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    Laser corneal surgery
    1.
    发明授权
    Laser corneal surgery 失效
    激光角膜手术

    公开(公告)号：US5423801A

    公开(公告)日：1995-06-13

    申请号：US810323

    申请日：1991-12-19

    申请人： John Marshall ,  David F. Muller

    发明人： John Marshall ,  David F. Muller

    IPC分类号： A61B17/30 ,  A61F9/008 ,  A61F9/009 ,  A61F9/01 ,  B23K26/06 ,  A61N5/06

    CPC分类号： A61F9/009 ,  A61F9/00804 ,  A61F9/00817 ,  B23K26/066 ,  A61B2017/306 ,  A61F2009/00872 ,  A61F9/00819

    摘要： A method and system for reshaping Bowman's membrane, which lies directly below the anterior epithelial surface of the cornea, to provide correction of refractive errors in the eye by photoablation of selective regions of the Bowman's membrane without substantial penetration into the stroma of the eye is disclosed including a laser and a beam-shaping mask, disposed between the laser and the surface of the cornea, which imposes a defined ablation profile upon the Bowman's membrane by laser radiation. The system can also include a feedback control for measuring the effectiveness of the laser during operation and for controlling the laser such that the reprofiling operation is substantially confined to the Bowman's membrane throughout the procedure. The beam-shaping mask can include either an aperture e.g., a beam-shaping stop means alone or in combination with a beam-shaping window, or an mask which is erodible or otherwise graded in its absorptive capacity to present a predefined profile of resistance to the laser radiation.

    摘要翻译： 公开了一种用于重塑形成在角膜前上皮表面正下方的Bowman膜的方法和系统，以通过对Bowman膜的选择性区域进行光照化来提供眼睛屈光不正的校正，而没有基本上穿透到眼睛的基质中 包括设置在激光和角膜表面之间的激光和光束成形掩模，其通过激光辐射在Bowman膜上施加限定的消融轮廓。 该系统还可以包括用于在操作期间测量激光器的有效性并且用于控制激光器的反馈控制，使得在整个过程中重复操作基本上限于Bowman膜。 光束成形掩模可以包括单独的光束整形停止装置或与光束整形窗口组合的光阑，或者可以被蚀刻或以其它方式分级的掩模，以呈现出预定的阻抗曲线 激光辐射。

    Surface shaping using lasers
    2.
    发明授权
    Surface shaping using lasers 失效
    使用激光的表面成形

    公开(公告)号：US4994058A

    公开(公告)日：1991-02-19

    申请号：US124101

    申请日：1988-01-15

    申请人： Antony L. Raven ,  John Marshall ,  David F. Muller

    发明人： Antony L. Raven ,  John Marshall ,  David F. Muller

    IPC分类号： A61F9/00 ,  A61B17/30 ,  A61F9/008 ,  A61F9/009 ,  A61F9/01 ,  B23K26/00 ,  B23K26/06

    CPC分类号： A61F9/009 ,  A61F9/00804 ,  A61F9/00819 ,  B23K26/066 ,  A61B2017/306 ,  A61F2009/00872

    摘要： A laser system and masking apparatus for reprofiling surfaces, such as corneal surfaces. The system includes a laser and a mask disposed between the laser and the surface to be reprofiled, the mask providing a pre-defined profile of resistance to laser radiation, such that upon irradiation, part of the radiation is selectively absorbed and part is transmitted to the surface in accordance with the masked profile, to selectively erode the surface. The masking apparatus may consist of a mask to be affixed to the surface or may further include a support structure to support and position the mask above the surface. The resistance profile can be created by varying the thickness or the composition of the mask.

    摘要翻译： 激光系统和掩模装置，用于重新编织表面，如角膜表面。 该系统包括激光器和设置在激光器和被重新表面的表面之间的掩模，掩模提供对激光辐射的抵抗力的预定义轮廓，使得在照射时，部分辐射被选择性地吸收并且部分被传输到 表面根据掩模的轮廓，选择性地侵蚀表面。 掩模装置可以由要粘贴到表面上的掩模组成，或者还可以包括用于支撑和定位掩模在表面上方的支撑结构。 可以通过改变掩模的厚度或组成来产生电阻分布。

    Adjustable Pillow
    3.
    发明申请
    Adjustable Pillow 审中-公开

    公开(公告)号：US20190008294A1

    公开(公告)日：2019-01-10

    申请号：US15642099

    申请日：2017-07-05

    申请人： John Marshall

    发明人： John Marshall

    IPC分类号： A47G9/10

    摘要： An adjustable pillow comprises an outer wall, an interior cavity having a volume defined by the outer wall, a composition of fill material dispersed about and contained within the interior cavity, and a drawstring for adjusting and fixing the volume of the interior cavity. The drawstring is defined by a base end, a distal end, an interior portion, and an exterior portion. It further comprises a cinching mechanism adjustably affixed to its exterior portion. A user can manipulate the volume of the interior cavity of the adjustable pillow, and, thus, the firmness of the adjustable pillow, by altering the position of the cinching mechanism along the drawstring. The drawstring further comprises a plurality of notations that provide the user with an indication of the firmness of the adjustable pillow at various positions of the cinching mechanism along the drawstring.

    CONTROLLING DISTRIBUTION OF RESOURCES IN A NETWORK
    5.
    发明申请
    CONTROLLING DISTRIBUTION OF RESOURCES IN A NETWORK 有权
    控制资源在网络中的分配

    公开(公告)号：US20130212278A1

    公开(公告)日：2013-08-15

    申请号：US13396356

    申请日：2012-02-14

    申请人： John Marshall ,  Adam Rykowski ,  Erich Stuntebeck ,  Jyothiprakash Halebeed

    发明人： John Marshall ,  Adam Rykowski ,  Erich Stuntebeck ,  Jyothiprakash Halebeed

    IPC分类号： G06F15/16

    CPC分类号： H04L47/70 ,  G06F21/31 ,  G06F21/6218 ,  H04L63/102

    摘要： Disclosed are various embodiments for controlling distribution of data on a network. In one embodiment, a distribution service receives a request from a user on a client device to access the distribution service. In response, the distribution service determines whether the user and the client device are authorized to access the distribution service. The distribution service identifies which of the resources are accessible to the user and the client device pairing based on a plurality of resource grouping identifiers. The distribution service then determines whether the client device complies with a plurality of distribution rules associated with the identified resources. Upon determining that the client device is compliant, the distribution service transmits the resources related to the compliance.

    摘要翻译： 公开了用于控制网络上的数据分发的各种实施例。 在一个实施例中，分发服务在客户端设备上接收来自用户的访问分发服务的请求。 作为响应，分发服务确定用户和客户端设备是否被授权访问分发服务。 分发服务基于多个资源分组标识符识别用户可访问哪些资源和客户端设备配对。 然后，分发服务确定客户端设备是否符合与所识别的资源相关联的多个分发规则。 在确定客户端设备是否兼容时，分发服务传输与合规性相关的资源。

    APPLICATION OF ENERGY IN MEDICAL TREATMENTS
    6.
    发明申请
    APPLICATION OF ENERGY IN MEDICAL TREATMENTS 审中-公开
    能源在医疗治疗中的应用

    公开(公告)号：US20130190737A1

    公开(公告)日：2013-07-25

    申请号：US13738675

    申请日：2013-01-10

    申请人： David Muller ,  John Marshall

    发明人： David Muller ,  John Marshall

    IPC分类号： A61F9/007

    CPC分类号： A61F9/0079 ,  A61F9/00736 ,  A61F9/008 ,  A61F2009/0087 ,  A61F2009/00887 ,  A61N5/062 ,  A61N2005/0661

    摘要： Embodiments apply light energy in medical treatments. To enhance or control the effect of the light energy, embodiments apply the light energy after tissue has been treated, e.g., with a photosensitizing agent. For example, embodiments may treat target tissue with riboflavin before exposure to ultraviolet light. For example, a system for cataract surgery includes a removal system configured to remove a first lens from an eye, wherein a capsular bag remains in the eye after removal of the first lens. The system includes an application system configured to treat lenticular epithelial cells in the capsular bag with the photosensitizing agent. The system includes a delivery system with a light source and an optical device. The optical device delivers light to the treated lenticular epithelial cells. Energy from the light destroys the lenticular epithelial cells in the capsular bag to reduce the growth of epithelial cells that cause posterior capsule opacification.

    摘要翻译： 实施例在光疗中应用光能。 为了增强或控制光能的效果，实施例在组织被处理后例如用光敏剂施加光能。 例如，实施方案可以在暴露于紫外线之前用核黄素治疗靶组织。 例如，用于白内障手术的系统包括被配置为从眼睛去除第一透镜的去除系统，其中在移除第一透镜之后，囊袋保留在眼睛中。 该系统包括被配置成用光敏剂治疗囊袋中的透镜上皮细胞的应用系统。 该系统包括具有光源和光学装置的传送系统。 光学器件将光递送到经处理的透镜上皮细胞。 来自光的能量破坏囊袋中的透镜上皮细胞以减少导致后囊不透明的上皮细胞的生长。

    Method for making structural changes in corneal fibrils
    7.
    发明授权
    Method for making structural changes in corneal fibrils 失效
    角膜原纤维结构变化的方法

    公开(公告)号：US08366689B2

    公开(公告)日：2013-02-05

    申请号：US12570959

    申请日：2009-09-30

    申请人： John Marshall ,  Ali Hussein ,  David Muller

    发明人： John Marshall ,  Ali Hussein ,  David Muller

    IPC分类号： A61M35/00 ,  A61B18/18

    CPC分类号： A61F9/008 ,  A61F9/0079 ,  A61F9/009 ,  A61F2009/00853 ,  A61F2009/00872

    摘要： In a system for stabilizing a pattern of structural changes in corneal fibrils, an eye treatment system causes corneal fibrils of a cornea of an eye to transition from a first structure to a second structure. An application device applies a cross-linking element to the corneal fibrils. An activating device applies an initiating element to the corneal fibrils and activates the cross-linking element. The cross-linking element causes cross-linking in the corneal fibrils to preserve the second structure of the corneal fibrils. Another application device may apply a cross-linking breaker to the corneal fibrils. The cross-linking breaker halts or reverses at least partially the cross-linking in the corneal fibrils. Another activating device applies an initiating element to the corneal fibrils and activates the cross-linking breaker. Advantageously, the cross-linking breaker provides greater control over the amount and progress of cross-linking that occurs in the corneal fibrils.

    摘要翻译： 在用于稳定角膜原纤维结构变化的模式的系统中，眼睛治疗系统使眼睛角膜的角膜原纤维从第一结构转变到第二结构。 应用装置将交联元件应用于角膜原纤维。 激活装置将起始元件施加到角膜原纤维并激活交联元件。 交联元件引起角膜原纤维中的交联以保留角膜原纤维的第二结构。 另一应用装置可以将交联断路器应用于角膜原纤维。 交联断路器至少部分地停止或逆转角膜原纤维中的交联。 另一激活装置将起始元件施加到角膜原纤维并激活交联断路器。 有利地，交联断路器对角膜原纤维中发生的交联的量和进展提供更大的控制。

    LONG TERM POTENTIATION WITH CYCLIC-GLUR6 ANALOGS
    9.
    发明申请
    LONG TERM POTENTIATION WITH CYCLIC-GLUR6 ANALOGS 有权
    长期稳定与周期性GLUR6模拟

    公开(公告)号：US20120149646A1

    公开(公告)日：2012-06-14

    申请号：US13389047

    申请日：2010-08-27

    申请人： John Marshall ,  Andrew Mallon

    发明人： John Marshall ,  Andrew Mallon

    IPC分类号： A61K38/12 ,  A61P25/00 ,  A61P25/28

    CPC分类号： A61K38/12 ,  A61K47/645

    摘要： This invention discloses CN2097-like compositions that facilitate the induction of long-term potentiation (LTP). In one embodiment the method comprises inducing long-term potentiation in a subject by the method of administering a therapeutically effective dose of a CN2907-like compound.

    摘要翻译： 本发明公开了促进长期增强（LTP）诱导的CN2097样组合物。 在一个实施方案中，该方法包括通过施用治疗有效剂量的CN2907样化合物的方法在受试者中诱导长期增强作用。