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    Microfluidic devices and methods
    1.
    发明申请
    Microfluidic devices and methods 审中-公开
    微流体装置和方法

    公开(公告)号：US20050000569A1

    公开(公告)日：2005-01-06

    申请号：US10794572

    申请日：2004-03-04

    申请人： Luc Bousse ,  Mingqi Zhao ,  John Stults ,  Jing Ni ,  Jonathan Heller ,  Uthara Srinivasan

    发明人： Luc Bousse ,  Mingqi Zhao ,  John Stults ,  Jing Ni ,  Jonathan Heller ,  Uthara Srinivasan

    IPC分类号： F15C1/04 ,  F16L58/04 ,  G01N20060101 ,  H01J49/04 ,  H01J49/16

    CPC分类号： H01J49/0018 ,  H01J49/165 ,  Y10T137/0402 ,  Y10T137/2082 ,  Y10T137/2191 ,  Y10T137/2224 ,  Y10T137/7036 ,  Y10T436/2575

    摘要： Microfluidic devices provide substances to a mass spectrometer. The microfluidic devices include first and second surfaces, at least one microchannel formed by the surfaces, and an outlet at an edge of the surfaces. Some embodiments also include a tip surface with one or more surface features for helping guide substances from the outlet of the device toward a mass spectrometer. In some embodiments, the surface feature(s) includes a groove, which may be hydrophilic along all or part of its length. Hydrophilic surfaces and/or hydrophobic surfaces may also help guide substances out of the outlet and/or toward the mass spectrometer. In some embodiments, the outlet and/or the tip surface is recessed back from an adjacent portion of the edge. A source of electrical potential can help move substances through the microchannel, separate substances and/or provide electrospray ionization.

    摘要翻译： 微流体装置向质谱仪提供物质。 微流体装置包括第一和第二表面，由表面形成的至少一个微通道和表面边缘处的出口。 一些实施例还包括具有一个或多个表面特征的尖端表面，用于帮助将物质从装置的出口引向质谱仪。 在一些实施例中，表面特征包括凹槽，其可以沿其长度的全部或部分亲水。 亲水表面和/或疏水表面还可以帮助将物质引出出口和/或朝向质谱仪。 在一些实施例中，出口和/或尖端表面从边缘的相邻部分向后凹陷。 电势源可以帮助物质通过微通道，分离物质和/或提供电喷雾电离。

    Method of drying passivated micromachines by dewetting from a liquid-based process
    3.
    发明授权
    Method of drying passivated micromachines by dewetting from a liquid-based process 失效
    通过从基于液体的方法脱水干燥钝化微机械的方法

    公开(公告)号：US6114044A

    公开(公告)日：2000-09-05

    申请号：US866833

    申请日：1997-05-30

    申请人： Michael R. Houston ,  Roger T. Howe ,  Roya Maboudian ,  Uthara Srinivasan

    发明人： Michael R. Houston ,  Roger T. Howe ,  Roya Maboudian ,  Uthara Srinivasan

    IPC分类号： B81B3/00 ,  B32B9/04

    CPC分类号： B81B3/0005 ,  B81C1/00928 ,  B81C2201/112 ,  B82Y30/00

    摘要： A method of fabricating a micromachine includes the step of constructing a low surface energy film on the micromachine. The micromachine is then rinsed with a rinse liquid that has a high surface energy, relative to the low surface energy film, to produce a contact angle of greater than 90.degree. between the low surface energy film and the rinse liquid. This relatively large contact angle causes any rinse liquid on the micromachine to be displaced from the micromachine when the micromachine is removed from the rinse liquid. In other words, the micromachine is dried by dewetting from a liquid-based process. Thus, a separate evaporative drying step is not required, as the micromachine is removed from the liquid-based process in a dry state. The relatively large contact angle also operates to prevent attractive capillary forces between micromachine components, thereby preventing contact and adhesion between adjacent microstructure surfaces. The low surface energy film may be constructed with a fluorinated self-assembled monolayer film. The processing of the invention avoids the use of environmentally harmful, health-hazardous chemicals.

    摘要翻译： 制造微机械的方法包括在微机械上构造低表面能膜的步骤。 然后用相对于低表面能膜的表面能高的漂洗液冲洗微机械，在低表面能膜和冲洗液之间产生大于90°的接触角。 当微冲洗液从冲洗液中移出时，这种相对大的接触角使微机械上的任何漂洗液体从微机械移位。 换句话说，微机器通过从基于液体的方法去除而被干燥。 因此，不需要单独的蒸发干燥步骤，因为微机器在干燥状态下从基于液体的方法中去除。 相对较大的接触角也用于防止微机械部件之间的有吸引力的毛细作用力，从而防止相邻微结构表面之间的接触和粘附。 低表面能膜可以由氟化的自组装单层膜构成。 本发明的加工避免使用对环境有害的健康危害的化学品。