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公开(公告)号：US09671413B2
公开(公告)日：2017-06-06
申请号：US13884195
申请日：2011-11-11
IPC分类号： G01N33/68 , G01N33/574 , G01N33/543 , C40B40/10
CPC分类号： G01N33/689 , C40B40/10 , G01N33/54386 , G01N33/57434
摘要： The invention relates to point of care diagnostic disposables, devices, methods, and systems for diagnosing or predicting prostate cancer. The present invention employs biomarker specific reagents in disposable cassettes or lab cards for use as analyzers, as well as software to evaluate and report test results. The system promises to improve point of care in vitro diagnostics.
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公开(公告)号：US20130274136A1
公开(公告)日：2013-10-17
申请号：US13884195
申请日：2011-11-11
IPC分类号： G01N33/68
CPC分类号： G01N33/689 , C40B40/10 , G01N33/54386 , G01N33/57434
摘要： The invention relates to point of care diagnostic disposables, devices, methods, and systems for diagnosing or predicting prostate cancer. The present invention employs biomarker specific reagents in disposable cassettes or lab cards for use as analyzers, as well as software to evaluate and report test results. The system promises to improve point of care in vitro diagnostics.
摘要翻译： 本发明涉及用于诊断或预测前列腺癌的诊断一次性用品，装置，方法和系统。 本发明在一次性盒或实验室卡中使用生物标志物特异性试剂用作分析仪，以及评估和报告测试结果的软件。 该系统有望改善体外诊断的护理点。
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公开(公告)号：US20080176253A1
公开(公告)日：2008-07-24
申请号：US11746941
申请日：2007-05-10
CPC分类号： G01N33/543 , G01N33/54366 , G01N33/6854
摘要： Methods, systems, and apparatus for detecting the presence of human or animal immunoglobin-E are described. A fluid or gas sample may pass through a particle-based detection system of a cartridge. Detection and analysis techniques may be applied to determine the identity and quantity of the captured IgE.
摘要翻译： 描述了用于检测人或动物免疫球蛋白E的存在的方法，系统和装置。 流体或气体样品可以通过药筒的基于粒子的检测系统。 可以应用检测和分析技术来确定捕获的IgE的身份和数量。
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4.发明申请CARDIBIOINDEX/CARDIBIOSCORE AND UTILITY OF SALIVARY PROTEOME IN CARDIOVASCULAR DIAGNOSTICS 审中-公开CARDIBIOINDEX / CARDIBIOSCORE以及心脏血管病变诊断的应用公开(公告)号：US20080300798A1
公开(公告)日：2008-12-04
申请号：US12104303
申请日：2008-04-16
申请人： John T. McDevitt , Nicolaos Christodoulides , Pierre N. Floriano , Craig S. Miller , Jeffrey L. Ebersole
发明人： John T. McDevitt , Nicolaos Christodoulides , Pierre N. Floriano , Craig S. Miller , Jeffrey L. Ebersole
IPC分类号： G01N33/50
CPC分类号： G01N33/6893 , G01N2800/32 , G01N2800/324
摘要： Embodiments of the invention include methods by which cardiac biomarkers are assigned an index (cardiovascular biomarker index-cardiobioindex, CBI) as a means to describe the utility of each biomarker, or combination of biomarkers for risk evaluation, diagnosis or prognosis of cardiovascular disease status.
摘要翻译： 本发明的实施方案包括将心脏生物标志物指定为指标（心血管生物标志物指数 - 心脏生物学指标，CBI）作为描述每种生物标志物的用途或用于心血管疾病状态的风险评估，诊断或预后的生物标志物的组合的方法。
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公开(公告)号：US09709580B2
公开(公告)日：2017-07-18
申请号：US14114925
申请日：2012-03-21
IPC分类号： G01N33/94 , G01N33/53 , A61B10/00 , B01L3/00 , A61B5/151 , A61F13/36 , A61B50/30 , G01N21/64
CPC分类号： G01N33/948 , A61B5/151 , A61B10/0051 , A61B10/007 , A61B50/30 , A61F13/36 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L2200/027 , B01L2300/0816 , B01L2300/0867 , B01L2400/0481 , G01N21/64 , G01N33/946 , G01N33/9486
摘要： A bio-nano-chip (BNC) technology that works in connection with non-invasive samples, such as saliva, cheek swab or urine samples that can be easily performed by non-specialists, such as security personnel and police officers is disclosed. The microfluidic system for drug testing includes an analyzer or reader having a housing containing a slot for receiving a cartridge, a drug testing cartridge, a processor having a user interface, an optical or energy sensing means, and a means for moving fluid.
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公开(公告)号：US20130295580A1
公开(公告)日：2013-11-07
申请号：US13884702
申请日：2011-11-11
申请人： John T. McDevitt , Nicolaos Christodoulides , Pierre N. Floriano , Martin Thornhill , Spencer Redding , Nadarajah Vigneswaran , Craig Murdoch , Paul Speight
发明人： John T. McDevitt , Nicolaos Christodoulides , Pierre N. Floriano , Martin Thornhill , Spencer Redding , Nadarajah Vigneswaran , Craig Murdoch , Paul Speight
IPC分类号： G01N33/574
CPC分类号： G01N33/57407 , G01N2333/47 , G01N2333/4703 , G01N2333/70596 , G01N2333/71
摘要： A point of care diagnostic test, device and disposables for determining a patient risk for oral cancer in the same visit that a sample is collected.
摘要翻译： 在收集样品的同一次访视中，用于确定患者口腔癌风险的诊断点诊断测试，设备和一次性物品。
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公开(公告)号：US09535068B2
公开(公告)日：2017-01-03
申请号：US13884702
申请日：2011-11-11
申请人： John T. McDevitt , Nicolaos Christodoulides , Pierre N. Floriano , Martin Thornhill , Spencer Redding , Nadarajah Vigneswaran , Craig Murdoch , Paul Speight
发明人： John T. McDevitt , Nicolaos Christodoulides , Pierre N. Floriano , Martin Thornhill , Spencer Redding , Nadarajah Vigneswaran , Craig Murdoch , Paul Speight
IPC分类号： G01N33/53 , G01N33/574
CPC分类号： G01N33/57407 , G01N2333/47 , G01N2333/4703 , G01N2333/70596 , G01N2333/71
摘要： A point of care diagnostic test, device and disposables for determining a patient risk for oral cancer in the same visit that a sample is collected.
摘要翻译： 在收集样品的同一次访视中，用于确定患者口腔癌风险的诊断点诊断测试，设备和一次性物品。
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公开(公告)号：US20140094391A1
公开(公告)日：2014-04-03
申请号：US14114925
申请日：2012-03-21
CPC分类号： G01N33/948 , A61B5/151 , A61B10/0051 , A61B10/007 , A61B50/30 , A61F13/36 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L2200/027 , B01L2300/0816 , B01L2300/0867 , B01L2400/0481 , G01N21/64 , G01N33/946 , G01N33/9486
摘要： A bio-nano-chip (BNC) technology that works in connection with non-invasive samples, such as saliva, cheek swab or urine samples that can be easily performed by non-specialists, such as security personnel and police officers is disclosed. The microfluidic system for drug testing includes an analyzer or reader having a housing containing a slot for receiving a cartridge, a drug testing cartridge, a processor having a user interface, an optical or energy sensing means, and a means for moving fluid.
摘要翻译： 公开了一种与非侵入性样品（例如唾液，颊拭子或尿液样本）相关的生物纳米芯片（BNC）技术，可以由非专家（如安全人员和警务人员）轻松执行。 用于药物测试的微流体系统包括具有壳体的分析器或读取器，该壳体包含用于容纳盒的狭槽，药物测试盒，具有用户界面的处理器，光学或能量感测装置以及用于移动流体的装置。
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9.发明申请METHODS AND COMPOSITIONS FOR DIAGNOSIS OF ACUTE MYOCARDIAL INFARCTION (AMI) 审中-公开急性心肌梗死（AMI）诊断方法与组合公开(公告)号：US20120208715A1
公开(公告)日：2012-08-16
申请号：US13390619
申请日：2010-08-20
申请人： John T. McDevitt , Craig S. Miller , Jeffrey L. Ebersole , Nicolaos Christodoulides , Pierre N. Floriano
发明人： John T. McDevitt , Craig S. Miller , Jeffrey L. Ebersole , Nicolaos Christodoulides , Pierre N. Floriano
IPC分类号： C40B30/04 , G01N33/573 , G01N33/566
CPC分类号： G01N33/6893 , G01N2800/324
摘要： Embodiments of the invention utilizes advanced detection methodologies, such as the lab-on-a-chip (LOC) technology, as a cost-effective, efficient, ultra-sensitive rapid method for diagnosing Acute Myocardial Infarction (AMI) in human subjects. In certain aspects, multiple biomarkers of AMI are concurrently detected and measured in serum and saliva to provide a more efficient, sensitive and accurate diagnosis of AMI.
摘要翻译： 本发明的实施例利用诸如片上实验室（LOC）技术的先进的检测方法作为用于诊断人类受试者的急性心肌梗塞（AMI）的成本有效，高效，超灵敏的快速方法。 在某些方面，在血清和唾液中同时检测和测量AMI的多种生物标志物，以提供AMI更有效，灵敏和准确的诊断。
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10.发明授权Methods and compositions related to determination and use of white blood cell counts 失效与确定和使用白细胞计数相关的方法和组合物公开(公告)号：US08377398B2
公开(公告)日：2013-02-19
申请号：US11997396
申请日：2006-05-31
申请人： John T. McDevitt , Nicolaos J. Christodoulides , Pierre N. Floriano , Gary N. Douglas , Patrick E. Rogers
发明人： John T. McDevitt , Nicolaos J. Christodoulides , Pierre N. Floriano , Gary N. Douglas , Patrick E. Rogers
IPC分类号： G01N21/00 , G01N33/00 , G01N33/543 , B01D21/00 , B01D35/00
CPC分类号： G01N21/6456 , G01N21/6428 , G01N33/56972 , G01N2021/6419 , G01N2021/6421 , Y10T436/112499 , Y10T436/25125 , Y10T436/25375 , Y10T436/255
摘要： Described herein is an analyte detection device and method related to a portable instrument suitable for point-of-care analyses. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and/or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and/or waste reservoirs. Use of a portable instrument may reduce the hazard to an operator by reducing an operator's contact with a sample for analysis. The device is capable of obtaining diagnostic information using cellular- and/or particle-based analyses and may be used in conjunction with membrane- and/or particle-based analysis cartridges. Analytes, including proteins and cells and/or microbes may be detected using the membrane and/or particle based analysis system.
摘要翻译： 本文描述了与适合于点护理分析的便携式仪器相关的分析物检测装置和方法。 在一些实施例中，便携式仪器可以包括一次性盒，光学检测器，样品收集装置和/或样品储存器，试剂递送系统，流体输送系统，一个或多个通道和/或废物储存器。 使用便携式仪器可能会降低操作员与样品的接触以分析危害操作员的危险。 该设备能够使用基于细胞和/或基于粒子的分析获得诊断信息，并且可以与基于膜和/或基于粒子的分析盒结合使用。 可以使用基于膜和/或基于粒子的分析系统检测分析物，包括蛋白质和细胞和/或微生物。
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