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    ANALYZING A WASHOUT PERIOD CHARACTERISTIC FOR PSYCHIATRIC DISORDER THERAPY DELIVERY
    3.
    发明申请
    ANALYZING A WASHOUT PERIOD CHARACTERISTIC FOR PSYCHIATRIC DISORDER THERAPY DELIVERY 有权
    分析精神疾病治疗方法的出院期特征

    公开(公告)号：US20090264957A1

    公开(公告)日：2009-10-22

    申请号：US12426065

    申请日：2009-04-17

    申请人： Jonathon E. Giftakis ,  Mark T. Rise ,  Paul H. Stypulkowski ,  Timothy J. Denison

    发明人： Jonathon E. Giftakis ,  Mark T. Rise ,  Paul H. Stypulkowski ,  Timothy J. Denison

    IPC分类号： A61N1/08 ,  A61N1/36 ,  A61M37/00

    CPC分类号： G16H40/63 ,  A61M5/14276 ,  A61M5/1723 ,  A61M2005/14208 ,  A61M2205/3561 ,  A61M2205/3592 ,  A61M2210/0693 ,  A61N1/08 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/37211 ,  G06F19/00 ,  G16H40/40

    摘要： A characteristic of a washout period following the delivery of therapy to a patient according to a therapy program may be determined based on a physiological parameter of the patient. A washout period includes the period of time during which a carryover effect from the therapy dissipates. The washout period characteristic may include, for example, a duration of the washout period, an amplitude or a trend in a physiological signal during the washout period or a power level or a ratio of power levels in frequency bands of the physiological signal. In some embodiments, washout period characteristics associated with a plurality of therapy programs may be used to compare the programs. In other embodiments, a washout period characteristic may be used to determine a mood state of the patient and, in some cases, modify a therapy program. Monitoring a washout period may also be useful for timing therapy program trials.

    摘要翻译： 根据治疗程序向患者输送治疗后的清洗期间的特征可以基于患者的生理参数来确定。 清洗期包括治疗所产生的结转效应消散的时间。 清洗期间特征可以包括例如清洗期间的持续时间，清洗期间的生理信号的幅度或趋势，或者生理信号的功率水平或功率水平的频率比。 在一些实施例中，可以使用与多个治疗程序相关联的清除期特征来比较程序。 在其他实施例中，清洗周期特征可以用于确定患者的情绪状态，并且在一些情况下可以修改治疗程序。 监测清洗期也可能对时间治疗方案试验有用。

    TIMING THERAPY EVALUATION TRIALS
    5.
    发明申请
    TIMING THERAPY EVALUATION TRIALS 审中-公开
    时间治疗评估试验

    公开(公告)号：US20090264967A1

    公开(公告)日：2009-10-22

    申请号：US12425922

    申请日：2009-04-17

    申请人： Jonathon E. Giftakis ,  Mark T. Rise ,  Paul H. Stypulkowski ,  Timothy J. Denison

    发明人： Jonathon E. Giftakis ,  Mark T. Rise ,  Paul H. Stypulkowski ,  Timothy J. Denison

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36135 ,  A61N1/0534 ,  A61N1/36082 ,  A61N1/37211 ,  A61N1/37247

    摘要： A characteristic of a washout period following the delivery of therapy to a patient according to a therapy program may be determined based on a physiological parameter of the patient. A washout period includes the period of time during which a carryover effect from the therapy delivery dissipates. Monitoring a washout period may be useful for timing the delivery of therapy according to different therapy programs during a therapy evaluation period. For example, at least one physiological signal of the patient may be monitored to automatically determine when a washout period has ended, e.g., when stimulation and carryover effects of therapy delivery according to a first therapy program have substantially dissipated, in order to determine when therapy delivery according to a second therapy program can be initiated.

    摘要翻译： 根据治疗程序向患者输送治疗后的清洗期间的特征可以基于患者的生理参数来确定。 清洗期包括治疗期间遗留结果消失的时间。 在治疗评估期间，根据不同的治疗方案，监测清除期可能有助于按时交付治疗。 例如，可以监测患者的至少一个生理信号，以便自动确定何时清除期已经结束，例如，当根据第一治疗程序的治疗递送的刺激和携带效应已经基本消散时，为了确定何时治疗 可以启动根据第二疗法程序的递送。

    PSYCHIATRIC DISORDER THERAPY CONTROL
    6.
    发明申请
    PSYCHIATRIC DISORDER THERAPY CONTROL 有权
    心理障碍治疗控制

    公开(公告)号：US20090264956A1

    公开(公告)日：2009-10-22

    申请号：US12425903

    申请日：2009-04-17

    申请人： Mark T. Rise ,  Jonathon E. Giftakis ,  Paul H. Stypulkowski ,  Timothy J. Denison ,  Nathan A. Torgerson

    发明人： Mark T. Rise ,  Jonathon E. Giftakis ,  Paul H. Stypulkowski ,  Timothy J. Denison ,  Nathan A. Torgerson

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36082 ,  A61B5/01 ,  A61B5/0488 ,  A61B5/08 ,  A61B5/0816 ,  A61B5/165 ,  A61B5/441 ,  A61B5/4836 ,  A61B5/7275 ,  G06F19/00 ,  G16H20/70 ,  G16H40/63

    摘要： A therapy system for managing a psychiatric disorder of the patient may be controlled based on a patient mood state. Therapy may be delivered to a patient according to a therapy program, and a physiological parameter of the patient may be monitored during or after therapy delivery. The patient mood state may be determined based on the monitored physiological parameter, and the therapy delivery may be controlled based on the determined mood state. In some embodiments, the therapy delivery is stopped prior to determining the patient mood state and the therapy delivery is restarted upon detecting a negative mood state. In other embodiments, therapy delivery is delivered until a positive mood state is detected, at which point the therapy delivery may be stopped.

    摘要翻译： 可以基于患者情绪状态来控制用于管理患者精神障碍的治疗系统。 治疗可以根据治疗程序递送到患者，并且可以在治疗递送期间或之后监测患者的生理参数。 可以基于所监测的生理参数来确定患者情绪状态，并且可以基于所确定的情绪状态来控制治疗递送。 在一些实施例中，在确定患者情绪状态之前停止治疗递送，并且在检测到负情绪状态时重新开始治疗递送。 在其它实施方案中，递送治疗递送直到检测到正状态，此时可以停止治疗递送。

    ANXIETY DISORDER MONITORING
    8.
    发明申请
    ANXIETY DISORDER MONITORING 审中-公开
    安静的异常监视

    公开(公告)号：US20100280336A1

    公开(公告)日：2010-11-04

    申请号：US12751537

    申请日：2010-03-31

    申请人： Jonathon E. Giftakis ,  Mark T. Rise ,  Paul H. Stypulkowski

    发明人： Jonathon E. Giftakis ,  Mark T. Rise ,  Paul H. Stypulkowski

    IPC分类号： A61B5/00

    CPC分类号： A61B5/0476 ,  A61B5/1118 ,  A61B5/165 ,  A61B5/4803 ,  A61B5/6846 ,  A61B5/7267

    摘要： An anxiety episode may be identified as being an anxiety event that is attributable to an anxiety disorder of a patient based on the patient activity associated with the anxiety episode. The patient activity may include, for example, patient motion, patient posture or voice activity. Detection of the activity component during an anxiety episode can help distinguish between a general anxiety state and an anxiety event that differs from the general anxiety state. Examples of anxiety events include, for example, an occurrence of a compulsion or a panic attack. The detected anxiety events can be used to evaluate an anxiety disorder of a patient, evaluate therapy programs implemented by a medical device to treat the anxiety disorder, or control therapy delivery. In some examples, a mood state transition is detected based on patient activity information and therapy delivery is controlled based on the detection of the mood state transition.

    摘要翻译： 基于与焦虑发作相关的患者活动，可能将焦虑事件确定为可归因于患者的焦虑症的焦虑事件。 患者活动可以包括例如患者运动，患者姿势或语音活动。 在焦虑症状期间检测活动成分可以帮助区分一般焦虑状态和与一般焦虑状态不同的焦虑事件。 焦虑事件的例子包括例如强迫或惊恐发作的发生。 检测到的焦虑事件可用于评估患者的焦虑症，评估由医疗装置实施的治疗程序以治疗焦虑症或控制治疗递送。 在一些示例中，基于患者活动信息检测情绪状态转换，并且基于心情状态转换的检测来控制治疗递送。

    TARGET THERAPY DELIVERY SITE SELECTION
    9.
    发明申请
    TARGET THERAPY DELIVERY SITE SELECTION 有权
    目标治疗交付网站选择

    公开(公告)号：US20120191157A1

    公开(公告)日：2012-07-26

    申请号：US13358179

    申请日：2012-01-25

    申请人： Paul H. Stypulkowski ,  Jonathon E. Giftakis

    发明人： Paul H. Stypulkowski ,  Jonathon E. Giftakis

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36064 ,  A61N1/0534 ,  A61N1/36135 ,  A61N1/36171 ,  A61N1/36185

    摘要： In some examples of selecting a target therapy delivery site for treating a patient condition, a relatively high frequency electrical stimulation signal is delivered to at least two areas within a first region (e.g., an anterior nucleus of the thalamus) of a brain of a patient, and changes in brain activity (e.g., as indicated by bioelectrical brain signals) within a second region (e.g., a hippocampus) of the brain of the patient in response to the delivered stimulation are determined. The target therapy delivery site, an electrode combination, or both, may be selected based on the changes in brain activity.

    摘要翻译： 在选择用于治疗患者状况的靶治疗递送部位的一些实例中，相对高频率的电刺激信号被递送到患者脑部的第一区域（例如，丘脑的前核）内的至少两个区域 并且确定响应于递送的刺激的患者脑的第二区域（例如，海马）中的脑活动（例如，由生物电脑信号所示）的变化。 可以基于脑活动的变化来选择靶治疗递送部位，电极组合或两者。