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16 条记录 (耗时 0.049 秒)

    Method of using cells expressing galanin receptor 3 (GALR3)
    1.
    发明授权
    Method of using cells expressing galanin receptor 3 (GALR3) 失效
    使用表达甘丙肽受体3（GALR3）的细胞的方法

    公开(公告)号：US07022489B2

    公开(公告)日：2006-04-04

    申请号：US10007132

    申请日：2001-12-03

    申请人： Jonathan A. Bard ,  Beth Borowsky ,  Kelli E. Smith ,  Theresa A. Branchek ,  Christophe P. G. Gerald ,  Kenneth A. Jones

    发明人： Jonathan A. Bard ,  Beth Borowsky ,  Kelli E. Smith ,  Theresa A. Branchek ,  Christophe P. G. Gerald ,  Kenneth A. Jones

    IPC分类号： G01N33/53

    CPC分类号： C07K16/2869 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/72 ,  G01N33/5088 ,  G01N33/74 ,  G01N2333/72 ,  G01N2500/10

    摘要： This invention provides an isolated nucleic acid encoding a mammalian galanin receptor, an isolated galanin receptor protein, vectors comprising isolated nucleic acid encoding a mammalian galanin receptor, cells comprising such vectors, antibodies directed to a mammalian galanin receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian galanin receptor, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding a mammalian galanin receptor, nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian galanin receptor, as well as methods of determining binding of compounds to mammalian galanin receptors.

    摘要翻译： 本发明提供编码哺乳动物甘丙肽受体的分离的核酸，分离的甘丙肽受体蛋白，包含编码哺乳动物甘丙肽受体的分离的核酸的载体，包含该载体的细胞，针对哺乳动物甘丙肽受体的抗体，用于检测核酸的核酸探针 编码哺乳动物甘丙肽受体的酸，与编码哺乳动物甘丙肽受体的核酸的唯一序列互补的反义寡核苷酸，表达编码正常或突变型哺乳动物甘丙肽受体的DNA的非人转基因动物，以及确定化合物与哺乳动物甘丙肽的结合的方法 受体。

    DNA encoding galanin GALR3 receptors and uses thereof
    2.
    发明授权
    DNA encoding galanin GALR3 receptors and uses thereof 失效
    编码甘丙肽GALR3受体的DNA及其用途

    公开(公告)号：US06287788B1

    公开(公告)日：2001-09-11

    申请号：US09199737

    申请日：1998-11-25

    申请人： Jonathan A. Bard ,  Beth Borowsky ,  Kelli E. Smith ,  Theresa A. Branchek ,  Christophe P. G. Gerald ,  Kenneth A. Jones

    发明人： Jonathan A. Bard ,  Beth Borowsky ,  Kelli E. Smith ,  Theresa A. Branchek ,  Christophe P. G. Gerald ,  Kenneth A. Jones

    IPC分类号： G01N3353

    CPC分类号： C07K16/2869 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/72 ,  G01N33/5088 ,  G01N33/74 ,  G01N2333/72 ,  G01N2500/10

    摘要： This invention provides an isolated nucleic acid encoding a mammalian galanin receptor, an isolated galanin receptor protein, vectors comprising isolated nucleic acid encoding a mammalian galanin receptor, cells comprising such vectors, antibodies directed to a mammalian galanin receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian galanin receptor, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding a mammalian galanin receptor, nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian galanin receptor, as well as methods of determining binding of compounds to mammalian galanin receptors.

    摘要翻译： 本发明提供编码哺乳动物甘丙肽受体的分离的核酸，分离的甘丙肽受体蛋白，包含编码哺乳动物甘丙肽受体的分离的核酸的载体，包含该载体的细胞，针对哺乳动物甘丙肽受体的抗体，用于检测核酸的核酸探针 编码哺乳动物甘丙肽受体的酸，与编码哺乳动物甘丙肽受体的核酸的唯一序列互补的反义寡核苷酸，表达编码正常或突变型哺乳动物甘丙肽受体的DNA的非人转基因动物，以及确定化合物与哺乳动物甘丙肽的结合的方法 受体。

    Method of preparing GALR2 receptors composition
    7.
    发明授权
    Method of preparing GALR2 receptors composition 失效
    制备GALR2受体组成的方法

    公开(公告)号：US07060449B2

    公开(公告)日：2006-06-13

    申请号：US10298992

    申请日：2002-11-18

    申请人： Kelli E. Smith ,  Christophe P. G. Gerald ,  Richard L. Weinshank ,  David Linemeyer ,  Theresa Branchek ,  Carlos Forray

    发明人： Kelli E. Smith ,  Christophe P. G. Gerald ,  Richard L. Weinshank ,  David Linemeyer ,  Theresa Branchek ,  Carlos Forray

    IPC分类号： G01N33/53

    CPC分类号： C12P21/02 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/72

    摘要： This invention provides isolated nucleic acids encoding mammalian galanin receptors, isolated galanin receptor proteins, vectors comprising isolated nucleic acid encoding a mammalian galanin receptor, cells comprising such vectors, antibodies directed to a mammalian galanin receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian galanin receptor, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding a mammalian galanin receptor, nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian galanin receptor, as well as methods of determining binding of compounds to mammalian galanin receptors.

    摘要翻译： 本发明提供了编码哺乳动物甘丙肽受体的分离的核酸，分离的甘丙肽受体蛋白，包含编码哺乳动物甘丙肽受体的分离的核酸的载体，包含这种载体的细胞，针对哺乳动物甘丙肽受体的抗体，用于检测编码 哺乳动物甘丙肽受体，与编码哺乳动物甘丙肽受体的核酸的唯一序列互补的反义寡核苷酸，表达编码正常或突变型哺乳动物甘丙肽受体的DNA的非人转基因动物，以及确定化合物与哺乳动物甘丙肽受体结合的方法。

    DNA encoding galanin GALR2 receptors
    8.
    发明授权
    DNA encoding galanin GALR2 receptors 失效
    编码甘露糖苷GALR2受体的DNA

    公开(公告)号：US06790656B1

    公开(公告)日：2004-09-14

    申请号：US09011553

    申请日：1998-06-04

    申请人： Kelli E. Smith ,  Christophe P. G. Gerald ,  Richard L. Weinshank ,  David Linemeyer ,  Theresa Branchek ,  Carlos Forray

    发明人： Kelli E. Smith ,  Christophe P. G. Gerald ,  Richard L. Weinshank ,  David Linemeyer ,  Theresa Branchek ,  Carlos Forray

    IPC分类号： C12N510

    CPC分类号： C12P21/02 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/72

    摘要： This invention provides isolated nucleic acids encoding mammalian galanin receptors, isolated galanin receptor proteins, vectors comprising isolated nucleic acid encoding a mammalian galanin receptor, cells comprising such vectors, antibodies directed to a mammalian galanin receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian galanin receptor, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding a mammalian galanin receptor, nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian galanin receptor, as well as methods of determining binding of compounds to mammalian galanin receptors.

    摘要翻译： 本发明提供了编码哺乳动物甘丙肽受体的分离的核酸，分离的甘丙肽受体蛋白，包含编码哺乳动物甘丙肽受体的分离的核酸的载体，包含这种载体的细胞，针对哺乳动物甘丙肽受体的抗体，用于检测编码 哺乳动物甘丙肽受体，与编码哺乳动物甘丙肽受体的核酸的唯一序列互补的反义寡核苷酸，表达编码正常或突变型哺乳动物甘丙肽受体的DNA的非人转基因动物，以及确定化合物与哺乳动物甘丙肽受体结合的方法。

    Method of identifying compounds that bind galanin receptor (GALR2)
    9.
    发明授权
    Method of identifying compounds that bind galanin receptor (GALR2) 失效
    识别结合甘丙肽受体（GALR2）的化合物的方法

    公开(公告)号：US06586191B2

    公开(公告)日：2003-07-01

    申请号：US08899112

    申请日：1997-07-23

    申请人： Kelli E. Smith ,  David Linemeyer ,  Christophe P. G. Gerald ,  Theresa Branchek ,  Richard L. Weinshank ,  Carlos Forray

    发明人： Kelli E. Smith ,  David Linemeyer ,  Christophe P. G. Gerald ,  Theresa Branchek ,  Richard L. Weinshank ,  Carlos Forray

    IPC分类号： G01N33566

    CPC分类号： C12P21/02 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/72

    摘要： This invention provides isolated nucleic acids encoding mammalian galanin receptors, isolated galanin receptor proteins, vectors comprising isolated nucleic acid encoding a mammalian galanin receptor, cells comprising such vectors, antibodies directed to a mammalian galanin receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian galanin receptor, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding a mammalian galanin receptor, nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian galanin receptor, as well as methods of determining binding of compounds to mammalian galanin receptors.

    摘要翻译： 本发明提供了编码哺乳动物甘丙肽受体的分离的核酸，分离的甘丙肽受体蛋白，包含编码哺乳动物甘丙肽受体的分离的核酸的载体，包含这种载体的细胞，针对哺乳动物甘丙肽受体的抗体，用于检测编码 哺乳动物甘丙肽受体，与编码哺乳动物甘丙肽受体的核酸的唯一序列互补的反义寡核苷酸，表达编码正常或突变型哺乳动物甘丙肽受体的DNA的非人转基因动物，以及确定化合物与哺乳动物甘丙肽受体结合的方法。

    DNA encoding a novel mammalian transporter homologous to neurotransmitter transporters and uses thereof
    10.
    发明授权
    DNA encoding a novel mammalian transporter homologous to neurotransmitter transporters and uses thereof 失效
    编码与神经递质转运蛋白同源的新型哺乳动物转运蛋白的DNA及其用途

    公开(公告)号：US5559021A

    公开(公告)日：1996-09-24

    申请号：US149100

    申请日：1993-11-09

    申请人： Kelli E. Smith ,  Richard L. Weinshank

    发明人： Kelli E. Smith ,  Richard L. Weinshank

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C12N5/06 ,  C12N1/19 ,  C12N1/21 ,  C12N15/63

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： This invention provides an isolated nucleic acid molecule encoding a mammalian rB21a transporter, an isolated protein which is a mammalian rB21a transporter, vectors comprising an isolated nucleic acid molecule encoding a mammalian rB21a transporter, mammalian cells comprising such vectors, antibodies directed to the mammalian rB21a transporter, nucleic acid probes useful for detecting a nucleic acid molecule encoding mammalian rB21a transporter, antisense oligonucleotides complementary to any unique sequences of a nucleic acid molecule which encodes a mammalian rB21a transporter, pharmaceutical compounds related to mammalian rB21a transporter, and nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian rB21a transporter. This invention further provides methods for determining substrate binding, detecting expression, drug screening, and treatments for alleviating abnormalities associated with the mammalian rB21a transporter.

    摘要翻译： 本发明提供编码哺乳动物rB21a转运蛋白的分离的核酸分子，其是哺乳动物rB21a转运蛋白的分离蛋白质，包含编码哺乳动物rB21a转运蛋白的分离的核酸分子的载体，包含该载体的哺乳动物细胞，针对哺乳动物rB21a转运蛋白的抗体 用于检测编码哺乳动物rB21a转运蛋白的核酸分子的核酸探针，与编码哺乳动物rB21a转运蛋白的核酸分子的任何独特序列互补的反义寡核苷酸，与哺乳动物rB21a转运蛋白相关的药物化合物和表达DNA的非人转基因动物 编码正常或突变的哺乳动物rB21a转运蛋白。 本发明还提供了确定底物结合，检测表达，药物筛选和用于减轻与哺乳动物rB21a转运蛋白相关的异常的治疗的方法。