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公开(公告)号：US6066327A
公开(公告)日：2000-05-23
申请号：US14232
申请日：1998-01-27
IPC分类号： A61K8/00 , A61K8/04 , A61K8/30 , A61K8/31 , A61K8/33 , A61K8/34 , A61K8/35 , A61K8/44 , A61K8/49 , A61K8/67 , A61K8/96 , A61K8/97 , A61K31/122 , A61K31/355 , A61K31/375 , A61K36/53 , A61P17/00 , A61Q19/00 , A61Q19/08 , A61K6/00 , A61K7/42
摘要： The present invention relates to cosmetic or pharmaceutical compositions for topical application to the skin, the compositions comprising effective amounts of at least one of each of the antioxidants selected from the group consisting of (a) tocopherol and derivatives thereof, (b) ascorbic acid and derivatives thereof, (c) a butylated phenol, (d) a rosemary extract, and (e)ubiquinone and derivatives thereof. The compositions are useful in treating and preventing the symptoms of photoaging.
摘要翻译： 本发明涉及用于局部施用于皮肤的化妆品或药物组合物，所述组合物包含有效量的至少一种抗氧化剂，其选自（a）生育酚及其衍生物，（b）抗坏血酸和 衍生物，（c）丁基化苯酚，（d）迷迭香提取物和（e）泛醌及其衍生物。 该组合物可用于治疗和预防光老化症状。
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公开(公告)号：US6068848A
公开(公告)日：2000-05-30
申请号：US992128
申请日：1997-12-17
摘要： The present invention relates to cosmetic or pharmaceutical compositions for topical application to the skin, the compositions comprising effective amounts of at least one of each of the antioxidants selected from the group consisting of (a) tocopherol and derivatives thereof, (b) ascorbic acid and derivatives thereof,(c) a butylated phenol, (d)N-acetyl cysteine, (e)a rosemary extract, and (f)ubiquinone and derivatives thereof. The compositions are useful in treating and preventing the symptoms of photoaging.
摘要翻译： 本发明涉及用于局部施用于皮肤的化妆品或药物组合物，该组合物包含有效量的至少一种抗氧化剂，其选自（a）生育酚及其衍生物，（b）抗坏血酸和 衍生物，（c）丁基化苯酚，（d）N-乙酰半胱氨酸，（e）迷迭香提取物和（f）泛醌及其衍生物。 该组合物可用于治疗和预防光老化症状。
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公开(公告)号：US6139855A
公开(公告)日：2000-10-31
申请号：US243362
申请日：1999-02-01
申请人： Gheorghe Cioca , Joseph Gubernick , Andrew J. Bevacqua , Nicolae Vrabie , Daniel H. Maes , Kenneth D. Marenus , Edward Pelle , Neelam Muizzuddin , Vasile Ionita-Manzatu , Mirela Cristina Ionita-Manzatu
发明人： Gheorghe Cioca , Joseph Gubernick , Andrew J. Bevacqua , Nicolae Vrabie , Daniel H. Maes , Kenneth D. Marenus , Edward Pelle , Neelam Muizzuddin , Vasile Ionita-Manzatu , Mirela Cristina Ionita-Manzatu
IPC分类号： A61K8/19 , A61K8/00 , A61K8/02 , A61K8/06 , A61K8/46 , A61K33/00 , A61K45/00 , A61K47/02 , A61Q19/00 , C02F1/00 , C02F1/461 , A61K9/10
CPC分类号： C02F1/4618 , A61K33/00 , C02F1/005 , C02F2103/026 , Y10S514/937
摘要： The invention relates to composition having enhanced biological activity, the compositions comprising at least one structured water. In particular, the compositions contain a combination of I and S waters and a biologically active agent, in which the activity of the agent is increased relative to its activity in a non-structured water composition.
摘要翻译： 本发明涉及具有增强的生物活性的组合物，所述组合物包含至少一种结构化水。 特别地，组合物含有I和S水的组合和生物活性剂，其中药物的活性相对于其在非结构化水组合物中的活性而增加。
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公开(公告)号：US08084496B2
公开(公告)日：2011-12-27
申请号：US12775206
申请日：2010-05-06
申请人： Daniel H. Maes , Fatemeh Mohammadi , Lisa Qu , Anna Czarnota , Thomas Mammone , Lieve Declercq , Julius R. Zecchino
发明人： Daniel H. Maes , Fatemeh Mohammadi , Lisa Qu , Anna Czarnota , Thomas Mammone , Lieve Declercq , Julius R. Zecchino
IPC分类号： A61K31/216 , A61K8/18 , A01N37/16
摘要： Resveratrol ferulate compounds and compositions.
摘要翻译： 白藜芦醇化合物和组合物。
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5.发明申请Emulsion Cosmetic Compositions Containing Resveratrol Derivatives And An Oil Phase Structuring Agent 审中-公开含白藜芦醇衍生物和油相结构剂的乳液化妆品组合物公开(公告)号：US20090035236A1
公开(公告)日：2009-02-05
申请号：US12127382
申请日：2008-05-27
申请人： Daniel H. Maes , Fatemeh Mohammadi , Lisa Qu , Anna Czarnota , Thomas Wammone , Lieve Declercq , Julius R. Zecchino
发明人： Daniel H. Maes , Fatemeh Mohammadi , Lisa Qu , Anna Czarnota , Thomas Wammone , Lieve Declercq , Julius R. Zecchino
摘要： An emulsion cosmetic composition comprising at least one resveratrol derivative, an aqueous phase, and an oil phase having at and at least one oil phase structuring agent, and a method for preparing emulsions capable of delivering active resveratrol to the skin.
摘要翻译： 包含至少一种白藜芦醇衍生物，水相和具有至少一种油相结构化剂的油相的乳液化妆品组合物和能够将活性白藜芦醇递送至皮肤的乳液的方法。
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6.发明授权Cosmetic compositions containing alpha glucosidase inhibitors and methods of use 有权含有α-葡糖苷酶抑制剂的化妆品组合物及其使用方法公开(公告)号：US09072717B2
公开(公告)日：2015-07-07
申请号：US11857105
申请日：2007-09-18
CPC分类号： A61K36/22 , A61K8/415 , A61K8/4913 , A61K8/4926 , A61K8/97 , A61K2800/782 , A61Q19/08
摘要： A composition containing at least one alpha glucosidase inhibitor, and a method for ameliorating the adverse effects of aging and sun damage on keratinous surfaces such as skin by treating with a composition containing at least one alpha glucosidase inhibitor; as well as regimens and kits for treating skin.
摘要翻译： 含有至少一种α葡糖苷酶抑制剂的组合物和通过用含有至少一种α葡糖苷酶抑制剂的组合物处理来改善老化和阳光损伤对角质表面如皮肤的不利影响的方法; 以及用于治疗皮肤的方案和试剂盒。
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公开(公告)号：US08666770B2
公开(公告)日：2014-03-04
申请号：US13060450
申请日：2009-09-04
摘要： Methods of developing equations for objectively assigning or predicting an apparent age are disclosed. Advantageously, the equations of objective apparent age may be based on a relatively small number of critical parameters combined in a way that accounts for all or most of the apparent skin aging in a defined population or sub-population. Despite the relatively small data collection requirements, the present invention includes an objective model of apparent age that is useful for evaluation of products, useful for predicting treatment outcomes and useful for predicting the effects of deteriorative factors. The formalization of an Objective Apparent Age Score allows one to identify the biophysical and biochemical parameters that mostly influence an individual's apparent age, and can be used to select specific anti-aging treatments with increased chances of visible success. The Objective Apparent Age Score may also be used to support marketing claims.
摘要翻译： 公开了客观分配或预测表观年龄的方程的方法。 有利地，客观表观年龄的方程可以基于相对较少数量的关键参数，其组合方式考虑了定义的群体或子群体中的所有或大部分明显的皮肤老化。 尽管数据收集要求相对较小，但是本发明包括可用于评估产品的明显年龄的客观模型，对预测治疗结果有用，并且可用于预测恶化因素的影响。 客观表观年龄分数的形式化允许人们识别主要影响个体表观年龄的生物物理和生物化学参数，并且可以用于选择具有可见成功机会的特定抗衰老治疗。 客观表观年龄分数也可用于支持营销声明。
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公开(公告)号：US08461200B2
公开(公告)日：2013-06-11
申请号：US13294229
申请日：2011-11-11
申请人： Daniel H. Maes , Fatemeh Mohammadi , Lisa Qu , Anna Czarnota , Thomas Mammone , Lieve Declercq , Julius R. Zecchino
发明人： Daniel H. Maes , Fatemeh Mohammadi , Lisa Qu , Anna Czarnota , Thomas Mammone , Lieve Declercq , Julius R. Zecchino
IPC分类号： A61K31/216 , A61K8/37
CPC分类号： A61K8/375 , A61K8/0241 , A61K8/062 , A61K8/064 , A61K8/066 , A61K8/25 , A61K8/347 , A61K8/37 , A61K8/42 , A61K8/585 , A61K8/60 , A61K8/602 , A61K8/891 , A61K8/97 , A61K31/05 , A61K2800/31 , A61K2800/43 , A61K2800/54 , A61K2800/591 , A61K2800/596 , A61Q1/02 , A61Q1/06 , A61Q1/08 , A61Q1/10 , A61Q1/12 , A61Q17/04 , A61Q19/00 , A61Q19/007 , A61Q19/08 , C07C69/017 , C07C69/30 , C07C69/604 , C07C69/94
摘要： Salicylic acid esters of resveratrol and topical compositions containing same.
摘要翻译： 白藜芦醇的水杨酸酯和含有它们的局部组合物。
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公开(公告)号：US20100216879A1
公开(公告)日：2010-08-26
申请号：US12775206
申请日：2010-05-06
申请人： Daniel H. Maes , Fatemeh Mohammadi , Lisa Qu , Anna Czarnota , Thomas Mammone , Lieve Declercq , Julius R. Zecchino
发明人： Daniel H. Maes , Fatemeh Mohammadi , Lisa Qu , Anna Czarnota , Thomas Mammone , Lieve Declercq , Julius R. Zecchino
IPC分类号： A61K8/37 , C07C69/736 , A61Q19/00
摘要： Resveratrol ferulate compounds and compositions.
摘要翻译： 白藜芦醇化合物和组合物。
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10.发明申请Emulsion Cosmetic Compositions Containing Resveratrol Derivatives And Linear Or Branched Silicone 有权包含白藜芦醇衍生物和线性或分支硅氧烷的乳液化妆品组合物公开(公告)号：US20090035242A1
公开(公告)日：2009-02-05
申请号：US12127439
申请日：2008-05-27
申请人： Daniel H. Maes , Fatemeh Mohammadi , Lisa Qu , Anna Czarnota , Thomas Mammone , Lieve Declercq , Julius R. Zecchino
发明人： Daniel H. Maes , Fatemeh Mohammadi , Lisa Qu , Anna Czarnota , Thomas Mammone , Lieve Declercq , Julius R. Zecchino
CPC分类号： A61K8/375 , A61K8/0241 , A61K8/062 , A61K8/064 , A61K8/066 , A61K8/25 , A61K8/347 , A61K8/37 , A61K8/42 , A61K8/585 , A61K8/60 , A61K8/602 , A61K8/891 , A61K8/97 , A61K31/05 , A61K2800/31 , A61K2800/43 , A61K2800/54 , A61K2800/591 , A61K2800/596 , A61Q1/02 , A61Q1/06 , A61Q1/08 , A61Q1/10 , A61Q1/12 , A61Q17/04 , A61Q19/00 , A61Q19/007 , A61Q19/08 , C07C69/017 , C07C69/30 , C07C69/604 , C07C69/94
摘要： An emulsion cosmetic composition comprising at least one resveratrol derivative, a water phase, and an oil phase containing at least one linear or branched volatile or near volatile silicone and a method for delivering active resveratrol to the skin.
摘要翻译： 一种乳液化妆品组合物，其包含至少一种白藜芦醇衍生物，水相和含有至少一种直链或支链挥发性或近似挥发性硅氧烷的油相和用于将活性白藜芦醇递送至皮肤的方法。
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