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    Annexin derivatives with endogenous chelation sites
    1.
    发明授权
    Annexin derivatives with endogenous chelation sites 失效
    具有内源性螯合位点的膜联蛋白衍生物

    公开(公告)号：US07204972B2

    公开(公告)日：2007-04-17

    申请号：US11012708

    申请日：2004-12-15

    申请人： Jonathan F. Tait ,  David S. Brown

    发明人： Jonathan F. Tait ,  David S. Brown

    IPC分类号： A61K51/00

    CPC分类号： C07K5/081 ,  A61K51/087 ,  A61K51/088 ,  C07K14/4721

    摘要： Modified annexins having an N-terminal chelation site comprising an amino acid extension are disclosed. The amino acid extension includes an amino acid sequence X1-Gly-X2, where X1 and X2 are selected from Gly and Cys, where at least one of X1 or X2 is Cys. Radionuclides are readily chelated by the modified annexins to provide radiolabeled annexins useful in imaging vascular thrombi and apoptosis in vivo.

    摘要翻译： 公开了具有包含氨基酸延伸的N-末端螯合位点的修饰的膜联蛋白。 氨基酸延伸包括氨基酸序列X 1 -Gly-X 2，其中X 1和X 2 选自Gly和Cys，其中X 1或X 2中的至少一个是Cys。 放射性核素容易被修饰的膜联蛋白螯合，以提供可用于体内血管血栓形成和细胞凋亡成像的放射性标记的膜联蛋白。

    Annexin derivatives with endogenous chelation sites
    2.
    发明授权
    Annexin derivatives with endogenous chelation sites 失效
    具有内源性螯合位点的膜联蛋白衍生物

    公开(公告)号：US06833448B2

    公开(公告)日：2004-12-21

    申请号：US09970969

    申请日：2001-10-03

    申请人： Jonathan F. Tait ,  David S. Brown

    发明人： Jonathan F. Tait ,  David S. Brown

    IPC分类号： C07K2102

    CPC分类号： C07K5/081 ,  A61K51/087 ,  A61K51/088 ,  C07K14/4721

    摘要： Modified annexins having an N-terminal chelation site comprising an amino acid extension are disclosed. The amino acid extension includes an amino acid sequence X1-Gly-X2, where X1 and X2 are selected from Gly and Cys, where at least one of X1 or X2 is Cys. Radionuclides are readily chelated by the modified annexins to provide radiolabeled annexins useful in imaging vascular thrombi and apoptosis in vivo.

    摘要翻译： 公开了具有包含氨基酸延伸的N-末端螯合位点的修饰的膜联蛋白。 氨基酸延伸包括氨基酸序列X1-Gly-X2，其中X1和X2选自Gly和Cys，其中X1或X2中的至少一个是Cys。 放射性核素容易被修饰的膜联蛋白螯合，以提供可用于体内血管血栓形成和细胞凋亡成像的放射性标记的膜联蛋白。

    Annexin derivative with endogenous chelation sites
    3.
    发明授权
    Annexin derivative with endogenous chelation sites 失效
    具有内源性螯合位点的膜联蛋白衍生物

    公开(公告)号：US06323313B1

    公开(公告)日：2001-11-27

    申请号：US09324096

    申请日：1999-06-01

    申请人： Jonathan F. Tait ,  David S. Brown

    发明人： Jonathan F. Tait ,  David S. Brown

    IPC分类号： C07K500

    CPC分类号： C07K5/081 ,  A61K51/087 ,  A61K51/088 ,  C07K14/4721

    摘要： Modified annexins having an N-terminal chelation site comprising an amino acid extension are disclosed. The amino acid extension includes an amino acid sequence X1-Gly-X2, where X1 and X2 are selected from Gly and Cys, where at least one of X1 or X2 is Cys. Radionuclides are readily chelated by the modified annexins to provide radiolabeled annexins useful in imaging vascular thrombi and apoptosis in vivo.

    摘要翻译： 公开了具有包含氨基酸延伸的N-末端螯合位点的修饰的膜联蛋白。 氨基酸延伸包括氨基酸序列X1-Gly-X2，其中X1和X2选自Gly和Cys，其中X1或X2中的至少一个是Cys。 放射性核素容易被修饰的膜联蛋白螯合，以提供可用于体内血管血栓形成和细胞凋亡成像的放射性标记的膜联蛋白。

    Diving regulator with valved mouthpiece
    4.
    发明授权
    Diving regulator with valved mouthpiece 失效
    潜水调节器带阀口

    公开(公告)号：US06354291B1

    公开(公告)日：2002-03-12

    申请号：US09612164

    申请日：2000-07-08

    申请人： Richard I. Brown ,  David S. Brown

    发明人： Richard I. Brown ,  David S. Brown

    IPC分类号： B63C1102

    CPC分类号： B63C11/2227 ,  B63C11/186

    摘要： A second stage diving regulator of the type used by scuba divers is provided. The regulator comprises a regulator housing and a mouthpiece. The regulator housing includes an inhalation chamber having a port, and a demand valve that releases air to the port in response to inhalation through the port. The mouthpiece comprises a unitary housing attachable to the regulator housing and includes a one-way exhalation pathway, thus obviating the need for an exhalation pathway in the regulator housing itself. Inhalation no-return valves can be additionally incorporated into the fluid pathway from the regulator housing to the diver to prevent fluids from flowing into the regulator housing through the mouthpiece. Saliva and exhaled air with its attendant moistures and pathogenic entities can thus be prevented from entering the regulator housing. The mouthpiece can be made easily detachable and can be sanitized between uses, making it particularly well suited for rental and instructional purposes. The disclosed invention keeps the interior spaces of the regulator clean and dry even when the regulator is not in place in the diver's mouth, thus extending regulator life and preventing a dangerous and irritating free-flow condition from occurring due to icing when used in cold water. The mouthpiece can be variously constructed to differentiate common-use mouthpieces from those owned individually.

    摘要翻译： 提供了潜水员使用的第二级潜水调节器。 调节器包括调节器外壳和接口。 调节器壳体包括具有端口的吸入室和响应于通过端口的吸入而将空气释放到端口的需求阀。 吸嘴包括可连接到调节器壳体的单一壳体，并且包括单向呼气路径，从而避免了调节器壳体本身中的呼出路径的需要。 吸入式止回阀可以额外地结合到从调节器壳体到潜水员的流体通道中，以防止流体通过接口管流入调节器壳体。 因此可以防止唾液和呼出的空气及其伴随的湿润和致病实体进入调节器壳体。 喉舌可以很容易地拆卸，并且可以在使用之间进行消毒，使其特别适用于出租和教学目的。 所公开的发明保持调节器的内部空间即使在调节器不在潜水员的嘴中就位时也能够清洁和干燥，从而延长了调节器的使用寿命，并且防止在冷水中使用时由于结冰而产生危险和刺激性的自由流动状况 。 喉舌可以进行各种不同的构造，以将通用口气与单独使用的吸嘴区分开来。

    Panel connector system
    5.
    发明授权
    Panel connector system 失效
    面板连接器系统

    公开(公告)号：US5560413A

    公开(公告)日：1996-10-01

    申请号：US478545

    申请日：1995-06-07

    申请人： David S. Brown

    发明人： David S. Brown

    IPC分类号： E04B1/61 ,  E04B2/74 ,  A47G5/00

    CPC分类号： E04B2/7425 ,  E04B1/6187 ,  E04B2001/6195 ,  Y10T403/73

    摘要： In the preferred embodiment of a panel connector system, the connectors are channel-shaped in cross section. Each of the connector's legs includes an inwardly extending lip, and the connector's base includes two inwardly extending studs. Each of the panels for the system includes a frame including upper and lower horizontal members and two vertical faces attached to the frame. The edges of the horizontal members include two orifices located near the vertical edges of the panel and adapted to engage a connector stud. When a connector is installed on two adjacent panels, one stud engages an orifice in the first panel and another stud engages an orifice in the second panel. When installed, the inwardly extending lips on the connector legs engage horizontally extending grooves in the vertical faces of the panel. The system includes connectors for connecting two aligned panels, two panels at a right angle, three panels, and four panels.

    摘要翻译： 在面板连接器系统的优选实施例中，连接器的横截面为通道形状。 每个连接器的腿包括向内延伸的唇缘，并且连接器的底座包括两个向内延伸的螺柱。 用于系统的每个面板包括包括上部和下部水平构件以及连接到框架的两个垂直面的框架。 水平构件的边缘包括位于面板的垂直边缘附近并适于接合连接器螺柱的两个孔。 当连接器安装在两个相邻的面板上时，一个螺柱与第一面板中的孔接合，另一个螺柱与第二面板中的孔连接。 当安装时，连接器腿上的向内延伸的唇缘接合在面板的垂直表面中的水平延伸的凹槽。 该系统包括用于连接两个对齐面板，两个直角板，三个面板和四个面板的连接器。

    Dynamic feedback arrangement scrambling technique keystream generator
    7.
    发明授权
    Dynamic feedback arrangement scrambling technique keystream generator 失效
    动态反馈排列扰码技术密钥流发生器

    公开(公告)号：US4860353A

    公开(公告)日：1989-08-22

    申请号：US194850

    申请日：1988-05-17

    申请人： David S. Brown

    发明人： David S. Brown

    IPC分类号： G09C1/00 ,  H04L9/22

    CPC分类号： H04L9/0662 ,  H04L2209/12

    摘要： A keystream generator including at least two feedback shift register structures. Each structure has input, intermediate and output stages through which data bits are shifted serially in response to a clock signal, a plurality of logic elements respectively located between predetermined pairs of register stages, means for feeding the data bit shifted from the output stage into the input stage and into predetermined ones of the logic elements in accordance with a polynomial code. The logic elements process a data bit shifted from the preceding stage with the data bit feedback from the output stage in accordance with the polynomial code for input into the succeeding register stage. The structure further includes means for processing the data bits shifted from a predetermined stage of each shift register structure to provide a keystream; and means for varying the polynomial code of at least one of the shift register structures by applying to the logic elements an enabling polynomial code signal that varies in accordance with the content of data bits shifted from a predetermined register range. The polynomial code of one of the shift register structures is not varied in response to the polynomial code signal. The bits that cause the polynomial code signal to be varied are not included in the keystream.

    Purifying feed for reforming over zeolite catalysts
    10.
    发明授权
    Purifying feed for reforming over zeolite catalysts 失效
    用于在沸石催化剂上重整的净化进料

    公开(公告)号：US5106484A

    公开(公告)日：1992-04-21

    申请号：US629879

    申请日：1990-12-19

    申请人： Murray Nadler ,  John F. Walsh ,  David S. Brown

    发明人： Murray Nadler ,  John F. Walsh ,  David S. Brown

    IPC分类号： C10G35/06 ,  C10G45/04 ,  C10G45/06 ,  C10G45/12 ,  C10G50/00 ,  C10G61/06 ,  C10G67/06 ,  C10G67/14 ,  C10G69/08

    CPC分类号： C10G61/06 ,  C10G67/06 ,  C10G69/08

    摘要： The present invention is directed to a process for treating hydrotreated naphtha which involves treating the naphtha over massive nickel catalyst followed by treating the naphtha over a metal oxide under conditions effective for removing impurities from said naphtha to result in substantially purified naphtha, wherein the metal oxide is selected from the group of metal oxides having a free energy of formation of sulfide which exceeds said free energy of formation of platinum sulfide, such as manganous oxide. In so doing, naphtha in the gas phase in the presence of hydrogen is passed over the manganous oxide at a temperature within the range of about 800.degree. F. and 1100.degree. F., a hydrogen to oil molar ratio between about 1:1 and 6:1, a whsv between about 2 and 8, and pressure between about 50 and 300 psig; and the naphtha in the liquid phase at a temperature between about 300.degree. F. and about 350.degree. F., and whsv less than about 5 is passed over the massive nickel.The naphtha in the liquid phase, at about ambient temperature, and at a whsv between 2 and 10, may also be passed over a Na Y mole sieve prior to treating over massive nickel and manganous oxide. In addition the naphtha be being passed over alumina after treating over massive nickel and prior to treating over manganous oxided in the liquid phase, at a temperature between 300.degree. F. and 350.degree. F., and a whsv between 2 and 10.The naphtha may also be passed over a mole sieve water trap in the liquid phase at ambient temperature and at a whsv between 2 and 10, prior to treating over massive nickel and manganous oxide.

    摘要翻译： 本发明涉及一种处理加氢处理的石脑油的方法，该方法涉及在大量镍催化剂上处理石脑油，然后在有效去除所述石脑油杂质的条件下在金属氧化物上处理石脑油，导致基本上纯化的石脑油，其中金属氧化物 选自具有形成硫化物的自由能的金属氧化物的组，其超过形成硫化铂的所述自由能，例如氧化锰。 在这样做的过程中，氢气存在下的气相中的石脑油在约800°F至1100°F的温度范围内通过二氧化锰，氢与油的摩尔比约为1:1至 6：1，约2至8之间的压力，压力在约50至300psig之间; 并且液相中的石脑油在约300°F至约350°F之间，小于约5°的温度通过块状镍。 液相中的石脑油在约环境温度和2至10秒之间也可以通过Na Y摩尔筛，然后处理大量的镍和氧化锰。 此外，石脑油在处理大量镍之后，在液相中处理过氧化锰之前，在300°F至350°F的温度和2至10°之间的范围内，通过氧化铝。石脑油 也可以在处理大量镍和氧化锰之前在环境温度和2至10℃之间的液相中通过摩尔筛捕集器。