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    Electrode and iontophoretic device and method
    1.
    发明授权
    Electrode and iontophoretic device and method 失效
    电极和离子电渗法器件及方法

    公开(公告)号：US6078842A

    公开(公告)日：2000-06-20

    申请号：US997404

    申请日：1997-12-23

    申请人： Joseph Gross ,  Zvi Nitzan ,  Izrail Tsals

    发明人： Joseph Gross ,  Zvi Nitzan ,  Izrail Tsals

    IPC分类号： A61N1/32 ,  A61N1/04

    CPC分类号： A61N1/044 ,  A61N1/0436 ,  A61N1/325

    摘要： An improved electrode and iontophoretic device and method where the electrode exhibits varied resistance. The electrode is made of a conductive material and applied to a flexible substrate. The variation in resistance can be achieved by varying the thickness of the electrode across its length or by varying the conductivity of the material across the area of the electrode or a combination of both. A pair of such electrodes may be used with a power source in electrical relation thereto and applied over a layer of agent to the skin to deliver the agent into the skin iontophoretically. The pair of electrodes may be shaped so as to cover a portion of the face, hands, feet or other body parts to iontophoretically apply particular agents to those areas.

    摘要翻译： 改进的电极和离子电渗疗法装置和方法，其中电极具有变化的电阻。 电极由导电材料制成并施加到柔性基底上。 电阻的变化可以通过改变电极在其长度上的厚度或通过改变电极区域上的材料的导电性或两者的组合来实现。 一对这样的电极可以与电源相关联的电源使用并施加到皮肤层上以将试剂输送到皮肤中的离子电渗。 一对电极可以被成形为覆盖面部，手部，脚部或其他身体部分的一部分，以将特定的药剂离子电渗应用于那些区域。

    Subcutaneous drug delivery device with improved filling system
    2.
    发明授权
    Subcutaneous drug delivery device with improved filling system 失效
    具有改善灌装系统的皮下给药装置

    公开(公告)号：US06186982B1

    公开(公告)日：2001-02-13

    申请号：US09072875

    申请日：1998-05-05

    申请人： Joseph Gross ,  Zvi Nitzan ,  Izrail Tsals ,  Mario Razonowich ,  Oz Cabiri ,  Haim Danon ,  Gilad Lavi

    发明人： Joseph Gross ,  Zvi Nitzan ,  Izrail Tsals ,  Mario Razonowich ,  Oz Cabiri ,  Haim Danon ,  Gilad Lavi

    IPC分类号： A61M3700

    CPC分类号： A61M5/14248 ,  A61M5/14276 ,  A61M5/14593 ,  A61M5/155 ,  A61M2005/14252 ,  A61M2005/1426 ,  A61M2005/14264

    摘要： A subcutaneous drug delivery device having a housing having an internal reservoir in communication with a drug delivery needle via a fluid path. An expandable chamber disposed adjacent to the reservoir forces drug from the reservoir to the needle when supplied with a gas. A flow regulating chamber, in communication with the fluid path, is capable of volumetric changes in response to temperature and/or pressure changes. An increase in the volume of the flow regulating chamber increases flow resistance to the needle and thereby counteracts the corresponding increase in delivery rate resulting from the expansion of the expandable chamber due to the same volumetric changes in response to temperature and/or pressure. The device also includes an improved filling system that enables the reservoir within the device to be filled with drug from a source without regard to filling position and with a decreased risk of injury from needles. Moreover, the filling system provides an accurate measure of drug transferred into the device thus enabling patients to fill the devices and to ensure proper dosage upon delivery.

    摘要翻译： 一种具有壳体的皮下药物输送装置，该壳体具有经由流体路径与药物输送针连通的内部储存器。 邻近储存器设置的可膨胀室在供应气体时迫使药物从储存器到针头。 与流体路径连通的流量调节室能够响应于温度和/或压力变化而发生体积变化。 流量调节室的体积的增加增加了对针的流动阻力，从而抵消由于响应于温度和/或压力的相同的体积变化而导致的可膨胀室膨胀导致的输送速率的相应增加。 还包括一种改进的填充系统，其使装置内的储存器能够从源处填充药物，而不考虑填充位置并且降低针头受伤的风险。 此外，填充系统提供了转移到装置中的药物的精确测量，从而使得患者能够填充装置并确保递送时的适当剂量。

    Automatic syringe
    5.
    发明授权
    Automatic syringe 有权
    自动注射器

    公开(公告)号：US06830560B1

    公开(公告)日：2004-12-14

    申请号：US09617340

    申请日：2000-07-17

    申请人： Joseph Gross ,  Gilad Lavi ,  Izrail Tsals

    发明人： Joseph Gross ,  Gilad Lavi ,  Izrail Tsals

    IPC分类号： A61M3700

    CPC分类号： A61M5/2046 ,  A61M5/3202 ,  A61M5/3257 ,  A61M5/3272 ,  A61M5/46 ,  A61M2005/2013 ,  A61M2005/3247 ,  A61M2005/3267

    摘要： A syringe comprises a barrel containing an internal cylindrical body containing a liquid and communicating with a delivery needle. The needle is covered before use by a removable sheath, and after the sheath is removed, the needle is concealed by a displaceable sleeve. In use the sleeve is pressed against the skin by applying pressure while holding the barrel. The sleeve is thereby retracted into the barrel allowing the needle to penetrate the skin. The movement of the sleeve also activates a gas generator which expels the liquid from the needle. When delivery is complete and the syringe is taken from the skin, a coil spring moves the sleeve back to the starting position again concealing the needle. The coil spring is torsionally biased before use and causes a rotational movement of the sleeve relative to the barrel when the sleeve moves into and out of the barrel. This rotational movement engages a locking mechanism which prevents further movement of the sleeve and thereby permanently conceals the needle.

    摘要翻译： 注射器包括容纳含有液体并与输送针连通的内部圆柱体的筒体。 针在使用前被可移除的护套覆盖，并且在护套被移除之后，针被可移位的套管隐藏。 在使用中，通过在保持桶的同时施加压力将套筒压靠在皮肤上。 因此套筒被缩回到镜筒中，允许针穿透皮肤。 套筒的运动还激活排出针头液体的气体发生器。 当输送完成并且从皮肤取出注射器时，螺旋弹簧将套筒移回到再次隐藏针的起始位置。 螺旋弹簧在使用前被扭转偏压，并且当套筒移入和移出筒体时，使套筒相对于筒体旋转运动。 该旋转运动接合锁定机构，该锁定机构防止套筒的进一步运动，从而永久地隐藏针头。

    Drug delivery systems and methods
    7.
    发明授权
    Drug delivery systems and methods 失效
    药物输送系统和方法

    公开(公告)号：US06478771B1

    公开(公告)日：2002-11-12

    申请号：US09439963

    申请日：1999-11-12

    申请人： Gilad Lavi ,  Gil Yigal ,  Izrail Tsals ,  Joseph Gross

    发明人： Gilad Lavi ,  Gil Yigal ,  Izrail Tsals ,  Joseph Gross

    IPC分类号： A61M3700

    CPC分类号： A61J1/2089 ,  A61J1/201 ,  A61J1/2013 ,  A61J1/2017 ,  A61J1/2051 ,  A61J1/2058 ,  A61J1/2082 ,  A61M5/148 ,  A61M5/162 ,  A61M5/1782 ,  A61M5/19 ,  A61M5/2046 ,  A61M5/2053 ,  A61M5/2425 ,  A61M5/2448 ,  A61M5/3234 ,  A61M2005/14252 ,  A61M2005/1581 ,  A61M2005/3128 ,  A61M2005/3223 ,  A61M2205/215 ,  A61M2205/583

    摘要： The present invention relates to a drug delivery device for mixing and delivering a drug by injection. The device includes a housing having a first port or opening therein that receives a first container that contains a fluid or powdered drug, for example a lyophilized drug. The housing can also include a second port or opening that receives a second container that contains a fluid to be mixed with the drug to form an injectable fluid. The device includes a manifold having a channel that fluidly connects the first and second containers. A penetrating membrane such as a needle is used to inject the drug into a patient which is in fluid communication with the first container. The needle is movable from a storage position in the housing to an injection position extending through the housing.

    摘要翻译： 本发明涉及通过注射混合和输送药物的药物递送装置。 该装置包括具有其中的第一端口或开口的壳体，其容纳包含流体或粉末状药物的第一容器，例如冻干药物。 壳体还可以包括接收第二容器的第二端口或开口，第二容器包含待与药物混合以形成可注射流体的流体。 该装置包括具有流体连接第一和第二容器的通道的歧管。 使用诸如针的穿透膜将药物注射到与第一容器流体连通的患者体内。 针可以从壳体中的存储位置移动到延伸穿过壳体的注射位置。