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1.发明申请公开(公告)号：US20170233268A1
公开(公告)日：2017-08-17
申请号：US15502119
申请日：2014-08-08
CPC分类号： C02F1/5227 , C02F11/14 , C02F2201/004 , C02F2201/005 , C02F2209/03 , C02F2209/44 , C02F2301/024 , C02F2301/066
摘要： The present invention relates to an apparatus (1), suitable for preparing and dispensing a flocculant solution to dewatering an aqueous process stream (4), wherein the apparatus (1) comprises a mixing pump (5) that mixes the flocculant solution and builds up a pressure onto the flocculant solution, and a maturing pressure tank (2), whereby the maturing pressure tank (2) is fluidly connected with the mixing pump (5), so that the pressurized diluted flocculant solution (3) is led from the mixing pump (5) into the maturing pressure tank (2) and matured therein under pressure that is above atmosphere pressure.
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2.发明授权公开(公告)号：US11319223B2
公开(公告)日：2022-05-03
申请号：US15502119
申请日：2014-08-08
IPC分类号： C02F1/52 , C02F11/14 , C02F11/147
摘要： An apparatus for preparing and dispensing a flocculant solution to dewatering an aqueous process stream includes a mixing pump, a maturing tank, and a feeding unit. The mixing pump mixes the flocculant solution and builds up a pressure onto the flocculant solution. The maturing pressure tank is fluidly connected with the mixing pump, so that the pressurized diluted flocculant solution is led from the mixing pump into the maturing pressure tank and matured therein under pressure that is above atmosphere pressure.
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公开(公告)号：US10145067B2
公开(公告)日：2018-12-04
申请号：US15271441
申请日：2016-09-21
申请人： ECOLAB USA, INC.
发明人： Yulin Zhao , Jun Li , Qing Long Rao , Stephen Ashton , Weiguo Cheng , Aleksandar Todorovic , Alan Smith
IPC分类号： D21H17/37 , D21H21/20 , D21H21/18 , D21H17/67 , D21H21/10 , D21C3/02 , D21C5/00 , D21C5/02 , D21H17/69 , D21H17/00 , D21H17/66
摘要： Methods of improving dewatering efficiency, increasing sheet wet web strength, increasing sheet wet strength, and enhancing filler retention in a papermaking process are disclosed. The methods improve the efficiency of drainage aids, wet web strength aids, and/or wet strength aids by coating at least some of the filler particles with a material that prevents the filler materials form adhering to a those additives.
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4.发明申请公开(公告)号：US20170328004A1
公开(公告)日：2017-11-16
申请号：US15531211
申请日：2015-10-27
申请人： Ecolab USA Inc.
发明人： Qinglong Rao , Yulin Zhao , Weiguo Cheng , Stephen B. Ashton , Aleksandar Todorovic , Alan Smith
摘要： A process for flocculating filler particles in water is provided. The process comprises adding a flocculant to a mixture comprising filler particles and water, wherein the flocculant has a reduced specific viscosity (“RSV”) of from about 5 dL/g to about 16 dL/g, a viscosity average molecular weight of from about 1,200,000 to about 7,500,000, and a cationic charge of from about 5 mol % to about 50 mol %. Flocs formed by flocculation of the filler particles and the flocculant have a median particle size of from about 10 um to about 150 um. The filler is not precipitated calcium carbonate alone. The flocs provided by the process are useful in increasing ash content of a paper product.
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公开(公告)号：US10697121B2
公开(公告)日：2020-06-30
申请号：US15531211
申请日：2015-10-27
申请人： Ecolab USA Inc.
发明人： Qinglong Rao , Yulin Zhao , Weiguo Cheng , Stephen B. Ashton , Aleksandar Todorovic , Alan Smith
摘要： A process for flocculating filler particles in water is provided. The process comprises adding a flocculant to a mixture comprising filler particles and water, wherein the flocculant has a reduced specific viscosity (“RSV”) of from about 5 dL/g to about 16 dL/g, a viscosity average molecular weight of from about 1,200,000 to about 7,500,000, and a cationic charge of from about 5 mol % to about 50 mol %. Flocs formed by flocculation of the filler particles and the flocculant have a median particle size of from about 10 μm to about 150 μm. The filler is not precipitated calcium carbonate alone. The flocs provided by the process are useful in increasing ash content of a paper product.
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公开(公告)号：US09078814B2
公开(公告)日：2015-07-14
申请号：US13541325
申请日：2012-07-03
IPC分类号： A61F13/00 , A61K31/445 , A01N43/40 , A01N43/16 , A61K31/35 , A61K9/00 , A61K31/4468
CPC分类号： A61K31/4468 , A61K9/0043 , A61K47/26 , A61K47/36 , A61M11/00 , A61M15/08
摘要： An intrasnal spray device contains a composition for the intranasal delivery of fentanyl or a pharmaceutically acceptable salt thereof to an animal includes an aqueous solution of fentanyl or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable additive selected from (i) a pectin and (ii) a poloxamer and chitosan or a salt or derivative thereof; provided that when the composition comprises a pectin it is substantially free of divalent metal ions; and which, in comparison to a simple aqueous solution of fentanyl administered intranasally at the same dose, provides a peak plasma concentration of fentanyl (Cmax) that is from 10 to 80% of that achieved using a simple aqueous solution of fentanyl administered intranasally at an identical fentanyl dose. A method for treating or managing pain by intranasally administering the composition is also disclosed.
摘要翻译： 包含用于将芬太尼或其药学上可接受的盐鼻内递送给动物的组合物包括芬太尼或其药学上可接受的盐的水溶液和选自以下的药学上可接受的添加剂：（i）果胶和（ii） 泊洛沙姆和壳聚糖或其盐或衍生物; 条件是当组合物包含果胶时，其基本上不含二价金属离子; 并且与以相同剂量鼻内施用的芬太尼的简单水溶液相比，提供了芬太尼（C max）的峰值血浆浓度，其为使用芬太尼简单的水溶液，其在鼻内给药时的10至80％ 芬太尼剂量相同。 还公开了通过鼻内施用组合物治疗或治疗疼痛的方法。
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公开(公告)号：US08710028B2
公开(公告)日：2014-04-29
申请号：US12675306
申请日：2008-08-29
申请人： Peter James Watts , Yu-Hui Cheng , Alan Smith , Jonathan Castile
发明人： Peter James Watts , Yu-Hui Cheng , Alan Smith , Jonathan Castile
CPC分类号： A61K9/0043 , A61K9/146 , A61K9/1652 , A61K9/1694 , A61K9/19 , A61K31/5513 , A61K31/5517
摘要： A powder composition for intranasal delivery includes a benzodiazepine drug and chitosan, a salt of chitosan, a derivative of chitosan or a salt of a derivative of chitosan.
摘要翻译： 用于鼻内递送的粉末组合物包括苯并二氮杂药物和壳聚糖，壳聚糖的盐，壳聚糖的衍生物或壳聚糖的衍生物的盐。
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公开(公告)号：US08709996B2
公开(公告)日：2014-04-29
申请号：US12766487
申请日：2010-04-23
申请人： Michael Leane , Alan Smith , Lisbeth Illum
发明人： Michael Leane , Alan Smith , Lisbeth Illum
IPC分类号： A61K31/722 , A61K38/28 , A61K38/16 , A61K33/42 , A61K38/12 , A61K38/21 , A61K38/20 , A61K9/48
CPC分类号： A61K9/4808 , A61K9/1617 , A61K9/1652 , A61K9/205 , A61K9/5047 , A61K9/5084 , A61K31/19 , A61K31/722 , A61K38/00
摘要： The present invention provides a solid composition for oral administration comprising: (i) a drug compound; (ii) chitosan or a derivative thereof or a salt of chitosan or salt of a derivative of chitosan; and (iii) an organic acid. Preferably the drug compound is a polar molecule having a molecular weight of 1 KDa or less, a peptide, a protein or a polysaccharide. The compositions of the invention provide enhance absorption of the drug compound.
摘要翻译： 本发明提供一种用于口服给药的固体组合物，其包含：（i）药物化合物; （ii）壳聚糖或其衍生物或壳聚糖的盐或壳聚糖衍生物的盐; 和（iii）有机酸。 优选地，药物化合物是分子量为1KDa或更小的极性分子，肽，蛋白质或多糖。 本发明的组合物提供药物化合物的增强吸收。
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公开(公告)号：US07947257B2
公开(公告)日：2011-05-24
申请号：US11004556
申请日：2004-12-03
申请人： Peter James Watts , Alan Smith , Jonathan Castile
发明人： Peter James Watts , Alan Smith , Jonathan Castile
CPC分类号： A61K9/0043 , A61K31/435
摘要： Compositions are provided for the intranasal administration of granisetron or a pharmaceutically acceptable salt thereof. Preferred compositions are in the form of an aqueous solution. Optionally, the compositions comprise chitosan, a salt or derivative thereof or a salt of a derivative of chitosan. The compositions can be used for the treatment or prevention of nausea and/or vomiting.
摘要翻译： 提供了用于格拉司琼或其药学上可接受的盐的鼻内给药的组合物。 优选的组合物是水溶液的形式。 任选地，组合物包含壳聚糖，其盐或衍生物或壳聚糖衍生物的盐。 该组合物可用于治疗或预防恶心和/或呕吐。
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公开(公告)号：US07384396B2
公开(公告)日：2008-06-10
申请号：US10435221
申请日：2003-05-08
IPC分类号： A61B5/00
CPC分类号： A61B5/14514 , A61B5/00 , A61B5/0002 , A61B5/14532 , A61B5/150022 , A61B5/150099 , A61B5/150809 , A61B5/150816 , A61B5/150824 , A61B5/150862 , A61B5/150969 , A61B5/150984 , A61B5/15134 , A61B5/155 , A61B5/157 , A61B10/0045 , A61B2010/008
摘要： A system and method for extracting a biological fluid from an organism and continuously monitoring its characteristics. The system includes a tissue interface device suitable for positioning on or about the surface of the biological membrane of the organism and a monitor and control unit coupled to the tissue interface device. The tissue interface device includes a sensor positioned in a flow path of the fluid for continuously sensing a characteristic of the biological fluid as it flows out from the one or more artificial openings formed in the biological membrane. The sensor generates a sensor signal representative thereof. The monitor and control unit electrically or optically reads the sensor to obtain a measurement of a characteristic, such as concentration of a particular analyte, of the biological fluid on a continuous basis.
摘要翻译： 一种用于从生物体提取生物流体并连续监测其特征的系统和方法。 该系统包括适于定位在生物体的生物膜的表面上或周围的组织界面装置以及耦合到组织界面装置的监测和控制单元。 组织接口装置包括定位在流体的流动路径中的传感器，用于在生物流体从形成在生物膜中的一个或多个人造开口流出时持续感测生物流体的特性。 传感器产生代表其的传感器信号。 监视器和控制单元以电或光学方式读取传感器，以连续的方式获得生物流体特性的浓度，例如特定分析物的浓度。
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