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公开(公告)号：US6066327A
公开(公告)日：2000-05-23
申请号：US14232
申请日：1998-01-27
IPC分类号： A61K8/00 , A61K8/04 , A61K8/30 , A61K8/31 , A61K8/33 , A61K8/34 , A61K8/35 , A61K8/44 , A61K8/49 , A61K8/67 , A61K8/96 , A61K8/97 , A61K31/122 , A61K31/355 , A61K31/375 , A61K36/53 , A61P17/00 , A61Q19/00 , A61Q19/08 , A61K6/00 , A61K7/42
摘要： The present invention relates to cosmetic or pharmaceutical compositions for topical application to the skin, the compositions comprising effective amounts of at least one of each of the antioxidants selected from the group consisting of (a) tocopherol and derivatives thereof, (b) ascorbic acid and derivatives thereof, (c) a butylated phenol, (d) a rosemary extract, and (e)ubiquinone and derivatives thereof. The compositions are useful in treating and preventing the symptoms of photoaging.
摘要翻译： 本发明涉及用于局部施用于皮肤的化妆品或药物组合物，所述组合物包含有效量的至少一种抗氧化剂，其选自（a）生育酚及其衍生物，（b）抗坏血酸和 衍生物，（c）丁基化苯酚，（d）迷迭香提取物和（e）泛醌及其衍生物。 该组合物可用于治疗和预防光老化症状。
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公开(公告)号：US6068848A
公开(公告)日：2000-05-30
申请号：US992128
申请日：1997-12-17
摘要： The present invention relates to cosmetic or pharmaceutical compositions for topical application to the skin, the compositions comprising effective amounts of at least one of each of the antioxidants selected from the group consisting of (a) tocopherol and derivatives thereof, (b) ascorbic acid and derivatives thereof,(c) a butylated phenol, (d)N-acetyl cysteine, (e)a rosemary extract, and (f)ubiquinone and derivatives thereof. The compositions are useful in treating and preventing the symptoms of photoaging.
摘要翻译： 本发明涉及用于局部施用于皮肤的化妆品或药物组合物，该组合物包含有效量的至少一种抗氧化剂，其选自（a）生育酚及其衍生物，（b）抗坏血酸和 衍生物，（c）丁基化苯酚，（d）N-乙酰半胱氨酸，（e）迷迭香提取物和（f）泛醌及其衍生物。 该组合物可用于治疗和预防光老化症状。
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公开(公告)号：US6139855A
公开(公告)日：2000-10-31
申请号：US243362
申请日：1999-02-01
申请人： Gheorghe Cioca , Joseph Gubernick , Andrew J. Bevacqua , Nicolae Vrabie , Daniel H. Maes , Kenneth D. Marenus , Edward Pelle , Neelam Muizzuddin , Vasile Ionita-Manzatu , Mirela Cristina Ionita-Manzatu
发明人： Gheorghe Cioca , Joseph Gubernick , Andrew J. Bevacqua , Nicolae Vrabie , Daniel H. Maes , Kenneth D. Marenus , Edward Pelle , Neelam Muizzuddin , Vasile Ionita-Manzatu , Mirela Cristina Ionita-Manzatu
IPC分类号： A61K8/19 , A61K8/00 , A61K8/02 , A61K8/06 , A61K8/46 , A61K33/00 , A61K45/00 , A61K47/02 , A61Q19/00 , C02F1/00 , C02F1/461 , A61K9/10
CPC分类号： C02F1/4618 , A61K33/00 , C02F1/005 , C02F2103/026 , Y10S514/937
摘要： The invention relates to composition having enhanced biological activity, the compositions comprising at least one structured water. In particular, the compositions contain a combination of I and S waters and a biologically active agent, in which the activity of the agent is increased relative to its activity in a non-structured water composition.
摘要翻译： 本发明涉及具有增强的生物活性的组合物，所述组合物包含至少一种结构化水。 特别地，组合物含有I和S水的组合和生物活性剂，其中药物的活性相对于其在非结构化水组合物中的活性而增加。
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公开(公告)号：US5736537A
公开(公告)日：1998-04-07
申请号：US527145
申请日：1995-09-12
申请人： Joseph Gubernick , Daniel H. Maes
发明人： Joseph Gubernick , Daniel H. Maes
IPC分类号： C07J1/00 , A61K31/565
CPC分类号： A61K8/63 , A61Q19/00 , A61Q19/007 , A61Q5/006 , C07J1/0011 , Y10S514/844 , Y10S514/859 , Y10S514/861 , Y10S514/863
摘要： Disclosed is the use of dehydroepiandrosterone salicylate in the treatment of skin atrophy. ##STR1## Such types skin atrophy to be treated include the thinning and/or general degradation of the dermis often characterized by a decrease in collagen and/or elastin as well as decreased number, size and doubling potential of fibroblast cells.
摘要翻译： 公开了使用脱水表雄酮水杨酸酯治疗皮肤萎缩。 这种类型的待治疗的皮肤萎缩包括真皮的变薄和/或一般降解，其特征在于胶原和/或弹性蛋白的减少以及成纤维细胞的数量，大小和倍数的减少。
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公开(公告)号：US6025347A
公开(公告)日：2000-02-15
申请号：US8444
申请日：1998-01-16
申请人： Joseph Gubernick , Daniel H. Maes
发明人： Joseph Gubernick , Daniel H. Maes
CPC分类号： A61K8/63 , A61Q19/00 , A61Q19/007 , A61Q5/006 , C07J1/0011 , Y10S514/844 , Y10S514/859 , Y10S514/861 , Y10S514/863
摘要： Novel steroid esters useful for regulating skin atrophy, and skin maladies, as well as compositions containing the esters and methods for their use are described. A preferred steroid ester is DHEA salicylate. Such types of skin atrophy to be treated include the thinning and/or general degradation of the dermis often characterized by a decrease in collagen and/or elastin as well as decreased number, size and doubling potential of fibroblast cells. Such skin maladies include but are not limited to dry skin, dandruff, acne, keratoses, psoriasis, eczema, pruritis, age spots, lentigines, melasmas, wrinkles, warts, blemished skin, hyperpigmented skin, hyperkeratotic skin, inflammatory dermatoses, age-related skin changes and skin in need of cleansers.
摘要翻译： 描述了可用于调节皮肤萎缩和皮肤疾病的新型类固醇酯，以及含有酯的组合物及其使用方法。 优选的类固醇酯是水杨酸DHEA。 待治疗的这种类型的皮肤萎缩包括真皮的变薄和/或一般降解，其特征在于胶原和/或弹性蛋白的减少以及成纤维细胞的数量，大小和倍数的减少。 这些皮肤疾病包括但不限于干性皮肤，头皮屑，痤疮，角化病，牛皮癣，湿疹，瘙痒症，老年斑，斑点，黑斑病，皱纹，疣，瑕疵皮肤，色素沉着过度皮肤，角化过度皮肤，炎性皮肤病，年龄相关 皮肤变化和皮肤需要清洁剂。
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公开(公告)号：US06284750B1
公开(公告)日：2001-09-04
申请号：US09491710
申请日：2000-01-26
申请人： Joseph Gubernick , Daniel H. Maes
发明人： Joseph Gubernick , Daniel H. Maes
IPC分类号： C07J100
CPC分类号： A61K8/63 , A61Q5/006 , A61Q19/00 , A61Q19/007 , C07J1/0011 , Y10S514/844 , Y10S514/859 , Y10S514/861 , Y10S514/863
摘要： Disclosed are compounds of formula II: wherein A is as defined by the specification. Also disclosed are compositions containing the esters and methods for their use in the regulation of skin atrophy and in the treatment of skin disorders such as dry skin, dandruff, acne and eczema.
摘要翻译： 公开了式II的化合物：其中A如说明书所定义。 还公开了含有酯的组合物及其用于调节皮肤萎缩和治疗皮肤疾病如干性皮肤，头皮屑，痤疮和湿疹的方法。
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公开(公告)号：US4005210A
公开(公告)日：1977-01-25
申请号：US593136
申请日：1975-07-03
申请人： Joseph Gubernick
发明人： Joseph Gubernick
CPC分类号： A61K8/64 , A61K8/37 , A61Q19/00 , Y10S514/873
摘要： An emollient composition which has utility as a skin moisturizer comprises from about 2 to about 20% isodecyl neopentanoate, from about 0.25 to 2% oleolyl polypeptide, and up to 97% mineral oil.
摘要翻译： 具有用作皮肤保湿剂的润肤剂组合物包含约2-约20％的新戊酸异癸酯，约0.25至2％的烯基多肽和至多97％的矿物油。
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公开(公告)号：US06306384B1
公开(公告)日：2001-10-23
申请号：US08724455
申请日：1996-10-01
IPC分类号： A61K3174
CPC分类号： A61Q19/00 , A61K8/19 , A61K8/73 , A61K2800/47 , A61K2800/75 , A61K2800/83 , A61N1/10 , A61N1/18 , A61N2/06 , A61Q19/007
摘要： The present invention relates to a method for preventing or treating skin damage which comprises applying to the skin a composition containing an effective amount of a cosmetically or pharmaceutically acceptable compound capable of acting as an electron donor, simultaneously or substantially simultaneously with the application of a composition containing an effective amount of a cosmetically or pharmaceutically acceptable compound capable of acting as an electron acceptor, whereby an exchange of electrons between the electron donor and electron acceptor results in generation of an electrical current on the skin.
摘要翻译： 本发明涉及一种预防或治疗皮肤损伤的方法，该方法包括向皮肤施用含有有效量的化妆品或药学上可接受的化合物，其能够作为电子给体，同时或基本上同时施用组合物 含有有效量的能够作为电子受体的化妆品或药学上可接受的化合物，由此电子给体和电子受体之间的电子交换导致在皮肤上产生电流。
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公开(公告)号：US6036965A
公开(公告)日：2000-03-14
申请号：US39013
申请日：1998-03-13
IPC分类号： A61K8/00 , A61K8/19 , A61K8/25 , A61K8/26 , A61Q1/02 , A61Q1/14 , A61Q5/02 , A61Q19/10 , A61K6/00
CPC分类号： A61K8/26 , A61Q19/10 , A61Q5/02 , A61K2800/28 , A61K2800/412 , Y10S514/846
摘要： The present invention relates to cosmetic skin or hair cleansing compositions comprising tourmaline.
摘要翻译： 本发明涉及包含电气石的化妆品皮肤或毛发清洁组合物。
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公开(公告)号：US6033655A
公开(公告)日：2000-03-07
申请号：US44502
申请日：1998-03-19
IPC分类号： A61N1/30 , A61K8/19 , A61K8/73 , A61K31/74 , A61K33/00 , A61N1/10 , A61N1/18 , A61N1/20 , A61N2/06 , A61P43/00 , A61Q19/00 , A61K7/02 , A61K7/48
CPC分类号： A61Q19/00 , A61K8/19 , A61K8/73 , A61N1/10 , A61N1/18 , A61N2/06 , A61K2800/47 , A61K2800/75 , A61K2800/83 , A61Q19/007
摘要： The present invention relates to cosmetic or pharmaceutical compositions comprising a magnetic metal species bound to an ion exchange resin as well as a method for preparing stable compositions of this type.
摘要翻译： 本发明涉及包含与离子交换树脂结合的磁性金属物质的化妆品或药物组合物以及制备这种类型的稳定组合物的方法。
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