公开(公告)号：US20060286603A1

公开(公告)日：2006-12-21

申请号：US11392108

申请日：2006-03-28

申请人： Joost Kolkman ,  Willem Stemmer ,  Per-Ola Freskgard

发明人： Joost Kolkman ,  Willem Stemmer ,  Per-Ola Freskgard

IPC分类号： C40B30/06 ,  C40B40/10

CPC分类号： C40B30/04 ,  A61K47/62 ,  B01J2219/00659 ,  B01J2219/00702 ,  B01J2219/00725 ,  C07K1/047 ,  C40B40/10 ,  G01N33/6845

摘要： Methods for identifying discrete monomer domains and immuno-domains with a desired property are provided. Methods for generating multimers from two or more selected discrete monomer domains are also provided, along with methods for identifying multimers possessing a desired property. Presentation systems are also provided which present the discrete monomer and/or immuno-domains, selected monomer and/or immuno-domains, multimers and/or selected multimers to allow their selection. Compositions, libraries and cells that express one or more library member, along with kits and integrated systems, are also included in the present invention.

公开(公告)号：US20050053973A1

公开(公告)日：2005-03-10

申请号：US10840723

申请日：2004-05-05

申请人： Joost Kolkman ,  Willem Stemmer ,  Per-Ola Freskgard

发明人： Joost Kolkman ,  Willem Stemmer ,  Per-Ola Freskgard

IPC分类号： C12Q1/68 ,  G01N33/53

CPC分类号： C07K1/047 ,  G01N33/6878

摘要： Methods for identifying discrete monomer domains and immuno-domains with a desired property are provided. Methods for generating multimers from two or more selected discrete monomer domains are also provided, along with methods for identifying multimers possessing a desired property. Presentation systems are also provided which present the discrete monomer and/or immuno-domains, selected monomer and/or immuno-domains, multimers and/or selected multimers to allow their selection. Compositions, libraries and cells that express one or more library member, along with kits and integrated systems, are also included in the present invention.

摘要翻译： 提供用于鉴定具有所需性质的离散单体结构域和免疫结构域的方法。 还提供了用于从两个或更多个选定的离散单体域产生多聚物的方法，以及用于鉴定具有所需性质的多聚物的方法。 还提供呈现系统，其呈现分立的单体和/或免疫结构域，选择的单体和/或免疫结构域，多聚体和/或选择的多聚体以允许其选择。 表达一个或多个文库成员的组合物，文库和细胞以及试剂盒和整合体系也包括在本发明中。

公开(公告)号：US20050048512A1

公开(公告)日：2005-03-03

申请号：US10693056

申请日：2003-10-24

申请人： Joost Kolkman ,  Willem Stemmer ,  Per-Ola Freskgard

发明人： Joost Kolkman ,  Willem Stemmer ,  Per-Ola Freskgard

IPC分类号： C12Q1/68 ,  G01N33/53 ,  G01N33/543

CPC分类号： G01N33/6845 ,  A61K47/62 ,  B01J2219/00659 ,  B01J2219/00702 ,  B01J2219/00725 ,  C07K1/047 ,  C40B30/04 ,  C40B40/10

摘要： Methods for identifying discrete monomer domains and immuno-domains with a desired property are provided. Methods for generating multimers from two or more selected discrete monomer domains are also provided, along with methods for identifying multimers possessing a desired property. Presentation systems are also provided which present the discrete monomer and/or immuno-domains, selected monomer and/or immuno-domains, multimers and/or selected multimers to allow their selection. Compositions, libraries and cells that express one or more library member, along with kits and integrated systems, are also included in the present invention.

公开(公告)号：US20060234299A1

公开(公告)日：2006-10-19

申请号：US11281256

申请日：2005-11-16

申请人： Willem Stemmer ,  Martin Vogt ,  Joost Kolkman ,  Josh Silverman ,  Candace Swimmer

发明人： Willem Stemmer ,  Martin Vogt ,  Joost Kolkman ,  Josh Silverman ,  Candace Swimmer

IPC分类号： C40B40/10

CPC分类号： C07K14/485 ,  C07K1/047 ,  C07K2319/70 ,  G01N33/6845 ,  G01N2333/485 ,  G01N2333/70546 ,  G01N2500/04

摘要： Specific monomer domains and multimers comprising the monomer domains are provided. Methods, compositions, libraries and cells that express one or more library member, along with kits and integrated systems, are also included in the present invention.

摘要翻译： 提供了包含单体域的特异性单体域和多聚物。 表达一个或多个文库成员的方法，组合物，文库和细胞以及试剂盒和整合体系也包括在本发明中。

公开(公告)号：US20060223114A1

公开(公告)日：2006-10-05

申请号：US11281245

申请日：2005-11-16

申请人： Willem Stemmer ,  Martin Vogt ,  Joost Kolkman ,  Josh Silverman

发明人： Willem Stemmer ,  Martin Vogt ,  Joost Kolkman ,  Josh Silverman

IPC分类号： C40B40/10

CPC分类号： C07K1/047 ,  C07K7/06 ,  C07K14/485 ,  C07K14/705 ,  C07K2319/00 ,  C12N15/1037 ,  C12N15/1044 ,  C40B40/02 ,  C40B50/06 ,  G01N33/6845 ,  G01N33/6878 ,  G01N33/84 ,  G01N33/92 ,  G01N2333/4718 ,  G01N2333/4724 ,  G01N2333/71

摘要： The present invention provides thrombospondin, thyroglobulin and trfoil/PD monomer domains and multimers comprising the monomer domains are provided. Methods, compositions, libraries and cells that express one or more library member, along with kits and integrated systems, are also included in the present invention.

摘要翻译： 本发明提供了血小板反应蛋白，甲状腺球蛋白和三叶形/ PD单体结构域和包含单体结构域的多聚体。 表达一个或多个文库成员的方法，组合物，文库和细胞以及试剂盒和整合体系也包括在本发明中。

公开(公告)号：US20050164301A1

公开(公告)日：2005-07-28

申请号：US10971679

申请日：2004-10-22

申请人： Joost Kolkman ,  Willem Stemmer

发明人： Joost Kolkman ,  Willem Stemmer

IPC分类号： C07H21/04 ,  C07K14/475 ,  C07K14/485 ,  C07K14/705 ,  C08F20060101 ,  G01N33/53

CPC分类号： C07H21/04 ,  C07K14/475 ,  C07K14/485 ,  C07K14/705 ,  C07K2319/00 ,  G01N33/53

摘要： Specific monomer domains and multimers comprising the monomer domains are provided. Methods, compositions, libraries and cells that express one or more library member, along with kits and integrated systems, are also included in the present invention.

摘要翻译： 提供了包含单体域的特异性单体域和多聚物。 表达一个或多个文库成员的方法，组合物，文库和细胞以及试剂盒和整合体系也包括在本发明中。

公开(公告)号：US20050221384A1

公开(公告)日：2005-10-06

申请号：US10966064

申请日：2004-10-15

申请人： Joost Kolkman ,  Willem Stemmer ,  Per-Ola Freskgard

发明人： Joost Kolkman ,  Willem Stemmer ,  Per-Ola Freskgard

IPC分类号： G01N33/53 ,  C07B61/00 ,  C07K1/04 ,  C07K14/47 ,  C12N15/09 ,  C12Q1/02 ,  C12Q1/68 ,  C40B30/04 ,  C40B40/10 ,  G01N33/68 ,  G01N37/00 ,  G01N33/543

CPC分类号： C40B30/04 ,  B01J2219/00659 ,  B01J2219/00702 ,  B01J2219/00725 ,  C07K1/047 ,  C40B40/10 ,  G01N33/6845

摘要： Methods for identifying discrete monomer domains and immuno-domains with a desired property are provided. Methods for generating multimers from two or more selected discrete monomer domains are also provided, along with methods for identifying multimers possessing a desired property. Presentation systems are also provided which present the discrete monomer and/or immuno-domains, selected monomer and/or immuno-domains, multimers and/or selected multimers to allow their selection. Compositions, libraries and cells that express one or more library member, along with kits and integrated systems, are also included in the present invention.

摘要翻译： 提供用于鉴定具有所需性质的离散单体结构域和免疫结构域的方法。 还提供了用于从两个或更多个选定的离散单体域产生多聚物的方法，以及用于鉴定具有所需性质的多聚物的方法。 还提供呈现系统，其呈现分立的单体和/或免疫结构域，选择的单体和/或免疫结构域，多聚体和/或选择的多聚体以允许其选择。 表达一个或多个文库成员的组合物，文库和细胞以及试剂盒和整合体系也包括在本发明中。

公开(公告)号：US20050089932A1

公开(公告)日：2005-04-28

申请号：US10871602

申请日：2004-06-17

申请人： Joost Kolkman ,  Willem Stemmer ,  Per-Ola Freskgard

发明人： Joost Kolkman ,  Willem Stemmer ,  Per-Ola Freskgard

IPC分类号： C07K7/08 ,  G01N33/53 ,  G01N33/543

CPC分类号： C07K7/06 ,  C07K14/485 ,  C07K14/705 ,  C07K2319/00 ,  C12N15/1037 ,  C40B40/02 ,  C40B50/06 ,  G01N33/6878 ,  G01N33/84 ,  G01N33/92 ,  G01N2333/4718 ,  G01N2333/4724 ,  G01N2333/71

摘要： Methods for identifying discrete monomer domains and immuno-domains with a desired property are provided. Methods for generating multimers from two or more selected discrete monomer domains are also provided, along with methods for identifying multimers possessing a desired property. Presentation systems are also provided which present the discrete monomer and/or immuno-domains, selected monomer and/or immuno-domains, multimers and/or selected multimers to allow their selection. Compositions, libraries and cells that express one or more library member, along with kits and integrated systems, are also included in the present invention.

公开(公告)号：US08716448B2

公开(公告)日：2014-05-06

申请号：US12806005

申请日：2010-08-02

申请人： Volker Schellenberger ,  Joshua Silverman ,  Willem Stemmer ,  Chia-wei Wang ,  Benjamin Spink ,  Nathan Geething ,  Wayne To

发明人： Volker Schellenberger ,  Joshua Silverman ,  Willem Stemmer ,  Chia-wei Wang ,  Benjamin Spink ,  Nathan Geething ,  Wayne To

IPC分类号： A61K38/36 ,  C07K14/745

CPC分类号： C12N9/644 ,  A61K38/00 ,  C07K14/001 ,  C07K2319/00 ,  C07K2319/31 ,  C07K2319/50 ,  C12N9/6437 ,  C12N15/70 ,  C12Y304/21022

摘要： The present invention relates to compositions comprising factor VII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions.

摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的因子VII凝血因子的组合物，编码组合物的分离的核酸和载体以及含有它们的宿主细胞，以及制备和使用这些组合物治疗凝血因子相关的方法 疾病，病症和状况。

公开(公告)号：US20080019988A1

公开(公告)日：2008-01-24

申请号：US11713514

申请日：2007-03-01

申请人： Juha Punnonen ,  Willem Stemmer ,  Russell Howard ,  Phillip Patten

发明人： Juha Punnonen ,  Willem Stemmer ,  Russell Howard ,  Phillip Patten

IPC分类号： A61K39/12 ,  A61P31/12 ,  C07K14/00 ,  C12N15/09

CPC分类号： A61K39/385 ,  A61K39/00 ,  A61K2039/53 ,  A61K2039/6037 ,  A61K2039/605 ,  C12N15/1037 ,  C12N15/85 ,  C12N2810/50 ,  C12N2810/85 ,  C12N2810/859

摘要： This invention provides methods of obtaining reagents for increasing the specificity of genetic vaccines for a desired target cell or tissue type. The invention also provides delivery vehicles for use to improve genetic vaccine specificity for a target cell or tissue type.

摘要翻译： 本发明提供获得用于增加所需靶细胞或组织类型的遗传疫苗的特异性的试剂的方法。 本发明还提供用于改善靶细胞或组织类型的遗传疫苗特异性的递送载体。