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13 条记录 (耗时 0.029 秒)

    Method of using cells expressing galanin receptor 3 (GALR3)
    1.
    发明授权
    Method of using cells expressing galanin receptor 3 (GALR3) 失效
    使用表达甘丙肽受体3（GALR3）的细胞的方法

    公开(公告)号：US07022489B2

    公开(公告)日：2006-04-04

    申请号：US10007132

    申请日：2001-12-03

    申请人： Jonathan A. Bard ,  Beth Borowsky ,  Kelli E. Smith ,  Theresa A. Branchek ,  Christophe P. G. Gerald ,  Kenneth A. Jones

    发明人： Jonathan A. Bard ,  Beth Borowsky ,  Kelli E. Smith ,  Theresa A. Branchek ,  Christophe P. G. Gerald ,  Kenneth A. Jones

    IPC分类号： G01N33/53

    CPC分类号： C07K16/2869 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/72 ,  G01N33/5088 ,  G01N33/74 ,  G01N2333/72 ,  G01N2500/10

    摘要： This invention provides an isolated nucleic acid encoding a mammalian galanin receptor, an isolated galanin receptor protein, vectors comprising isolated nucleic acid encoding a mammalian galanin receptor, cells comprising such vectors, antibodies directed to a mammalian galanin receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian galanin receptor, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding a mammalian galanin receptor, nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian galanin receptor, as well as methods of determining binding of compounds to mammalian galanin receptors.

    摘要翻译： 本发明提供编码哺乳动物甘丙肽受体的分离的核酸，分离的甘丙肽受体蛋白，包含编码哺乳动物甘丙肽受体的分离的核酸的载体，包含该载体的细胞，针对哺乳动物甘丙肽受体的抗体，用于检测核酸的核酸探针 编码哺乳动物甘丙肽受体的酸，与编码哺乳动物甘丙肽受体的核酸的唯一序列互补的反义寡核苷酸，表达编码正常或突变型哺乳动物甘丙肽受体的DNA的非人转基因动物，以及确定化合物与哺乳动物甘丙肽的结合的方法 受体。

    DNA encoding galanin GALR3 receptors and uses thereof
    3.
    发明授权
    DNA encoding galanin GALR3 receptors and uses thereof 失效
    编码甘丙肽GALR3受体的DNA及其用途

    公开(公告)号：US06287788B1

    公开(公告)日：2001-09-11

    申请号：US09199737

    申请日：1998-11-25

    申请人： Jonathan A. Bard ,  Beth Borowsky ,  Kelli E. Smith ,  Theresa A. Branchek ,  Christophe P. G. Gerald ,  Kenneth A. Jones

    发明人： Jonathan A. Bard ,  Beth Borowsky ,  Kelli E. Smith ,  Theresa A. Branchek ,  Christophe P. G. Gerald ,  Kenneth A. Jones

    IPC分类号： G01N3353

    CPC分类号： C07K16/2869 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/72 ,  G01N33/5088 ,  G01N33/74 ,  G01N2333/72 ,  G01N2500/10

    摘要： This invention provides an isolated nucleic acid encoding a mammalian galanin receptor, an isolated galanin receptor protein, vectors comprising isolated nucleic acid encoding a mammalian galanin receptor, cells comprising such vectors, antibodies directed to a mammalian galanin receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian galanin receptor, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding a mammalian galanin receptor, nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian galanin receptor, as well as methods of determining binding of compounds to mammalian galanin receptors.

    摘要翻译： 本发明提供编码哺乳动物甘丙肽受体的分离的核酸，分离的甘丙肽受体蛋白，包含编码哺乳动物甘丙肽受体的分离的核酸的载体，包含该载体的细胞，针对哺乳动物甘丙肽受体的抗体，用于检测核酸的核酸探针 编码哺乳动物甘丙肽受体的酸，与编码哺乳动物甘丙肽受体的核酸的唯一序列互补的反义寡核苷酸，表达编码正常或突变型哺乳动物甘丙肽受体的DNA的非人转基因动物，以及确定化合物与哺乳动物甘丙肽的结合的方法 受体。

    Methods of identifying agonists and antagonists of mammalian NPFF receptor
    5.
    发明授权
    Methods of identifying agonists and antagonists of mammalian NPFF receptor 失效
    识别哺乳动物NPFF受体的激动剂和拮抗剂的方法

    公开(公告)号：US07041461B2

    公开(公告)日：2006-05-09

    申请号：US09866248

    申请日：2001-05-25

    申请人： Christophe P. G. Gerald ,  Kenneth A. Jones ,  James A. Bonini ,  Beth Borowsky

    发明人： Christophe P. G. Gerald ,  Kenneth A. Jones ,  James A. Bonini ,  Beth Borowsky

    IPC分类号： G01N33/566 ,  C12N15/00 ,  C12N15/12 ,  C12N15/63 ,  C07K14/00

    CPC分类号： C07K14/70571 ,  A01K2217/075

    摘要： This invention provides isolated nucleic acids encoding mammalian NPFF receptors, purified mammalian NPFF receptors, vectors comprising nucleic acid encoding mammalian NPFF receptors, cells comprising such vectors, antibodies directed to mammalian NPFF receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian NPFF receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian NPFF receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian NPFF receptors, methods of isolating mammalian NPFF receptors, methods of treating an abnormality that is linked to the activity of the mammalian NPFF receptors, as well as methods of determining binding of compounds to mammalian NPFF receptors, methods of identifying agonists and antagonists of NPFF receptors, and agonists and antagonists so identified.

    摘要翻译： 本发明提供编码哺乳动物NPFF受体的分离的核酸，纯化的哺乳动物NPFF受体，包含编码哺乳动物NPFF受体的核酸的载体，包含该载体的细胞，针对哺乳动物NPFF受体的抗体，用于检测编码哺乳动物NPFF受体的核酸的核酸探针， 与编码哺乳动物NPFF受体的核酸的独特序列互补的反义寡核苷酸，其表达编码正常或突变型哺乳动物NPFF受体的DNA的转基因非人动物，分离哺乳动物NPFF受体的方法，治疗与哺乳动物活性相关的异常的方法 NPFF受体，以及确定化合物与哺乳动物NPFF受体的结合的方法，识别NPFF受体的激动剂和拮抗剂的方法，以及如此鉴定的激动剂和拮抗剂。

    DNA encoding SNORF33 receptor
    6.
    发明申请
    DNA encoding SNORF33 receptor 失效

    公开(公告)号：US20060074233A1

    公开(公告)日：2006-04-06

    申请号：US11217710

    申请日：2005-09-01

    申请人： Beth Borowsky ,  Kristine Ogozalek ,  Kenneth Jones

    发明人： Beth Borowsky ,  Kristine Ogozalek ,  Kenneth Jones

    IPC分类号： C07K14/705 ,  C07H21/04 ,  C12P21/06

    CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K48/00

    摘要： This invention provides isolated nucleic acids encoding mammalian SNORF33 receptors, purified mammalian SNORF33 receptors, vectors comprising nucleic acid encoding mammalian SNORF33 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF33 receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian SNORF33 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian SNORF33 receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian SNORF33 receptors, methods of isolating mammalian SNORF33 receptors, methods of treating an abnormality that is linked to the activity of the mammalian SNORF33 receptors, as well as methods of determining binding of compounds to mammalian SNORF33 receptors, methods of identifying agonists and antagonists of SNORF33 receptors, and agonists and antagonists so identified.

    Methods of identifying or screening for agents that binds the Ob-Re
    8.
    发明授权
    Methods of identifying or screening for agents that binds the Ob-Re 失效
    鉴定或筛选结合Ob-Re的药剂的方法

    公开(公告)号：US06770444B2

    公开(公告)日：2004-08-03

    申请号：US09116676

    申请日：1998-07-16

    申请人： Nika Adham ,  Beth Borowsky ,  Nigel Levens ,  Radek Ctirad Skoda

    发明人： Nika Adham ,  Beth Borowsky ,  Nigel Levens ,  Radek Ctirad Skoda

    IPC分类号： G01N3353

    CPC分类号： A61K31/70 ,  A61K38/00 ,  C07K14/705 ,  C12N2799/026

    摘要： This invention provides an isolated nucleic acid encoding a polypeptide, a purified polypeptide, vectors comprising isolated nucleic acid encoding a polypeptide, cells comprising such vectors, antibodies directed to a polypeptide, nucleic acid probes useful for detecting nucleic acid encoding a polypeptide, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding a polypeptide, nonhuman transgenic animals which express DNA encoding a normal or a mutant polypeptide, methods of isolating a polypeptide, methods of treatment eating disorders as well as methods of determining binding of compounds to polypeptides.

    摘要翻译： 本发明提供了编码多肽的分离的核酸，纯化的多肽，包含分离的编码多肽的核酸，包含此类载体的细胞，针对多肽的抗体，可用于检测编码多肽的核酸的核酸探针，反义寡核苷酸互补 编码多肽的独特的核酸序列，表达编码正常或突变多肽的DNA的非人类转基因动物，分离多肽的方法，进食障碍的治疗方法以及确定化合物与多肽结合的方法。