摘要:
The present invention relates to a novel sulfamide derivative, a pharmaceutically acceptable salt thereof and a pharmaceutical composition for upregulation of lipid metabolism comprising same as an active ingredient.
摘要:
The inventive imidazopyridine derivative can be used in a pharmaceutical composition for preventing or treating diseases such as diabetes, obesity, dementia, cancer, and inflammation, since it can efficiently inhibit the activities of several protein kinases including glycogen synthase kinase-3 (GSK-3), aurora kinase, extracellular signal-regulated kinase (ERK), protein kinase B (AKT), and the likes, to control signal transductions thereof.
摘要:
Disclosed herein are pyridine derivatives, or a pharmaceutically acceptable salt, ester, amide, or prodrug thereof, pharmaceutical compositions comprising the same, and methods of modulating the level or activity of HIF in a subject, inhibiting hydroxylation of HIF α in a subject, modulating expression of HIF-regulated genes in a subject, treating an HIF-related disorder in a subject, increasing levels of endogenous EPO in a subject, or treating a disorder in a subject, using the disclosed compounds.
摘要:
An object of the present invention is to provide compounds which are useful as protein kinase inhibitors.Disclosed is a 2-aminoquinazoline derivative represented by the following formula (I): wherein R1 represents a lower alkyl group which may be substituted with a halogen atom, or a halogen atom; R2 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group, a halogen atom, a hydroxyl group, a substituted or unsubstituted lower alkoxy group, a substituted or unsubstituted amino group, a substituted or unsubstituted acylamino group, a carboxyl group, a lower alkoxycarbonyl group, a carbamoyl group, or a substituted or unsubstituted lower alkylureido group; and X, Y and Z each independently represents a hydrogen atom, a substituted or unsubstituted lower alkyl group, a halogen atom, a hydroxyl group, a carboxyl group, a lower alkoxycarbonyl group, a cyano group, a carbamoyl group, a substituted or unsubstituted lower alkoxy group, a substituted or unsubstituted amino group, a substituted or unsubstituted lower alkoxycarbonylamino group, a substituted or unsubstituted lower alkylaminocarbonyl group, a lower alkylsulfonylamino group, a substituted or unsubstituted lower alkylureido group, or a substituted or unsubstituted acylamino group, or X and Y may be combined to form a 5- to 6-membered ring forming a bicyclic fused ring, wherein the 5- to 6-membered ring may optionally have a substituent, provided that when X and Y are not combined to form a fused ring, R2 represents a hydrogen atom and, when X and Y are combined to form a fused ring, a saturated or unsaturated, bicyclic alicyclic or heterocyclic fused ring can be formed.
摘要翻译:本发明的目的是提供可用作蛋白激酶抑制剂的化合物。 公开了由下式(I)表示的2-氨基喹唑啉衍生物:其中R1表示可被卤素原子或卤素原子取代的低级烷基; R 2表示氢原子,取代或未取代的低级烷基,卤素原子,羟基,取代或未取代的低级烷氧基,取代或未取代的氨基,取代或未取代的酰氨基,羧基,低级 烷氧基羰基,氨基甲酰基或取代或未取代的低级烷基脲基; X,Y和Z各自独立地表示氢原子,取代或未取代的低级烷基,卤素原子,羟基,羧基,低级烷氧基羰基,氰基,氨基甲酰基,取代或未取代的 取代或未取代的低级烷氧基羰基氨基,取代或未取代的低级烷基氨基羰基,低级烷基磺酰基氨基,取代或未取代的低级烷基脲基,或取代或未取代的酰基氨基,或X 并且Y可以组合形成一个形成双环稠合环的5至6元环,其中5至6元环可以任选地具有取代基,条件是当X和Y不组合形成稠环时 R2表示氢原子,当X和Y组合形成稠环时,可以形成饱和或不饱和的双环脂环或杂环稠合环。