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    Radiation-based timer for implantable medical devices
    1.
    发明授权
    Radiation-based timer for implantable medical devices 有权
    用于可植入医疗器械的基于辐射的计时器

    公开(公告)号：US07935935B2

    公开(公告)日：2011-05-03

    申请号：US12394179

    申请日：2009-02-27

    申请人： Jonathan P. Roberts ,  James D. Reinke ,  Jeffrey D. Wilkinson

    发明人： Jonathan P. Roberts ,  James D. Reinke ,  Jeffrey D. Wilkinson

    IPC分类号： G01J1/42

    CPC分类号： A61N1/372 ,  A61N1/025 ,  A61N1/3702 ,  A61N1/37276 ,  G04F5/16

    摘要： A radiation-based timer for use in an implantable medical device (IMD) includes a radiation source and a radiation detection circuit. The radiation source emits radiation particles during a process referred to as radioactive decay. The radiation detection circuit detects the radiation particles emitted during the decay process and tracks the number of radiation particles detected. When the number of radiation particles detected reaches a threshold value, a timer signal is generated. In this manner, the radiation-based timer generates a timer signal as a function of the radioactive decay of the radiation source. The timer signal may be used by one or more components of the IMD for any of a number of functions, including as a wakeup trigger for a communications and/or a sensor event.

    摘要翻译： 用于可植入医疗装置（IMD）的基于辐射的定时器包括辐射源和放射线检测电路。 辐射源在被称为放射性衰变的过程中发射辐射粒子。 辐射检测电路检测在衰变过程中发射的辐射粒子，并跟踪检测到的辐射粒子的数量。 当检测到的辐射粒子的数量达到阈值时，产生定时器信号。 以这种方式，基于辐射的定时器产生作为辐射源的放射性衰减的函数的定时器信号。 定时器信号可以由IMD的一个或多个组件用于多个功能中的任何一个，包括用于通信和/或传感器事件的唤醒触发。

    RADIATION-BASED TIMER FOR IMPLANTABLE MEDICAL DEVICES
    2.
    发明申请
    RADIATION-BASED TIMER FOR IMPLANTABLE MEDICAL DEVICES 有权
    用于可植入医疗器械的基于辐射的定时器

    公开(公告)号：US20100219351A1

    公开(公告)日：2010-09-02

    申请号：US12394179

    申请日：2009-02-27

    申请人： Jonathan P. Roberts ,  James D. Reinke ,  Jeffrey D. Wilkinson

    发明人： Jonathan P. Roberts ,  James D. Reinke ,  Jeffrey D. Wilkinson

    IPC分类号： G01J1/42 ,  G04B47/00

    CPC分类号： A61N1/372 ,  A61N1/025 ,  A61N1/3702 ,  A61N1/37276 ,  G04F5/16

    摘要： A radiation-based timer for use in an implantable medical device (IMD) includes a radiation source and a radiation detection circuit. The radiation source emits radiation particles during a process referred to as radioactive decay. The radiation detection circuit detects the radiation particles emitted during the decay process and tracks the number of radiation particles detected. When the number of radiation particles detected reaches a threshold value, a timer signal is generated. In this manner, the radiation-based timer generates a timer signal as a function of the radioactive decay of the radiation source. The timer signal may be used by one or more components of the IMD for any of a number of functions, including as a wakeup trigger for a communications and/or a sensor event.

    摘要翻译： 用于可植入医疗装置（IMD）的基于辐射的定时器包括辐射源和放射线检测电路。 辐射源在被称为放射性衰变的过程中发射辐射粒子。 辐射检测电路检测在衰变过程中发射的辐射粒子，并跟踪检测到的辐射粒子的数量。 当检测到的辐射粒子的数量达到阈值时，产生定时器信号。 以这种方式，基于辐射的定时器产生作为辐射源的放射性衰减的函数的定时器信号。 定时器信号可以由IMD的一个或多个组件用于多个功能中的任何一个，包括用于通信和/或传感器事件的唤醒触发。

    Fault tolerant implantable pulse generators and implantable cardioverter-defibrillators incorporating physiologic sensors and methods for implementing fault tolerance in same
    5.
    发明授权
    Fault tolerant implantable pulse generators and implantable cardioverter-defibrillators incorporating physiologic sensors and methods for implementing fault tolerance in same 有权
    容错植入式脉冲发生器和植入式心律转复除颤器，其结合生理传感器和实现相同容错的方法

    公开(公告)号：US08155758B2

    公开(公告)日：2012-04-10

    申请号：US11380567

    申请日：2006-04-27

    申请人： Glenn M. Roline ,  Michael B. Terry ,  Jonathan P. Roberts ,  James D. Reinke ,  Robert A. Corey

    发明人： Glenn M. Roline ,  Michael B. Terry ,  Jonathan P. Roberts ,  James D. Reinke ,  Robert A. Corey

    IPC分类号： A61N1/37

    CPC分类号： A61N1/36564 ,  A61N1/3605 ,  A61N1/36514 ,  A61N1/36557 ,  A61N2001/083

    摘要： This disclosure relates to fault tolerant instantiations of a cardiac therapy delivery device such as an implantable cardiac stimulator (e.g., an implantable pulse generator, IPG, and/or an implantable cardioverter-defibrillator, ICD) coupled to an implantable physiologic sensor (IPS). According to the disclosure delivery of cardiac pacing and/or cardioversion-defibrillator therapy delivery can cause errors in output signals from an IPS. Resolution of such errors involves selectively energizing (or disconnecting the output signal from) the IPS during pacing and/or defibrillation therapy delivery. Programmable signal “blanking” in lieu of or in addition to the foregoing also improves the integrity of the output signal (i.e., continuously energize the IPS and ignore parts of the output signal). An ICD having a transient weakness in an insulated conductor used for the IPS signal can likewise have the IPS de-energized and/or blank the IPS output signal during high voltage therapy delivery.

    摘要翻译： 本公开涉及心脏治疗递送装置的容错实例，例如可植入的心脏刺激器（例如，可植入脉冲发生器，IPG和/或植入式心律转复除颤器，ICD），其与可植入生理传感器（IPS）耦合。 根据心脏起搏和/或心脏复律 - 除颤器治疗传递的披露递送可能导致来自IPS的输出信号的错误。 这种错误的解决涉及在起搏和/或除颤治疗递送期间选择性地激励（或断开输出信号）IPS。 代替或除了上述之外的可编程信号“消隐”还提高了输出信号的完整性（即，连续地激励IPS并忽略输出信号的部分）。 在IPS信号中使用的绝缘导体具有瞬时弱点的ICD同样可以在高电压治疗传送期间使IPS不通电和/或空白IPS输出信号。

    LOW-POWER SYSTEM CLOCK CALIBRATION BASED ON A HIGH- ACCURACY REFERENCE CLOCK
    7.
    发明申请
    LOW-POWER SYSTEM CLOCK CALIBRATION BASED ON A HIGH- ACCURACY REFERENCE CLOCK 有权
    基于高精度参考时钟的低功率系统时钟校准

    公开(公告)号：US20120109259A1

    公开(公告)日：2012-05-03

    申请号：US12915832

    申请日：2010-10-29

    申请人： Matthew Bond ,  Charles R. Gordon ,  Weizheng Liang ,  James D. Reinke ,  Jonathan P. Roberts

    发明人： Matthew Bond ,  Charles R. Gordon ,  Weizheng Liang ,  James D. Reinke ,  Jonathan P. Roberts

    IPC分类号： A61N1/08 ,  H03L7/00

    CPC分类号： A61N1/37264 ,  A61N1/025 ,  A61N1/08 ,  A61N1/372 ,  A61N1/37276 ,  G06F1/04 ,  G06F1/12

    摘要： Various techniques are described for periodically performing a calibration routine to calibrate a low-power system clock within an implantable medical device (IMD) based on a high accuracy reference clock also included in the IMD. The system clock is powered continuously, and the reference clock is only powered on during the calibration routine. The techniques include determining a clock error of the system clock based on a difference between frequencies of the system clock and the reference clock over a fixed number of clock cycles, and adjusting a trim value of the system clock to compensate for the clock error. Calibrating the system clock with a delta-sigma loop, for example, reduces the clock error over time. This allows accurate adjustment of the system clock to compensate for errors due to trim resolution, circuit noise and temperature.

    摘要翻译： 描述了各种技术，用于周期性地执行校准例程以基于也包括在IMD中的高精度参考时钟校准可植入医疗设备（IMD）内的低功率系统时钟。 系统时钟连续供电，参考时钟仅在校准程序中打开电源。 这些技术包括基于系统时钟的频率和固定数量的时钟周期上的参考时钟之间的差异来确定系统时钟的时钟误差，以及调整系统时钟的修整值以补偿时钟误差。 例如，用delta-sigma循环校准系统时钟可以减少时间误差。 这允许系统时钟的精确调整，以补偿由于调整分辨率，电路噪声和温度引起的误差。