利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

22 条记录 (耗时 0.029 秒)

    Method of obtaining compositions
    1.
    发明授权
    Method of obtaining compositions 失效
    获得组合物的方法

    公开(公告)号：US06432655B1

    公开(公告)日：2002-08-13

    申请号：US09332837

    申请日：1999-06-14

    申请人： Jonathan A. Bard ,  Theresa Branchek ,  Richard L. Weinshank

    发明人： Jonathan A. Bard ,  Theresa Branchek ,  Richard L. Weinshank

    IPC分类号： G01N33567

    CPC分类号： C12N15/8509 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2217/072 ,  A01K2217/075 ,  A01K2227/10 ,  A01K2227/105 ,  A01K2267/03 ,  A01K2267/0356 ,  A01K2267/0375 ,  A61K38/00 ,  C07K14/70571

    摘要： This invention provides an isolated nucleic acid molecule encoding a mammalian 5-HT4B receptor and an isolated nucleic acid molecule encoding a human 5-HT4B receptor, an isolated protein which is a mammalian 5-HT4B receptor, vectors comprising an isolated nucleic acid molecule encoding a mammalian 5-HT4B receptor, mammalian cells comprising such vectors, antibodies directed to the 5-HT4B receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian or human 5-HT4B receptor, antisense oligonucleotides complementary to any sequences of a nucleic acid molecule which encodes a mammalian or human 5-HT4B receptor, pharmaceutical compounds related to the human 5-HT4B receptor. This invention further provides methods for determining ligand binding, detecting expression, drug screening, and treatments for alleviating abnormalities associated with a human 5-HT4B receptor.

    摘要翻译： 本发明提供编码哺乳动物5-HT4B受体的分离的核酸分子和编码人5-HT4B受体的分离的核酸分子，分离的核酸分子是哺乳动物5-HT4B受体的分离的蛋白，载体包含分离的核酸分子，其编码 哺乳动物5-HT4B受体，包含此类载体的哺乳动物细胞，针对5-HT4B受体的抗体，用于检测编码哺乳动物或人类5-HT4B受体的核酸的核酸探针，与核酸分子的任何序列互补的反义寡核苷酸 其编码哺乳动物或人类5-HT4B受体，与人类5-HT4B受体相关的药物化合物。 本发明还提供了用于确定配体结合，检测表达，药物筛选和用于减轻与人5-HT4B受体相关的异常的治疗的方法。

    Method of using cells expressing galanin receptor 3 (GALR3)
    4.
    发明授权
    Method of using cells expressing galanin receptor 3 (GALR3) 失效
    使用表达甘丙肽受体3（GALR3）的细胞的方法

    公开(公告)号：US07022489B2

    公开(公告)日：2006-04-04

    申请号：US10007132

    申请日：2001-12-03

    申请人： Jonathan A. Bard ,  Beth Borowsky ,  Kelli E. Smith ,  Theresa A. Branchek ,  Christophe P. G. Gerald ,  Kenneth A. Jones

    发明人： Jonathan A. Bard ,  Beth Borowsky ,  Kelli E. Smith ,  Theresa A. Branchek ,  Christophe P. G. Gerald ,  Kenneth A. Jones

    IPC分类号： G01N33/53

    CPC分类号： C07K16/2869 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/72 ,  G01N33/5088 ,  G01N33/74 ,  G01N2333/72 ,  G01N2500/10

    摘要： This invention provides an isolated nucleic acid encoding a mammalian galanin receptor, an isolated galanin receptor protein, vectors comprising isolated nucleic acid encoding a mammalian galanin receptor, cells comprising such vectors, antibodies directed to a mammalian galanin receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian galanin receptor, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding a mammalian galanin receptor, nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian galanin receptor, as well as methods of determining binding of compounds to mammalian galanin receptors.

    摘要翻译： 本发明提供编码哺乳动物甘丙肽受体的分离的核酸，分离的甘丙肽受体蛋白，包含编码哺乳动物甘丙肽受体的分离的核酸的载体，包含该载体的细胞，针对哺乳动物甘丙肽受体的抗体，用于检测核酸的核酸探针 编码哺乳动物甘丙肽受体的酸，与编码哺乳动物甘丙肽受体的核酸的唯一序列互补的反义寡核苷酸，表达编码正常或突变型哺乳动物甘丙肽受体的DNA的非人转基因动物，以及确定化合物与哺乳动物甘丙肽的结合的方法 受体。

    DNA encoding human alpha 1 adrenergic receptors and uses thereof
    9.
    发明授权
    DNA encoding human alpha 1 adrenergic receptors and uses thereof 失效
    编码人α1肾上腺素能受体的DNA及其用途

    公开(公告)号：US06448011B1

    公开(公告)日：2002-09-10

    申请号：US09688415

    申请日：2000-10-16

    申请人： Jonathan A. Bard ,  Richard L. Weinshank ,  Carlos C. Forray

    发明人： Jonathan A. Bard ,  Richard L. Weinshank ,  Carlos C. Forray

    IPC分类号： C12Q1568

    CPC分类号： C12Q1/6876 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2217/075 ,  A01K2227/10 ,  A01K2227/105 ,  A01K2267/02 ,  A01K2267/03 ,  A01K2267/0393 ,  A61K38/00 ,  C07K14/70571 ,  C12N15/85 ,  C12N15/8509 ,  C12Q1/6897 ,  C12Q2600/158 ,  G01N33/9433 ,  G01N2500/10

    摘要： This invention provides an isolated nucleic acid, vectors, transformed mammalian cells and non-human transgenic animals that encode and express normal or mutant alpha 1a, alpha 1b and alpha 1c adrenergic receptor genes. This invention also provides a protein, and an antibody directed to the protein and pharmaceutical compounds related to alpha 1a, alpha 1b and alpha 1c adrenergic receptors. This invention provides nucleic acid probes, and antisense oligonucleotides complementary to alpha 1a, alpha 1b and alpha 1c adrenergic receptor genes. This invention further provides methods for determining ligand binding, detecting expression, drug screening, and treatments for alleviating abnormalities associated with human alpha 1a, alpha 1b and alpha 1c adrenergic receptors.

    摘要翻译： 本发明提供了分离的核酸，载体，转化的哺乳动物细胞和编码并表达正常或突变的α1a，α1b和α1c肾上腺素能受体基因的非人转基因动物。 本发明还提供了一种蛋白质和针对与α1a，α1b和α1c肾上腺素能受体相关的蛋白质和药物化合物的抗体。 本发明提供核酸探针和与α1a，α1b和α1c肾上腺素能受体基因互补的反义寡核苷酸。 本发明还提供了确定配体结合，检测表达，药物筛选和治疗以减轻与人α1a，α1b和α1c肾上腺素能受体相关的异常的方法。