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公开(公告)号：US5817676A
公开(公告)日：1998-10-06
申请号：US782478
申请日：1997-01-10
申请人： John T. Catlow , Marlene L. Cohen , Michael O. Martinelli , John M. Schaus , Steven Swanson , Dennis C. Thompson , Thomas M. Wilson
发明人： John T. Catlow , Marlene L. Cohen , Michael O. Martinelli , John M. Schaus , Steven Swanson , Dennis C. Thompson , Thomas M. Wilson
IPC分类号： A61K31/415 , A61K31/4427 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/535 , A61K31/55 , A61P1/00 , A61P9/06 , A61P25/18 , A61P25/20 , A61P25/28 , C07D231/56 , C07D401/12
CPC分类号： C07D231/56 , C07D401/12
摘要： Indazolecarboxamides are used as antagonists and partial agonists for the serotonin receptor 5-HT.sub.4 and provide therapeutic methods for treatment of disorders caused by or affected by dysfunction of the 5-HT.sub.4 receptor.
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公开(公告)号：US5798367A
公开(公告)日：1998-08-25
申请号：US781421
申请日：1997-01-10
申请人： John T. Catlow , Marlene L. Cohen , Michael J. Martinelli , John M. Schaus , Steven Swanson , Dennis C. Thompson , Thomas M. Wilson
发明人： John T. Catlow , Marlene L. Cohen , Michael J. Martinelli , John M. Schaus , Steven Swanson , Dennis C. Thompson , Thomas M. Wilson
IPC分类号： A61K31/415 , A61K31/4427 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/535 , A61K31/55 , A61P1/00 , A61P9/06 , A61P25/18 , A61P25/20 , A61P25/28 , C07D231/56 , C07D401/12
CPC分类号： C07D231/56 , C07D401/12
摘要： Indazolecarboxamides are used as antagonists and partial agonists for the serotonin receptor 5-HT.sub.4 and provide therapeutic methods for treatment of disorders caused by or affected by dysfunction of the 5-HT.sub.4 receptor.
摘要翻译： Indazolecarboxamides用作5-羟色胺受体5-HT4的拮抗剂和部分激动剂，并提供用于治疗由5-HT4受体功能障碍引起或受其影响的病症的治疗方法。
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公开(公告)号：US5654320A
公开(公告)日：1997-08-05
申请号：US485956
申请日：1995-06-07
IPC分类号： C07D231/56 , C07D401/12 , A61K31/445 , C07D403/12
CPC分类号： C07D231/56 , C07D401/12
摘要： Indazolecarboxamides are used as antagonists and partial agonists for the serotonin receptor 5-HT.sub.4 and provide therapeutic methods for treatment of disorders caused by or affected by dysfunction of the 5-HT.sub.4 receptor.
摘要翻译： Indazolecarboxamides用作5-羟色胺受体5-HT4的拮抗剂和部分激动剂，并提供用于治疗由5-HT4受体功能障碍引起或受其影响的病症的治疗方法。
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公开(公告)号：US6117882A
公开(公告)日：2000-09-12
申请号：US338707
申请日：1999-06-23
IPC分类号： A61K31/4427 , A61K31/4523 , A61K31/454 , A61K31/46 , A61P1/04 , A61P1/08 , A61P1/10 , A61P1/14 , A61P9/06 , A61P13/02 , A61P25/04 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P43/00 , C07D401/12 , C07D401/14 , C07D451/04 , A61K31/44
CPC分类号： C07D451/04 , C07D401/12
摘要： Compounds of formula I: ##STR1## are used as antagonists and partial agonists for the serotonin receptor 5-HT.sub.4 and provide therapeutic methods for treatment of disorders caused by or affected by dysfunction of the 5-HT.sub.4 receptor.
摘要翻译： 式I化合物用作5-羟色胺受体5-HT4的拮抗剂和部分激动剂，并提供用于治疗由5-HT 4受体的功能障碍引起或受其影响的病症的治疗方法。
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公开(公告)号：US6069152A
公开(公告)日：2000-05-30
申请号：US946495
申请日：1997-10-07
IPC分类号： A61K31/4427 , A61K31/4523 , A61K31/454 , A61K31/46 , A61P1/04 , A61P1/08 , A61P1/10 , A61P1/14 , A61P9/06 , A61P13/02 , A61P25/04 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P43/00 , C07D401/12 , C07D401/14 , C07D451/04 , A61K31/445 , A61K31/495 , C07D231/56
CPC分类号： C07D451/04 , C07D401/12
摘要： Compounds of formula I: ##STR1## are used as antagonists and partial agonists for the serotonin receptor 5-HT.sub.4 and provide therapeutic methods for treatment of disorders caused by or affected by dysfunction of the 5-HT.sub.4 receptor.
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公开(公告)号：US5576321A
公开(公告)日：1996-11-19
申请号：US468900
申请日：1995-06-06
申请人： Joseph H. Krushinski, Jr. , Kurt Rasmussen , Vincent P. Rocco , John M. Schaus , Dennis C. Thompson
发明人： Joseph H. Krushinski, Jr. , Kurt Rasmussen , Vincent P. Rocco , John M. Schaus , Dennis C. Thompson
IPC分类号： C07D237/28 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/495 , A61K31/50 , A61K31/502 , A61K31/505 , A61K31/517 , A61K31/55 , A61P3/04 , A61P9/12 , A61P13/02 , A61P15/00 , A61P25/04 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , A61P25/30 , A61P43/00 , C07D209/08 , C07D209/32 , C07D237/30 , C07D239/72 , C07D241/40 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D451/14 , C07D471/02 , C07D471/08 , C07D471/10 , C07D491/10 , C07D491/107 , C07D491/20 , C07D495/10 , C07D498/04 , C07D513/04 , A61K31/40 , C07D209/10 , C07D209/12 , C07D209/14
CPC分类号： C07D209/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/08 , C07D471/10 , C07D491/10 , C07D495/10 , C07D513/04
摘要： A series of hetero-oxy alkanamines are effective pharmaceuticals for the treatment of conditions related to or affected by the reuptake of serotonin and by the serotonin 1.sub.A receptor. The compounds are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal, and for the treatment of depression and other conditions for which serotonin reuptake inhibitors are used.
摘要翻译： 一系列异烷基链烷胺是用于治疗与5-羟色胺和5-羟色胺1A受体再摄取相关或受其影响的病症的有效药物。 该化合物特别可用于缓解尼古丁和烟草戒断症状，以及用于治疗抑郁症和使用5-羟色胺再摄取抑制剂的其它病症。
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公开(公告)号：US5789402A
公开(公告)日：1998-08-04
申请号：US471121
申请日：1995-06-06
申请人： James E. Audia , David J. Hibschman , Joseph H. Krushinski, Jr. , Thomas E. Mabry , Jeffrey S. Nissen , Kurt Rasmussen , Vincent P. Rocco , John M. Schaus , Dennis C. Thompson , David T. Wong
发明人： James E. Audia , David J. Hibschman , Joseph H. Krushinski, Jr. , Thomas E. Mabry , Jeffrey S. Nissen , Kurt Rasmussen , Vincent P. Rocco , John M. Schaus , Dennis C. Thompson , David T. Wong
IPC分类号： C07D209/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/08 , C07D471/10 , C07D491/10 , C07D491/20 , C07D495/10 , C07D513/04 , A61K31/55 , C07D401/00 , C07D405/00 , C07D409/00
CPC分类号： C07D209/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/08 , C07D471/10 , C07D491/10 , C07D495/10 , C07D513/04
摘要： A series of hetero-oxy alkanamines are effective pharmaceuticals for the treatment of conditions related to or affected by the reuptake of serotonin and by the serotonin 1.sub.A receptor. The compounds are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal, and for the treatment of depression and other conditions for which serotonin reuptake inhibitors are used.
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公开(公告)号：US5741789A
公开(公告)日：1998-04-21
申请号：US467434
申请日：1995-06-06
申请人： David J. Hibschman , Joseph H. Krushinski, Jr. , Kurt Rasmussen , Vincent P. Rocco , John M. Schaus , Dennis C. Thompson
发明人： David J. Hibschman , Joseph H. Krushinski, Jr. , Kurt Rasmussen , Vincent P. Rocco , John M. Schaus , Dennis C. Thompson
IPC分类号： C07D209/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/08 , C07D471/10 , C07D491/10 , C07D491/20 , C07D495/10 , C07D513/04 , C07D227/00 , A61K31/395 , A61K31/445
CPC分类号： C07D209/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/08 , C07D471/10 , C07D491/10 , C07D495/10 , C07D513/04
摘要： A series of hetero-oxy alkanamines are effective pharmaceuticals for the treatment of conditions related to or affected by the reuptake of serotonin and by the serotonin 1.sub.A receptor. The compounds are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal, and for the treatment of depression and other conditions for which serotonin reuptake inhibitors are used.
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公开(公告)号：US5627196A
公开(公告)日：1997-05-06
申请号：US468948
申请日：1995-06-06
申请人： James E. Audia , David J. Hibschman , Joseph H. Krushinski, Jr. , Thomas E. Mabry , Jeffrey S. Nissen , Kurt Rasmussen , Vincent P. Rocco , John M. Schaus , Dennis C. Thompson , David T. Wong
发明人： James E. Audia , David J. Hibschman , Joseph H. Krushinski, Jr. , Thomas E. Mabry , Jeffrey S. Nissen , Kurt Rasmussen , Vincent P. Rocco , John M. Schaus , Dennis C. Thompson , David T. Wong
IPC分类号： C07D209/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/08 , C07D471/10 , C07D491/10 , C07D491/20 , C07D495/10 , C07D513/04 , A61K31/445 , C07D409/00
CPC分类号： C07D209/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/08 , C07D471/10 , C07D491/10 , C07D495/10 , C07D513/04
摘要： A series of hetero-oxy alkanamines are effective pharmaceuticals for the treatment of conditions related to or affected by the reuptake of serotonin and by the serotonin 1.sub.A receptor. The compounds are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal, and for the treatment of depression and other conditions for which serotonin reuptake inhibitors are used.
摘要翻译： 一系列异烷基链烷胺是用于治疗与5-羟色胺和5-羟色胺1A受体再摄取相关或受其影响的病症的有效药物。 该化合物特别可用于缓解尼古丁和烟草戒断症状，以及用于治疗抑郁症和使用5-羟色胺再摄取抑制剂的其它病症。
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公开(公告)号：US06172073B2
公开(公告)日：2001-01-09
申请号：US09049837
申请日：1998-03-27
申请人： James E. Audia , David J. Hibschman , Joseph H. Krushinski, Jr. , Thomas E. Mabry , Jeffrey S. Nissen , Kurt Rasmussen , Vincent P. Rocco , John M. Schaus , Dennis C. Thompson , David T. Wong
发明人： James E. Audia , David J. Hibschman , Joseph H. Krushinski, Jr. , Thomas E. Mabry , Jeffrey S. Nissen , Kurt Rasmussen , Vincent P. Rocco , John M. Schaus , Dennis C. Thompson , David T. Wong
IPC分类号： A61K31445
CPC分类号： C07D209/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/08 , C07D471/10 , C07D491/10 , C07D495/10 , C07D513/04
摘要： A series of hetero-oxy alkanamines are effective pharmaceuticals for the treatment of conditions related to or affected by the reuptake of serotonin and by the serotonin 1A receptor. The compounds are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal, and for the treatment of depression and other conditions for which serotonin reuptake inhibitors are used.
摘要翻译： 一系列异烷基链烷胺是用于治疗与5-羟色胺和5-羟色胺1A受体再摄取相关或受其影响的病症的有效药物。 该化合物特别可用于缓解尼古丁和烟草戒断症状，以及用于治疗抑郁症和使用5-羟色胺再摄取抑制剂的其它病症。
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