含培养基和微生物的样品悬浮在怀疑包含细菌病原体的微生物中; 将样品，吸附剂和第一溶液混合在容器中; 从介质和大部分第一溶液中分离吸附剂和微生物，并从容器中除去介质和第一溶液的体积; 向容器中加入第二溶液以重新悬浮吸附剂和微生物; 并检测吸附剂的凝集，其中吸附剂的凝集表示细菌病原体存在于样品中。

    Identification and/or characterization of a microbial agent using taxonomic hierarchical classification
    3.
    发明授权
    Identification and/or characterization of a microbial agent using taxonomic hierarchical classification 有权
    使用分类层次分类鉴定和/或表征微生物

    公开(公告)号：US08666673B2

    公开(公告)日：2014-03-04

    申请号：US12800379

    申请日：2010-05-14

    申请人： Michael Ullery ,  Erin Mathias ,  Jones M. Hyman ,  John D. Walsh

    发明人： Michael Ullery ,  Erin Mathias ,  Jones M. Hyman ,  John D. Walsh

    IPC分类号： G01N33/50

    CPC分类号： C12Q1/04 ,  G01N21/6486 ,  G06F19/24

    摘要： A method for identification and/or characterization of a microbial agent present in a sample includes a step of analytical test data (e.g., obtaining intrinsic fluorescence values over a range of emission wavelengths) from the microbial agent. The analytical test data is transformed thereby minimizing strain to strain variations within an organism group. With the aid of a programmed computer, a multi-level classification algorithm coded as a set of processing instructions operates on the transformed analytic test data. The multiple levels correspond to different levels in a taxonomic hierarchy for microbial agents suspected of being in the sample.

    摘要翻译： 用于鉴定和/或表征样品中存在的微生物剂的方法包括从微生物剂中分析测试数据（例如，在发射波长范围内获得固有荧光值）的步骤。 转化分析试验数据，从而使生物体组内的应变变化最小化。 借助编程的计算机，编码为一组处理指令的多级分类算法对转换的分析测试数据进行操作。 多个级别对应于涉嫌在样品中的微生物剂的分类层级中的不同水平。

    System for rapid identification and/or characterization of a microbial agent in a sample
    7.
    发明申请
    System for rapid identification and/or characterization of a microbial agent in a sample 有权
    用于在样品中快速鉴定和/或表征微生物剂的系统

    公开(公告)号：US20100291669A1

    公开(公告)日：2010-11-18

    申请号：US12800388

    申请日：2010-05-14

    申请人： Ronnie J. Robinson ,  Mark S. Wilson ,  Christopher S. Ronsick ,  John D. Walsh ,  Jones M. Hyman ,  Bradford G. Clay

    发明人： Ronnie J. Robinson ,  Mark S. Wilson ,  Christopher S. Ronsick ,  John D. Walsh ,  Jones M. Hyman ,  Bradford G. Clay

    IPC分类号： C12M1/34

    CPC分类号： C12Q1/24 ,  G01N35/0099 ,  G01N35/1079 ,  Y10S901/30

    摘要： An automated instrument for identification and/or characterization of a microbial agent present in a sample. The instrument includes (a) a sample removal apparatus operative to remove a test sample from a specimen container and add the test sample to a disposable separation device; (b) a separation and concentration apparatus operative on the separation device to separate the microbial agent from other components which may be present in the test sample and concentrate the microbial agent within the separation device; and (c) a identification and/or characterization module interrogating the concentrated microbial agent to identify and/or characterize the microbial agent.

    摘要翻译： 用于鉴定和/或表征样品中存在的微生物剂的自动化仪器。 仪器包括（a）样品去除装置，用于从试样容器中取出测试样品，并将测试样品加入到一次性分离装置中; （b）分离和浓缩装置，其在分离装置上操作以将微生物剂与可能存在于测试样品中的其它组分分离，并将微生物剂浓缩在分离装置内; 和（c）识别和/或表征模块，询问浓缩的微生物剂以鉴定和/或表征微生物剂。

    Device for sampling a specimen container
    8.
    发明申请
    Device for sampling a specimen container 有权
    用于取样样品容器的装置

    公开(公告)号：US20100288060A1

    公开(公告)日：2010-11-18

    申请号：US12800392

    申请日：2010-05-14

    申请人： Christopher S. Ronsick ,  Mark S. Wilson ,  Ronnie J. Robinson ,  John D. Walsh ,  Jones M. Hyman

    发明人： Christopher S. Ronsick ,  Mark S. Wilson ,  Ronnie J. Robinson ,  John D. Walsh ,  Jones M. Hyman

    IPC分类号： G01N1/12

    CPC分类号： C12Q1/24 ,  G01N35/0099 ,  G01N35/1079 ,  Y10S901/30

    摘要： A sampling device for a specimen container having a closure sealing the interior of the specimen container from the environment includes a needle, a body coupled to the needle and defining a chamber in fluid communication with the needle, the body further comprising a port forming an opening in the body, the port in fluid communication with the chamber. A multitude of the sampling devices may be stored in a cassette. The sampling devices may include a second chamber for separation and concentration of a microbial agent present in a sample. In this configuration second chamber is connected to the first chamber via a valve or the like.

    摘要翻译： 用于样本容器的采样装置具有将样本容器的内部与环境密封的封闭件，其包括：针头，与所述针头相连并且限定与所述针流体连通的室，所述主体还包括形成开口 在身体中，与腔室流体连通的端口。 多个采样装置可以存储在盒中。 采样装置可以包括用于分离和浓缩样品中存在的微生物剂的第二室。 在该构造中，第二室通过阀等连接到第一室。

    Methods for detecting bacterial pathogens
    9.
    发明授权
    Methods for detecting bacterial pathogens 有权
    检测细菌病原体的方法

    公开(公告)号：US07387883B2

    公开(公告)日：2008-06-17

    申请号：US11005668

    申请日：2004-12-07

    申请人： John D. Walsh ,  Jones M. Hyman

    发明人： John D. Walsh ,  Jones M. Hyman

    IPC分类号： C12Q1/14 ,  C14Q1/04

    CPC分类号： G01N33/56938 ,  C12Q1/14

    摘要： The present invention provides for methods for detecting Staphylococcus aureus in a sample. A preferred method includes the steps of: mixing a sample comprising a medium and microorganisms with a first solution in a vessel, the microorganisms suspected of comprising Staphylococcus aureus; separating the microorganisms from the medium and the bulk of the first solution and removing the medium and the bulk of the first solution from the vessel; adding a second solution to the vessel to resuspend the microorganisms; and detecting Staphylococcus aureus in the resulting suspension of step (c) by using an agglutination test.

    摘要翻译： 本发明提供了在样品中检测金黄色葡萄球菌的方法。 优选的方法包括以下步骤：将包含培养基和微生物的样品与容器中的第一溶液混合，所述微生物怀疑包括金黄色葡萄球菌; 从培养基和大部分第一溶液中分离微生物并从容器中除去介质和第一溶液的体积; 向容器中加入第二溶液以重悬微生物; 并通过使用凝集试验在步骤（c）的所得悬浮液中检测金黄色葡萄球菌。