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    Systems and methods for surgical microscope and optical coherence tomography (OCT) imaging
    2.
    发明授权
    Systems and methods for surgical microscope and optical coherence tomography (OCT) imaging 有权
    手术显微镜和光学相干断层扫描（OCT）成像的系统和方法

    公开(公告)号：US08366271B2

    公开(公告)日：2013-02-05

    申请号：US13010497

    申请日：2011-01-20

    申请人： Joseph A. Izatt ,  Yuankai K. Tao ,  Cynthia A. Toth

    发明人： Joseph A. Izatt ,  Yuankai K. Tao ,  Cynthia A. Toth

    IPC分类号： A61B3/14 ,  A61B3/00

    CPC分类号： G01B9/02091 ,  A61B3/102 ,  A61B3/13 ,  G01B9/0203

    摘要： A surgical microscope assembly includes a microscope main objective and microscope imaging optics. The microscope main objective and microscope imaging optics define a viewing beam path that passes from a sample through the microscope main objective and the microscope imaging optics. The assembly includes an optical coherence tomography (OCT) unit having an illumination beam and a collection beam and a beamsplitter between the microscope main objective and the microscope imaging optics. The beamsplitter is configured to direct a portion of light from the microscope main objective to the microscope imaging optics and to direct another portion of light from the microscope main objective to the OCT unit collection beam. The beamsplitter is further configured to direct an illumination beam from the OCT unit to the microscope main objective and to the sample. A beam forming unit is between the OCT unit and the beamsplitter. The beam forming unit is configured to form the illumination beam of the OCT unit so as to generally correspond to a size of the microscope main objective.

    摘要翻译： 手术显微镜组件包括显微镜主要目标和显微镜成像光学元件。 显微镜主要目标和显微镜成像光学器件定义了从样品通过显微镜主要目标和显微镜成像光学器件的观察光束路径。 组件包括具有照明光束和收集光束的光学相干断层摄影（OCT）单元和在显微镜主要物镜和显微镜成像光学器件之间的分束器。 分束器被配置为将来自显微镜主物镜的光的一部分引导到显微镜成像光学器件，并将来自显微镜主物镜的另一部分光引导到OCT单元收集光束。 分束器还被配置成将来自OCT单元的照明光束引导到显微镜主目标和样品。 光束形成单元位于OCT单元和分束器之间。 光束形成单元被配置为形成OCT单元的照明光束，以便大致对应于显微镜主要物镜的尺寸。

    Depth-resolved spectroscopic optical coherence tomography
    4.
    再颁专利
    Depth-resolved spectroscopic optical coherence tomography 有权
    深度分辨光谱相干断层扫描

    公开(公告)号：USRE42641E1

    公开(公告)日：2011-08-23

    申请号：US10020041

    申请日：2001-12-14

    申请人： Joseph A. Izatt ,  Manish D. Kulkarni ,  Michael V. Sivak

    发明人： Joseph A. Izatt ,  Manish D. Kulkarni ,  Michael V. Sivak

    IPC分类号： G01B9/02

    CPC分类号： G01J3/4412 ,  G01B9/02002 ,  G01B9/02007 ,  G01B9/02069 ,  G01B9/02072 ,  G01B9/02083 ,  G01B9/02091 ,  G01B2290/35

    摘要： A method is described for determining depth-resolved backscatter characteristics of scatterers within a sample, comprising the steps of: acquiring a plurality of sets of cross-correlation interferogram data using an interferometer having a sample arm with the sample in the sample arm, wherein the sample includes a distribution of scatterers therein, and wherein the acquiring step includes the step of altering the distribution of scatterers within the sample with respect to the sample arm for substantially each acquisition; and averaging, in the Fourier domain, the cross-correlation interferogram data, thereby revealing backscattering characteristics of the scatterers within the sample.

    摘要翻译： 描述了一种用于确定样本内的散射体的深度分辨后向散射特性的方法，包括以下步骤：使用具有样本臂的样本臂与样本臂中的样本的干涉仪获取多组互相干涉图数据，其中， 样本包括其中散射体的分布，并且其中所述获取步骤包括基本上每次获取相对于所述样本臂改变所述样本内的散射体的分布的步骤; 并且在傅里叶域中平均互相关干涉图数据，从而揭示样品内的散射体的后向散射特性。

    SEGMENTATION AND IDENTIFICATION OF LAYERED STRUCTURES IN IMAGES
    5.
    发明申请
    SEGMENTATION AND IDENTIFICATION OF LAYERED STRUCTURES IN IMAGES 有权
    图像中层状结构的分割和识别

    公开(公告)号：US20110182517A1

    公开(公告)日：2011-07-28

    申请号：US13010448

    申请日：2011-01-20

    申请人： Sina Farsiu ,  Stephanie J. Chiu ,  Cynthia A. Toth ,  Joseph A. Izatt ,  Xiao T. Li ,  Peter Christopher Nicholas

    发明人： Sina Farsiu ,  Stephanie J. Chiu ,  Cynthia A. Toth ,  Joseph A. Izatt ,  Xiao T. Li ,  Peter Christopher Nicholas

    IPC分类号： G06K9/66

    CPC分类号： G06T7/11 ,  A61B3/0025 ,  A61B3/102 ,  A61B5/0066 ,  A61B5/7203 ,  A61B2576/02 ,  G06K9/34 ,  G06T7/0012 ,  G06T7/162 ,  G06T2207/10004 ,  G06T2207/10101 ,  G06T2207/30041

    摘要： Disclosed herein are systems and method for segmentation and identification of structured features in images. According to an aspect, a method may include representing an image as a graph of nodes connected together by edges. For example, the image may be an ocular image showing layered structures or other features of the retina. The method may also include adding, to the graph, nodes adjacent to nodes along first and second sides of the graph. The added nodes may have edge weights less than the nodes along the first and second sides of the graph. Further, the method may include assigning start and end points to any of the added nodes along the first and second sides, respectively. The method may also include graph cutting between the start and end points for identifying a feature in the image.

    摘要翻译： 这里公开了用于分割和识别图像中的结构化特征的系统和方法。 根据一个方面，一种方法可以包括将图像表示为由边缘连接在一起的节点的图形。 例如，图像可以是显示视网膜的分层结构或其他特征的眼睛图像。 该方法还可以包括向图中添加与图的第一和第二侧相邻的节点相邻的节点。 添加的节点可以具有小于沿图的第一和第二侧的节点的边权重。 此外，该方法可以包括分别将起点和终点分配给沿着第一和第二侧的任何添加的节点。 该方法还可以包括用于识别图像中的特征的开始点和结束点之间的图形切割。

    Interferometers for optical coherence domain reflectometry
    8.
    发明授权
    Interferometers for optical coherence domain reflectometry 有权
    用于光学相干畴反射测量的干涉仪

    公开(公告)号：US07362444B2

    公开(公告)日：2008-04-22

    申请号：US11470079

    申请日：2006-09-05

    申请人： Joseph A. Izatt ,  Andrew M. Rollins

    发明人： Joseph A. Izatt ,  Andrew M. Rollins

    IPC分类号： G01B11/02 ,  G01B9/02

    CPC分类号： G01B9/02091 ,  G01B9/02022 ,  G01B2290/35 ,  G01B2290/70 ,  G01N21/4795

    摘要： An interferometer system includes an optical radiation source, an optical circulator connected between the optical radiation source and a sample location for transmitting optical radiation from the optical radiation source to the sample location, an output of the optical circulator connected to direct optical radiation to an optical detector. Various embodiments of such a system are possible. A method of performing OCDR or OCT imaging of a sample which involves the steps of: (a) producing low coherence optical radiation; (b) directing at least some of the low coherence optical radiation through an optical circulator to the sample; (c) reflecting at least some of the low coherence optical radiation off of the sample; and (d) detecting at least some of the reflected low coherence optical radiation and producing an electrical signal corresponding thereto.

    摘要翻译： 干涉仪系统包括光辐射源，连接在光辐射源和用于将光辐射从光辐射源传送到采样位置的采样位置之间的光循环器，连接到直接光辐射的光循环器的输出到光学 探测器。 这种系统的各种实施例是可能的。 执行样本的OCDR或OCT成像的方法，其包括以下步骤：（a）产生低相干光辐射; （b）将至少一些低相干光辐射通过光循环器引导到样品; （c）反射离开样品的至少一些低相干光辐射; 和（d）检测至少一些反射的低相干光辐射并产生与其对应的电信号。

    Depth-resolved spectroscopic optical coherence tomography
    9.
    发明授权
    Depth-resolved spectroscopic optical coherence tomography 失效
    深度分辨光谱相干断层扫描

    公开(公告)号：US6002480A

    公开(公告)日：1999-12-14

    申请号：US88519

    申请日：1998-06-02

    申请人： Joseph A. Izatt ,  Manish D. Kulkarni ,  Michael V. Sivak

    发明人： Joseph A. Izatt ,  Manish D. Kulkarni ,  Michael V. Sivak

    IPC分类号： G01B9/02 ,  G01J3/28

    CPC分类号： G01J3/4412 ,  G01B9/02002 ,  G01B9/02007 ,  G01B9/02069 ,  G01B9/02072 ,  G01B9/02083 ,  G01B9/02091 ,  G01B2290/35

    摘要： A method is described for determining depth-resolved backscatter characteristics of scatterers within a sample, comprising the steps of: acquiring a plurality of sets of cross-correlation interferogram data using an interferometer having a sample arm with the sample in the sample arm, wherein the sample includes a distribution of scatterers therein, and wherein the acquiring step includes the step of altering the distribution of scatterers within the sample with respect to the sample arm for substantially each acquisition; and averaging, in the Fourier domain, the cross-correlation interferogram data, thereby revealing backscattering characteristics of the scatterers within the sample.

    摘要翻译： 描述了一种用于确定样本内的散射体的深度分辨后向散射特性的方法，包括以下步骤：使用具有样本臂的样本臂与样本臂中的样本的干涉仪获取多组互相干涉图数据，其中， 样本包括其中散射体的分布，并且其中所述获取步骤包括基本上每次获取相对于所述样本臂改变所述样本内的散射体的分布的步骤; 并且在傅里叶域中平均互相关干涉图数据，从而揭示样品内的散射体的后向散射特性。

    Systems and methods for complex conjugate artifact resolved optical coherence tomography
    10.
    发明授权
    Systems and methods for complex conjugate artifact resolved optical coherence tomography 有权
    复杂结合伪影解析光学相干断层扫描的系统和方法

    公开(公告)号：US09279659B2

    公开(公告)日：2016-03-08

    申请号：US13355381

    申请日：2012-01-20

    申请人： Joseph A. Izatt ,  Al-Hafeez Dhalla

    发明人： Joseph A. Izatt ,  Al-Hafeez Dhalla

    IPC分类号： G01B9/02 ,  A61B3/10

    CPC分类号： G01B9/02091 ,  A61B3/102 ,  G01B9/02004 ,  G01B9/0201 ,  G01B9/02078

    摘要： Systems and methods are disclosed for optical coherence tomography (OCT). For example, imaging can use optical phase modulators based on optical delay lines that, in conjunction with a swept-source laser, can be used to achieve heterodyne swept source optical coherence tomography (SSOCT). These techniques resolve the complex conjugate ambiguity in SSOCT, thereby doubling the usable imaging range. This increased imaging range has numerous important clinical applications in ophthalmology, cardiology and radiology, as well as applications in small animal and non-biological imaging. These methods are superior to prior disclosed methods requiring acousto-optic or electro-optic modulators with respect to complexity, efficiency, imaging speed and image quality.

    摘要翻译： 公开了用于光学相干断层摄影（OCT）的系统和方法。 例如，成像可以使用基于光学延迟线的光学相位调制器，其结合扫频激光器可用于实现外差扫描光学相干断层扫描（SSOCT）。 这些技术解决了SSOCT中复杂的共轭歧义，从而使可用成像范围翻倍。 这种增加的成像范围在眼科，心脏病学和放射学以及小动物和非生物成像中的应用具有许多重要的临床应用。 这些方法优于先前公开的在复杂性，效率，成像速度和图像质量方面需要声光或电光调制器的方法。