摘要:
The present invention is directed to 1,2,3,4,10,10a,-hexahydropyrazino[1,2-a]indole derivatives as well as pharmaceutically acceptable salts, solvates and esters thereof, wherein R1 to R8 have the significance given in claim 1 be used in the form of pharmaceutical preparations for the treatment or prevention of disorders of the central nervous system, damage to the central nervous system, cardiovascular disorders, gastrointestinal disorders, diabetes insipidus, obesity and sleep apnea.
摘要:
The present invention provides piperazine derivatives in accordance with formula (I) as well as salts, hydrates and esters thereof. The substituent designations are as provided in the specification. The compounds of the present invention can be used in the treatment of type II diabetes or obesity.
摘要:
The present invention is directed to 1,2,3,4,10,10a,-hexahydropyrazino[1,2-a]indole derivatives as well as pharmaceutically acceptable salts, solvates and esters thereof, wherein R1 to R8 have the significance given in claim 1 be used in the form of pharmaceutical preparations for the treatment or prevention of disorders of the central nervous system, damage to the central nervous system, cardiovascular disorders, gastrointestinal disorders, diabetes insipidus, obesity and sleep apnea.
摘要:
The present invention is directed to 1,2,3,4,10,10a,-hexahydropyrazino[1,2-a] indole derivatives as well as pharmaceutically acceptable salts, solvates and esters thereof, wherein R1 to R8 have the significance given in claim 1 be used in the form of pharmaceutical preparations for the treatment or prevention of disorders of the central nervous system, damage to the central nervous system, cardiovascular disorders, gastrointestinal disorders, diabetes insipidus, obesity and sleep apnea.
摘要:
The present invention is directed to 1,2,3,4,10,10a-hexahydropyrazino [1,2-a]indole derivatives of formula (I): as well as pharmaceutically acceptable salts, hydrates and esters thereof, wherein the substituents have the meanings provided in the specification. Compounds of the present invention may be used in the treatment or prevention of obesity or Type II diabetes.
摘要:
A method of communicating data in a system having a plurality of transmitters each adapted to transmit a radio signal, and a receiver situated at a distance from the transmitters to receive and process the signals transmitted by the transmitters, information for transmission being subdivided into N-bit symbols, the method consisting in: giving a numerical value to each symbol; and compressing the data using a CHIP encoding technique in which the values of the symbols are transposed to an encoded value having x digits in a base B, each digit subsequently being represented in the form of n chips, the base B, the number n of chips, and the number x of digits for an encoded value satisfying the following conditions: B≦2&ngr; and 2N≦B&xgr; so that the total number of chips x.n representing the coded value is less than 2.N.
摘要:
The present invention relates to vitamin D derivatives of the formula I ##STR1## wherein X is C.dbd.CH.sub.2 or CH.sub.2 ;Y is hydrogen, fluorine or hydroxyZ is hydroxyn is 1 or 2R.sup.1 is lower alkyl,R.sup.2 is a branched alkyl having 3 to 8 carbon atoms which is unsubstituted or substituted with one or more halogen or OH substituents, or is a phenyl group which is unsubstituted or substituted with a branched alkyl having 3 to 8 carbon atoms which is unsubstituted or substituted with one or more halogen or OH substituents;and the dotted carbon-carbon bond in ring D is --C--C-- or --C.dbd.C--; or a pharmaceutically usable salt thereof.
摘要:
This method which enables two periodic signals having the same waveform and the same theoretical period to be synchronized is of the type in which the second signal is synthesized iteratively at a phase that is adjusted as a function of a measure of the correlation between the first and second signals. Synchronization is obtained by progressively shifting the phase of the second signal until a correlation maximum is detected, after which said signal is locked onto the correlation peak by phase skips on either side thereof.
摘要:
A rear suspension system for a two wheel cycle such as a bicycle or motorcycle having a main frame which includes a rearwardly or downwardly inclined down tube. A vertically pivotable rear frame assembly includes a pair of swing arms which extend rearwardly from pivotal connections on the main frame. Rear wheel fitments are carried by the swing arms. A pair of elongated tubelike or rodlike chain stays extend forwardly from the rear fitments at a fixed angle relative to the swing arms. A tubular shock absorber assembly is supported on the down tube and has a spring urging a coupler portion thereof in a forward and upward direction. A double-pivoted link is pivotally connected between the forward ends of the chain stays and a bell crank assembly which is pivotally connected to the underside of the frame, and in turn, connects the double-pivoted link to the coupler portion of the shock absorber assembly. Upward impacts on the rear wheel are reacted on the main frame as a downward and rearward force with a largely downward force component so pitching motion at the rear end of the main frame is minimized when moving over ground or highway irregularities or rough terrain encountered in off road riding. In one embodiment, the shock absorber assembly is supported on the forward side of the down tube; in another embodiment, the shock absorber assembly is inside an open-rear-ended down tube.
摘要:
A process for manufacturing a compound of Formula (I) which has cis-conformation and wherein R1 represents a 1-phenyl-C1-C4alkyl or 1-naphthyl-C1-C4alkyl group, wherein the phenyl or naphthyl moiety of R1 is unsubstituted or substituted with one or more C1-C4alkoxy groups and the carbon atoms in 2-, 3-, and/or 4-position of the alkyl part of R1 are, independently of the phenyl or naphthyl moiety of R1 and independently of one another, unsubstituted or substituted with C1-C4alkoxy and/or silyloxy or, preferably, are unsubstituted or substituted with one C1-C4alkoxy group and/or silyloxy group per carbon atom, and R2 represents a C1-C6alkyl group or an unsubstituted or substituted benzyl group, in which process a compound of Formula (II) wherein R3 represents a C1-C6alkyl group or an unsubstituted or substituted benzyl group, and R1 and R2 have the same meaning as in formula (I); is treated with a base at a temperature of 0° C. or less in a liquid aprotic solvent for a time period sufficient to obtain the compound of formula (I).