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公开(公告)号：US20100219351A1
公开(公告)日：2010-09-02
申请号：US12394179
申请日：2009-02-27
CPC分类号： A61N1/372 , A61N1/025 , A61N1/3702 , A61N1/37276 , G04F5/16
摘要： A radiation-based timer for use in an implantable medical device (IMD) includes a radiation source and a radiation detection circuit. The radiation source emits radiation particles during a process referred to as radioactive decay. The radiation detection circuit detects the radiation particles emitted during the decay process and tracks the number of radiation particles detected. When the number of radiation particles detected reaches a threshold value, a timer signal is generated. In this manner, the radiation-based timer generates a timer signal as a function of the radioactive decay of the radiation source. The timer signal may be used by one or more components of the IMD for any of a number of functions, including as a wakeup trigger for a communications and/or a sensor event.
摘要翻译： 用于可植入医疗装置（IMD）的基于辐射的定时器包括辐射源和放射线检测电路。 辐射源在被称为放射性衰变的过程中发射辐射粒子。 辐射检测电路检测在衰变过程中发射的辐射粒子，并跟踪检测到的辐射粒子的数量。 当检测到的辐射粒子的数量达到阈值时，产生定时器信号。 以这种方式，基于辐射的定时器产生作为辐射源的放射性衰减的函数的定时器信号。 定时器信号可以由IMD的一个或多个组件用于多个功能中的任何一个，包括用于通信和/或传感器事件的唤醒触发。
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公开(公告)号：US07935935B2
公开(公告)日：2011-05-03
申请号：US12394179
申请日：2009-02-27
IPC分类号： G01J1/42
CPC分类号： A61N1/372 , A61N1/025 , A61N1/3702 , A61N1/37276 , G04F5/16
摘要： A radiation-based timer for use in an implantable medical device (IMD) includes a radiation source and a radiation detection circuit. The radiation source emits radiation particles during a process referred to as radioactive decay. The radiation detection circuit detects the radiation particles emitted during the decay process and tracks the number of radiation particles detected. When the number of radiation particles detected reaches a threshold value, a timer signal is generated. In this manner, the radiation-based timer generates a timer signal as a function of the radioactive decay of the radiation source. The timer signal may be used by one or more components of the IMD for any of a number of functions, including as a wakeup trigger for a communications and/or a sensor event.
摘要翻译： 用于可植入医疗装置（IMD）的基于辐射的定时器包括辐射源和放射线检测电路。 辐射源在被称为放射性衰变的过程中发射辐射粒子。 辐射检测电路检测在衰变过程中发射的辐射粒子，并跟踪检测到的辐射粒子的数量。 当检测到的辐射粒子的数量达到阈值时，产生定时器信号。 以这种方式，基于辐射的定时器产生作为辐射源的放射性衰减的函数的定时器信号。 定时器信号可以由IMD的一个或多个组件用于多个功能中的任何一个，包括用于通信和/或传感器事件的唤醒触发。
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公开(公告)号：US06985775B2
公开(公告)日：2006-01-10
申请号：US10059601
申请日：2002-01-29
申请人： James D. Reinke , Jeffrey D. Wilkinson , Ron Kalin , Laurie D. Foerster , Volkert A. Zeijlemaker
发明人： James D. Reinke , Jeffrey D. Wilkinson , Ron Kalin , Laurie D. Foerster , Volkert A. Zeijlemaker
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/086 , A61N1/3718
摘要： An electrical lead end cap includes a body defining a bore therein capable of receiving and retaining an end of an electrical lead and a connector capable of electrically coupling conductors leading to at least two electrodes. A method includes routing an electrical current induced in an electrical lead conductor disposed within body tissue to a plurality of electrodes, electrically coupled with the body tissue, via a circuit within an end cap attached to the electrical lead.
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4.发明授权公开(公告)号：US06871091B2
公开(公告)日：2005-03-22
申请号：US09999381
申请日：2001-10-31
摘要： An electrical lead includes an elongate body having a proximal end portion and a distal end portion, a first electrode disposed adjacent and joined to the distal end portion of the elongate body, and a first conductor extending between the proximal end portion and the distal end portion of the elongate body and being electrically coupled to the first electrode. The medical electrical lead further comprises a second electrode disposed adjacent the first electrode and joined to the elongate body and a capacitive device electrically coupled to the first conductor and the second electrode.
摘要翻译： 电引线包括具有近端部分和远端部分的细长主体，与细长主体的远端部分相邻并连接的第一电极，以及在近端部分和远端部分之间延伸的第一导体 并且电耦合到第一电极。 医疗电引线还包括邻近第一电极设置并连接到细长主体的第二电极和电耦合到第一导体和第二电极的电容性装置。
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5.发明授权Cyclic redundancy calculation circuitry for use in medical devices and methods regarding same 有权用于医疗器械的循环冗余计算电路及其相关方法公开(公告)号：US06456875B1
公开(公告)日：2002-09-24
申请号：US09416667
申请日：1999-10-12
IPC分类号： H03M1309
CPC分类号： H03M13/091
摘要： Cyclic redundancy calculations are provided by operating on a data stream, e.g., a data stream in an implantable medical device, to perform a polynomial division thereon using one of a first cyclic redundancy code generator polynomial and a second cyclic redundancy code generator polynomial. The first cyclic redundancy code generator polynomial is a higher order polynomial than the second cyclic redundancy code generator polynomial and contains all terms of the second cyclic redundancy code generator polynomial. The polynomial division may be implemented using linear feedback shift register circuitry and circuitry to select between the use of the first or second cyclic redundancy code generator polynomial.
摘要翻译： 通过对数据流（例如可植入医疗装置中的数据流）进行操作，使用第一循环冗余码生成多项式和第二循环冗余码生成多项式之一对其执行多项式除法来提供循环冗余计算。 第一循环冗余码生成多项式是比第二循环冗余码生成多项式更高阶的多项式，并且包含第二循环冗余码生成多项式的所有项。 可以使用线性反馈移位寄存器电路和电路来实现多项式除法，以在使用第一或第二循环冗余码生成多项式之间进行选择。
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公开(公告)号：US08755885B2
公开(公告)日：2014-06-17
申请号：US11116569
申请日：2005-04-28
IPC分类号： A61N1/362
CPC分类号： A61N1/3625 , A61N1/365 , A61N1/3956
摘要： The invention relates to medical devices such as pacemakers, pulse generators, cardioverter-defibrillators and the like and more particularly relates to modular and reconfigurable medical system platforms and methods of designing, testing, controlling and implementing diverse therapies, diagnostics, physiologic sensors and related instrumentation using said medical system platforms. Methods, systems and devices provide a new design platform for implantable and external medical devices such as pacemakers, defibrillators, neurostimulators, heart monitors, etc. A real-time, highly flexible system of software and hardware modules enables both prototypes and products to respond to patient and customer needs with greater design and manufacturing efficiency. Certain embodiments integrate a general-purpose processor with interface circuitry to provide a standard platform for implementing new and conventional therapies with software models rather than custom circuitry. The platform described may be used as a simulation environment, development and test platform and/or may be used as architecture for building new medical devices.
摘要翻译： 本发明涉及诸如起搏器，脉冲发生器，心律转复除颤器等的医疗装置，更具体地涉及模块化和可重构医疗系统平台以及设计，测试，控制和实施多种疗法，诊断，生理传感器和相关仪器的方法 使用医疗系统平台。 方法，系统和设备为植入式和外部医疗设备（如起搏器，除颤器，神经刺激器，心脏监测器等）提供了新的设计平台。实时，高度灵活的软件和硬件模块系统使原型和产品能够响应 耐用和客户需求更大的设计和制造效率。 某些实施例将通用处理器与接口电路集成，以提供用于使用软件模型而不是定制电路实现新的和常规治疗的标准平台。 所描述的平台可以用作模拟环境，开发和测试平台和/或可以用作构建新的医疗设备的架构。
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7.发明授权Method and apparatus for increasing the low frequency dynamic range of a system for measuring physiological signals with an implantable medical device 失效用于通过可植入医疗装置增加用于测量生理信号的系统的低频动态范围的方法和装置公开(公告)号：US06317625B1
公开(公告)日：2001-11-13
申请号：US09713455
申请日：2000-11-15
申请人： Dana J. Olson , David W. Van Ess , Robert W. Stadler , Steven N. Lu , Jeffrey D. Wilkinson , Tara N. Ptak
发明人： Dana J. Olson , David W. Van Ess , Robert W. Stadler , Steven N. Lu , Jeffrey D. Wilkinson , Tara N. Ptak
IPC分类号： A61B50402
CPC分类号： A61B5/0428 , A61B5/7232 , A61N1/3925 , Y10S128/901 , Y10S128/902
摘要： A signal measuring system for use with an Implantable Medical Device (IMD) is provided for measuring physiologic signals having a relatively large effective dynamic range. In one embodiment, the system includes a High-Pass Filter (HPF), an Analog-to-Digital Converter (ADC), a Decimation Filter (DF), and a Compensation Filter (CF). The HPF receives an input signal that includes both the baseline wander imposed on a physiological signal. According to one aspect of the invention, the HPF attenuates low frequency components of the input signal, including a portion of the frequency band within the desired output signal bandwidth. The ADC then oversamples the output signal of the HPF. The DF receives the output samples from the ADC and generates output samples at rate that is at least twice the maximum frequency of the desired output signal. The CF then amplifies the low frequency end of the DF output samples. The gain and cutoff frequency of the CF are selected to offset the HPF attenuation of those low frequency components of the input signal below the cutoff frequency of the HPF and above the minimum frequency of the desired output signal. In one embodiment, the DF and CF are implemented by a processing circuit executing programmed instructions. The processing circuit may be included within the IMD, or may be partially or fully implemented within a device that is external to the IMD.
摘要翻译： 提供了一种用于可植入医疗器械（IMD）的信号测量系统，用于测量具有相对较大有效动态范围的生理信号。 在一个实施例中，该系统包括高通滤波器（HPF），模数转换器（ADC），抽取滤波器（DF）和补偿滤波器（CF）。 HPF接收包括施加在生理信号上的基线漂移的输入信号。 根据本发明的一个方面，HPF衰减输入信号的低频分量，包括期望输出信号带宽内的一部分频带。 ADC然后对HPF的输出信号进行过采样。 DF从ADC接收输出采样，并以至少是所需输出信号的最大频率的两倍的速率生成输出采样。 CF然后放大DF输出样本的低频端。 选择CF的增益和截止频率以将输入信号的那些低频分量的HPF衰减降低到低于HPF的截止频率并且高于所需输出信号的最小频率。 在一个实施例中，DF和CF由执行编程指令的处理电路实现。 处理电路可以包括在IMD内，或者可以部分地或完全地实现在IMD外部的设备中。
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8.发明授权Methods and apparatus for reducing deleterious effects of x-ray radiation upon implantable medical device circuitry 有权减少x射线辐射对可植入医疗器械电路的有害影响的方法和装置公开(公告)号：US09205182B2
公开(公告)日：2015-12-08
申请号：US11096801
申请日：2005-03-31
申请人： Wesley J. Clement , Hiroshi Fujimoto , Jeffrey D. Wilkinson , John R. Buysman , Girard B. Borgerding
发明人： Wesley J. Clement , Hiroshi Fujimoto , Jeffrey D. Wilkinson , John R. Buysman , Girard B. Borgerding
CPC分类号： A61L31/18 , A61N1/37 , A61N1/3718 , A61N1/375 , H01L2224/48137 , H01L2224/49171 , H01L2224/49431 , H01L2924/19105
摘要： According to the invention methods and structures for determining whether impingement of x-ray radiation upon potentially vulnerable discrete components, circuits and/or circuit pathways of an implantable medical device (IMD) causes modifications or damage thereto. The invention includes structures for deflecting impingement of x-ray radiation from said potentially vulnerable components, circuits and/or circuit pathways. The x-ray radiation can be generated by various imaging modalities or unknown sources. Myriad IMDs can utilize the teaching of the present invention, including for example, a pacemaker, a drug delivery pump, a nerve stimulation device, a muscle stimulation device, an implantable cardioverter-defibrillator, a subcutaneous defibrillator, a deep brain stimulator or the like.
摘要翻译： 根据本发明的用于确定是否将x射线辐射照射到可植入式医疗装置（IMD）的潜在易受影响的分立部件，电路和/或电路路径上的方法和结构对其进行修改或损坏。 本发明包括用于偏转来自所述潜在易损组件，电路和/或电路路径的x射线辐射的冲击的结构。 X射线辐射可以通过各种成像方式或未知来源产生。 无数IMD可以利用本发明的教导，包括例如起搏器，药物输送泵，神经刺激装置，肌肉刺激装置，植入式心律转复除颤器，皮下除颤器，深脑刺激器等 。
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公开(公告)号：US5267150A
公开(公告)日：1993-11-30
申请号：US741289
申请日：1991-08-07
申请人： Jeffrey D. Wilkinson
发明人： Jeffrey D. Wilkinson
IPC分类号： A61B5/00 , A61B5/0428 , H04M1/21
CPC分类号： A61B5/0006 , A61B5/04282 , A61B5/7217 , Y10S128/904
摘要： An apparatus for communicating an electrical signal from a first portion of circuitry to a second, wherein there is no direct electrical contact between the two portions. In one embodiment, an EKG transmitter is disclosed which receives surface EKG signals from a patient, amplifies the EKG signals, modulates an oscillating carrier signal with the EKG signals, and transmits the resulting modulated signal across an optocoupled boundary. The modulated signal is then digitized directly, without demodulation, using phase progression digitization. The digitized information, from which the patient's EKG signal may be reconstructed, is then transmitted via a modem over conventional telephone lines. DC power drawn from the telephone line may be used directly to power the modem and phase progression digitizer, and may also be coupled via an isolating DC-to-DC transformer, to the frequency modulator and amplifier. For components of the patient's EKG signal which cannot be accurately re-created after modulation, separate, isolated circuitry can detect and process these components prior to modulation, and a separate optocoupled boundary can be established for conveying information about these components to the modem or digitizer.
摘要翻译： 一种用于将电信号从电路的第一部分传递到第二部分的装置，其中在两个部分之间不存在直接的电接触。 在一个实施例中，公开了一种EKG发射器，其接收来自患者的表面EKG信号，放大EKG信号，用EKG信号调制振荡载波信号，并将所得到的调制信号跨越光耦合边界发送。 然后使用相位进行数字化，调制信号直接数字化，无需解调。 然后可以经由调制解调器通过常规电话线路发送可以重建患者的EKG信号的数字化信息。 可以直接使用从电话线抽取的直流电力来为调制解调器和相位进程数字转换器供电，并且还可以经由隔离DC-DC变压器耦合到频率调制器和放大器。 对于在调制后无法准确重新创建的患者EKG信号的组件，单独的隔离电路可以在调制之前检测和处理这些组件，并且可以建立单独的光耦合边界，用于将关于这些组件的信息传送到调制解调器或数字化仪 。
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10.发明申请METHODS AND APPARATUS FOR REDUCING SPURIOUS SIGNALS IN IMPLANTABLE MEDICAL DEVICES CAUSED BY X-RAY RADIATION 失效用于减少由X射线辐射引起的可植入医疗器械中的SPURIOUS信号的方法和装置公开(公告)号：US20100204743A1
公开(公告)日：2010-08-12
申请号：US12759443
申请日：2010-04-13
申请人： Wesley J. Clement , Hiroshi Fujimoto , Jeffrey D. Wilkinson , John R. Buysman , Girard B. Borgerding
发明人： Wesley J. Clement , Hiroshi Fujimoto , Jeffrey D. Wilkinson , John R. Buysman , Girard B. Borgerding
IPC分类号： A61N1/37
CPC分类号： A61N1/37 , A61B5/0428 , A61N1/3718
摘要： An implantable medical device (IMD) includes a detector for detecting the presence of x-ray radiation, where the presence of x-ray radiation is detected in response to the strength of the x-ray radiation exceeding a first threshold. In one embodiment, the IMD includes a processor for adjusting a cardiac stimulation rate IMD in response to determining that the strength of the detected x-ray radiation exceeds a second threshold. The second pre-selected x-ray radiation threshold is greater than the first pre-selected x-ray radiation threshold. In another embodiment, the implantable device includes a detector for detecting the presence of any amount x-ray radiation and a processor for adjusting a stimulation rate provided by the IMD in response to detected x-ray radiation to reduce the chance of over-sampling artifacts or inappropriate therapy delivery.
摘要翻译： 可植入医疗装置（IMD）包括用于检测X射线辐射的存在的检测器，其中响应于x射线辐射的强度超过第一阈值检测x射线辐射的存在。 在一个实施例中，IMD包括用于响应于确定检测到的X射线辐射的强度超过第二阈值来调整心脏刺激速率IMD的处理器。 第二预选x射线辐射阈值大于第一预选x射线辐射阈值。 在另一个实施例中，可植入装置包括用于检测任何量X射线辐射的存在的检测器和用于响应于检测到的X射线辐射来调整由IMD提供的刺激速率的处理器，以减少过度采样伪像的机会 或不适当的治疗递送。
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