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公开(公告)号：US08962023B2
公开(公告)日：2015-02-24
申请号：US11236943
申请日：2005-09-28
申请人： Roger Labrecque , Philip McNamara , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Keith Faucher , Thomas M. Swanick
发明人： Roger Labrecque , Philip McNamara , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Keith Faucher , Thomas M. Swanick
IPC分类号： A61K9/00 , A61L27/54 , A61F13/02 , A61K9/06 , A61K31/225 , A61K31/355 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/08 , A61L2/20 , A61L27/36 , A61L27/52 , A61L31/00 , A61L31/10 , A61L31/14 , A61F2/06 , B05D3/06
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A method of UV curing and corresponding resulting non-polymeric cross-linked gel are provided. The cross-linked gel can be combined with a medical device structure. The cross-linked gel can provide anti-adhesion characteristics, in addition to improved healing and anti-inflammatory response. The cross-linked gel is generally formed of a naturally occurring oil, or an oil composition formed in part of a naturally occurring oil, that is at least partially cured forming a cross-linked gel derived from at least one fatty acid compound. In addition, the oil composition can include a therapeutic agent component, such as a drug or other bioactive agent. The curing method can vary the application of UV light in both intensity and duration to achieve a desired amount of cross-linking forming the gel.
摘要翻译： 提供UV固化方法和相应的所得非聚合交联凝胶。 交联凝胶可以与医疗装置结构组合。 除了改善愈合和抗炎反应之外，交联凝胶还可提供抗粘附特性。 交联凝胶通常由天然存在的油或部分天然存在的油形成的油组合物形成，其至少部分固化形成由至少一种脂肪酸化合物衍生的交联凝胶。 此外，油组合物可以包括治疗剂组分，例如药物或其它生物活性剂。 固化方法可以改变UV光在强度和持续时间上的应用，以实现形成凝胶的所需量的交联。
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公开(公告)号：US08795703B2
公开(公告)日：2014-08-05
申请号：US11237264
申请日：2005-09-28
申请人： Thomas M. Swanick , Joseph Ferraro , Paul Martakos , Lisa Rogers , Theodore Karwoski , Steve A. Herweck , Keith Faucher , Philip McNamara
发明人： Thomas M. Swanick , Joseph Ferraro , Paul Martakos , Lisa Rogers , Theodore Karwoski , Steve A. Herweck , Keith Faucher , Philip McNamara
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A stand-alone film is derived at least in part from fatty acids. The stand-alone film can have anti-adhesive, anti-inflammatory, non-inflammatory, and wound healing properties, and can additionally include one or more therapeutic agents incorporated therein. Corresponding methods of making the stand-alone film include molding, casting, or otherwise applying a liquid or gel to a substrate, and curing or otherwise treating to form the stand-alone film. The resulting stand-alone film is bioabsorbable.
摘要翻译： 至少部分地从脂肪酸衍生独立的膜。 独立膜可以具有抗粘连，抗炎，非炎性和伤口愈合性质，并且还可以包括一种或多种掺入其中的治疗剂。 制造独立膜的相应方法包括将液体或凝胶成型，铸造或以其它方式施加到基底，以及固化或以其他方式处理以形成独立的膜。 所得到的独立膜是生物可吸收的。
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公开(公告)号：US09801913B2
公开(公告)日：2017-10-31
申请号：US11237420
申请日：2005-09-28
申请人： Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Keith Faucher , Philip McNamara
发明人： Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Keith Faucher , Philip McNamara
IPC分类号： A61K35/60 , A61K38/13 , A61L27/36 , A61L27/52 , A61K9/00 , A61K9/06 , A61K31/225 , A61K31/355 , A61K47/12 , A61K47/14 , A61L31/10 , A61L27/54 , A61F13/02 , A61L2/07 , A61L2/08 , A61L2/20 , A61L31/00 , A61L31/14 , A61F2/06 , B05D3/06
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A barrier layer and corresponding method of making provide anti-inflammatory, non-inflammatory, and anti-adhesion functionality for a medical device implantable in a patient. The barrier layer can be combined with a medical device structure to provide anti-adhesion characteristics, in addition to improved healing, non-inflammatory, and anti-inflammatory response. The barrier layer is generally formed of a naturally occurring oil, or an oil composition formed in part of a naturally occurring oil, that is at least partially cured forming a cross-linked gel. In addition, the oil composition can include a therapeutic agent component, such as a drug or other bioactive agent.
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公开(公告)号：US08367099B2
公开(公告)日：2013-02-05
申请号：US11525390
申请日：2006-09-22
申请人： Steve A. Herweck , Thomas M. Swanick , Joseph Ferraro , Paul Martakos , Lisa Rogers , Theodore Karwoski , Keith M. Faucher , Philip McNamara , Roger Labrecque , Suzanne Conroy , Trevor Carlton
发明人： Steve A. Herweck , Thomas M. Swanick , Joseph Ferraro , Paul Martakos , Lisa Rogers , Theodore Karwoski , Keith M. Faucher , Philip McNamara , Roger Labrecque , Suzanne Conroy , Trevor Carlton
IPC分类号： A61L15/16
CPC分类号： B65B55/18 , A61B2017/00004 , A61B2017/320044 , A61B2090/0816 , A61F2/0059 , A61F2/0095 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/14 , A61L2/186 , A61L2/206 , A61L2/208 , A61L31/00 , A61L31/145 , A61L31/148 , A61L2202/24 , B26F1/18 , B29C39/02 , B65B31/04 , Y10T83/0481
摘要： A bio-absorbable stand-alone film is derived at least in part from fatty acids. The bio-absorbable stand-alone film can have anti-adhesive, anti-inflammatory, non-inflammatory, and wound healing properties, and can additionally include one or more therapeutic agents incorporated therein. The stand-alone film has one or more perforations or depressions formed therein. Corresponding methods of making the bio-absorbable stand-alone film with one or more perforations or depressions include molding, cutting, carving, puncturing or otherwise suitable methods to create the perforations or depressions in the bio-absorbable stand-alone film. The resulting stand-alone film is bioabsorbable.
摘要翻译： 生物可吸收的独立膜至少部分地由脂肪酸衍生。 生物吸收性独立膜可以具有抗粘连性，抗炎性，非炎性和伤口愈合性，并且还可以包括一种或多种掺入其中的治疗剂。 独立膜具有形成在其中的一个或多个穿孔或凹陷。 使具有一个或多个穿孔或凹陷的生物吸收性独立薄膜的相应方法包括成型，切割，雕刻，穿刺或以其它方式适当地在生物吸收性独立薄膜中产生穿孔或凹陷的方法。 所得到的独立膜是生物可吸收的。
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公开(公告)号：US08858978B2
公开(公告)日：2014-10-14
申请号：US11237263
申请日：2005-09-28
申请人： Roger Labrecque , Philip McNamara , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Keith M. Faucher , Thomas M. Swanick
发明人： Roger Labrecque , Philip McNamara , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Keith M. Faucher , Thomas M. Swanick
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A method of curing and corresponding resulting non-polymeric cross-linked gel are provided. The cross-linked gel can be combined with a medical device structure. The cross-linked gel can provide anti-adhesion characteristics, in addition to improved healing and anti-inflammatory response. The cross-linked gel is generally formed of a naturally occurring oil, or an oil composition formed in part of a naturally occurring oil, that is at least partially cured forming a cross-linked gel derived from at least one fatty acid compound. In addition, the oil composition can include a therapeutic agent component, such as a drug or other bioactive agent. The curing method can vary the application of heat in both temperature and duration to achieve a desired amount of cross-linking forming the gel.
摘要翻译： 提供固化方法和相应的所得非聚合交联凝胶。 交联凝胶可以与医疗装置结构组合。 除了改善愈合和抗炎反应之外，交联凝胶还可提供抗粘附特性。 交联凝胶通常由天然存在的油或部分天然存在的油形成的油组合物形成，其至少部分固化形成由至少一种脂肪酸化合物衍生的交联凝胶。 此外，油组合物可以包括治疗剂组分，例如药物或其它生物活性剂。 固化方法可以在温度和持续时间内改变热量的应用以实现形成凝胶的所需量的交联。
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公开(公告)号：US20070071798A1
公开(公告)日：2007-03-29
申请号：US11525390
申请日：2006-09-22
申请人： Steve Herweck , Thomas Swanick , Joseph Ferraro , Paul Martakos , Lisa Rogers , Theodore Karwoski , Keith Faucher , Philip McNamara , Roger Labrecque , Suzanne Conroy , Trevor Carlton
发明人： Steve Herweck , Thomas Swanick , Joseph Ferraro , Paul Martakos , Lisa Rogers , Theodore Karwoski , Keith Faucher , Philip McNamara , Roger Labrecque , Suzanne Conroy , Trevor Carlton
IPC分类号： A61K9/70
CPC分类号： B65B55/18 , A61B2017/00004 , A61B2017/320044 , A61B2090/0816 , A61F2/0059 , A61F2/0095 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/14 , A61L2/186 , A61L2/206 , A61L2/208 , A61L31/00 , A61L31/145 , A61L31/148 , A61L2202/24 , B26F1/18 , B29C39/02 , B65B31/04 , Y10T83/0481
摘要： A bio-absorbable stand-alone film is derived at least in part from fatty acids. The bio-absorbable stand-alone film can have anti-adhesive, anti-inflammatory, non-inflammatory, and wound healing properties, and can additionally include one or more therapeutic agents incorporated therein. The stand-alone film has one or more perforations or depressions formed therein. Corresponding methods of making the bio-absorbable stand-alone film with one or more perforations or depressions include molding, cutting, carving, puncturing or otherwise suitable methods to create the perforations or depressions in the bio-absorbable stand-alone film. The resulting stand-alone film is bioabsorbable.
摘要翻译： 生物可吸收的独立膜至少部分地由脂肪酸衍生。 生物吸收性独立膜可以具有抗粘连性，抗炎性，非炎性和伤口愈合性，并且还可以包括一种或多种掺入其中的治疗剂。 独立膜具有形成在其中的一个或多个穿孔或凹陷。 使具有一个或多个穿孔或凹陷的生物吸收性独立薄膜的相应方法包括成型，切割，雕刻，穿刺或以其它方式适当地在生物吸收性独立薄膜中产生穿孔或凹陷的方法。 所得到的独立膜是生物可吸收的。
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公开(公告)号：US20060078586A1
公开(公告)日：2006-04-13
申请号：US11237420
申请日：2005-09-28
申请人： Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve Herweck , Keith Faucher , Philip McNamara
发明人： Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve Herweck , Keith Faucher , Philip McNamara
IPC分类号： A61F2/00
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A barrier layer and corresponding method of making provide anti-inflammatory, non-inflammatory, and anti-adhesion functionality for a medical device implantable in a patient. The barrier layer can be combined with a medical device structure to provide anti-adhesion characteristics, in addition to improved healing, non-inflammatory, and anti-inflammatory response. The barrier layer is generally formed of a naturally occurring oil, or an oil composition formed in part of a naturally occurring oil, that is at least partially cured forming a cross-linked gel. In addition, the oil composition can include a therapeutic agent component, such as a drug or other bioactive agent.
摘要翻译： 阻挡层和相应的制备方法为可植入患者体内的医疗装置提供抗炎，非炎症和抗粘附功能。 除了改善的愈合，非炎性和抗炎反应之外，阻挡层可以与医疗装置结构组合以提供抗粘附特性。 阻挡层通常由天然存在的油或由天然存在的油的一部分形成的油组合物形成，其至少部分固化形成交联凝胶。 此外，油组合物可以包括治疗剂组分，例如药物或其它生物活性剂。
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公开(公告)号：US20060067976A1
公开(公告)日：2006-03-30
申请号：US11238532
申请日：2005-09-28
申请人： Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve Herweck , Keith Faucher , Philip Mcnamara , William Quigley , Mark Avella , Rick Chenel
发明人： Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve Herweck , Keith Faucher , Philip Mcnamara , William Quigley , Mark Avella , Rick Chenel
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A barrier layer and corresponding method of making provide anti-inflammatory and anti-adhesion functionality for a medical device implantable in a patient. The barrier layer can be combined with a medical device structure to provide anti-adhesion characteristics, in addition to improved healing and anti-inflammatory response. The barrier layer is generally formed of a naturally occurring oil, or an oil composition formed in part of a naturally occurring oil, that is at least partially cured forming a cross-linked gel derived from at least one fatty acid compound. In addition, the oil composition can include a therapeutic agent component, such as a drug or other bioactive agent.
摘要翻译： 阻挡层和相应的制备方法为可植入患者的医疗装置提供抗炎和抗粘附功能。 除了改善的愈合和抗炎反应之外，阻挡层可以与医疗装置结构组合以提供抗粘附特性。 阻挡层通常由天然存在的油或部分天然存在的油形成的油组合物形成，其至少部分固化形成由至少一种脂肪酸化合物衍生的交联凝胶。 此外，油组合物可以包括治疗剂组分，例如药物或其它生物活性剂。
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公开(公告)号：US20060067975A1
公开(公告)日：2006-03-30
申请号：US11236943
申请日：2005-09-28
申请人： Roger Labrecque , Philip McNamara , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve Herweck , Keith Faucher , Thomas Swanick
发明人： Roger Labrecque , Philip McNamara , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve Herweck , Keith Faucher , Thomas Swanick
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A method of UV curing and corresponding resulting non-polymeric cross-linked gel are provided. The cross-linked gel can be combined with a medical device structure. The cross-linked gel can provide anti-adhesion characteristics, in addition to improved healing and anti-inflammatory response. The cross-linked gel is generally formed of a naturally occurring oil, or an oil composition formed in part of a naturally occurring oil, that is at least partially cured forming a cross-linked gel derived from at least one fatty acid compound. In addition, the oil composition can include a therapeutic agent component, such as a drug or other bioactive agent. The curing method can vary the application of UV light in both intensity and duration to achieve a desired amount of cross-linking forming the gel.
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公开(公告)号：US20060110457A1
公开(公告)日：2006-05-25
申请号：US11237263
申请日：2005-09-28
申请人： Roger Labrecque , Philip McNamara , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve Herweck , Keith Faucher , Thomas Swanick
发明人： Roger Labrecque , Philip McNamara , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve Herweck , Keith Faucher , Thomas Swanick
IPC分类号： A61K9/14 , A61K31/225
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A method of curing and corresponding resulting non-polymeric cross-linked gel are provided. The cross-linked gel can be combined with a medical device structure. The cross-linked gel can provide anti-adhesion characteristics, in addition to improved healing and anti-inflammatory response. The cross-linked gel is generally formed of a naturally occurring oil, or an oil composition formed in part of a naturally occurring oil, that is at least partially cured forming a cross-linked gel derived from at least one fatty acid compound. In addition, the oil composition can include a therapeutic agent component, such as a drug or other bioactive agent. The curing method can vary the application of heat in both temperature and duration to achieve a desired amount of cross-linking forming the gel.
摘要翻译： 提供固化方法和相应的所得非聚合交联凝胶。 交联凝胶可以与医疗装置结构组合。 除了改善愈合和抗炎反应之外，交联凝胶还可提供抗粘附特性。 交联凝胶通常由天然存在的油或部分天然存在的油形成的油组合物形成，其至少部分固化形成由至少一种脂肪酸化合物衍生的交联凝胶。 此外，油组合物可以包括治疗剂组分，例如药物或其它生物活性剂。 固化方法可以在温度和持续时间内改变热量的应用以实现形成凝胶的所需量的交联。
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