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公开(公告)号：US20120282264A1
公开(公告)日：2012-11-08
申请号：US13498125
申请日：2010-09-24
申请人： John R. Mascola , Richard Wyatt , Xueling Wu , Yuxing Li , Carl-Magnus Hogerkorp , Mario Roederer , Zhi-yong Yang , Gary Nabel , Peter Kwong , Tongqing Zhou , Mark Connors , Gilad Ofek , Lawrence Shapiro , Jiang Zhu , William R. Schief
发明人： John R. Mascola , Richard Wyatt , Xueling Wu , Yuxing Li , Carl-Magnus Hogerkorp , Mario Roederer , Zhi-yong Yang , Gary Nabel , Peter Kwong , Tongqing Zhou , Mark Connors , Gilad Ofek , Lawrence Shapiro , Jiang Zhu , William R. Schief
IPC分类号： C07K16/10 , A61K39/42 , C12N15/13 , C12N1/21 , C12N15/74 , G01N33/569 , A61P31/18 , G01N33/577 , C12N9/96 , C12N15/63
CPC分类号： C07K16/1063 , A61K39/42 , A61K45/06 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N2740/10011 , C12N2740/16011 , C12N2740/16111
摘要： Monoclonal neutralizing antibodies are disclosed that specifically bind to the CD4 binding site of HIV-1 gp120. Monoclonal neutralizing antibodies also are disclosed that specifically bind to HIV-1 gp41. The identification of these antibodies, and the use of these antibodies are also disclosed. Methods are also provided for enhancing the binding and neutralizing activity of any antibody using epitope scaffold probes.
摘要翻译： 公开了特异性结合HIV-1 gp120的CD4结合位点的单克隆中和抗体。 还公开了特异性结合HIV-1 gp41的单克隆中和抗体。 还公开了这些抗体的鉴定，以及这些抗体的用途。 还提供了用于增强使用表位支架探针的任何抗体的结合和中和活性的方法。
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公开(公告)号：US20120237523A1
公开(公告)日：2012-09-20
申请号：US13429286
申请日：2012-03-23
申请人： John R. Mascola , Richard T. Wyatt , Xueling Wu , Yuxing Li , Carl-Magnus Hogerkorp , Mario Roederer , Zhi-yong Yang , Gary J. Nabel , Peter D. Kwong , Tongqing Zhou , Mark Connors , Gilad Ofek , Lawrence Shapiro , Jiang Zhu , William R. Schief
发明人： John R. Mascola , Richard T. Wyatt , Xueling Wu , Yuxing Li , Carl-Magnus Hogerkorp , Mario Roederer , Zhi-yong Yang , Gary J. Nabel , Peter D. Kwong , Tongqing Zhou , Mark Connors , Gilad Ofek , Lawrence Shapiro , Jiang Zhu , William R. Schief
IPC分类号： A61K39/42 , C12N15/13 , A61P31/18 , G01N33/566 , G01N33/569 , C12N1/21 , C12N5/10 , C12N1/19 , C07K16/10 , C12N15/63
CPC分类号： C07K16/1063 , A61K39/42 , A61K45/06 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N2740/10011 , C12N2740/16011 , C12N2740/16111
摘要： Monoclonal neutralizing antibodies are disclosed that specifically bind to the CD4 binding site of HIV-1 gp120. Monoclonal neutralizing antibodies also are disclosed that specifically bind to HIV-1 gp41. The identification of these antibodies, and the use of these antibodies are also disclosed. Methods are also provided for enhancing the binding and neutralizing activity of any antibody using epitope scaffold probes.
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公开(公告)号：US20120244166A1
公开(公告)日：2012-09-27
申请号：US13429279
申请日：2012-03-23
申请人： John R. Mascola , Richard T. Wyatt , Xueling Wu , Yuxing Li , Carl-Magnus Hogerkorp , Mario Roederer , Zhi-yong Yang , Gary J. Nabel , Peter D. Kwong , Tongqing Zhou , Mark Connors , Gilad Ofek , Lawrence Shapiro , Jiang Zhu , William R. Schief
发明人： John R. Mascola , Richard T. Wyatt , Xueling Wu , Yuxing Li , Carl-Magnus Hogerkorp , Mario Roederer , Zhi-yong Yang , Gary J. Nabel , Peter D. Kwong , Tongqing Zhou , Mark Connors , Gilad Ofek , Lawrence Shapiro , Jiang Zhu , William R. Schief
IPC分类号： A61K39/395 , C12N15/63 , C12N1/21 , C12N1/19 , A61P31/18 , C12N15/74 , G01N21/64 , C07K16/10 , C12N15/13 , C12N9/96 , C12N5/10
CPC分类号： C07K16/1063 , A61K39/42 , A61K45/06 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N2740/10011 , C12N2740/16011 , C12N2740/16111
摘要： Monoclonal neutralizing antibodies are disclosed that specifically bind to the CD4 binding site of HIV-1 gp120. Monoclonal neutralizing antibodies also are disclosed that specifically bind to HIV-1 gp41. The identification of these antibodies, and uses of these antibodies, are also disclosed. Methods are also provided for enhancing the binding and neutralizing activity of any antibody using epitope scaffold probes.
摘要翻译： 公开了特异性结合HIV-1 gp120的CD4结合位点的单克隆中和抗体。 还公开了特异性结合HIV-1 gp41的单克隆中和抗体。 还公开了这些抗体的鉴定以及这些抗体的用途。 还提供了用于增强使用表位支架探针的任何抗体的结合和中和活性的方法。
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公开(公告)号：US20100068217A1
公开(公告)日：2010-03-18
申请号：US12438913
申请日：2007-08-24
申请人： Peter D. Kwong , Gilad Ofek , Javier Guenaga , Richard Wyatt , Zhi-yong Yang , Tongqing Zhou , Gary J Nabel , Min Tang , William Schief , David Baker
发明人： Peter D. Kwong , Gilad Ofek , Javier Guenaga , Richard Wyatt , Zhi-yong Yang , Tongqing Zhou , Gary J Nabel , Min Tang , William Schief , David Baker
CPC分类号： G16B15/00
摘要： Computational protocols for the design of epitope-protein scaffolds which elicit selected neutralizing antibodies are disclosed, and related compositions and uses.
摘要翻译： 公开了引发选定的中和抗体的表位 - 蛋白质支架设计的计算方案，以及相关的组合物和用途。
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5.发明授权Human immunodeficiency virus (HIV) immunization strategies employing conformationally-stabilized, surface-occluded peptides comprising a gp41 2F5 epitope in association with lipid 有权使用构象稳定的表面封闭肽的人免疫缺陷病毒（HIV）免疫策略，其包含与脂质相关的gp41 2F5表位公开(公告)号：US08147840B2
公开(公告)日：2012-04-03
申请号：US11596494
申请日：2005-05-13
申请人： Gilad Ofek , Peter D. Kwong , Richard Wyatt , Min Tang
发明人： Gilad Ofek , Peter D. Kwong , Richard Wyatt , Min Tang
IPC分类号： A61K39/21 , A61K39/385 , A61K9/127
CPC分类号： C07K16/1063 , A61K2039/505 , A61K2039/53 , A61K2039/555 , A61K2039/6056 , A61K2039/64 , C07K14/005 , C07K2299/00 , C12N2740/16122
摘要： This invention relates to novel peptide immunogens that generate an immune response in mammals against HIV gp41, to pharmaceutical compositions that comprise such immunogens, and to methods of treating Immunodeficiency disease, especially HIV infection and AIDS, that employ such pharmaceutical compositions.
摘要翻译： 本发明涉及在哺乳动物中产生针对HIV gp41的免疫应答的新型肽免疫原，包含这种免疫原的药物组合物以及使用这种药物组合物的治疗免疫缺陷病，特别是HIV感染和AIDS的方法。
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6.发明申请HIV vaccine immunogens and immunization strategies to elicit broadly-neutralizing anti-HIV-1 antibodies against the membrane proximal domain of HIV GP41 有权艾滋病毒疫苗免疫原和免疫策略，以引发广泛中和抗HIV-1抗体针对HIV GP41的膜近端结构域公开(公告)号：US20090220536A1
公开(公告)日：2009-09-03
申请号：US11596494
申请日：2005-05-13
申请人： Gilad Ofek , Peter D. Kwong , Richard Wyatt , Min Tang
发明人： Gilad Ofek , Peter D. Kwong , Richard Wyatt , Min Tang
CPC分类号： C07K16/1063 , A61K2039/505 , A61K2039/53 , A61K2039/555 , A61K2039/6056 , A61K2039/64 , C07K14/005 , C07K2299/00 , C12N2740/16122
摘要： This invention relates to novel peptide immunogens that generate an immune response in mammals against HIV gp41, to pharmaceutical compositions that comprise such immunogens, and to methods of treating Immunodeficiency disease, especially HIV infection and AIDS, that employ such pharmaceutical compositions.
摘要翻译： 本发明涉及在哺乳动物中产生针对HIV gp41的免疫应答的新型肽免疫原，包含这种免疫原的药物组合物以及使用这种药物组合物的治疗免疫缺陷病，特别是HIV感染和AIDS的方法。
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