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    NOVEL CELLULAR GLYCAN COMPOSITIONS
    6.
    发明申请
    NOVEL CELLULAR GLYCAN COMPOSITIONS 审中-公开
    新颖的糖果组合物

    公开(公告)号：US20090317834A1

    公开(公告)日：2009-12-24

    申请号：US12306774

    申请日：2007-06-29

    申请人： Jarmo Laine ,  Tero Satomaa ,  Jari Natunen ,  Annamari Heiskanen ,  Juhani Saarinen ,  Taina Jaatinen ,  Milla Mikkola ,  Suvi Natunen

    发明人： Jarmo Laine ,  Tero Satomaa ,  Jari Natunen ,  Annamari Heiskanen ,  Juhani Saarinen ,  Taina Jaatinen ,  Milla Mikkola ,  Suvi Natunen

    IPC分类号： G01N33/567 ,  C12N5/06

    CPC分类号： G01N33/6848 ,  C08B37/0006 ,  C08B37/006 ,  C12N5/0606 ,  G01N33/56966 ,  G01N2400/10

    摘要： The invention describes novel compositions of glycans, glycomes, from human embryonic stem cells, and especially novel subcompositions of the glycomes with specific monosaccharide compositions and glycan structures. The invention is further directed to methods for modifying the glycomes and analysis of the glycomes and the modified glycomes. Furthermore, the invention is directed to stem cells carrying the modified glycomes on their surfaces. The glycomes are preferably analysed by profiling methods able to detect reproducibly and quantitatively numerous individual glycan structures at the same time. The most preferred type of the profile is a mass spectrometric profile. The invention specifically revealed novel target structures and is especially directed to the development of reagents recognizing the structures.

    摘要翻译： 本发明描述了来自人胚胎干细胞的聚糖，糖原的新组合物，特别是具有特异性单糖组成和聚糖结构的糖链的新型亚组合物。 本发明进一步涉及用于修改糖尿病和分析糖尿病和修饰的糖尿病的方法。 此外，本发明涉及在其表面上携带修饰的糖基的干细胞。 优选地通过能够同时检测可重复地和定量地检测许多个体聚糖结构的分析方法来分析糖分。 轮廓的最优选类型是质谱分布。 本发明特别揭示了新颖的靶结构，特别涉及识别结构的试剂的开发。