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公开(公告)号：US5576321A
公开(公告)日：1996-11-19
申请号：US468900
申请日：1995-06-06
申请人： Joseph H. Krushinski, Jr. , Kurt Rasmussen , Vincent P. Rocco , John M. Schaus , Dennis C. Thompson
发明人： Joseph H. Krushinski, Jr. , Kurt Rasmussen , Vincent P. Rocco , John M. Schaus , Dennis C. Thompson
IPC分类号： C07D237/28 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/495 , A61K31/50 , A61K31/502 , A61K31/505 , A61K31/517 , A61K31/55 , A61P3/04 , A61P9/12 , A61P13/02 , A61P15/00 , A61P25/04 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , A61P25/30 , A61P43/00 , C07D209/08 , C07D209/32 , C07D237/30 , C07D239/72 , C07D241/40 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D451/14 , C07D471/02 , C07D471/08 , C07D471/10 , C07D491/10 , C07D491/107 , C07D491/20 , C07D495/10 , C07D498/04 , C07D513/04 , A61K31/40 , C07D209/10 , C07D209/12 , C07D209/14
CPC分类号： C07D209/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/08 , C07D471/10 , C07D491/10 , C07D495/10 , C07D513/04
摘要： A series of hetero-oxy alkanamines are effective pharmaceuticals for the treatment of conditions related to or affected by the reuptake of serotonin and by the serotonin 1.sub.A receptor. The compounds are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal, and for the treatment of depression and other conditions for which serotonin reuptake inhibitors are used.
摘要翻译： 一系列异烷基链烷胺是用于治疗与5-羟色胺和5-羟色胺1A受体再摄取相关或受其影响的病症的有效药物。 该化合物特别可用于缓解尼古丁和烟草戒断症状，以及用于治疗抑郁症和使用5-羟色胺再摄取抑制剂的其它病症。
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公开(公告)号：US5789402A
公开(公告)日：1998-08-04
申请号：US471121
申请日：1995-06-06
申请人： James E. Audia , David J. Hibschman , Joseph H. Krushinski, Jr. , Thomas E. Mabry , Jeffrey S. Nissen , Kurt Rasmussen , Vincent P. Rocco , John M. Schaus , Dennis C. Thompson , David T. Wong
发明人： James E. Audia , David J. Hibschman , Joseph H. Krushinski, Jr. , Thomas E. Mabry , Jeffrey S. Nissen , Kurt Rasmussen , Vincent P. Rocco , John M. Schaus , Dennis C. Thompson , David T. Wong
IPC分类号： C07D209/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/08 , C07D471/10 , C07D491/10 , C07D491/20 , C07D495/10 , C07D513/04 , A61K31/55 , C07D401/00 , C07D405/00 , C07D409/00
CPC分类号： C07D209/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/08 , C07D471/10 , C07D491/10 , C07D495/10 , C07D513/04
摘要： A series of hetero-oxy alkanamines are effective pharmaceuticals for the treatment of conditions related to or affected by the reuptake of serotonin and by the serotonin 1.sub.A receptor. The compounds are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal, and for the treatment of depression and other conditions for which serotonin reuptake inhibitors are used.
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公开(公告)号：US5741789A
公开(公告)日：1998-04-21
申请号：US467434
申请日：1995-06-06
申请人： David J. Hibschman , Joseph H. Krushinski, Jr. , Kurt Rasmussen , Vincent P. Rocco , John M. Schaus , Dennis C. Thompson
发明人： David J. Hibschman , Joseph H. Krushinski, Jr. , Kurt Rasmussen , Vincent P. Rocco , John M. Schaus , Dennis C. Thompson
IPC分类号： C07D209/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/08 , C07D471/10 , C07D491/10 , C07D491/20 , C07D495/10 , C07D513/04 , C07D227/00 , A61K31/395 , A61K31/445
CPC分类号： C07D209/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/08 , C07D471/10 , C07D491/10 , C07D495/10 , C07D513/04
摘要： A series of hetero-oxy alkanamines are effective pharmaceuticals for the treatment of conditions related to or affected by the reuptake of serotonin and by the serotonin 1.sub.A receptor. The compounds are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal, and for the treatment of depression and other conditions for which serotonin reuptake inhibitors are used.
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公开(公告)号：US5627196A
公开(公告)日：1997-05-06
申请号：US468948
申请日：1995-06-06
申请人： James E. Audia , David J. Hibschman , Joseph H. Krushinski, Jr. , Thomas E. Mabry , Jeffrey S. Nissen , Kurt Rasmussen , Vincent P. Rocco , John M. Schaus , Dennis C. Thompson , David T. Wong
发明人： James E. Audia , David J. Hibschman , Joseph H. Krushinski, Jr. , Thomas E. Mabry , Jeffrey S. Nissen , Kurt Rasmussen , Vincent P. Rocco , John M. Schaus , Dennis C. Thompson , David T. Wong
IPC分类号： C07D209/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/08 , C07D471/10 , C07D491/10 , C07D491/20 , C07D495/10 , C07D513/04 , A61K31/445 , C07D409/00
CPC分类号： C07D209/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/08 , C07D471/10 , C07D491/10 , C07D495/10 , C07D513/04
摘要： A series of hetero-oxy alkanamines are effective pharmaceuticals for the treatment of conditions related to or affected by the reuptake of serotonin and by the serotonin 1.sub.A receptor. The compounds are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal, and for the treatment of depression and other conditions for which serotonin reuptake inhibitors are used.
摘要翻译： 一系列异烷基链烷胺是用于治疗与5-羟色胺和5-羟色胺1A受体再摄取相关或受其影响的病症的有效药物。 该化合物特别可用于缓解尼古丁和烟草戒断症状，以及用于治疗抑郁症和使用5-羟色胺再摄取抑制剂的其它病症。
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公开(公告)号：US06172073B2
公开(公告)日：2001-01-09
申请号：US09049837
申请日：1998-03-27
申请人： James E. Audia , David J. Hibschman , Joseph H. Krushinski, Jr. , Thomas E. Mabry , Jeffrey S. Nissen , Kurt Rasmussen , Vincent P. Rocco , John M. Schaus , Dennis C. Thompson , David T. Wong
发明人： James E. Audia , David J. Hibschman , Joseph H. Krushinski, Jr. , Thomas E. Mabry , Jeffrey S. Nissen , Kurt Rasmussen , Vincent P. Rocco , John M. Schaus , Dennis C. Thompson , David T. Wong
IPC分类号： A61K31445
CPC分类号： C07D209/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/08 , C07D471/10 , C07D491/10 , C07D495/10 , C07D513/04
摘要： A series of hetero-oxy alkanamines are effective pharmaceuticals for the treatment of conditions related to or affected by the reuptake of serotonin and by the serotonin 1A receptor. The compounds are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal, and for the treatment of depression and other conditions for which serotonin reuptake inhibitors are used.
摘要翻译： 一系列异烷基链烷胺是用于治疗与5-羟色胺和5-羟色胺1A受体再摄取相关或受其影响的病症的有效药物。 该化合物特别可用于缓解尼古丁和烟草戒断症状，以及用于治疗抑郁症和使用5-羟色胺再摄取抑制剂的其它病症。
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公开(公告)号：US5614523A
公开(公告)日：1997-03-25
申请号：US470512
申请日：1995-06-06
申请人： James E. Audia , Joseph H. Krushinski, Jr. , Kurt Rasmussen , Vincent P. Rocco , John M. Schaus , Dennis C. Thompson , David T. Wong
发明人： James E. Audia , Joseph H. Krushinski, Jr. , Kurt Rasmussen , Vincent P. Rocco , John M. Schaus , Dennis C. Thompson , David T. Wong
IPC分类号： C07D209/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/08 , C07D471/10 , C07D491/10 , C07D491/20 , C07D495/10 , C07D513/04 , A61K31/50 , C07D241/04
CPC分类号： C07D209/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/08 , C07D471/10 , C07D491/10 , C07D495/10 , C07D513/04
摘要： A series of hetero-oxy alkanamines are effective pharmaceuticals for the treatment of conditions related to or affected by the reuptake of serotonin and by the serotonin 1.sub.A receptor. The compounds are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal, and for the treatment of depression and other conditions for which serotonin reuptake inhibitors are used.
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公开(公告)号：US5023269A
公开(公告)日：1991-06-11
申请号：US499940
申请日：1990-03-27
IPC分类号： C07D213/38 , C07D277/28 , C07D307/52 , C07D333/20 , C07D333/28
CPC分类号： C07D213/38 , C07D277/28 , C07D307/52 , C07D333/20 , C07D333/28 , Y10S514/811 , Y10S514/813 , Y10S514/91
摘要： The present invention provides 3-aryloxy-3-substituted propanamines capable of inhibiting the uptake of serotonin and norepinephrine.
摘要翻译： 本发明提供能够抑制5-羟色胺和去甲肾上腺素摄取的3-芳氧基-3-取代的丙胺。
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公开(公告)号：US5874427A
公开(公告)日：1999-02-23
申请号：US59768
申请日：1998-04-14
IPC分类号： A61P25/04 , A61K31/437 , A61K31/4375 , A61K31/55 , A61P25/06 , A61P43/00 , C07D455/02 , C07D455/03 , C07D471/04 , C07D519/00 , A61K31/435
CPC分类号： C07D455/00 , C07D471/04
摘要： This invention provides novel 5-HT.sub.1F agonists of the Formula ##STR1## in which X, Y, E, R, A, B, and n are as defined in the specification, which are useful for the treatment of migraine and associated disorders.
摘要翻译： 本发明提供了本发明的新颖的5-HT1F激动剂，其中X，Y，E，R，A，B和n如说明书中所定义，其可用于治疗偏头痛及相关疾病。
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公开(公告)号：US4956388A
公开(公告)日：1990-09-11
申请号：US462925
申请日：1990-01-12
IPC分类号： C07D213/38 , C07D277/28 , C07D307/52 , C07D333/20 , C07D333/28
CPC分类号： C07D213/38 , C07D277/28 , C07D307/52 , C07D333/20 , C07D333/28 , Y10S514/811 , Y10S514/813 , Y10S514/91
摘要： The present invention provides 3-aryloxy-3-substituted propanamines capable of inhibiting the uptake of serotonin and norepinephrine.
摘要翻译： 本发明提供能够抑制5-羟色胺和去甲肾上腺素摄取的3-芳氧基-3-取代的丙胺。
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公开(公告)号：US06869957B1
公开(公告)日：2005-03-22
申请号：US10668565
申请日：2003-09-23
申请人： Sung Y. Cho , Thomas A. Crowell , Bruce D. Gitter , Philip A. Hipskind , J. Jeffry Howbert , Joseph H. Krushinski, Jr. , Karen L. Lobb , Brian S. Muehl , James A. Nixon
发明人： Sung Y. Cho , Thomas A. Crowell , Bruce D. Gitter , Philip A. Hipskind , J. Jeffry Howbert , Joseph H. Krushinski, Jr. , Karen L. Lobb , Brian S. Muehl , James A. Nixon
IPC分类号： C07C233/44 , C07C233/78 , C07C271/20 , C07D209/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/12 , C07D409/14 , A61K31/4045 , C07D209/20
CPC分类号： C07D401/12 , C07C233/44 , C07C233/78 , C07C271/20 , C07D209/16 , C07D401/14 , C07D403/12 , C07D409/12 , C07D409/14
摘要： This invention provides a novel series of non-peptidyl compounds which are useful in the treatment or prevention of a physiological disorder associated with an excess of tachykinins. This invention also provides methods for the treatment of such physiological disorders as well as pharmaceutical formulations which employ these novel compounds.
摘要翻译： 本发明提供了一系列非肽基化合物，其可用于治疗或预防与超速激肽相关的生理障碍。 本发明还提供了治疗这种生理疾病的方法以及采用这些新化合物的药物制剂。
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