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公开(公告)号：US20120282264A1
公开(公告)日：2012-11-08
申请号：US13498125
申请日：2010-09-24
申请人： John R. Mascola , Richard Wyatt , Xueling Wu , Yuxing Li , Carl-Magnus Hogerkorp , Mario Roederer , Zhi-yong Yang , Gary Nabel , Peter Kwong , Tongqing Zhou , Mark Connors , Gilad Ofek , Lawrence Shapiro , Jiang Zhu , William R. Schief
发明人： John R. Mascola , Richard Wyatt , Xueling Wu , Yuxing Li , Carl-Magnus Hogerkorp , Mario Roederer , Zhi-yong Yang , Gary Nabel , Peter Kwong , Tongqing Zhou , Mark Connors , Gilad Ofek , Lawrence Shapiro , Jiang Zhu , William R. Schief
IPC分类号： C07K16/10 , A61K39/42 , C12N15/13 , C12N1/21 , C12N15/74 , G01N33/569 , A61P31/18 , G01N33/577 , C12N9/96 , C12N15/63
CPC分类号： C07K16/1063 , A61K39/42 , A61K45/06 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N2740/10011 , C12N2740/16011 , C12N2740/16111
摘要： Monoclonal neutralizing antibodies are disclosed that specifically bind to the CD4 binding site of HIV-1 gp120. Monoclonal neutralizing antibodies also are disclosed that specifically bind to HIV-1 gp41. The identification of these antibodies, and the use of these antibodies are also disclosed. Methods are also provided for enhancing the binding and neutralizing activity of any antibody using epitope scaffold probes.
摘要翻译： 公开了特异性结合HIV-1 gp120的CD4结合位点的单克隆中和抗体。 还公开了特异性结合HIV-1 gp41的单克隆中和抗体。 还公开了这些抗体的鉴定，以及这些抗体的用途。 还提供了用于增强使用表位支架探针的任何抗体的结合和中和活性的方法。
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公开(公告)号：US20100068217A1
公开(公告)日：2010-03-18
申请号：US12438913
申请日：2007-08-24
申请人： Peter D. Kwong , Gilad Ofek , Javier Guenaga , Richard Wyatt , Zhi-yong Yang , Tongqing Zhou , Gary J Nabel , Min Tang , William Schief , David Baker
发明人： Peter D. Kwong , Gilad Ofek , Javier Guenaga , Richard Wyatt , Zhi-yong Yang , Tongqing Zhou , Gary J Nabel , Min Tang , William Schief , David Baker
CPC分类号： G16B15/00
摘要： Computational protocols for the design of epitope-protein scaffolds which elicit selected neutralizing antibodies are disclosed, and related compositions and uses.
摘要翻译： 公开了引发选定的中和抗体的表位 - 蛋白质支架设计的计算方案，以及相关的组合物和用途。
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公开(公告)号：US20120034255A1
公开(公告)日：2012-02-09
申请号：US13232775
申请日：2011-09-14
申请人： Peter Kwong , John Mascola , Gary Nabel , Richard Wyatt , Barna Dey , Ling Xu , Tongqing Zhou , Joseph Sodroski , Wen Yuan , Shi-Hua Xiang
发明人： Peter Kwong , John Mascola , Gary Nabel , Richard Wyatt , Barna Dey , Ling Xu , Tongqing Zhou , Joseph Sodroski , Wen Yuan , Shi-Hua Xiang
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/54 , A61K2039/545 , C07K14/70514 , C12N2740/15022 , C12N2740/16122 , C12N2740/16134
摘要： Stabilized forms of gp120 polypeptide, nucleic acids encoding these stabilized forms, vectors comprising these nucleic acids, and methods of using these polypeptides, nucleic acids, vectors and host cells are disclosed. Crystal structures and computer systems including atomic coordinates for stabilized forms of gp120, and gp120 with an extended V3 loop, and methods of using these structures and computer systems are also disclosed.
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4.发明申请CONFORMATIONALLY STABILIZED HIV ENVELOPE IMMUNOGENS AND TRIGGERING HIV-1 ENVELOPE TO REVEAL CRYPTIC V3-LOOP EPITOPES 有权持续稳定的艾滋病毒环境免疫调节因子和引发HIV-1环境来重现CR-V3环状病毒公开(公告)号：US20090191235A1
公开(公告)日：2009-07-30
申请号：US12065894
申请日：2006-09-06
申请人： Peter Kwong , John Mascola , Gary Nabel , Richard Wyatt , Barna Dey , Ling Xu , Tongqing Zhou , Chih-Chin Huang , Joseph Sodroski , Wen Yuan , Shi-Hua Xiang
发明人： Peter Kwong , John Mascola , Gary Nabel , Richard Wyatt , Barna Dey , Ling Xu , Tongqing Zhou , Chih-Chin Huang , Joseph Sodroski , Wen Yuan , Shi-Hua Xiang
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/54 , A61K2039/545 , C07K14/70514 , C12N2740/15022 , C12N2740/16122 , C12N2740/16134
摘要： Stabilized forms of gp120 polypeptide, nucleic acids encoding these stabilized forms, vectors comprising these nucleic acids, and methods of using these polypeptides, nucleic acids, vectors and host cells are disclosed. Crystal structures and computer systems including atomic coordinates for stabilized forms of gp120, and gp120 with an extended V3 loop, and methods of using these structures and computer systems are also disclosed.
摘要翻译： 公开了稳定形式的gp120多肽，编码这些稳定形式的核酸，包含这些核酸的载体，以及使用这些多肽，核酸，载体和宿主细胞的方法。 还公开了包括gp120的稳定形式的原子坐标和具有扩展的V3循环的gp120的晶体结构和计算机系统，以及使用这些结构和计算机系统的方法。
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公开(公告)号：US20120328641A1
公开(公告)日：2012-12-27
申请号：US13585700
申请日：2012-08-14
申请人： Peter Kwong , John Mascola , Gary Nabel , Richard Wyatt , Barna Dey , Ling Xu , Tongqing Zhou , Joseph Sodroski , Wen Yuan , Shi-Hua Xiang
发明人： Peter Kwong , John Mascola , Gary Nabel , Richard Wyatt , Barna Dey , Ling Xu , Tongqing Zhou , Joseph Sodroski , Wen Yuan , Shi-Hua Xiang
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/54 , A61K2039/545 , C07K14/70514 , C12N2740/15022 , C12N2740/16122 , C12N2740/16134
摘要： Stabilized forms of gp120 polypeptide, nucleic acids encoding these stabilized forms, vectors comprising these nucleic acids, and methods of using these polypeptides, nucleic acids, vectors and host cells are disclosed. Crystal structures and computer systems including atomic coordinates for stabilized forms of gp120, and gp120 with an extended V3 loop, and methods of using these structures and computer systems are also disclosed.
摘要翻译： 公开了稳定形式的gp120多肽，编码这些稳定形式的核酸，包含这些核酸的载体，以及使用这些多肽，核酸，载体和宿主细胞的方法。 还公开了包括gp120的稳定形式的原子坐标和具有扩展的V3循环的gp120的晶体结构和计算机系统，以及使用这些结构和计算机系统的方法。
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公开(公告)号：US08268323B2
公开(公告)日：2012-09-18
申请号：US13232775
申请日：2011-09-14
申请人： Peter Kwong , John Mascola , Gary Nabel , Richard Wyatt , Barna Dey , Ling Xu , Tongqing Zhou , Joseph Sodroski , Wen Yuan , Shi-Hua Xiang
发明人： Peter Kwong , John Mascola , Gary Nabel , Richard Wyatt , Barna Dey , Ling Xu , Tongqing Zhou , Joseph Sodroski , Wen Yuan , Shi-Hua Xiang
IPC分类号： A61K39/21 , A61K39/385 , A61K9/127 , G01N33/53
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/54 , A61K2039/545 , C07K14/70514 , C12N2740/15022 , C12N2740/16122 , C12N2740/16134
摘要： Stabilized forms of gp120 polypeptide, nucleic acids encoding these stabilized forms, vectors comprising these nucleic acids, and methods of using these polypeptides, nucleic acids, vectors and host cells are disclosed. Crystal structures and computer systems including atomic coordinates for stabilized forms of gp120, and gp120 with an extended V3 loop, and methods of using these structures and computer systems are also disclosed.
摘要翻译： 公开了稳定形式的gp120多肽，编码这些稳定形式的核酸，包含这些核酸的载体，以及使用这些多肽，核酸，载体和宿主细胞的方法。 还公开了包括gp120的稳定形式的原子坐标和具有扩展的V3循环的gp120的晶体结构和计算机系统，以及使用这些结构和计算机系统的方法。
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7.发明授权Conformationally stabilized HIV envelope immunogens and triggering HIV-I envelope to reveal cryptic V3-loop epitopes 有权构象稳定的艾滋病毒包膜免疫原，并引发HIV-1信封揭示神秘的V3环表位公开(公告)号：US08044185B2
公开(公告)日：2011-10-25
申请号：US12065894
申请日：2006-09-06
申请人： Peter Kwong , John Mascola , Gary Nabel , Richard Wyatt , Barna Dey , Ling Xu , Tongqing Zhou , Chih-Chin Huang , Joseph Sodroski , Wen Yuan , Shi-Hua Xiang
发明人： Peter Kwong , John Mascola , Gary Nabel , Richard Wyatt , Barna Dey , Ling Xu , Tongqing Zhou , Chih-Chin Huang , Joseph Sodroski , Wen Yuan , Shi-Hua Xiang
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/54 , A61K2039/545 , C07K14/70514 , C12N2740/15022 , C12N2740/16122 , C12N2740/16134
摘要： Stabilized forms of gp120 polypeptide, nucleic acids encoding these stabilized forms, vectors comprising these nucleic acids, and methods of using these polypeptides, nucleic acids, vectors and host cells are disclosed. Crystal structures and computer systems including atomic coordinates for stabilized forms of gp120, and gp120 with an extended V3 loop, and methods of using these structures and computer systems are also disclosed.
摘要翻译： 公开了稳定形式的gp120多肽，编码这些稳定形式的核酸，包含这些核酸的载体，以及使用这些多肽，核酸，载体和宿主细胞的方法。 还公开了包括gp120的稳定形式的原子坐标和具有扩展的V3循环的gp120的晶体结构和计算机系统，以及使用这些结构和计算机系统的方法。
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公开(公告)号：US08715686B2
公开(公告)日：2014-05-06
申请号：US13585700
申请日：2012-08-14
申请人： Peter Kwong , John Mascola , Gary Nabel , Richard Wyatt , Barna Dey , Ling Xu , Tongqing Zhou , Joseph Sodroski , Wen Yuan , Shi-Hua Xiang
发明人： Peter Kwong , John Mascola , Gary Nabel , Richard Wyatt , Barna Dey , Ling Xu , Tongqing Zhou , Joseph Sodroski , Wen Yuan , Shi-Hua Xiang
IPC分类号： A61K39/21
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/54 , A61K2039/545 , C07K14/70514 , C12N2740/15022 , C12N2740/16122 , C12N2740/16134
摘要： Isolated immunogens including a HIV-1 gp120 polypeptide or immunogenic fragment thereof stabilized in a CD4 bound confirmation by crosslinked cysteines, and methods of their use are disclosed. The immunogens are useful, for example, for generating an immune response to HIV-1 gp120 in a subject.
摘要翻译： 公开了包含通过交联半胱氨酸稳定在CD4结合确认中的HIV-1 gp120多肽或其免疫原性片段的分离的免疫原及其使用方法。 免疫原可用于例如在受试者中产生对HIV-1 gp120的免疫应答。
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9.发明申请公开(公告)号：US20090110690A1
公开(公告)日：2009-04-30
申请号：US12065883
申请日：2006-09-06
申请人： Peter D. Kwong , Tongqing Zhou , Ling Xu , Gary Nabel , Barna Dey , Richard Wyatt , James Arthos , Joseph Sodroski , Shi-Hua Xiang , Dennis Burton
发明人： Peter D. Kwong , Tongqing Zhou , Ling Xu , Gary Nabel , Barna Dey , Richard Wyatt , James Arthos , Joseph Sodroski , Shi-Hua Xiang , Dennis Burton
IPC分类号： A61K39/21 , C07K14/16 , C07H21/04 , C12N15/63 , C12N5/06 , A61P31/18 , C12N5/22 , A61K38/16 , A61K31/7052
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/54 , A61K2039/545 , C07K14/70514 , C12N2740/15022 , C12N2740/16122 , C12N2740/16134
摘要： The present disclosure relates to stabilized forms of the HIV gp120 envelope protein in complex with the broadly neutralizing CD4-binding site antibody b12, to crystalline forms of the stabilized forms of the HIV gp120 envelope protein in complex with the broadly neutralizing CD4-binding site antibody b12, and to the high resolution structure obtained from these crystals by X-ray diffraction methods. Methods for identifying immunogenic polypeptides based on these structures are also disclosed.
摘要翻译： 本公开涉及与广泛中和的CD4结合位点抗体b12复合的HIV gp120包膜蛋白的稳定形式，与广泛中和的CD4结合位点抗体复合的HIV gp120包膜蛋白的稳定形式的结晶形式 b12，以及通过X射线衍射法从这些晶体获得的高分辨率结构。 还公开了基于这些结构鉴定免疫原性多肽的方法。
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10.发明授权Human immunodeficiency virus (HIV) immunization strategies employing conformationally-stabilized, surface-occluded peptides comprising a gp41 2F5 epitope in association with lipid 有权使用构象稳定的表面封闭肽的人免疫缺陷病毒（HIV）免疫策略，其包含与脂质相关的gp41 2F5表位公开(公告)号：US08147840B2
公开(公告)日：2012-04-03
申请号：US11596494
申请日：2005-05-13
申请人： Gilad Ofek , Peter D. Kwong , Richard Wyatt , Min Tang
发明人： Gilad Ofek , Peter D. Kwong , Richard Wyatt , Min Tang
IPC分类号： A61K39/21 , A61K39/385 , A61K9/127
CPC分类号： C07K16/1063 , A61K2039/505 , A61K2039/53 , A61K2039/555 , A61K2039/6056 , A61K2039/64 , C07K14/005 , C07K2299/00 , C12N2740/16122
摘要： This invention relates to novel peptide immunogens that generate an immune response in mammals against HIV gp41, to pharmaceutical compositions that comprise such immunogens, and to methods of treating Immunodeficiency disease, especially HIV infection and AIDS, that employ such pharmaceutical compositions.
摘要翻译： 本发明涉及在哺乳动物中产生针对HIV gp41的免疫应答的新型肽免疫原，包含这种免疫原的药物组合物以及使用这种药物组合物的治疗免疫缺陷病，特别是HIV感染和AIDS的方法。
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