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34 条记录 (耗时 0.042 秒)

    Anti-fusion assay
    5.
    发明申请
    Anti-fusion assay 审中-公开
    抗融合测定

    公开(公告)号：US20050208678A1

    公开(公告)日：2005-09-22

    申请号：US10490716

    申请日：2002-09-27

    申请人： Dong Xie ,  John Erickson ,  Paul Grulich

    发明人： Dong Xie ,  John Erickson ,  Paul Grulich

    IPC分类号： A61K45/00 ,  A61P31/18 ,  C07K7/00 ,  C07K14/47 ,  G01N27/447 ,  G01N33/15 ,  G01N33/48 ,  G01N33/50 ,  G01N33/561 ,  G01N33/569 ,  G01N33/68 ,  G06F19/00

    CPC分类号： G01N33/56988 ,  G01N33/6803 ,  G01N2333/162 ,  G01N2500/02

    摘要： Methods of identifying a fusion inhibitor and inhibitors of gp41-mediated membrane fusion are disclosed. The methods comprise, for example, providing a first helical polypeptide comprising a sequence of IQN17 (SEQ ID NO: 1); providing a second helical polypeptide of 34 or less than 34 amino acids comprising the amino acid sequence W-X1-X2-W-X3-X4-X5-I, wherein X1, X2, X3, X4, and X5 are each independently chosen from any amino acid except proline; measuring, by capillary zone electrophoresis, the degree of complex formation between these peptides; and comparing the measured degree of complex formation to the degree in the presence of a test composition.

    摘要翻译： 公开了鉴定融合抑制剂和gp41介导的膜融合抑制剂的方法。 所述方法包括例如提供包含IQN17（SEQ ID NO：1）序列的第一螺旋多肽; 提供包含氨基酸序列W-X1-X2-W-X3-X4-X5-I的34个或小于34个氨基酸的第二螺旋多肽，其中X1，X2，X3，X4和X5各自独立地选自 除脯氨酸以外的任何氨基酸; 通过毛细管区带电泳测量这些肽之间的复合物形成程度; 并将测量的复合物形成程度与存在测试组合物的程度进行比较。

    Encrypting and decrypting a data stream
    6.
    发明授权
    Encrypting and decrypting a data stream 有权
    加密和解密数据流

    公开(公告)号：US08121288B2

    公开(公告)日：2012-02-21

    申请号：US12250144

    申请日：2008-10-13

    申请人： Dong Xie ,  Rong Yan ,  Jian Zhang

    发明人： Dong Xie ,  Rong Yan ,  Jian Zhang

    IPC分类号： H04K1/04 ,  H04L9/00 ,  H04L9/32 ,  G06F11/30

    CPC分类号： H04N21/44055 ,  H04L9/0637 ,  H04L9/088 ,  H04L29/06027 ,  H04L65/607 ,  H04N7/1675 ,  H04N21/23476

    摘要： The present invention provides methods, systems and apparatus for encrypting and for decrypting a data stream, for securely sending a data stream and for securely receiving a data stream, and for secure transmission of a data stream. The data stream, after at least a part of it being encrypted, is transmitted from a sender to a receiver via a channel. An exemplary method for encrypting comprises: adjusting encryption attributes during transmission; encrypting the data stream according to the adjusted encryption attributes; and transmitting the encrypted data stream and information of the encryption attributes to the receiver.

    摘要翻译： 本发明提供了用于加密和解密数据流的方法，系统和装置，用于安全地发送数据流和用于安全地接收数据流以及数据流的安全传输。 数据流在其至少一部分被加密之后，经由信道从发送者发送到接收者。 一种用于加密的示例性方法包括：在传输期间调整加密属性; 根据调整后的加密属性加密数据流; 并将加密的数据流和加密属性的信息发送到接收机。

    METHOD AND SYSTEM FOR REORDERING THE REQUEST QUEUE OF A HARDWARE ACCELERATOR
    7.
    发明申请
    METHOD AND SYSTEM FOR REORDERING THE REQUEST QUEUE OF A HARDWARE ACCELERATOR 审中-公开
    用于重新加密硬件加速器的请求队列的方法和系统

    公开(公告)号：US20110276737A1

    公开(公告)日：2011-11-10

    申请号：US13091511

    申请日：2011-04-21

    申请人： Xiaolu Mei ,  Dong Xie ,  Jun Zheng ,  Xiaotao Chang ,  Kuan Feng

    发明人： Xiaolu Mei ,  Dong Xie ,  Jun Zheng ,  Xiaotao Chang ,  Kuan Feng

    IPC分类号： G06F13/12

    CPC分类号： G06F9/3881

    摘要： The invention discloses a system and method for reordering the request queue of the hardware accelerator, wherein, the request queue stores therein a plurality of coprocessor request blocks (CRBs) to be input into the hardware accelerator. The system including: content addressable memory connected to the request queue for storing the state pointer of each CRB in the request queue at a same physical storage location in the request queue, receiving the state pointer of a new CRB in response to the new CRB asking to join in the request queue and outputting the physical storage location of a CRB in the request queue whose state pointer stored in the content addressable memory is the same as the state pointer of the new CRB; and CRB insertion module for receiving the physical storage location of a CRB in the request queue whose state pointer is the same as the state pointer of the new CRB and inputting the new CRB in the request queue and the CRB in the request queue whose state pointer is the same as the state pointer of the new CRB adjacently into the hardware accelerator in the order of entering the request queue. The system and method can improve the process efficiency of the hardware accelerator.

    摘要翻译： 本发明公开了一种用于对硬件加速器的请求队列进行重新排序的系统和方法，其中，请求队列中存储要输入硬件加速器的多个协处理器请求块（CRB）。 该系统包括：连接到请求队列的内容寻址存储器，用于将请求队列中的每个CRB的状态指针存储在请求队列中的相同物理存储位置处，响应于新的CRB请求接收新CRB的状态指针 加入请求队列并将CRB的物理存储位置输出到存储在内容可寻址存储器中的状态指针与新CRB的状态指针相同的请求队列中; CRB插入模块，用于在状态指针与新CRB的状态指针相同的接收请求队列中接收CRB的物理存储位置，并将新的CRB输入到请求队列中，并在请求队列中输入CRB，状态指针 与进入硬件加速器的新CRB的状态指针按照进入请求队列的顺序相同。 该系统和方法可以提高硬件加速器的处理效率。

    PEPTIDE DERIVATIVE FUSION INHIBITORS OF HIV INFECTION
    8.
    发明申请
    PEPTIDE DERIVATIVE FUSION INHIBITORS OF HIV INFECTION 有权
    艾滋病毒感染的肽衍生物融合抑制剂

    公开(公告)号：US20110003735A1

    公开(公告)日：2011-01-06

    申请号：US12567250

    申请日：2009-09-25

    申请人： Dong Xie ,  He Jiang

    发明人： Dong Xie ,  He Jiang

    IPC分类号： A61K38/16 ,  C07K14/00 ,  C12N5/00 ,  A61P31/18

    CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K38/162 ,  A61K45/06 ,  A61K47/643 ,  A61K2121/00 ,  C07K14/162 ,  C12N2740/16122

    摘要： This invention relates to gp41 peptide derivatives that are inhibitors of viral infection and/or exhibit antifusogenic properties. In particular, this invention relates to gp41 derivatives having inhibiting activity against human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) with enhanced duration of action for the treatment of the respective viral infections.

    摘要翻译： 本发明涉及作为病毒感染抑制剂和/或显示抗融合性质的gp41肽衍生物。 特别地，本发明涉及具有抑制人体免疫缺陷病毒（HIV）和猿猴免疫缺陷病毒（SIV）的活性的gp41衍生物，其具有用于治疗各自病毒感染的作用持续时间。