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    Method of operating ion trap detector in MS/MS mode
    2.
    发明授权
    Method of operating ion trap detector in MS/MS mode 失效
    在MS / MS模式下操作离子阱检测器的方法

    公开(公告)号：US4736101A

    公开(公告)日：1988-04-05

    申请号：US84518

    申请日：1987-08-11

    申请人： John E. P. Syka ,  John N. Louris ,  Paul E. Kelley ,  George C. Stafford ,  Walter E. Reynolds

    发明人： John E. P. Syka ,  John N. Louris ,  Paul E. Kelley ,  George C. Stafford ,  Walter E. Reynolds

    IPC分类号： G01N27/62 ,  G21K1/087 ,  H01J49/42

    CPC分类号： H01J49/424 ,  H01J49/0063 ,  H01J49/0081 ,  H01J49/429

    摘要： A simple and economical method of mass analyzing a sample by means of a quadrupole ion trap mass spectrometer in an MS/MS mode comprises the steps of forming ions within a trap structure, changing the RF and DC voltages in such a way that the ions with mass-to-charge ratios within a desired range will be and remain trapped within the trap structure, dissociating such ions into fragments by collisions and increasing the field intensity again so that the generated fragments will become unstable and exit the trap volume sequentially to be detected. A supplementary AC field may be applied additionally to provide various scan modes as well as dissociate the ions.

    摘要翻译： 以MS / MS模式通过四极离子阱质谱仪对样品进行质量分析的简单而经济的方法包括以下步骤：在捕获结构内形成离子，改变RF和DC电压，使得离子与 在所需范围内的质荷比将被捕获在陷阱结构内，并且通过碰撞将这些离子解离成碎片，并再次增加场强，使得所产生的片段将变得不稳定并顺序地离开陷阱体积以被检测 。 附加的AC场可以另外施加以提供各种扫描模式以及离子离解。

    Mass spectrometry method with two applied trapping fields having same spatial form
    6.
    发明授权
    Mass spectrometry method with two applied trapping fields having same spatial form 失效
    具有两个具有相同空间形式的捕获场的质谱法

    公开(公告)号：US5679951A

    公开(公告)日：1997-10-21

    申请号：US691841

    申请日：1996-08-01

    申请人： Paul E. Kelley ,  John N. Louris

    发明人： Paul E. Kelley ,  John N. Louris

    IPC分类号： H01J49/42

    CPC分类号： H01J49/424 ,  H01J49/4265 ,  H01J49/429

    摘要： A mass spectrometry method in which an improved field comprising two or more trapping fields having substantially identical spatial form is established and at least one parameter of the improved field is changed to excite selected trapped ions sequentially for detection. The changing improved field (preferably with a supplemental field superimposed therewith) can sequentially eject selected ones of the trapped ions from the improved field for detection. An improved field comprising two quadrupole trapping fields can be established in a region defined by the ring and end electrodes of a three-dimensional quadrupole ion trap, and the amplitude of an RF (and/or DC) component (and/or the frequency of the RF component) of one or both trapping fields can be changed to sequentially excite trapped ions. Preferably, a trapping field capable of storing ions having mass to charge ratio within a selected range is established, an improved field is established by superimposing the trapping field with a second trapping field of substantially identical spatial form, and a supplemental field is also superimposed with the trapping field to cause at least some of the trapped ions in the trap region to move away from the center of the trap region.

    摘要翻译： 一种质谱方法，其中建立了包括具有基本上相同的空间形式的两个或更多个俘获场的改进场，改变场的至少一个参数被改变以顺序地激发选定的捕获的离子用于检测。 改变的改变场（优选地与其叠加的补充场）可以顺序地从改进的场中排出被捕获的离子的所选择的一部分用于检测。 可以在由三维四极离子阱的环和端电极限定的区域以及RF（和/或DC）分量的振幅（和/或/或DC）的范围内建立包括两个四极捕获场的改进场 一个或两个捕获场的RF分量）可以改变以顺序地激发捕获的离子。 优选地，能够将具有质荷比的离子存储在选定范围内的俘获场被建立，通过将俘获场与基本上相同的空间形式的第二俘获场叠加来建立改进的场，并且补充场也与 捕获场引起捕获区域中的至少一些捕获的离子离开陷阱区域的中心。

    Mass spectrometry method with two applied trapping fields having the same spatial form
    7.
    发明授权
    Mass spectrometry method with two applied trapping fields having the same spatial form 失效
    具有两个具有相同空间形式的捕获场的质谱法

    公开(公告)号：US5864136A

    公开(公告)日：1999-01-26

    申请号：US879731

    申请日：1997-06-20

    申请人： Paul E. Kelley ,  John N. Louris

    发明人： Paul E. Kelley ,  John N. Louris

    IPC分类号： H01J49/42

    CPC分类号： H01J49/424 ,  H01J49/4265 ,  H01J49/429

    摘要： A mass spectrometry method in which an improved field comprising two or more trapping fields having substantially identical spatial form is established and at least one parameter of the improved field is changed to excite selected trapped ions sequentially for detection. The changing improved field (preferably with a supplemental field superimposed therewith) can sequentially eject selected ones of the trapped ions from the improved field for detection. An improved field comprising two quadrupole trapping fields can be established in a region defined by the ring and end electrodes of a three-dimensional quadrupole ion trap, and the amplitude of an RF (and/or DC) component (and/or the frequency of the RF component) of one or both trapping fields can be changed to sequentially excite trapped ions. Preferably, a trapping field capable of storing ions having mass to charge ratio within a selected range is established, an improved field is established by superimposing the trapping field with a second trapping field of substantially identical spatial form, and a supplemental field is also superimposed with the trapping field to cause at least some of the trapped ions in the trap region to move away from the center of the trap region.

    摘要翻译： 一种质谱方法，其中建立了包括具有基本上相同的空间形式的两个或更多个俘获场的改进场，改变场的至少一个参数被改变以顺序地激发选定的捕获的离子用于检测。 改变的改变场（优选地与其叠加的补充场）可以顺序地从改进的场中排出被捕获的离子的所选择的一部分用于检测。 可以在由三维四极离子阱的环和端电极限定的区域以及RF（和/或DC）分量的振幅（和/或/或DC）的范围内建立包括两个四极捕获场的改进场 一个或两个捕获场的RF分量）可以改变以顺序地激发捕获的离子。 优选地，能够将具有质荷比的离子存储在选定范围内的俘获场被建立，通过将俘获场与基本上相同的空间形式的第二俘获场叠加来建立改进的场，并且补充场也与 捕获场引起捕获区域中的至少一些捕获的离子离开陷阱区域的中心。

    Mass spectrometry method with two applied quadrupole fields
    8.
    发明授权
    Mass spectrometry method with two applied quadrupole fields 失效
    两种应用四极场的质谱法

    公开(公告)号：US5561291A

    公开(公告)日：1996-10-01

    申请号：US409322

    申请日：1995-03-23

    申请人： Paul E. Kelley ,  John N. Louris

    发明人： Paul E. Kelley ,  John N. Louris

    IPC分类号： H01J49/42

    CPC分类号： H01J49/424 ,  H01J49/4265 ,  H01J49/429

    摘要： A mass spectrometry method in which an improved field comprising two or more trapping fields having substantially identical spatial form is established and at least one parameter of the improved field is changed to excite selected trapped ions sequentially for detection. The changing improved field (preferably with a supplemental field superimposed therewith) can sequentially eject selected ones of the trapped ions from the improved field for detection. An improved field comprising two quadrupole trapping fields can be established in a region defined by the ring and end electrodes of a three-dimensional quadrupole ion trap, and the amplitude of an RF (and/or DC) component (and/or the frequency of the RF component) of one or both trapping fields can be changed to sequentially excite trapped ions. Preferably, a trapping field capable of storing ions having mass to charge ratio within a selected range is established, an improved field is established by superimposing the trapping field with a second trapping field of substantially identical spatial form, and a supplemental field is also superimposed with the trapping field to cause at least some of the trapped ions in the trap region to move away from the center of the trap region.

    摘要翻译： 一种质谱方法，其中建立了包括具有基本上相同的空间形式的两个或更多个俘获场的改进场，改变场的至少一个参数被改变以顺序地激发选定的捕获的离子用于检测。 改变的改变场（优选地与其叠加的补充场）可以顺序地从改进的场中排出被捕获的离子的所选择的一部分用于检测。 可以在由三维四极离子阱的环和端电极限定的区域以及RF（和/或DC）分量的振幅（和/或/或DC）的范围内建立包括两个四极捕获场的改进场 一个或两个捕获场的RF分量）可以改变以顺序地激发捕获的离子。 优选地，能够将具有质荷比的离子存储在选定范围内的俘获场被建立，通过将俘获场与基本上相同的空间形式的第二俘获场叠加来建立改进的场，并且补充场也与 捕获场引起捕获区域中的至少一些捕获的离子离开陷阱区域的中心。

    Mass spectrometry method with two applied trapping fields having same spatial form
    9.
    发明授权
    Mass spectrometry method with two applied trapping fields having same spatial form 失效
    具有两个具有相同空间形式的捕获场的质谱法

    公开(公告)号：US5436445A

    公开(公告)日：1995-07-25

    申请号：US252436

    申请日：1994-05-31

    申请人： Paul E. Kelley ,  John N. Louris

    发明人： Paul E. Kelley ,  John N. Louris

    IPC分类号： H01J49/42

    CPC分类号： H01J49/424 ,  H01J49/4265 ,  H01J49/429

    摘要： A mass spectrometry method in which an improved field comprising two or more trapping fields having substantially identical spatial form is established and at least one parameter of the improved field is changed to excite selected trapped ions sequentially for detection. The changing improved field (preferably with a supplemental field superimposed therewith) can sequentially eject selected ones of the trapped ions from the improved field for detection. An improved field comprising two quadrupole trapping fields can be established in a region defined by the ring and end electrodes of a three-dimensional quadrupole ion trap, and the amplitude of an RF (and/or DC) component (and/or the frequency of the RF component) of one or both trapping fields can be changed to sequentially excite trapped ions. Preferably, a trapping field capable of storing ions having mass to charge ratio within a selected range is established, an improved field is established by superimposing the trapping field with a second trapping field of substantially identical spatial form, and a supplemental field is also superimposed with the trapping field to cause at least some of the trapped ions in the trap region to move away from the center of the trap region.

    摘要翻译： 一种质谱方法，其中建立了包括具有基本上相同的空间形式的两个或更多个俘获场的改进场，改变场的至少一个参数被改变以顺序地激发选定的捕获的离子用于检测。 改变的改变场（优选地与其叠加的补充场）可以顺序地从改进的场中排出被捕获的离子的所选择的一部分用于检测。 可以在由三维四极离子阱的环和端电极限定的区域以及RF（和/或DC）分量的振幅（和/或/或DC）的范围内建立包括两个四极捕获场的改进场 一个或两个捕获场的RF分量）可以改变以顺序地激发捕获的离子。 优选地，能够将具有质荷比的离子存储在选定范围内的俘获场被建立，通过将俘获场与基本上相同的空间形式的第二俘获场叠加来建立改进的场，并且补充场也与 捕获场引起捕获区域中的至少一些捕获的离子离开陷阱区域的中心。

    Method of mass analyzing a sample by use of a quadrupole ion trap
    10.
    发明授权
    Method of mass analyzing a sample by use of a quadrupole ion trap 失效
    通过使用四极离子阱对样品进行质量分析的方法

    公开(公告)号：US4540884A

    公开(公告)日：1985-09-10

    申请号：US454351

    申请日：1982-12-29

    申请人： George C. Stafford ,  Paul E. Kelley ,  David R. Stephens

    发明人： George C. Stafford ,  Paul E. Kelley ,  David R. Stephens

    IPC分类号： H01J49/38 ,  G01N27/62 ,  H01J49/42 ,  B01D59/44

    CPC分类号： H01J49/424 ,  H01J49/429

    摘要： In a quadrupole ion store or ion trap type mass spectometer, significantly improved mass selection is achieved by simultaneously trapping ions within the mass range of interest and then scanning the applied RF and DC voltages or the frequency .omega. to sequentially render unstable trapped ions of consecutive specific masses. These are passed out through apertures in an end cap to a high gain electron multiplier to provide a signal indicative of the ion mass. Sensitivity and mass resolution is also enhanced by operating the ion trap at a relatively high pressure in the range 1.times.10.sup.-1 to 1.times.10.sup.-5 torr. The presence of collision gas molecules, such as helium, improves sensitivity and mass resolution. In addition, the structure itself is built of stacked units, sealed by O-rings, which are easily disassembled for cleaning.

    摘要翻译： 在四极离子存储或离子阱型质谱仪中，通过在感兴趣的质量范围内同时捕获离子然后扫描所施加的RF和DC电压或频率ω，来实现显着改进的质量选择，以顺序地呈现连续特定的不稳定捕获的离子 群众 它们通过端盖中的孔传递到高增益电子倍增器，以提供指示离子质量的信号。 通过在1x10-1至1×10-5乇范围内的较高压力下操作离子阱也可以提高灵敏度和质量分辨率。 碰撞气体分子（如氦气）的存在提高了灵敏度和质量分辨率。 此外，结构本身由堆叠单元构成，由O型圈密封，易于拆卸清洁。