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公开(公告)号：US08916560B2
公开(公告)日：2014-12-23
申请号：US13408893
申请日：2012-02-29
申请人： John M. McCall , John McKearn , Donna L. Romero , Michael Clare
发明人： John M. McCall , John McKearn , Donna L. Romero , Michael Clare
IPC分类号： A61K31/50 , A61K31/495 , C07D241/36 , C07D241/54 , A61K45/06 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/04 , C07D409/04
CPC分类号： C07D241/44 , A61K45/06 , C07D241/54 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D413/04 , C07D471/04
摘要： Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human or animal subject are also provided for the treatment of diseases such as diabetes mellitus.
摘要翻译： 本文公开了新的杂环化合物和组合物及其作为用于治疗疾病的药物的应用。 还提供了抑制人或动物受试者中PAS激酶（PASK）活性的方法用于治疗糖尿病等疾病。
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公开(公告)号：US20120165318A1
公开(公告)日：2012-06-28
申请号：US13408893
申请日：2012-02-29
申请人： John M. McCall , John McKearn , Donna L. Romero , Michael Clare
发明人： John M. McCall , John McKearn , Donna L. Romero , Michael Clare
IPC分类号： A61K31/498 , C07D401/14 , C07D413/04 , C07D241/44 , C07D403/14 , C07D403/10 , C07D405/10 , C07D405/14 , C07D405/04 , C07D417/04 , A61K31/55 , A61K31/5377 , A61K31/551 , A61K31/538 , A61K31/541 , A61P3/00 , A61P35/00 , C07D401/04 , C07D471/04 , C07D409/04 , C07D403/04
CPC分类号： C07D241/44 , A61K45/06 , C07D241/54 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D413/04 , C07D471/04
摘要： Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human or animal subject are also provided for the treatment of diseases such as diabetes mellitus.
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公开(公告)号：US20120225846A1
公开(公告)日：2012-09-06
申请号：US13410378
申请日：2012-03-02
申请人： John M. McCall , Donna L. Romero , Michael Clare
发明人： John M. McCall , Donna L. Romero , Michael Clare
IPC分类号： A61K31/404 , C07D241/12 , A61K31/4965 , C07D413/04 , A61K31/5377 , C07D471/04 , C07D487/04 , A61K31/55 , C07F9/572 , A61K31/675 , C07F5/02 , A61K31/69 , C07F9/6506 , A61P35/00 , A61P3/00 , A61P3/10 , A61P3/06 , A61P1/16 , A61P3/04 , A61P5/48 , C12N9/99 , C07D209/10
CPC分类号： A61K31/404 , C07D209/10 , C07D209/18 , C07D213/74 , C07D241/12 , C07D405/14 , C07D413/04 , C07D471/04 , C07D487/04 , C07F5/025 , C07F9/5728 , C07F9/65068 , C07F9/650952 , C12N9/1205
摘要： Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human or animal subject are also provided for the treatment of diseases such as diabetes mellitus.
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公开(公告)号：US08912188B2
公开(公告)日：2014-12-16
申请号：US13410650
申请日：2012-03-02
申请人： John M. McCall , Donna L. Romero , Robert C. Kelly
发明人： John M. McCall , Donna L. Romero , Robert C. Kelly
IPC分类号： A61K31/498 , C07D241/44 , C07D413/04 , C07D403/04 , C07D409/14 , C07D401/12 , C07D417/14 , C07D405/04 , C07D413/14 , C07D417/04 , C07D403/14 , C07D405/14 , C07D401/14 , C07D409/04 , C07D401/04
CPC分类号： C07D405/04 , C07D241/44 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： Disclosed herein are substituted quinoxaline carboxylic acids of Formula (I): and compositions thereof, which may be useful as inhibitors of PAS Kinase (PASK) activity in a human or animal for the treatment of diseases such as diabetes mellitus.
摘要翻译： 本文公开了式（I）的取代喹喔啉羧酸及其组合物，其可用作人或动物中用于治疗诸如糖尿病的疾病的PAS激酶（PASK）活性的抑制剂。
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公开(公告)号：US08916561B2
公开(公告)日：2014-12-23
申请号：US13410720
申请日：2012-03-02
申请人： John M. McCall , Donna L. Romero
发明人： John M. McCall , Donna L. Romero
IPC分类号： A61K31/41 , A61K31/498 , C07D241/44 , C07D257/04 , A61K45/06 , C07D241/46 , C07D405/14 , C07D405/04 , C07D403/14 , C07D241/42 , C07D401/04
CPC分类号： C07D241/46 , A61K45/06 , C07D241/42 , C07D401/04 , C07D403/14 , C07D405/04 , C07D405/14
摘要： Disclosed herein are substituted quinoxaline of Formula (I): and compositions thereof, which may be useful as inhibitors of PAS Kinase (PASK) activity in a human or animal for the treatment of diseases such as diabetes mellitus.
摘要翻译： 本文公开了式（I）的取代喹喔啉及其组合物，其可用作人或动物中用于治疗诸如糖尿病的疾病的PAS激酶（PASK）活性的抑制剂。
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公开(公告)号：US10953012B2
公开(公告)日：2021-03-23
申请号：US13456838
申请日：2012-04-26
申请人： John M. McCall , Robert C. Kelly , Donna L. Romero
发明人： John M. McCall , Robert C. Kelly , Donna L. Romero
IPC分类号： A61P3/10 , A61P3/04 , A61P3/06 , A61P3/00 , C07D487/04 , A61K31/519 , A61K31/5377 , C07D401/14 , C07D401/04 , C07D265/32 , C07D487/22 , C07D407/06
摘要： Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human or animal subject are also provided for the treatment of diseases such as diabetes mellitus.
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公开(公告)号：US20120277224A1
公开(公告)日：2012-11-01
申请号：US13456838
申请日：2012-04-26
申请人： John M. McCall , Robert C. Kelly , Donna L. Romero
发明人： John M. McCall , Robert C. Kelly , Donna L. Romero
IPC分类号： A61K31/519 , A61K31/5377 , A61P35/00 , A61P3/00 , C12N5/07 , A61P3/06 , A61P3/04 , A61P7/00 , C12N9/99 , C07D487/04 , A61P3/10
CPC分类号： A61K31/519 , A61K31/5377 , C07D487/04
摘要： Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human or animal subject are also provided for the treatment of diseases such as diabetes mellitus.
摘要翻译： 本文公开了新的杂环化合物和组合物及其作为用于治疗疾病的药物的应用。 还提供了抑制人或动物受试者中PAS激酶（PASK）活性的方法用于治疗糖尿病等疾病。
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公开(公告)号：US20120225863A1
公开(公告)日：2012-09-06
申请号：US13410720
申请日：2012-03-02
申请人： John M. McCall , Donna L. Romero
发明人： John M. McCall , Donna L. Romero
IPC分类号： A61K31/498 , C07D413/04 , A61K31/5377 , C07D405/14 , A61K31/55 , C12N9/99 , A61P3/00 , A61P3/10 , A61P3/06 , A61P1/16 , A61P3/04 , A61P5/48 , C07D241/46 , A61P35/00
CPC分类号： C07D241/46 , A61K45/06 , C07D241/42 , C07D401/04 , C07D403/14 , C07D405/04 , C07D405/14
摘要： Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human or animal subject are also provided for the treatment of diseases such as diabetes mellitus.
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9.发明授权公开(公告)号：US09073902B2
公开(公告)日：2015-07-07
申请号：US13343831
申请日：2012-01-05
申请人： John M. McCall , Donna L. Romero
发明人： John M. McCall , Donna L. Romero
IPC分类号： A61K31/498 , C07D241/44 , C07D405/14 , A61K45/06 , C07D401/14 , C07D401/04 , C07D413/04 , C07D491/04
CPC分类号： C07D405/14 , A61K31/498 , A61K45/06 , C07D401/04 , C07D401/14 , C07D413/04 , C07D491/04 , A61L2300/00 , A61K2300/00
摘要： Disclosed herein are substituted quinoxaline carboxylic acids of Formula (I): and compositions thereof, which may be useful as inhibitors of PAS Kinase (PASK) activity in a human or animal for the treatment of diseases such as diabetes mellitus.
摘要翻译： 本文公开了式（I）的取代喹喔啉羧酸及其组合物，其可用作人或动物中用于治疗疾病如糖尿病的PAS激酶（PASK）活性的抑制剂。
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公开(公告)号：US20140128392A1
公开(公告)日：2014-05-08
申请号：US12727231
申请日：2010-03-19
申请人： John M. McCall , Donna L. Romero
发明人： John M. McCall , Donna L. Romero
IPC分类号： A61K31/5377 , A61K31/498 , A61P35/00 , A61P3/10 , A61K31/47 , A61P3/06 , A61P1/16 , C12N9/99 , C07D413/12 , C07D215/14 , C07D241/42 , A61P5/50
CPC分类号： A61K31/5377 , A61K31/47 , A61K31/498 , C07D241/42 , C07D241/44 , C07D401/04 , C07D405/04 , C07D405/14 , C07D409/04
摘要： Disclosed herein are new heterocyclic compounds of Formula IIa: and compositions thereof, and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human or animal subject are also provided for the treatment of diseases such as diabetes mellitus.
摘要翻译： 本文公开了式IIa的新型杂环化合物及其组合物及其作为用于治疗疾病的药物的应用。 还提供了抑制人或动物受试者中PAS激酶（PASK）活性的方法用于治疗糖尿病等疾病。
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