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公开(公告)号：US08534031B2
公开(公告)日：2013-09-17
申请号：US12641483
申请日：2009-12-18
IPC分类号： B65B55/18
CPC分类号： A61L12/086 , A61L12/00 , G02B1/043 , C08L85/04 , C08L51/085 , C08L83/10
摘要： Packaging systems for storing ophthalmic devices such as contact lenses and to methods for packaging such ophthalmic devices with solutions to improve the comfort of the lenses during wear are disclosed.
摘要翻译： 公开了用于存储诸如隐形眼镜的眼科装置的包装系统，以及用于包装这些眼科装置的方法以提供穿戴期间镜片的舒适度的解决方案。
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公开(公告)号：US08377126B2
公开(公告)日：2013-02-19
申请号：US12641422
申请日：2009-12-18
IPC分类号： A61F2/16
CPC分类号： G02B1/043 , A61L27/34 , A61L29/085 , A61L31/10 , A61L2400/18 , A61L2430/16
摘要： Disclosed are biomedical devices having a hydrophilic coating on a portion of a surface thereof, the biomedical device comprising: (a) a biomedical device obtained from a polymerization product of a monomeric mixture comprising (i) a polymerizable monomer containing a boronic acid moiety and an electron withdrawing moiety; and (ii) a biomedical device-forming comonomer; and (b) a hydrophilic reactive polymer having complementary reactive functionalities along the polymer chain, wherein the complementary reactive functionalities along the polymer chain of the hydrophilic reactive polymer of (b) bind with the boronic acid moieties of the biomedical device of (a), thereby producing a biocompatible coating which can be removed and re-applied to restore the surface properties of the biomedical device to substantially as-new condition. Methods for treating the biomedical device are also disclosed.
摘要翻译： 公开了在其表面的一部分上具有亲水涂层的生物医学装置，所述生物医学装置包括：（a）由单体混合物的聚合产物获得的生物医学装置，其包含（i）含有硼酸部分的可聚合单体和 吸电子部分; 和（ii）生物医学装置形成共聚单体; 和（b）沿着聚合物链具有互补的反应性官能团的亲水性反应性聚合物，其中沿着（b）的亲水性反应性聚合物的聚合物链的互补反应性官能团与（a）的生物医学装置的硼酸部分结合， 从而产生生物相容性涂层，其可以被去除并重新施加以将生物医学装置的表面性质恢复到基本上新的状态。 还公开了用于治疗生物医学装置的方法。
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公开(公告)号：US08454689B2
公开(公告)日：2013-06-04
申请号：US12641473
申请日：2009-12-18
IPC分类号： A61F2/16 , C08F30/06 , C08F275/00
CPC分类号： G02B1/043 , A61F2/1613 , A61L27/34 , C08F290/046 , C08L33/26 , C08L85/04 , C08L39/06 , C08F230/06 , C08L51/003
摘要： Brush copolymers containing (a) monomeric units derived from an ethylenically unsaturated monomer containing one or more boronic acid moieties and; and (b) monomeric units derived from an ethylenically unsaturated-containing hydrophilic macromonomer are disclosed.
摘要翻译： 含有（a）衍生自含有一个或多个硼酸部分的烯属不饱和单体的单体单元的刷共聚物; 和（b）衍生自含烯键式不饱和的亲水性大分子单体的单体单元。
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公开(公告)号：US08419792B2
公开(公告)日：2013-04-16
申请号：US12641490
申请日：2009-12-18
IPC分类号： A61F2/16 , C08F30/06 , C08F275/00
CPC分类号： A61F2/16 , A61F2002/009 , C08F230/06 , C08F275/00 , C08F290/00 , C08F290/06 , C08F291/00 , C08L51/003 , C08L2666/02
摘要： Brush copolymers containing (a) monomeric units derived from an ethylenically unsaturated-containing monomer containing one or more boronic acid moieties; and (b) monomeric units derived from an ethylenically unsaturated-containing macromonomer having hydrophilic units and boronic acid units are disclosed.
摘要翻译： 含有（a）源自含有烯属不饱和单体的含有一个或多个硼酸部分的单体单元的刷共聚物; 和（b）衍生自具有亲水单元和硼酸单元的含烯属不饱和的大分子单体的单体单元。
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公开(公告)号：US07988988B2
公开(公告)日：2011-08-02
申请号：US11283632
申请日：2005-11-21
CPC分类号： C08J7/047 , A61L27/34 , C08J2443/00 , G02B1/043 , C08L101/02
摘要： A biomedical device, such as a contact lens, has a surface linked to a polymer comprising boronic acid moieties. The boronic acid monomeric units may be derived from an ethylenically unsaturated monomer containing a boronic acid moiety, such as a vinylphenyl boronic acid or a (meth)acrylamido phenyl boronic acid. The boronic acid moieties may be complexed with mucin, especially epithelial mucin.
摘要翻译： 诸如隐形眼镜的生物医学装置具有与包含硼酸部分的聚合物连接的表面。 硼酸单体单元可以衍生自含有硼酸部分的乙烯性不饱和单体，例如乙烯基苯基硼酸或（甲基）丙烯酰胺基苯基硼酸。 硼酸部分可能与粘蛋白，特别是上皮粘蛋白复合。
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公开(公告)号：US08631631B2
公开(公告)日：2014-01-21
申请号：US12641434
申请日：2009-12-18
CPC分类号： C08F290/04 , B65B25/008 , C08F290/046 , C11D3/0078 , C11D3/3765 , C11D3/3773 , C11D3/3776 , C08F230/06
摘要： Packaging systems for storing ophthalmic devices such as contact lenses and to methods for packaging such ophthalmic devices with solutions to improve the comfort of the lenses during wear are disclosed. A packaging system includes an ophthalmic device stored in an aqueous packaging solution comprising a brush copolymer comprising (a) monomeric units derived from an ethylenically unsaturated monomer containing one or more boronic acid moieties; and (b) monomeric units derived from an ethylenically unsaturated-containing hydrophilic macromonomer.
摘要翻译： 公开了用于存储诸如隐形眼镜的眼科装置的包装系统，以及用于包装这些眼科装置的方法以提供穿戴期间镜片的舒适度的解决方案。 包装系统包括存储在含水包装溶液中的眼科装置，其包含刷共聚物，其包含（a）衍生自含有一个或多个硼酸部分的烯属不饱和单体的单体单元; 和（b）衍生自含烯键式不饱和的亲水性大分子单体的单体单元。
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7.发明授权Renewable surface treatment of silicone medical devices with reactive hydrophilic polymers 失效具有反应性亲水聚合物的有机硅医疗器械的可再生表面处理公开(公告)号：US06858310B2
公开(公告)日：2005-02-22
申请号：US10427055
申请日：2003-04-30
CPC分类号： G02B1/043 , A61L27/34 , C08J7/047 , Y10T428/31511 , Y10T428/31663 , C08L83/00 , C08L43/04
摘要： The present invention is directed toward the renewable surface treatment of medical devices such as contact lenses and medical implants. In particular, the present invention is directed to a method of modifying the surface of a medical device to increase its biocompatibility or hydrophilicity by coating the device with a removable hydrophilic polymer by means of reaction between reactive functionalities on the hydrophilic polymer which functionalities are complementary to reactive functionalities on or near the surface of the medical device. The present invention is also directed to a contact lens or other medical device having such a surface coating.
摘要翻译： 本发明涉及医疗装置如隐形眼镜和医用植入物的可再生表面处理。 特别地，本发明涉及通过借助亲水性聚合物上的反应性官能团之间的反应涂覆具有可去除的亲水性聚合物的装置来改变医疗装置的表面以增加其生物相容性或亲水性的方法，其功能性与 在医疗装置的表面上或附近的反应性功能。 本发明还涉及具有这种表面涂层的隐形眼镜或其它医疗装置。
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公开(公告)号：US5364918A
公开(公告)日：1994-11-15
申请号：US38384
申请日：1993-03-29
IPC分类号： C08F2/00 , C08F290/00 , C08F290/04 , C08F290/06 , C08F290/14 , C08F299/00 , C08J7/04 , C08L101/00 , G02B1/04 , G02C7/04 , C08F18/20 , C08F12/30 , C08F20/10
CPC分类号： C08F290/14 , C08F290/04 , G02B1/043
摘要： A method of modifying the surfaces of the polymeric objects by adding a polymerizable surfactant to the monomer mix used to form the object. Also disclosed are surface-modified objects prepared by this method, which is particularly suited for modifying the surfaces of contact lenses.
摘要翻译： 通过向用于形成物体的单体混合物中加入可聚合表面活性剂来改性聚合物体的表面的方法。 还公开了通过该方法制备的表面改性物体，其特别适用于改变隐形眼镜的表面。
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公开(公告)号：US5336797A
公开(公告)日：1994-08-09
申请号：US998346
申请日：1992-12-30
IPC分类号： G02C7/04 , C08F2/38 , C08F30/08 , C08F290/00 , C08F290/04 , C08F299/00 , G02B1/04 , C07F7/08 , C08F228/02 , C08F230/08
CPC分类号： C08F290/04 , C08F2/38 , G02B1/043
摘要： Siloxane macromonomers are disclosed which can be copolymerized with hydrophilic monomers or hydrophobic monomers to prepare polymeric materials useful as biomedical devices. The copolymers made from hydrophilic monomers exhibit good oxygen permeability and are particularly suitable for use in contact lenses.
摘要翻译： 公开了可与亲水单体或疏水单体共聚以制备可用作生物医学装置的聚合物材料的硅氧烷大分子单体。 由亲水性单体制得的共聚物表现出良好的透氧性，特别适用于隐形眼镜。
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公开(公告)号：US5219965A
公开(公告)日：1993-06-15
申请号：US619282
申请日：1990-11-27
IPC分类号： C08F2/00 , C08F290/00 , C08F290/04 , C08F290/06 , C08F290/14 , C08F299/00 , C08J7/04 , C08L101/00 , G02B1/04 , G02C7/04
CPC分类号： C08F290/14 , C08F290/04 , G02B1/043
摘要： A method of modifying the surfaces of polymeric objects by adding a polymerizable surfactant to the monomer mix used to form the object. Also disclosed are surface-modified objects prepared by this method, which is particularly suited for modifying the surfaces of contact lenses.
摘要翻译： 一种通过向用于形成物体的单体混合物中加入可聚合表面活性剂来改性聚合物体表面的方法。 还公开了通过该方法制备的表面改性物体，其特别适用于改变隐形眼镜的表面。
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