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公开(公告)号：US20050065075A1
公开(公告)日：2005-03-24
申请号：US10478811
申请日：2002-05-31
申请人： John Erickson , Dominique Bridon , Martin Robitaille , Grant Krafft , Dong Xie , Elena Afonina , Jun Liang , Sandra DeMeyer
发明人： John Erickson , Dominique Bridon , Martin Robitaille , Grant Krafft , Dong Xie , Elena Afonina , Jun Liang , Sandra DeMeyer
IPC分类号： A61K47/48 , A61K38/00 , A61P31/14 , A61P31/18 , C07K1/113 , C07K14/00 , C07K14/16 , A61K38/16 , C07K14/47
CPC分类号： C07K14/005 , A61K38/00 , C07K2319/00 , C12N2740/16122
摘要： The present invention relates to C34 peptide derivatives that are inhibitors of viral infection and/or exhibit antifusogenic properties. In particular, this invention relates to C34 derivatives having inhibiting activity against human immunodeficiency virus (HIV), respiratory syncytial virus (RSV), human parainfluenza virus (HPV), measles virus (MeV), and simian immunodeficiency virus (SIV) with long duration of action for the treatment of the respective viral infections.
摘要翻译： 本发明涉及作为病毒感染抑制剂和/或显示抗融合性质的C34肽衍生物。 特别地，本发明涉及具有长期持续时间的针对人免疫缺陷病毒（HIV），呼吸道合胞病毒（RSV），人副流感病毒（HPV），麻疹病毒（MeV）和猿猴免疫缺陷病毒（SIV））具有抑制活性的C34衍生物 的治疗各自病毒感染的作用。
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公开(公告)号：US07741453B2
公开(公告)日：2010-06-22
申请号：US10478811
申请日：2002-05-31
申请人： John W. Erickson , Dominique P. Bridon , Martin Robitaille , Grant A. Krafft , Dong Xie , Elena Afonina , Jun Liang , Sandra DeMeyer
发明人： John W. Erickson , Dominique P. Bridon , Martin Robitaille , Grant A. Krafft , Dong Xie , Elena Afonina , Jun Liang , Sandra DeMeyer
IPC分类号： C08H1/00
CPC分类号： C07K14/005 , A61K38/00 , C07K2319/00 , C12N2740/16122
摘要： The present invention relates to C34 peptide derivatives that are inhibitors of viral infection and/or exhibit antifusogenic properties. In particular, this invention relates to C34 derivatives having inhibiting activity against human immunodeficiency virus (HIV), respiratory syncytial virus (RSV), human parainfluenza virus (HPV), measles virus (MeV), and simian immunodeficiency virus (SIV) with long duration of action for the treatment of the respective viral infections.
摘要翻译： 本发明涉及作为病毒感染抑制剂和/或显示抗融合性质的C34肽衍生物。 特别地，本发明涉及具有长期持续时间的针对人免疫缺陷病毒（HIV），呼吸道合胞病毒（RSV），人副流感病毒（HPV），麻疹病毒（MeV）和猿猴免疫缺陷病毒（SIV））具有抑制活性的C34衍生物 的治疗各自病毒感染的作用。
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公开(公告)号：US20110166061A1
公开(公告)日：2011-07-07
申请号：US12767646
申请日：2010-04-26
申请人： John W. Erickson , Dominique P. Bridon , Martin Robitaille , Grant A. Krafft , Dong Xie , Elena Afonina , Jun Liang , Sandra De Meyer
发明人： John W. Erickson , Dominique P. Bridon , Martin Robitaille , Grant A. Krafft , Dong Xie , Elena Afonina , Jun Liang , Sandra De Meyer
CPC分类号： C07K14/005 , A61K38/00 , C07K2319/00 , C12N2740/16122
摘要： The present invention is concerned with This invention relates to C34 peptide derivatives that are inhibitors of viral infection and/or exhibit antifusogenic properties. In particular, this invention relates to C34 derivatives having inhibiting activity against human immunodeficiency virus (HIV), respiratory syncytial virus (RSV), human parainfluenza virus (HPV), measles virus (MeV), and simian immunodeficiency virus (SIV) with long duration of action for the treatment of the respective viral infections.
摘要翻译： 本发明涉及作为病毒感染抑制剂和/或表现出抗融合性质的C34肽衍生物。 特别地，本发明涉及具有长期持续时间的针对人免疫缺陷病毒（HIV），呼吸道合胞病毒（RSV），人副流感病毒（HPV），麻疹病毒（MeV）和猿猴免疫缺陷病毒（SIV））具有抑制活性的C34衍生物 的治疗各自病毒感染的作用。
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公开(公告)号：US20050176641A1
公开(公告)日：2005-08-11
申请号：US11040810
申请日：2005-01-21
申请人： Peter Bakis , Dominique Bridon , Julie Carette , France Leclaire , Roger Leger , Martin Robitaille
发明人： Peter Bakis , Dominique Bridon , Julie Carette , France Leclaire , Roger Leger , Martin Robitaille
CPC分类号： A61K38/2242 , A61K47/62
摘要： This invention relates to long lasting natriuretic peptide (NP) derivatives. The NP derivative has a NP peptide and a reactive entity coupled to the NP peptide. The reactive entity is able to covalently bond with a functionality on a blood component. In particular, this invention relates to NP derivatives having an extended in vivo half-life, and method for the treatment of cardiovascular diseases and disorders such as acute decompensated congestive heart failure (CHF) and chronic CHF.
摘要翻译： 本发明涉及长效利钠肽（NP）衍生物。 NP衍生物具有NP肽和与NP肽偶联的反应性实体。 反应性实体能够与血液成分上的官能团共价键合。 特别地，本发明涉及具有延长的体内半衰期的NP衍生物，以及用于治疗心血管疾病和疾病如急性失代偿性充血性心力衰竭（CHF）和慢性CHF的方法。
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公开(公告)号：US20060241019A1
公开(公告)日：2006-10-26
申请号：US10565900
申请日：2004-07-26
CPC分类号： A61K38/28 , A61K47/643 , C07K14/62
摘要： The present invention relates to an insulin derivative comprising an insulin molecule and a reactive group for covalently bonding a blood component, wherein preferably the insulin molecule is human natural insulin molecule and the reactive group is coupled to an amino acid of the insulin molecule at a position selected from the positions Gly A1, Phe B1 and Lys B29.
摘要翻译： 本发明涉及包含胰岛素分子和用于共价键合血液成分的反应性基团的胰岛素衍生物，其中优选地，胰岛素分子是人天然胰岛素分子，并且反应性基团与胰岛素分子的氨基酸在位置 选自Gly A1，Phe B1和Lys B29。
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公开(公告)号：US20050176643A1
公开(公告)日：2005-08-11
申请号：US11067556
申请日：2005-02-25
申请人： Dominique Bridon , Roger Leger , Xicai Huang , Karen Thibaudeau , Martin Robitaille , Peter Milner
发明人： Dominique Bridon , Roger Leger , Xicai Huang , Karen Thibaudeau , Martin Robitaille , Peter Milner
CPC分类号： C07K14/57545 , A61K38/00 , C07K19/00 , C07K2319/01
摘要： The present invention relates to a compound comprising a PYY peptide or a functional derivative thereof, which is coupled to a reactive group. Such a reactive group is capable of reacting on a blood component so as to form a stable covalent bond therewith. The present invention also relates to a conjugate comprising such a compound which is covalently bonded to a blood component. Moreover, the invention also relates to a method of enhancing, in a patient, the anti-obesity activity of a PYY peptide or functional derivative thereof.
摘要翻译： 本发明涉及包含与反应性基团偶联的PYY肽或其功能性衍生物的化合物。 这样的反应性基团能够对血液成分进行反应，与其形成稳定的共价键。 本发明还涉及包含共价键合到血液成分上的化合物的缀合物。 此外，本发明还涉及在患者中增强PYY肽或其功能性衍生物的抗肥胖活性的方法。
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公开(公告)号：US20050070475A1
公开(公告)日：2005-03-31
申请号：US10950010
申请日：2004-09-24
IPC分类号： A61K38/00 , A61P31/12 , A61P31/16 , A61P31/18 , C07K14/00 , C07K14/155 , C07K14/16 , A61K38/17 , C07K14/47
CPC分类号： C07K14/005 , A61K38/00 , C12N2740/16122
摘要： Peptides exhibiting anti-viral and anti-fusogenic activity are modified to provide greater stability and improved half-life in vivo. The selected peptides include fusion inhibitors DP178 and DP107 and related peptides and analogs thereof. The modified peptides are capable of forming covalent bonds with one or more blood components, preferably a mobile blood component.
摘要翻译： 展示抗病毒和抗融合活性的肽被修饰以提供更大的稳定性和改善的体内半衰期。 所选择的肽包括融合抑制剂DP178和DP107及其相关肽及其类似物。 修饰的肽能够与一种或多种血液成分，优选移动血液成分形成共价键。
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8.发明申请Long lasting glucagon-like peptide 2 (GLP-2) for the treatment of gastrointestinal diseases and disorders 失效持久的胰高血糖素样肽2（GLP-2）用于治疗胃肠道疾病和病症公开(公告)号：US20060217304A1
公开(公告)日：2006-09-28
申请号：US11318323
申请日：2005-12-23
申请人： Dominique Bridon , Nissab Boudjellab , Roger Leger , Martin Robitaille , Karen Thibaudeau , Julie Carette
发明人： Dominique Bridon , Nissab Boudjellab , Roger Leger , Martin Robitaille , Karen Thibaudeau , Julie Carette
IPC分类号： A61K38/26 , C07K14/605
CPC分类号： C07K14/605 , A61K38/26 , A61K38/38 , A61K47/643 , C07K2319/00 , A61K2300/00
摘要： This invention relates to glucagon-like peptide 2 (GLP-2) derivatives. In particular, this invention relates to GLP-2 peptide derivatives having an extended in vivo half-life, for the treatment or prevention of gastrointestinal disorders or diseases such as inflammatory bowel disease and other gastrointestinal functions, from any segment of the gastrointestinal tract, from the oesophagus to the anus.
摘要翻译： 本发明涉及胰高血糖素样肽2（GLP-2）衍生物。 特别地，本发明涉及具有延长的体内半衰期的GLP-2肽衍生物，用于治疗或预防胃肠道疾病或疾病如炎症性肠病和其他胃肠功能，从胃肠道的任何部分，从 食道到肛门。
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9.发明申请公开(公告)号：US20100000686A1
公开(公告)日：2010-01-07
申请号：US12166947
申请日：2008-07-02
申请人： Martin Robitaille , Steve Gagnon
发明人： Martin Robitaille , Steve Gagnon
CPC分类号： B65H59/04 , B65H2701/37 , B65H2701/375
摘要： The present invention discloses a roll holder for tape dispenser and a tape dispenser assembly therewith. The roll holder comprises a cylindrical body and an annular portion made from a material having a high friction coefficient, the annular portion being fixed inside the cylindrical body. The roll holder tape dispenser is supported by a shaft. Two cylindrical bodies are connected to a roll of tape, one at each extremity of the tape spool by press-fitting. The shaft passes through the annular portion and the friction occurring between the shaft and annular portion induce a tension in the tape when the tape is unwound from the roll.
摘要翻译： 本发明公开了一种用于胶带分配器的卷筒保持器和一个带分配器组件。 辊保持器包括圆筒体和由具有高摩擦系数的材料制成的环形部分，环形部分固定在圆柱体内。 卷筒胶带分配器由轴支撑。 两个圆柱体连接到一卷胶带，一个通过压配合在带卷轴的每个末端。 轴通过环形部分，并且当带从卷上展开时，在轴和环形部分之间产生的摩擦引起带中的张力。
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10.发明授权Long-lasting antiviral fusion inhibitor peptide conjugates comprising albumin and human immunodeficiency virus (HIV) peptides 失效包含白蛋白和人类免疫缺陷病毒（HIV）肽的长效抗病毒融合抑制剂肽缀合物公开(公告)号：US07582301B1
公开(公告)日：2009-09-01
申请号：US09623533
申请日：2000-05-17
申请人： Dominique P. Bridon , Robert P. Dufresne , Nissab Boudjellab , Martin Robitaille , Peter G. Milner
发明人： Dominique P. Bridon , Robert P. Dufresne , Nissab Boudjellab , Martin Robitaille , Peter G. Milner
IPC分类号： A61K39/385 , A61K39/21
CPC分类号： C07K14/005 , A61K38/00 , C12N2740/16122
摘要： Peptides exhibiting anti-viral and anti-fusogenic activity are modified to provide greater stability and improved half-life in vivo. The selected peptides include fusion inhibitors DP178 and DP107 and related peptides and analogs thereof. The modified peptides are capable of forming covalent bonds with one or more blood components, preferably a mobile blood component.
摘要翻译： 展示抗病毒和抗融合活性的肽被修饰以提供更大的稳定性和改善的体内半衰期。 所选择的肽包括融合抑制剂DP178和DP107及其相关肽及其类似物。 修饰的肽能够与一种或多种血液成分，优选移动血液成分形成共价键。
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