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23 条记录 (耗时 0.024 秒)

    High Resolution Label-Free Sensor
    1.
    发明申请
    High Resolution Label-Free Sensor 审中-公开
    高分辨率无标签传感器

    公开(公告)号：US20120301914A1

    公开(公告)日：2012-11-29

    申请号：US13480523

    申请日：2012-05-25

    申请人： John Stephen Peanasky ,  Vitor Marino Schneider ,  Elizabeth Tran ,  Qi Wu

    发明人： John Stephen Peanasky ,  Vitor Marino Schneider ,  Elizabeth Tran ,  Qi Wu

    IPC分类号： G02B6/00 ,  C12Q1/02 ,  G01N21/17

    CPC分类号： G01N21/7743 ,  G02B5/18 ,  G02B5/1809 ,  G02B5/1814 ,  G02B6/00

    摘要： An optical sensor for label-independent detection, having improved spatial resolution and reduced angular sensitivity, the sensor including: a substrate; a waveguide grating adjacent the substrate; and a waveguide coat layer adjacent or over the waveguide grating, the waveguide coat layer having a thickness (W) of from 30 nm to 300 nm, the waveguide grating having a teeth height (H) of from 0.2×W to 1×W, and for example, a waveguide core thickness (Wcore=W−H) from 5 nm to 50 nm. Also disclosed is a well-plate article, a well-plate reader system, and methods of using the well-plate and sensor articles, as defined herein.

    摘要翻译： 一种用于标签独立检测的光学传感器，具有改善的空间分辨率和降低的角度灵敏度，所述传感器包括：基板; 邻近衬底的波导光栅; 以及与所述波导光栅相邻或相邻的波导涂层，所述波导涂层的厚度（W）为30nm〜300nm，所述波导光栅的齿高（H）为0.2×W〜1×W， 例如，5nm至50nm的波导芯厚度（Wcore = W-H）。 还公开了一种井板制品，井板读取器系统以及如本文所定义的使用井板和传感器制品的方法。

    Methods and Devices for Cell Signaling Under Pulse Stimulation
    2.
    发明申请
    Methods and Devices for Cell Signaling Under Pulse Stimulation 审中-公开
    脉冲刺激下细胞信号传导的方法和装置

    公开(公告)号：US20100129856A1

    公开(公告)日：2010-05-27

    申请号：US12624062

    申请日：2009-11-23

    申请人： Ye Fang ,  Vasiliy Nikolaevich Goral ,  Joydeep Lahiri ,  Deepti Jayaraman Mudaliar ,  Elizabeth Tran ,  Qi Wu

    发明人： Ye Fang ,  Vasiliy Nikolaevich Goral ,  Joydeep Lahiri ,  Deepti Jayaraman Mudaliar ,  Elizabeth Tran ,  Qi Wu

    IPC分类号： C12Q1/02 ,  C12M1/34

    CPC分类号： G01N15/06 ,  G01N21/553 ,  G01N21/774 ,  G01N2015/0693

    摘要： The disclosure provides a device for measuring cellular responses under controlled environments. The disclosure also provides an array of devices for measuring cellular responses under controlled environments. The disclosure also provides methods to study cell signaling using the devices. By using microfluidics, the disclosure enables study of cell signaling under well-defined environment conditions. Such capability can be used for differentiating long-acting ligands from short-acting ligands, for determining the kinetics of receptor resensitization and functional recovery of receptor signaling, and for differentiating the sensitivity of a cell type to laminar flow-induced stress force. Through combination with conventional static label-free cell assays, the full spectrum of a drug compound can be studied in details, thus creating a complete representation of its pharmacology acting on living cells.

    摘要翻译： 本公开提供了一种用于在受控环境下测量细胞反应的装置。 本公开还提供了用于在受控环境下测量细胞反应的装置阵列。 本公开还提供了使用该装置研究细胞信号传导的方法。 通过使用微流体，本公开使得能够在明确的环境条件下研究细胞信号。 这种能力可以用于区分长效配体的长效配体，用于确定受体复苏的功能恢复和受体信号的功能恢复的动力学，以及区分细胞类型对层流引起的应力的敏感性。 通过与常规静态无标记细胞测定法的组合，可以详细研究药物化合物的全谱，从而创建其作用于活细胞的药理学的完整表示。

    Cervical brace
    5.
    发明申请
    Cervical brace 审中-公开
    子宫颈大括号

    公开(公告)号：US20050245854A1

    公开(公告)日：2005-11-03

    申请号：US11110121

    申请日：2005-04-20

    申请人： Eric Leuthardt ,  Dennis Rivet ,  Guy Genin ,  Stuart Rosenberg ,  Laura Seger ,  Elizabeth Tran

    发明人： Eric Leuthardt ,  Dennis Rivet ,  Guy Genin ,  Stuart Rosenberg ,  Laura Seger ,  Elizabeth Tran

    IPC分类号： A61F5/00 ,  A61F5/02 ,  A61F5/055

    CPC分类号： A61F5/026 ,  A61F5/055

    摘要： A cervical brace for restraining movement of a head and neck vertebra of a patient relative to at least one of a chest and an abdomen of the patient. The brace includes a mount sized and shaped for attachment to at least one of the chest and the abdomen of the patient and a support extending upward from the mount to a position in use adjacent a rearward surface of the head of the patient. The brace includes a loop sized and shaped for receiving the head of the patient cantilevered from the support. The support includes at least one joint for adjusting at least one of a pitch, a yaw and a roll of the loop relative to the mount.

    摘要翻译： 一种用于限制患者的头颈部颈部相对于患者的胸部和腹部中的至少一个的运动的子宫颈支架。 支架包括尺寸和形状的安装件，用于附接到患者的胸部和腹部中的至少一个，以及从安装件向上延伸到使用中邻近患者头部的后表面的位置的支撑件。 支架包括尺寸和形状适于接收从支撑件悬臂的患者的头部的环。 该支撑件包括至少一个接头，用于相对于座架调整环路的俯仰，偏转和滚动中的至少一个。