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    Systems and method of delivering fluids to a patient of varying concentration
    2.
    发明授权
    Systems and method of delivering fluids to a patient of varying concentration 有权
    向不同浓度的患者输送流体的系统和方法

    公开(公告)号：US09233176B2

    公开(公告)日：2016-01-12

    申请号：US12302907

    申请日：2007-06-06

    申请人： Ruediger Lawaczek ,  John F. Kalafut

    发明人： Ruediger Lawaczek ,  John F. Kalafut

    IPC分类号： A61K49/18 ,  A61M5/00 ,  A61M31/00 ,  A61K49/04

    CPC分类号： A61K49/0452 ,  A61K49/0438 ,  A61K49/0447 ,  A61K49/18 ,  A61M5/007 ,  A61M31/005

    摘要： A method for injection of an imaging contrast into a patient, includes: a. in a first phase, injecting a fluid having a first concentration of contrast agent for a first period of time; and b. in a second phase, injecting a fluid having a second concentration of contrast agent for a second period of time. The osmolarity of the second phase is higher than the osmolarity of the first phase. The method can further include: c. in a third phase, subsequent to the second phase, injecting a fluid having a third concentration of contrast agent for a third period of time. The osmolarity of the third phase is lower than the osmolarity of the second phase. In embodiments in which the composition of the contrast agent of the third phase is the same as the composition of the contrast agent of the second phase, the third concentration can be lower than the second concentration.

    摘要翻译： 一种用于将成像对比度注射到患者体内的方法包括：a。 在第一阶段中，将具有第一浓度的造影剂的流体注射第一时间段; 和b。 在第二阶段中，将具有第二浓度的造影剂的流体注射第二时间段。 第二相的渗透压高于第一相的渗透压浓度。 该方法还可以包括：c。 在第三阶段中，在第二阶段之后，将具有第三浓度的造影剂的流体注射第三时间段。 第三相的渗透压低于第二相的渗透压。 在第三相造影剂的组成与第二相造影剂的组成相同的实施方案中，第三浓度可低于第二浓度。

    Systems and methods of modeling pharmaceutical propagation in a patient
    3.
    发明授权
    Systems and methods of modeling pharmaceutical propagation in a patient 有权
    在患者体内药物传播建模的系统和方法

    公开(公告)号：US08197437B2

    公开(公告)日：2012-06-12

    申请号：US11691748

    申请日：2007-03-27

    申请人： John F. Kalafut ,  Arthur E. Uber, III

    发明人： John F. Kalafut ,  Arthur E. Uber, III

    IPC分类号： A61M31/00

    CPC分类号： A61M5/007 ,  A61B5/0044 ,  A61B5/02028 ,  A61B5/0205 ,  A61B5/026 ,  A61B5/029 ,  A61B5/0295 ,  A61B5/055 ,  A61B5/7257 ,  A61B6/032 ,  A61B6/481 ,  A61B6/504 ,  A61B6/507 ,  A61B6/583 ,  A61B8/13 ,  A61B8/481 ,  A61K49/0002 ,  G01R33/5601 ,  G06F19/00 ,  G06F19/321 ,  G06F19/3468 ,  G16H50/50

    摘要： An injection system includes an injector for injecting a fluid into a patient and a controller in operative communication with the injector for control thereof. The controller controls a diagnostic injection of the fluid based upon at least one mathematical model individualized to the patient. The model(s) are determined by collecting data corresponding to a time response curve resulting from at least one test injection of the fluid into the patient. The time response curve represents a response of a region of interest of the patient over time due to the fluid passing therethrough. An imaging system having such an injection system is also disclosed, as is a system for effecting a medical procedure. A method of delivering such a fluid to a patient using such an injection system is also disclosed, as is a method of modeling propagation of such a fluid in a patient.

    摘要翻译： 注射系统包括用于将流体注射到患者体内的注射器和与注射器可操作地连通以控制的控制器。 控制器基于对患者个体化的至少一个数学模型来控制流体的诊断注射。 模型通过收集对应于由流体进入至少一次试验注射到患者体内而产生的时间响应曲线的数据来确定。 时间响应曲线表示由于流体通过其而使患者随时间变化的感兴趣区域的响应。 还公开了具有这种注射系统的成像系统，以及用于实现医疗程序的系统。 还公开了使用这种注射系统将这种流体递送到患者的方法，以及模拟患者体内这种流体的传播的方法。

    DEVICES AND SYSTEMS FOR DETERMINATION OF PARAMETERS FOR A PROCEDURE, FOR ESTIMATION OF CARDIOPULMONARY FUNCTION AND FOR FLUID DELIVERY
    6.
    发明申请
    DEVICES AND SYSTEMS FOR DETERMINATION OF PARAMETERS FOR A PROCEDURE, FOR ESTIMATION OF CARDIOPULMONARY FUNCTION AND FOR FLUID DELIVERY 有权
    用于确定程序参数的装置和系统，用于估计心脏功能和流体输送

    公开(公告)号：US20130253314A1

    公开(公告)日：2013-09-26

    申请号：US13786935

    申请日：2013-03-06

    申请人： John F. Kalafut ,  Corey Kemper

    发明人： John F. Kalafut ,  Corey Kemper

    IPC分类号： A61B6/00

    CPC分类号： A61B6/481 ,  A61B5/055 ,  A61B6/504 ,  A61B6/507

    摘要： A method of determining at least one parameter for an imaging procedure including the injection of a contrast enhancement fluid which includes a contrast enhancing agent, includes: substituting into a model discrete point data determined from at least one contrast time enhancement curve measured using an imaging system for a first region of interest resulting from injection of a bolus of the contrast enhancement fluid. In several embodiments, a sufficient number of data points can be substituted into the model to determine values for physiological variables in the model. The variables can, for example, be related to cardiopulmonary function. At least one data point from at least a second contrast time enhancement curve for a second region of interest measured using the imaging system can also substituted into the model.

    摘要翻译： 一种确定用于成像过程的至少一个参数的方法，该成像过程包括注射包含对比度增强剂的对比度增强流体，包括：将由使用成像系统测量的至少一个对比度时间增强曲线确定的模型离散点数据替换 用于由注射大量对比度增强液体引起的第一感兴趣区域。 在几个实施例中，足够数量的数据点可以被替换到模型中以确定模型中的生理变量的值。 变量可以例如与心肺功能相关。 使用成像系统测量的第二感兴趣感兴趣区域的至少一个对比度时间增强曲线的至少一个数据点也可以代入该模型。

    Injection system having readable information stores and method for controlling the operation thereof
    9.
    发明授权
    Injection system having readable information stores and method for controlling the operation thereof 有权
    具有可读信息存储器的注入系统和用于控制其操作的方法

    公开(公告)号：US07905861B2

    公开(公告)日：2011-03-15

    申请号：US11943735

    申请日：2007-11-21

    申请人： Edward J. Rhinehart ,  Dennis P. Hack ,  David M. Reilly ,  John F. Kalafut

    发明人： Edward J. Rhinehart ,  Dennis P. Hack ,  David M. Reilly ,  John F. Kalafut

    IPC分类号： A61M1/00

    CPC分类号： A61M5/1422 ,  A61M5/002 ,  A61M5/007 ,  A61M5/16827 ,  A61M5/16881 ,  A61M2205/128 ,  A61M2206/22

    摘要： An injection system includes a fluid delivery system, a drive mechanism, a controller and a tubing set. The fluid delivery system includes a fluid container and a pumping mechanism having an inlet in fluid connection with the fluid container and an outlet. The tubing set is adapted to be placed in removable fluid connection with the outlet of the pumping mechanism and a patient. The drive mechanism is in operative connection with the pumping mechanism to pump fluid from the fluid container. First and second information stores, such as bar codes or RFID tags, are associated with the pumping mechanism and the tubing set, respectively. The controller is in operative connection with the drive mechanism and adapted to read the first information store and the second information store to at least partly control the operation of the drive mechanism based thereon.

    摘要翻译： 注射系统包括流体递送系统，驱动机构，控制器和管道组。 流体输送系统包括流体容器和泵送机构，其具有与流体容器和出口流体连接的入口。 管组适于放置在与泵送机构的出口和患者的可移除的流体连接中。 驱动机构与泵送机构操作连接以从流体容器泵送流体。 第一和第二信息存储（例如条形码或RFID标签）分别与泵送机构和管道组相关联。 控制器与驱动机构可操作地连接，并且适于读取第一信息存储器和第二信息存储器，以至少部分地基于此控制驱动机构的操作。