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公开(公告)号：US20080019988A1
公开(公告)日：2008-01-24
申请号：US11713514
申请日：2007-03-01
申请人： Juha Punnonen , Willem Stemmer , Russell Howard , Phillip Patten
发明人： Juha Punnonen , Willem Stemmer , Russell Howard , Phillip Patten
CPC分类号： A61K39/385 , A61K39/00 , A61K2039/53 , A61K2039/6037 , A61K2039/605 , C12N15/1037 , C12N15/85 , C12N2810/50 , C12N2810/85 , C12N2810/859
摘要： This invention provides methods of obtaining reagents for increasing the specificity of genetic vaccines for a desired target cell or tissue type. The invention also provides delivery vehicles for use to improve genetic vaccine specificity for a target cell or tissue type.
摘要翻译： 本发明提供获得用于增加所需靶细胞或组织类型的遗传疫苗的特异性的试剂的方法。 本发明还提供用于改善靶细胞或组织类型的遗传疫苗特异性的递送载体。
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公开(公告)号：US20050260605A1
公开(公告)日：2005-11-24
申请号：US10805054
申请日：2004-03-19
申请人： Juha Punnonen , Willem Stemmer , Russell Howard , Phillip Patten
发明人： Juha Punnonen , Willem Stemmer , Russell Howard , Phillip Patten
IPC分类号： A61K39/385 , C12N15/85 , C12Q1/68
CPC分类号： A61K39/385 , A61K39/00 , A61K2039/53 , A61K2039/6037 , A61K2039/605 , C12N15/1037 , C12N15/85 , C12N2810/50 , C12N2810/85 , C12N2810/859
摘要： This invention provides methods of obtaining reagents for increasing the specificity of genetic vaccines for a desired target cell or tissue type. The invention also provides delivery vehicles for use to improve genetic vaccine specificity for a target cell or tissue type.
摘要翻译： 本发明提供获得用于增加所需靶细胞或组织类型的遗传疫苗的特异性的试剂的方法。 本发明还提供用于改善靶细胞或组织类型的遗传疫苗特异性的递送载体。
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公开(公告)号：US20050064464A1
公开(公告)日：2005-03-24
申请号：US10877035
申请日：2004-06-25
申请人： Juha Punnonen , Willem Stemmer , Robert Whalen , Russell Howard
发明人： Juha Punnonen , Willem Stemmer , Robert Whalen , Russell Howard
IPC分类号： A61K39/00 , C07K14/02 , C07K14/16 , C07K14/24 , C12N15/10 , C40B40/02 , C12Q1/68 , A61K48/00 , C12P19/34
CPC分类号： C40B40/02 , A61K39/00 , A61K2039/53 , C07K14/005 , C07K14/24 , C07K2319/02 , C07K2319/40 , C07K2319/74 , C12N15/1027 , C12N15/1034 , C12N15/1037 , C12N15/1093 , C12N2730/10122 , C12N2740/16222
摘要： This invention provides methods for obtaining molecules that can modulate an immune response, and immunomodulatory molecules obtained using the methods. The molecules find use, for example, in the tailoring of an immune response induced by a genetic vaccine for a desired purpose.
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公开(公告)号：US20070087373A1
公开(公告)日：2007-04-19
申请号：US11607035
申请日：2006-12-01
申请人： Juha Punnonen , Willem Stemmer , Robert Whalen , Russell Howard
发明人： Juha Punnonen , Willem Stemmer , Robert Whalen , Russell Howard
CPC分类号： C40B40/02 , A61K39/00 , A61K2039/53 , C07K14/005 , C07K14/24 , C07K2319/02 , C07K2319/40 , C07K2319/74 , C12N15/1027 , C12N15/1034 , C12N15/1037 , C12N15/1093 , C12N2730/10122 , C12N2740/16222
摘要： This invention provides methods for obtaining molecules that can modulate an immune response, and immunomodulatory molecules obtained using the methods. The molecules find use, for example, in the tailoring of an immune response induced by a genetic vaccine for a desired purpose.
摘要翻译： 本发明提供了获得可调节免疫应答的分子的方法，以及使用该方法获得的免疫调节分子。 分子可用于例如为了期望目的而定制由遗传疫苗诱导的免疫应答。
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公开(公告)号：US20060045888A1
公开(公告)日：2006-03-02
申请号：US10980556
申请日：2004-11-03
申请人： Juha Punnonen , Steven Bass , Robert Whalen , Russell Howard , Willem Stemmer
发明人： Juha Punnonen , Steven Bass , Robert Whalen , Russell Howard , Willem Stemmer
IPC分类号： A61K39/295 , A61K39/116 , C07H21/04
CPC分类号： C40B40/02 , A61K39/00 , A61K39/0011 , A61K39/015 , A61K39/0225 , A61K39/0258 , A61K39/0291 , A61K39/085 , A61K39/105 , A61K39/107 , A61K39/12 , A61K39/35 , A61K2039/53 , A61K2039/70 , C07K14/005 , C07K14/24 , C07K2319/02 , C07K2319/40 , C07K2319/74 , C12N15/1027 , C12N15/1034 , C12N15/1037 , C12N15/62 , C12N2710/16634 , C12N2730/10134 , C12N2740/16134 , C12N2760/12134 , C12N2770/24134 , C12N2770/24234 , C12N2770/36134 , Y02A50/474
摘要： This invention is directed to antigen library immunization, which provides methods for obtaining antigens having improved properties for therapeutic and other uses. The methods are useful for obtaining improved antigens that can induce an immune response against pathogens, cancer, and other conditions, as well as antigens that are effective in modulating allergy, inflammatory and autoimmune diseases.
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公开(公告)号：US20050164222A1
公开(公告)日：2005-07-28
申请号：US10877846
申请日：2004-06-25
申请人： Juha Punnonen , Willem Stemmer , Robert Whalen , Russell Howard
发明人： Juha Punnonen , Willem Stemmer , Robert Whalen , Russell Howard
IPC分类号： A61K39/00 , C07K14/02 , C07K14/16 , C07K14/24 , C12N15/10 , C40B40/02 , C12Q1/68 , C12P19/34
CPC分类号： C40B40/02 , A61K39/00 , A61K2039/53 , C07K14/005 , C07K14/24 , C07K2319/02 , C07K2319/40 , C07K2319/74 , C12N15/1027 , C12N15/1034 , C12N15/1037 , C12N15/1093 , C12N2730/10122 , C12N2740/16222
摘要： This invention provides methods for obtaining molecules that can modulate an immune response, and immunomodulatory molecules obtained using the methods. The molecules find use, for example, in the tailoring of an immune response induced by a genetic vaccine for a desired purpose.
摘要翻译： 本发明提供了获得可调节免疫应答的分子的方法，以及使用该方法获得的免疫调节分子。 分子可用于例如为了期望目的而定制由遗传疫苗诱导的免疫应答。
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公开(公告)号：US20070087374A1
公开(公告)日：2007-04-19
申请号：US11607038
申请日：2006-12-01
申请人： Juha Punnonen , Willem Stemmer , Robert Whalen , Russell Howard
发明人： Juha Punnonen , Willem Stemmer , Robert Whalen , Russell Howard
CPC分类号： C40B40/02 , A61K39/00 , A61K2039/53 , C07K14/005 , C07K14/24 , C07K2319/02 , C07K2319/40 , C07K2319/74 , C12N15/1027 , C12N15/1034 , C12N15/1037 , C12N15/1093 , C12N2730/10122 , C12N2740/16222
摘要： This invention provides methods for obtaining molecules that can modulate an immune response, and immunomodulatory molecules obtained using the methods. The molecules find use, for example, in the tailoring of an immune response induced by a genetic vaccine for a desired purpose.
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公开(公告)号：US20050222069A1
公开(公告)日：2005-10-06
申请号：US10981535
申请日：2004-11-05
申请人： Juha Punnonen , Willem Stemmer , Robert Whalen , Russell Howard
发明人： Juha Punnonen , Willem Stemmer , Robert Whalen , Russell Howard
IPC分类号： A61K39/00 , C07K14/02 , C07K14/16 , C07K14/24 , C12N15/10 , C40B40/02 , A61K48/00 , C12Q1/68
CPC分类号： C40B40/02 , A61K39/00 , A61K2039/53 , C07K14/005 , C07K14/24 , C07K2319/02 , C07K2319/40 , C07K2319/74 , C12N15/1027 , C12N15/1034 , C12N15/1037 , C12N15/1093 , C12N2730/10122 , C12N2740/16222
摘要： This invention provides methods for obtaining molecules that can modulate an immune response, and immunomodulatory molecules obtained using the methods. The molecules find use, for example, in the tailoring of an immune response induced by a genetic vaccine for a desired purpose.
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公开(公告)号：US20050059109A1
公开(公告)日：2005-03-17
申请号：US10667868
申请日：2003-09-22
申请人： Phillip Patten , Willem Stemmer
发明人： Phillip Patten , Willem Stemmer
IPC分类号： C12N15/09 , A61K38/45 , A61K48/00 , C07K14/435 , C07K14/47 , C07K14/545 , C07K14/56 , C07K16/00 , C12N7/00 , C12N9/02 , C12N9/10 , C12N9/12 , C12N9/38 , C12N9/86 , C12N15/10 , C12N15/52 , C12N15/64 , C12P21/02 , C12Q1/68 , C40B40/02 , G01N33/68 , C12N15/85 , C12P19/34
CPC分类号： C12N15/1031 , A61K38/45 , A61K48/00 , C07K14/43595 , C07K14/545 , C07K14/56 , C07K16/00 , C07K2317/565 , C07K2317/622 , C12N7/00 , C12N9/0069 , C12N9/1007 , C12N9/16 , C12N9/86 , C12N15/10 , C12N15/1027 , C12N15/1034 , C12N15/1037 , C12N15/1058 , C12N15/52 , C12N15/64 , C12N15/67 , C12N2795/14043 , C12N2795/14143 , C12Q1/6811 , C12Q1/6853 , C12Q1/686 , C40B40/02 , C40B40/08 , C40B50/06 , G01N33/68 , G01N33/6845
摘要： Methods are provided for the evolution of proteins of industrial and pharmaceutical interest, including methods for effecting recombination and selection. Compositions produced by these methods are also disclosed.
摘要翻译： 提供了用于工业和医药兴趣蛋白质进化的方法，包括进行重组和选择的方法。 还公开了通过这些方法制备的组合物。
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公开(公告)号：US20070054313A1
公开(公告)日：2007-03-08
申请号：US11595919
申请日：2006-11-13
申请人： Andreas Crameri , Willem Stemmer , Jeremy Minshull , Steven Bass , Mark Welch , Jon Ness , Claes Gustafsson , Phillip Patten
发明人： Andreas Crameri , Willem Stemmer , Jeremy Minshull , Steven Bass , Mark Welch , Jon Ness , Claes Gustafsson , Phillip Patten
CPC分类号： C12P21/06
摘要： Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided.
摘要翻译： 提供重组核酸的方法，包括同源核酸。 还提供了基因改组寡核苷酸家族及其在重组过程中的应用，以及聚合酶和连接酶介导的重组方法。
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