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    Method of isolating ependymal neural stem cells
    1.
    发明授权
    Method of isolating ependymal neural stem cells 有权
    分离室管膜神经干细胞的方法

    公开(公告)号：US07279332B2

    公开(公告)日：2007-10-09

    申请号：US10326438

    申请日：2002-12-20

    申请人： Jonas Frisén ,  Ann Marie Janson ,  Clas Johansson ,  Stefan Momma ,  Diana Clarke ,  Ming Zhao ,  Urban Lendahl ,  Kioumars Delfani

    发明人： Jonas Frisén ,  Ann Marie Janson ,  Clas Johansson ,  Stefan Momma ,  Diana Clarke ,  Ming Zhao ,  Urban Lendahl ,  Kioumars Delfani

    IPC分类号： C12N5/00 ,  C12N5/02 ,  C12N5/08

    CPC分类号： C12N5/0623 ,  C12N2510/00

    摘要： The present invention relates to a method of determining whether a test compound is a proliferation-inducing or proliferation-inhibiting agent of ependymal neural stem cells. The method comprises: (a) contacting an ependymal neural stem cell with the test compound: and (b) determining the proliferation of the ependymal neural stem cell, wherein if the proliferation of the ependymal neural stem cell is increased in the presence of the test compound as compared to the absence of the test compound, the test compound is identified as a proliferation-inducing agent or wherein if the proliferation of the ependymal neural stem cell is decreased in the presence of the test compound as compared to the absence of the test compound, the test compound is identified as a proliferation-inhibiting agent.

    摘要翻译： 本发明涉及一种测定化合物是否是室管膜神经干细胞增殖诱导或增殖抑制剂的方法。 该方法包括：（a）将室管膜神经干细胞与测试化合物接触：（b）确定室管膜神经干细胞的增殖，其中如果在试验存在的情况下增加室管膜神经干细胞的增殖 化合物与不存在测试化合物相比，被测化合物被鉴定为增殖诱导剂，或者如果在不存在测试的情况下，在测试化合物存在的情况下降低室管膜神经干细胞的增殖 化合物，测试化合物被鉴定为增殖抑制剂。

    Ependymal neural stem cells and method for their isolation
    2.
    发明授权
    Ependymal neural stem cells and method for their isolation 有权
    室管膜神经干细胞及其分离方法

    公开(公告)号：US07320872B2

    公开(公告)日：2008-01-22

    申请号：US10183728

    申请日：2002-06-27

    申请人： Ann Marie Janson ,  Jonas Frisen ,  Clas Johansson ,  Stefan Momma ,  Diana Clarke ,  Ming Zhao ,  Urban Lendahl ,  Kioumars Delfani

    发明人： Ann Marie Janson ,  Jonas Frisen ,  Clas Johansson ,  Stefan Momma ,  Diana Clarke ,  Ming Zhao ,  Urban Lendahl ,  Kioumars Delfani

    IPC分类号： G01N33/567

    CPC分类号： C12N5/0623 ,  A61K35/12

    摘要： The invention relates to an ependymal neural CNS stem cell, which cell expresses the surface protein Notch 1 together with at least one surface protein chosen from the group of Notch 2, Notch 3, CAR (transmembrane protein binding adenovirus) and CFTR cystic fibrosis transmembrane conductance regulator), and which cell also comprises at least one cilium. The invention also relates to preparations, including pharmaceutical preparations, comprising ependymal neural CNS stem cells, in vitro and in vivo assays based thereon and various other uses of the novel ependymal cells according to the invention.

    摘要翻译： 本发明涉及室管膜神经CNS干细胞，该细胞表达蛋白Notch1以及至少一种选自Notch 2，Notch 3，CAR（跨膜蛋白结合腺病毒）和CFTR囊性纤维化跨膜电导的表面蛋白 调节剂），哪个细胞还包含至少一个纤毛。 本发明还涉及包括室管膜神经CNS干细胞的药物制剂，其中基于其的体外和体内测定法以及根据本发明的新型室管膜细胞的各种其它用途的制剂。

    Method of isolating ependymal neural stem cells
    3.
    发明授权
    Method of isolating ependymal neural stem cells 失效
    分离室管膜神经干细胞的方法

    公开(公告)号：US06541247B1

    公开(公告)日：2003-04-01

    申请号：US09104772

    申请日：1998-06-25

    申请人： Jonas Frisën ,  Ann Marie Janson ,  Clas Johansson ,  Stefan Momma ,  Diana Clarke ,  Ming Zhao ,  Urban Lendahl ,  Kioumars Delfani

    发明人： Jonas Frisën ,  Ann Marie Janson ,  Clas Johansson ,  Stefan Momma ,  Diana Clarke ,  Ming Zhao ,  Urban Lendahl ,  Kioumars Delfani

    IPC分类号： C12N500

    CPC分类号： C12N5/0623 ,  C12N2510/00

    摘要： The present invention relates to a method of isolating ependymal neural CNS stem cells from a post-natal animal or a human, which method comprises the steps of (a) screening single cells obtained by dissociating CNS tissue from said animal for cells exhibiting at least one characteristic of an ependymal neural stem cell; and (b) recovering the cells that exhibit the characteristic or characteristics screened for in step (a). The screening may be performed for a specific cell surface protein or by previously labeling the ependymal cells. The invention also relates to isolated ependymal neural CNS stem cells, in vitro and in vivo assays based on the findings according to the invention and various uses of the ependymal neural stem cells according to the invention.

    摘要翻译： 本发明涉及一种从产后动物或人体分离室管膜神经CNS干细胞的方法，该方法包括以下步骤：（a）筛选通过从所述动物解离CNS组织获得的细胞，所述单细胞显示至少一种 室管膜神经干细胞的特征; （b）回收表现出在步骤（a）中筛选的特征或特征的细胞。可以对特定的细胞表面蛋白进行筛选或通过预先标记室管膜细胞进行筛选。本发明还涉及分离的室管膜神经中枢神经系统干细胞 基于根据本发明的发现和根据本发明的室管膜神经干细胞的各种用途的体外和体内测定。

    Classification of a string as a typographical error based on feedback
    8.
    发明授权
    Classification of a string as a typographical error based on feedback 有权
    基于反馈将字符串分类为排印错误

    公开(公告)号：US09514120B1

    公开(公告)日：2016-12-06

    申请号：US13532183

    申请日：2012-06-25

    申请人： Hong Chen ,  Michael Patrick Bacus ,  Ming Zhao

    发明人： Hong Chen ,  Michael Patrick Bacus ,  Ming Zhao

    IPC分类号： G06F17/00 ,  G06F17/27

    CPC分类号： G06F17/273 ,  G06F17/2735 ,  G06F17/274

    摘要： A computing device hosting a server identifies one or more potential typographical errors in a work using an initial reference. The computing device sends data indicative of the presence of the potential typographical errors to users. The computing device collects feedback for the work from the users. The feedback for the work indicates whether the potential typographical errors are author-intended strings. The computing device combines the user feedback for the work with user feedback for other works and sorts the combined user feedback based on one or more selected parameters. The computing device determines, based on the sorted user feedback, that one or more of the potential typographical errors includes an acceptable string and updates the initial reference to include the acceptable string.

    摘要翻译： 托管服务器的计算设备使用初始参考来识别作品中的一个或多个潜在的排印错误。 计算设备向用户发送指示潜在印刷错误存在的数据。 计算设备从用户收集工作的反馈。 工作的反馈意味着潜在的印刷错误是否是作者意图的字符串。 计算设备将用于工作的用户反馈与其他作品的用户反馈相结合，并且基于一个或多个所选参数对组合的用户反馈进行排序。 计算设备基于排序的用户反馈确定一个或多个潜在的排印错误包括可接受的字符串，并更新初始参考以包括可接受的字符串。

    Mobile broadband device and assisted positioning method therefor
    10.
    发明申请
    Mobile broadband device and assisted positioning method therefor 审中-公开
    移动宽带设备及其辅助定位方法

    公开(公告)号：US20140256354A1

    公开(公告)日：2014-09-11

    申请号：US14349950

    申请日：2011-12-29

    申请人： Ming Zhao ,  Wentao Zhang

    发明人： Ming Zhao ,  Wentao Zhang

    IPC分类号： H04W4/02

    CPC分类号： H04W4/029 ,  G01C21/28 ,  G01S19/05 ,  G01S19/06 ,  G01S19/25 ,  H04L67/18

    摘要： A mobile broadband device and an assisted positioning method therefore are disclosed. A host initiates a positioning request to the mobile broadband device; a firmware of the mobile broadband device determines whether an assisted positioning function is needed for the positioning request received from the host, and when the assisted positioning function is needed, the device software initiates a request for acquiring assisted positioning data to the host; after receiving the request for acquiring the assisted positioning data from a device side, the host initiates the request for acquiring the assisted positioning data to a Secure User Plane Location (SUPL) server; the SUPL server sends positioning data to the host; after receiving the assisted positioning data, the host sends the assisted positioning data to the mobile broadband device; and the firmware of the mobile broadband device calculates standard Global Positioning System (GPS) data using the received assisted positioning data, and then outputs the standard GPS data to a positioning application program of the hose side. The disclosure enhances user experience, saves traffic for a user, increases benefits for the user, greatly reduces the load of the device side, improves the performance index of the product, and expands the application scope for the assisted positioning function.

    摘要翻译： 因此，公开了一种移动宽带设备和辅助定位方法。 主机向移动宽带设备发起定位请求; 移动宽带设备的固件确定是否需要从主机接收的定位请求的辅助定位功能，并且当需要辅助定位功能时，设备软件发起向主机获取辅助定位数据的请求; 在接收到从设备侧获得辅助定位数据的请求之后，主机向安全用户平面位置（SUPL）服务器发起获取辅助定位数据的请求; SUPL服务器向主机发送定位数据; 在接收到辅助定位数据之后，主机将辅助定位数据发送到移动宽带设备; 并且移动宽带设备的固件使用接收的辅助定位数据计算标准全球定位系统（GPS）数据，然后将标准GPS数据输出到软管侧的定位应用程序。 本发明增强了用户体验，为用户节省了流量，增加了用户的利益，大大降低了设备侧的负载，提高了产品的性能指标，扩大了辅助定位功能的应用范围。