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公开(公告)号：US09273134B2
公开(公告)日：2016-03-01
申请号：US12602235
申请日：2008-06-05
申请人： Joseph Schlessinger , Irit Lax , Satoru Yuzawa , Yarden Opatowsky , Yan Yang
发明人： Joseph Schlessinger , Irit Lax , Satoru Yuzawa , Yarden Opatowsky , Yan Yang
CPC分类号： C07K16/2803 , C07K2317/34 , C07K2317/76 , C07K2317/77
摘要： The present invention provides moieties that bind to an Ig-like domain, e.g., D4 or D5, of a human receptor tyrosine kinase, e.g., the human Kit RTK or the PDGFR RTK, or the D7 domain of a type V receptor tyrosine kinase wherein the moieties lock the ectodomain of the receptor tyrosine kinase in an inactive state thereby antagonizing the activity of the receptor tyrosine kinase.
摘要翻译： 本发明提供结合人类受体酪氨酸激酶例如人类Kit RTK或PDGFR RTK或V型受体酪氨酸激酶的D7结构域的Ig样结构域例如D4或D5的部分，其中， 该部分将受体酪氨酸激酶的胞外域锁定在无活性状态，从而拮抗受体酪氨酸激酶的活性。
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2.发明申请公开(公告)号：US20110311538A1
公开(公告)日：2011-12-22
申请号：US12602235
申请日：2008-06-05
申请人： Joseph Schlessinger , Irit Lax , Satoru Yuzawa , Yarden Opatowsky , Yan Yang
发明人： Joseph Schlessinger , Irit Lax , Satoru Yuzawa , Yarden Opatowsky , Yan Yang
IPC分类号： A61K39/395 , C12N5/16 , C07K7/06 , C07K7/08 , C07K5/117 , G01N33/573 , C07K5/113 , A61P35/00 , A61P19/02 , A61P27/02 , A61P9/10 , C07K16/40 , C07K5/11
CPC分类号： C07K16/2803 , C07K2317/34 , C07K2317/76 , C07K2317/77
摘要： The present invention provides moieties that bind to an Ig-like domain, e.g., D4 or D5, of a human receptor tyrosine kinase, e.g., the human Kit RTK or the PDGFR RTK, or the D7 domain of a type V receptor tyrosine kinase wherein the moieties lock the ectodomain of the receptor tyrosine kinase in an inactive state thereby antagonizing the activity of the receptor tyrosine kinase.
摘要翻译： 本发明提供结合人类受体酪氨酸激酶例如人类Kit RTK或PDGFR RTK或V型受体酪氨酸激酶的D7结构域的Ig样结构域例如D4或D5的部分，其中， 该部分将受体酪氨酸激酶的胞外域锁定在无活性状态，从而拮抗受体酪氨酸激酶的活性。
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公开(公告)号：US07135320B2
公开(公告)日：2006-11-14
申请号：US09731660
申请日：2000-12-08
CPC分类号： C07K14/4705 , C07K2319/00
摘要： The present invention relates generally to a newly identified adaptor protein FRS2 and related products and methods. FRS2 links protein kinases to activating partners in cells. The invention also relates to nucleic acid molecules encoding portions of FRS2, nucleic acid vectors containing FRS2 related nucleic acid molecules, recombinant cells containing such nucleic acid vectors, polypeptides purified from such recombinant cells, antibodies to such polypeptides, and methods of identifying compounds that enhance or block FRS2 interactions with natural binding partners. Also disclosed are methods for diagnosing abnormal conditions in an organism with FRS2 related molecules or compounds.
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公开(公告)号：US06310181B1
公开(公告)日：2001-10-30
申请号：US08980523
申请日：1997-12-01
IPC分类号： C07K1400
CPC分类号： C07K14/4705 , C07K2319/00
摘要： The present invention relates generally to a newly identified adaptor protein FRS2 and related products and methods. FRS2 links protein kinases to activating partners in cells. The invention also relates to nucleic acid molecules encoding portions of FRS2, nucleic acid vectors containing FRS2 related nucleic acid molecules, recombinant cells containing such nucleic acid vectors, polypeptides purified from such recombinant cells, antibodies to such polypeptides, and methods of identifying compounds that enhance or block FRS2 interactions with natural binding partners. Also disclosed are methods for diagnosing abnormal conditions in an organism with FRS2 related molecules or compounds.
摘要翻译： 本发明一般涉及新鉴定的接头蛋白FRS2及其相关产品和方法。 FRS2将蛋白激酶与细胞中的激活配偶体连接。 本发明还涉及编码部分FRS2的核酸分子，含有FRS2相关核酸分子的核酸载体，含有此类核酸载体的重组细胞，从这些重组细胞纯化的多肽，对这些多肽的抗体，以及鉴定增强的化合物的方法 或阻断与天然结合配偶体的FRS2相互作用。 还公开了用于诊断具有FRS2相关分子或化合物的生物体中的异常状况的方法。
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5.发明申请INHIBITORS OF RECEPTOR TYROSINE KINASES (RTK) AND METHODS OF USE THEREOF 审中-公开受体TYROSINE KINASES（RTK）的抑制剂及其使用方法公开(公告)号：US20120328599A1
公开(公告)日：2012-12-27
申请号：US13519837
申请日：2011-01-13
申请人： Jae Hyun Bae , Irit Lax , Joseph Schlessinger
发明人： Jae Hyun Bae , Irit Lax , Joseph Schlessinger
IPC分类号： C07K16/28 , C07D239/90 , C07D243/24 , C07D281/10 , C07D281/02 , C07K14/00 , A61K31/4375 , A61K31/517 , A61K31/5513 , A61K31/554 , A61K38/16 , A61P19/08 , A61P35/00 , A61K39/395 , C12N5/12 , G01N33/573 , C07D471/04
CPC分类号： G01N33/573 , C07K14/71 , G01N2500/04
摘要： The present invention provides moieties that bind to the asymmetric contact interface of a receptor tyrosine kinase (RTK), wherein the moieties inhibit ligand induced trans autophosphorylation of the RTK. The present invention also provides methods of treating or preventing an RTK-associated disease and methods for identifying moieties that bind to an asymmetric contact interface of an RTK.
摘要翻译： 本发明提供结合受体酪氨酸激酶（RTK）的不对称接触界面的部分，其中所述部分抑制配体诱导的RTK的自由磷酸化。 本发明还提供了治疗或预防RTK相关疾病的方法以及用于鉴定结合RTK的不对称接触界面的部分的方法。
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公开(公告)号：US5783568A
公开(公告)日：1998-07-21
申请号：US258307
申请日：1994-06-10
申请人： Joseph Schlessinger , Irit Lax , John E. Ladbury , Peng Cho Tang
发明人： Joseph Schlessinger , Irit Lax , John E. Ladbury , Peng Cho Tang
IPC分类号： A61K31/70 , A61K31/737 , A61K38/18 , C07K14/71 , A61K31/715 , C08B37/10
CPC分类号： A61K31/7024 , A61K31/70 , A61K31/7016 , A61K31/737 , A61K38/1825 , C07K14/71
摘要： The present invention relates to a method of treating in a mammal certain cancers, other cell proliferative diseases, and/or angiogenesis by using a salt or complex of a sulfated saccharide. The invention also relates to the use of mutant heparin binding growth factors that bind to the growth factor receptor, but not to heparin. The invention also provides pharmaceutical compositions for such methods.
摘要翻译： 本发明涉及通过使用硫酸化糖的盐或配合物在哺乳动物中治疗某些癌症，其它细胞增殖性疾病和/或血管发生的方法。 本发明还涉及结合生长因子受体而不是肝素的突变肝素结合生长因子的用途。 本发明还提供了用于这种方法的药物组合物。
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7.发明申请INHIBITORS OF VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) RECEPTORS AND METHODS OF USE THEREOF 审中-公开血管内皮生长因子（VEGF）受体的抑制剂及其使用方法公开(公告)号：US20130071397A1
公开(公告)日：2013-03-21
申请号：US13519839
申请日：2010-12-20
申请人： Joseph Schlessinger , Yan Yang
发明人： Joseph Schlessinger , Yan Yang
IPC分类号： A61K39/395 , G01N33/573 , C07K2/00 , C07K16/28 , C12N15/01
CPC分类号： A61K39/3955 , C07K2/00 , C07K16/2803 , C07K16/2863 , C07K2317/34 , C12N15/01 , G01N33/573
摘要： The present invention provides moieties that bind to the most membrane-proximal Ig-like domain of the ectodomain (D7) of vascular endothelial growth factor (VEGF) receptors, wherein the moieties antagonize the activity of the VEGF receptor.
摘要翻译： 本发明提供结合血管内皮生长因子（VEGF）受体的胞外域（D7）的最近膜近端Ig样结构域的部分，其中部分拮抗VEGF受体的活性。
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公开(公告)号：US20130315934A1
公开(公告)日：2013-11-28
申请号：US13881623
申请日：2011-10-28
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C07K14/4722 , C12N9/14 , G01N33/5743 , G01N2333/82 , G01N2800/52
摘要： The invention relates to methods and compositions for identifying mutations associated with cancer, such as melanoma. More particularly, the invention relates to methods and compositions for assessing particular mutations as markers for cancer, such as melanoma. Such methods and compositions allow medical providers to diagnose cancer, such as melanoma, based upon the presence of one or more particular mutations in a subject, as compared with an otherwise healthy control. The methods and compositions are also useful in guiding the type of therapy to be applied, and monitoring the effects of the therapy applied.
摘要翻译： 本发明涉及用于鉴定与癌症相关的突变的方法和组合物，例如黑素瘤。 更具体地，本发明涉及用于评估特定突变作为癌症标志物的方法和组合物，例如黑素瘤。 与其他健康对照相比，这样的方法和组合物允许医疗提供者基于受试者中一种或多种特定突变的存在来诊断癌症，例如黑素瘤。 方法和组合物也可用于指导所应用的治疗类型，并监测所施用的治疗效果。
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公开(公告)号：US20050036999A1
公开(公告)日：2005-02-17
申请号：US10777145
申请日：2004-02-13
申请人： Joseph Schlessinger , Jan Sap
发明人： Joseph Schlessinger , Jan Sap
IPC分类号： C07K14/705 , C12N9/16 , C07H21/04 , A61K38/46 , C07K16/40
CPC分类号： C07K14/705 , C07K2319/00 , C12N9/16
摘要： A novel receptor-type protein tyrosine phosphatase (RPTP) protein or glycoprotein and the DNA coding therefor is expressed in a wide variety of mammalian tissues. Included in this family of proteins are human RPTPα, human RPTPβ and human RPTPγ. The RPTP protein or glycoprotein may be produced by recombinant means. Antibodies to the proteins, methods for measuring the quantity of the proteins, methods for screening compounds, such as drugs, which can bind to the proteins and inhibit or stimulate their activity, are provided.
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10.发明申请Methods for treatment or diagnosis of disease or disorders associated with an APB domain 审中-公开用于治疗或诊断与APB结构域相关的疾病或病症的方法公开(公告)号：US20050032689A1
公开(公告)日：2005-02-10
申请号：US10704128
申请日：2003-11-10
CPC分类号： C07K14/71 , A61K38/00 , C07K2319/00
摘要： The present invention concerns methods for diagnosis and treatment of diseases or disorders characterized by abnormal cellular signal transduction involving a newly identified region, herein termed the “APB domain.” APB domain binding between proteins is believed to play an important role in signal transduction pathways and, thereby, influence cellular events. Thus, APB mediated activity plays a role in signal transduction pathways and agents modulating APB mediated activity can be used to treat diseases or disorders involving proteins containing APB domains.
摘要翻译： 本发明涉及用于诊断和治疗特征在于涉及新鉴定区域的异常细胞信号转导的疾病或病症的方法，这里称为“APB结构域”。 认为蛋白质之间的APB结构域结合在信号转导途径中起重要作用，从而影响细胞事件。 因此，APB介导的活性在信号转导途径中起作用，并且调节APB介导的活性的试剂可用于治疗涉及含有APB结构域的蛋白质的疾病或病症。
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