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21 条记录 (耗时 0.025 秒)

    Anthrax antitoxins
    1.
    发明申请
    Anthrax antitoxins 失效
    炭疽毒素

    公开(公告)号：US20070172500A1

    公开(公告)日：2007-07-26

    申请号：US11340424

    申请日：2006-01-26

    申请人： John Young ,  Heather Scobie ,  G. Jonah Rainey ,  Kenneth Bradley

    发明人： John Young ,  Heather Scobie ,  G. Jonah Rainey ,  Kenneth Bradley

    IPC分类号： A61K39/07 ,  C07H21/04 ,  C07K14/32 ,  C12N15/74 ,  C12N1/21

    CPC分类号： C07K16/1278 ,  A61K38/00 ,  C07K14/705 ,  C07K14/78

    摘要： The present invention provides compositions useful in preparing and/or serving as antitoxins against Bacillus anthracis, the causative agent of anthrax. The present invention also provides polypeptides and polynucleotides relating to the capillary morphogenisis gene 2 (CMG-2), vectors containing the polynucleotides and polypeptides, and host cells containing related polynucleotide molecules, all used in association with the treatment of, or the research and development of treatments for anthrax. The present invention also relates to methods for identifying molecules that bind CMG-2 and molecules that reduce the toxicity of anthrax toxin. Finally, the present invention provides methods for treating human and non-human animals suffering from anthrax.

    摘要翻译： 本发明提供了可用于制备和/或用作抗炭疽杆菌（Anthracis）的抗毒素的组合物，炭疽芽孢杆菌的致病因子。 本发明还提供了与毛细血管形成形成发生基因2（CMG-2）相关的多肽和多核苷酸，含有多核苷酸和多肽的载体，以及包含相关多核苷酸分子的宿主细胞，所有这些都与治疗或研究和开发相结合 的炭疽治疗。 本发明还涉及用于鉴定结合CMG-2的分子和降低炭疽毒素毒性的分子的方法。 最后，本发明提供了治疗患有炭疽的人类和非人类动物的方法。

    RECEPTOR FOR B. ANTHRACIS TOXIN
    2.
    发明申请
    RECEPTOR FOR B. ANTHRACIS TOXIN 有权
    受体拮抗剂

    公开(公告)号：US20060110801A1

    公开(公告)日：2006-05-25

    申请号：US09970076

    申请日：2001-10-03

    申请人： John Young ,  Kenneth Bradley ,  R. Collier ,  Jeremy Mogridge

    发明人： John Young ,  Kenneth Bradley ,  R. Collier ,  Jeremy Mogridge

    IPC分类号： C07H21/04 ,  C12N15/74 ,  C12N1/21 ,  C07K14/32 ,  C07K14/705

    CPC分类号： C07K14/705 ,  A61K38/00

    摘要： The present invention relates to mammalian anthrax toxin receptor polypeptides and polynucleotides encoding same as well as related polypeptides and polynucleotides, vectors containing the polynucleotides and polypeptides, host cells containing related polynucleotide molecules, and cells displaying no anthrax toxin receptor on an exterior surface of the cells-minus cell lines and animals. The present invention also relates to methods for identifying molecules that bind the anthrax toxin receptor and molecules that reduce the toxicity of anthrax toxin. Finally, the present invention provides methods for treating human and non-human animals suffering from anthrax.

    摘要翻译： 本发明涉及哺乳动物炭疽毒素受体多肽和编码其的多核苷酸以及相关多肽和多核苷酸，含有多核苷酸和多肽的载体，含有相关多核苷酸分子的宿主细胞和在细胞外表面上不显示炭疽毒素受体的细胞 - 细胞系和动物。 本发明还涉及用于鉴定结合炭疽毒素受体的分子和降低炭疽毒素毒性的分子的方法。 最后，本发明提供了治疗患有炭疽的人类和非人类动物的方法。

    Receptor for B. anthracis toxin
    3.
    发明申请
    Receptor for B. anthracis toxin 审中-公开
    炭疽杆菌毒素受体

    公开(公告)号：US20060083746A1

    公开(公告)日：2006-04-20

    申请号：US11047224

    申请日：2005-01-31

    申请人： John Young ,  Kenneth Bradley ,  R. Collier ,  Jeremy Mogridge

    发明人： John Young ,  Kenneth Bradley ,  R. Collier ,  Jeremy Mogridge

    IPC分类号： A61K39/40 ,  C07H21/04 ,  C12N15/74 ,  C12N1/21 ,  C07K14/32

    CPC分类号： C07K14/705 ,  A61K38/00

    摘要： The present invention relates to mammalian anthrax toxin receptor polypeptides and polynucleotides encoding same as well as related polypeptides and polynucleotides, vectors containing the polynucleotides and polypeptides, host cells containing related polynucleotide molecules, and cells displaying no anthrax toxin receptor on an exterior surface of the cells-minus cell lines and animals. The present invention also relates to methods for identifying molecules that bind the anthrax toxin receptor and molecules that reduce the toxicity of anthrax toxin. Finally, the present invention provides methods for treating human and non-human animals suffering from anthrax.

    摘要翻译： 本发明涉及哺乳动物炭疽毒素受体多肽和编码其的多核苷酸以及相关多肽和多核苷酸，含有多核苷酸和多肽的载体，含有相关多核苷酸分子的宿主细胞和在细胞外表面上不显示炭疽毒素受体的细胞 - 细胞系和动物。 本发明还涉及用于鉴定结合炭疽毒素受体的分子和降低炭疽毒素毒性的分子的方法。 最后，本发明提供了治疗患有炭疽的人类和非人类动物的方法。

    Receptor for B. anthracis toxin
    4.
    发明申请
    Receptor for B. anthracis toxin 审中-公开
    炭疽杆菌毒素受体

    公开(公告)号：US20070117159A1

    公开(公告)日：2007-05-24

    申请号：US11483872

    申请日：2006-07-10

    申请人： John Young ,  Kenneth Bradley ,  R. Collier ,  Jeremy Mogridge

    发明人： John Young ,  Kenneth Bradley ,  R. Collier ,  Jeremy Mogridge

    IPC分类号： G01N33/567 ,  C07H21/04 ,  C12P21/06 ,  C12N1/21 ,  C07K14/74 ,  C07K14/32 ,  C12N15/74

    CPC分类号： C07K14/705 ,  A61K38/00

    摘要： The present invention relates to mammalian anthrax toxin receptor polypeptides and polynucleotides encoding same as well as related polypeptides and polynucleotides, vectors containing the polynucleotides and polypeptides, host cells containing related polynucleotide molecules, and cells displaying no anthrax toxin receptor on an exterior surface of the cells-minus cell lines and animals. The present invention also relates to methods for identifying molecules that bind the anthrax toxin receptor and molecules that reduce the toxicity of anthrax toxin. Finally, the present invention provides methods for treating human and non-human animals suffering from anthrax.

    摘要翻译： 本发明涉及哺乳动物炭疽毒素受体多肽和编码其的多核苷酸以及相关多肽和多核苷酸，含有多核苷酸和多肽的载体，含有相关多核苷酸分子的宿主细胞和在细胞外表面上不显示炭疽毒素受体的细胞 - 细胞系和动物。 本发明还涉及用于鉴定结合炭疽毒素受体的分子和降低炭疽毒素毒性的分子的方法。 最后，本发明提供了治疗患有炭疽的人类和非人类动物的方法。

    Receptor for B. anthracis toxin
    5.
    发明申请
    Receptor for B. anthracis toxin 失效
    炭疽杆菌毒素受体

    公开(公告)号：US20050196407A1

    公开(公告)日：2005-09-08

    申请号：US11047278

    申请日：2005-01-31

    申请人： John Young ,  Kenneth Bradley ,  R. John Collier ,  Jeremy Mogridge

    发明人： John Young ,  Kenneth Bradley ,  R. John Collier ,  Jeremy Mogridge

    IPC分类号： A61K38/00 ,  C07K14/705 ,  C12N15/12 ,  C12Q1/68 ,  A61K39/02 ,  A61K39/07 ,  C07H21/04 ,  C07K14/32 ,  C12N1/21

    CPC分类号： C07K14/705 ,  A61K38/00

    摘要： The present invention relates to mammalian anthrax toxin receptor polypeptides and polynucleotides encoding same as well as related polypeptides and polynucleotides, vectors containing the polynucleotides and polypeptides, host cells containing related polynucleotide molecules, and cells displaying no anthrax toxin receptor on an exterior surface of the cells—minus cell lines and animals. The present invention also relates to methods for identifying molecules that bind the anthrax toxin receptor and molecules that reduce the toxicity of anthrax toxin. Finally, the present invention provides methods for treating human and non-human animals suffering from anthrax.

    摘要翻译： 本发明涉及哺乳动物炭疽毒素受体多肽和编码其的多核苷酸以及相关多肽和多核苷酸，含有多核苷酸和多肽的载体，含有相关多核苷酸分子的宿主细胞和在细胞外表面上不显示炭疽毒素受体的细胞 - 细胞系和动物。 本发明还涉及用于鉴定结合炭疽毒素受体的分子和降低炭疽毒素毒性的分子的方法。 最后，本发明提供了治疗患有炭疽的人类和非人类动物的方法。

    Surface Mapping by Optical Manipulation of Particles in Relation to a Functionalized Surface
    6.
    发明申请
    Surface Mapping by Optical Manipulation of Particles in Relation to a Functionalized Surface 有权
    通过光学操作颗粒与功能化表面的表面贴图

    公开(公告)号：US20110026009A1

    公开(公告)日：2011-02-03

    申请号：US12440949

    申请日：2007-09-14

    申请人： Christopher Knutson ,  Crystal Duke ,  Gary Stacey ,  Dan Mueth ,  Evan Tanner ,  Osman Akcakir ,  Haojun Fu ,  Robert Lancelot ,  Tania Chakrabarty ,  Kenneth Bradley

    发明人： Christopher Knutson ,  Crystal Duke ,  Gary Stacey ,  Dan Mueth ,  Evan Tanner ,  Osman Akcakir ,  Haojun Fu ,  Robert Lancelot ,  Tania Chakrabarty ,  Kenneth Bradley

    IPC分类号： G01N33/48 ,  G01B11/30

    CPC分类号： G01N33/48 ,  G01N33/54373 ,  G01N33/80

    摘要： Methods and apparatus for analyzing surface properties of particles are provided. A method for analyzing the surface properties of the particle includes a associating a first particle with a first capture zone having a specific binding affinity for a first chemical species, applying an optical force to the first particle, sensing a response of the first particle to the optical force, and using the sensed response to determine the presence, absence or quantity of the first chemical species on the first particle surface. This process may be repeated in parallel to test multiple particles. In addition to directly testing the surface properties of the particles, the method can be used in direct, indirect and competitive assays to determine the presence, absence or quantity of free or immobilized analytes. A fluidic cartridge with capture zones having avidities that are tuned for the use of optical forces is provided. A software routine for performing the method is also provided.

    摘要翻译： 提供了分析颗粒表面性质的方法和装置。 用于分析颗粒的表面性质的方法包括将第一颗粒与对第一化学物质具有特异性结合亲和力的第一捕获区缔合，向第一颗粒施加光学力，感测第一颗粒对第一颗粒的响应 并且使用感测到的响应来确定第一颗粒表面上的第一化学物质的存在，不存在或数量。 该过程可以并行重复以测试多个颗粒。 除了直接测试颗粒的表面性质之外，该方法可用于直接，间接和竞争性测定，以确定游离或固定化分析物的存在，不存在或数量。 提供了一种具有捕获区域的流体盒，其具有被调整以用于光学力的空间。 还提供了用于执行该方法的软件程序。

    System and method for manipulating and processing materials using holographic optical trapping
    9.
    发明申请
    System and method for manipulating and processing materials using holographic optical trapping 审中-公开
    使用全息光学捕获来操纵和处理材料的系统和方法

    公开(公告)号：US20090002790A1

    公开(公告)日：2009-01-01

    申请号：US12230430

    申请日：2008-08-28

    申请人： Joseph Plewa ,  Evan Tanner ,  Dan Mueth ,  Lewis Gruber ,  Kenneth Bradley

    发明人： Joseph Plewa ,  Evan Tanner ,  Dan Mueth ,  Lewis Gruber ,  Kenneth Bradley

    IPC分类号： G03H1/04 ,  G02F1/29 ,  G02B27/40

    CPC分类号： B82Y10/00 ,  G03H1/08 ,  G03H1/2294 ,  G03H2001/0077 ,  G03H2225/32

    摘要： An apparatus for manipulating particles (micro, nano, and pico) having one or more characteristics with an optical trap formed by modulating a laser beam with a Diffractive Optical Element (DOE). At least one characteristic of the material is selected; and a laser beam having a selected wavelength corresponding to the at least one selected characteristic of the material is generated. Values of the DOE are calculated corresponding to the at least one selected characteristic of the material. The beam and the DOE are modulated to produce a holographic optical trap having properties corresponding to the at least one selected characteristic; the trap is focused to a beam focus or selected spot size; and the beam focus is located near a particle location for trapping the particle therein.

    摘要翻译： 一种用于通过用衍射光学元件（DOE）调制激光束而形成的光阱来操纵具有一个或多个特性的微粒（微，纳米和微微）的装置。 选择材料的至少一种特性; 并且产生具有与材料的至少一个所选特征对应的选定波长的激光束。 根据材料的至少一个所选特征计算DOE的值。 光束和DOE被调制以产生具有对应于至少一个所选特征的性质的全息光阱; 陷阱聚焦到光束焦点或选定的光斑尺寸; 并且束聚焦位于颗粒位置附近以将颗粒捕获在其中。