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32 条记录 (耗时 0.046 秒)

    Humanized anti-prostate stem cell antigen monoclonal antibody
    5.
    发明授权
    Humanized anti-prostate stem cell antigen monoclonal antibody 有权
    人源化抗前列腺干细胞抗原单克隆抗体

    公开(公告)号：US08088908B2

    公开(公告)日：2012-01-03

    申请号：US11432304

    申请日：2006-05-10

    申请人： Mark A. Sherman ,  Anna M. Wu ,  Robert E. Reiter

    发明人： Mark A. Sherman ,  Anna M. Wu ,  Robert E. Reiter

    IPC分类号： C07H21/04

    CPC分类号： C07K16/3069 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/565

    摘要： Prostate stem cell antigen (PSCA) is expressed in the majority of prostate cancer patients, making it an ideal target for cancer immunotherapy. Murine monoclonal antibody 1G8 binds to PSCA with nanomolar affinity, but its efficacy as a therapeutic agent is limited by the generation of a HAMA response. The present invention discloses humanized 1G8 antibodies in which the majority of the mouse-derived epitopes have been removed. These humanized antibodies bind PSCA with high affinity and specificity, and have been shown to reduce human bladder tumor take in a nude mouse model. These characteristics make the humanized antibodies of the present invention attractive agents for the treatment and detection of tumors expressing PSCA.

    摘要翻译： 前列腺干细胞抗原（PSCA）在大多数前列腺癌患者中表达，使其成为癌症免疫治疗的理想靶标。 鼠单克隆抗体1G8以纳摩尔亲和力结合PSCA，但其作为治疗剂的功效受到HAMA反应的产生的限制。 本发明公开了大部分小鼠来源的表位已被除去的人源化1G8抗体。 这些人源化抗体以高亲和力和特异性结合PSCA，并已显示可以减少人膀胱肿瘤的裸鼠模型。 这些特征使得本发明的人源化抗体用于治疗和检测表达PSCA的肿瘤的吸引剂。

    LUCIFERASES AND METHODS FOR MAKING AND USING THE SAME
    6.
    发明申请
    LUCIFERASES AND METHODS FOR MAKING AND USING THE SAME 有权
    润滑剂及其制备和使用方法

    公开(公告)号：US20110229955A1

    公开(公告)日：2011-09-22

    申请号：US13070665

    申请日：2011-03-24

    申请人： Sanjiv S. Gambhir ,  Andreas M. Loening ,  Anna M. Wu

    发明人： Sanjiv S. Gambhir ,  Andreas M. Loening ,  Anna M. Wu

    IPC分类号： C12N9/02 ,  C07H21/00 ,  C12N15/63 ,  C12N5/10 ,  C12N1/00

    CPC分类号： C12Q1/66

    摘要： Briefly described, embodiments of this disclosure include polynucleotides that encode mutant Cnidarian luciferases that exhibit modulated properties as compared to the corresponding wild-type luciferases, and the modulated properties include at least one of: modulated stability; enhanced light output; and modulated emission maximum. Embodiments of the present disclosure also include polypeptides or fragments thereof encoded by the polynucleotides, constructs including the polynucleotide, expression cassettes, cells, methods of producing the polynucleotides and polypeptides, antibodies, transgenic cells and/or animals, kits, and the like.

    摘要翻译： 简要描述，本公开的实施方案包括编码与相应的野生型萤光素酶相比表现出调节特性的突变型雀巢萤光素酶的多核苷酸，并且调节的性质包括以下至少一种：调节的稳定性; 增强光输出; 并调制发射最大值。 本公开的实施方案还包括由多核苷酸编码的多肽或其片段，包括多核苷酸的构建体，表达盒，细胞，产生多核苷酸和多肽的方法，抗体，转基因细胞和/或动物，试剂盒等。

    Split Enzyme Linked Immunosorbent and Nucleic Acid Assays
    8.
    发明申请
    Split Enzyme Linked Immunosorbent and Nucleic Acid Assays 审中-公开
    分离酶联免疫吸附剂和核酸测定

    公开(公告)号：US20080248463A1

    公开(公告)日：2008-10-09

    申请号：US10593059

    申请日：2005-03-14

    申请人： Shimon Weiss ,  Anna M. Wu ,  L. Jean Perry

    发明人： Shimon Weiss ,  Anna M. Wu ,  L. Jean Perry

    IPC分类号： C12Q1/68 ,  G01N33/573 ,  G01N33/567 ,  C12Q1/02 ,  C40B30/04

    CPC分类号： G01N33/581 ,  G01N33/54306

    摘要： A method for detecting the presence of an analyte in a solution. The analyte includes at least two mutually exclusive recognition sites that are capable of binding to corresponding recognition molecules. Biosensors are provided that include the recognition molecules, which are attached to the inactive portions of a split enzyme. The recognition sites are located such that the inactive enzyme portions combine to form a detectable biologically active enzyme when the recognition molecules bind to recognition sites.

    摘要翻译： 用于检测溶液中分析物的存在的方法。 分析物包括能够结合相应的识别分子的至少两个相互排斥的识别位点。 提供生物传感器，其包括识别分子，其连接到裂解酶的无活性部分。 定位识别位点使得当识别分子与识别位点结合时，无活性酶部分结合形成可检测的生物活性酶。

    Luciferases and methods for making and using the same
    10.
    发明授权
    Luciferases and methods for making and using the same 有权
    萤光素酶及其制备和使用方法

    公开(公告)号：US08378086B2

    公开(公告)日：2013-02-19

    申请号：US13562881

    申请日：2012-07-31

    申请人： Sanjiv S. Gambhir ,  Andreas M. Loening ,  Anna M. Wu

    发明人： Sanjiv S. Gambhir ,  Andreas M. Loening ,  Anna M. Wu

    IPC分类号： C07H21/04 ,  C12N5/00

    CPC分类号： C12Q1/66

    摘要： Briefly described, embodiments of this disclosure include polynucleotides that encode mutant Cnidarian luciferases that exhibit modulated properties as compared to the corresponding wild-type luciferases, and the modulated properties include at least one of: modulated stability; enhanced light output; and modulated emission maximum. Embodiments of the present disclosure also include polypeptides or fragments thereof encoded by the polynucleotides, constructs including the polynucleotide, expression cassettes, cells, methods of producing the polynucleotides and polypeptides, antibodies, transgenic cells and/or animals, kits, and the like.

    摘要翻译： 简要描述，本公开的实施方案包括编码与相应的野生型萤光素酶相比表现出调节特性的突变型雀巢萤光素酶的多核苷酸，并且调节的性质包括以下至少一种：调节的稳定性; 增强光输出; 并调制发射最大值。 本公开的实施方案还包括由多核苷酸编码的多肽或其片段，包括多核苷酸的构建体，表达盒，细胞，产生多核苷酸和多肽的方法，抗体，转基因细胞和/或动物，试剂盒等。