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    Microsensor Device
    2.
    发明申请
    Microsensor Device 审中-公开
    微传感器装置

    公开(公告)号：US20080218165A1

    公开(公告)日：2008-09-11

    申请号：US12065612

    申请日：2006-09-07

    申请人： Josephus Arnoldus Henricus Maria Kahlman ,  Bart Michiel De Boer ,  Albert Hendrik Jan Immink ,  Jeroen Hans Nieuwenhuis

    发明人： Josephus Arnoldus Henricus Maria Kahlman ,  Bart Michiel De Boer ,  Albert Hendrik Jan Immink ,  Jeroen Hans Nieuwenhuis

    IPC分类号： G01N27/72

    CPC分类号： G01N33/54326 ,  G01N27/745

    摘要： The invention relates to a microsensor device like a magnetic biosensor (100). The microsensor device comprises an array of probe-sensors (10.1, 10.2, 10.3) for the measurement of a physical quantity, for example the concentration of molecules labeled with magnetic beads in a sample chamber. The array further comprises a reference-sensor (10.4) that is disposed close to the probe-sensors (10.1, 10.2, 10.3) but shielded from the physical quantity to be measured. The measuring signal of the reference-sensor (10.4) reflects the influence of environmental conditions like temperature and can therefore be used to correct the measuring signals of the probe-sensors (10.1, 10.2, 10.3). The sensors (10.1, 10.2, 10.3, 10.4) are connected via a multiplexer to the same detector unit for further processing in order to minimize variations and to reduce hardware complexity.

    摘要翻译： 本发明涉及一种诸如磁性生物传感器（100）的微传感器装置。 微传感器装置包括用于测量物理量的探针传感器阵列（10.1,10.2,10.3），例如在样品室中用磁珠标记的分子的浓度。 该阵列还包括靠近探头传感器（10.1,10.2,10.3）设置但与被测量的物理量屏蔽的参考传感器（10.4）。 参考传感器（10.4）的测量信号反映了诸如温度等环境条件的影响，因此可用于校正探头传感器（10.1,10.2,10.3）的测量信号。 传感器（10.1,10.2,10.3,10.4）通过多路复用器连接到相同的检测器单元以进行进一步处理，以便最小化变化并降低硬件复杂度。

    SENSOR DEVICE FOR TARGET PARTICLES IN A SAMPLE
    4.
    发明申请
    SENSOR DEVICE FOR TARGET PARTICLES IN A SAMPLE 有权
    传感器装置在样品中的目标颗粒

    公开(公告)号：US20100259254A1

    公开(公告)日：2010-10-14

    申请号：US12738317

    申请日：2008-10-21

    申请人： Coen Adrianus Johannes Verschuren ,  Josephus Arnoldus Henricus Maria Kahlman ,  Albert Hendrik Jan Immink ,  Mischa Megens ,  Jeroen Veen ,  Bart Michiel De Boer ,  Theodorus Petrus Henricus Gerardus Jansen

    发明人： Coen Adrianus Johannes Verschuren ,  Josephus Arnoldus Henricus Maria Kahlman ,  Albert Hendrik Jan Immink ,  Mischa Megens ,  Jeroen Veen ,  Bart Michiel De Boer ,  Theodorus Petrus Henricus Gerardus Jansen

    IPC分类号： G01R33/02 ,  G01N33/00 ,  G01N21/55

    CPC分类号： G01N15/06 ,  G01N15/0656 ,  G01N2015/0693 ,  G01R33/1269

    摘要： The invention relates to a sensor device (100) and a method for the determination of the amount of target particles (1) at a contact surface (112) adjacent to a sample chamber (2). Target particles (1) in the sample chamber are detected by a sensor element (SE) and at least one corresponding sensor-signal (s, s′) is provided. An evaluation unit (EU) then determines the amount of target particles (1) in a first zone (Z1) immediately at the contracts surface (112) and a second zone (Z2) a distance (z) away from the contact surface based on this sensor-signal. In an optical measurement approach, frustrated total internal reflection taking place under different operating conditions (e.g. wavelength, angle of incidence) may be used to extract information about the first and second zones (Z1, Z2). In a magnetic measurement approach, different magnetic excitation fields may be used to excite magnetic target particles differently in the first and second zone (Z2). Moreover, the temporal course of a sensor-signal (s, s′) can be evaluated, particularly with respect to stochastic movements of the target particles (1).

    摘要翻译： 本发明涉及一种传感器装置（100）和用于确定在与样品室（2）相邻的接触表面（112）处的目标颗粒（1）的量的方法。 通过传感器元件（SE）检测样品室中的目标颗粒（1），并提供至少一个对应的传感器信号（s，s'）。 然后，评估单元（EU）基于紧接表面（112）立即确定第一区域（Z1）中的目标颗粒（1）的数量和远离接触表面的距离（z）的第二区域（Z2），基于 这个传感器信号。 在光学测量方法中，可以使用在不同操作条件（例如波长，入射角）下发生的沮丧的全内反射来提取关于第一和第二区（Z1，Z2）的信息。 在磁测量方法中，可以使用不同的磁激励场来在第一和第二区（Z2）中不同地激励磁目标颗粒。 此外，可以评估传感器信号（s，s'）的时间过程，特别是关于目标颗粒（1）的随机运动。

    MICROELECTRONIC SENSOR DEVICE FOR CONCENTRATION MEASUREMENTS
    5.
    发明申请
    MICROELECTRONIC SENSOR DEVICE FOR CONCENTRATION MEASUREMENTS 审中-公开
    用于浓度测量的微电子传感器装置

    公开(公告)号：US20090219012A1

    公开(公告)日：2009-09-03

    申请号：US12299698

    申请日：2007-04-24

    申请人： Jeroen Hans Nieuwenhuis ,  Hans Van Zon ,  Josephus Arnoldus Henricus Maria Kahlman ,  Jeroen Veen ,  Bart Michiel De Boer ,  Theodorus Petrus Henricus Gerardus Jansen

    发明人： Jeroen Hans Nieuwenhuis ,  Hans Van Zon ,  Josephus Arnoldus Henricus Maria Kahlman ,  Jeroen Veen ,  Bart Michiel De Boer ,  Theodorus Petrus Henricus Gerardus Jansen

    IPC分类号： G01N27/74

    CPC分类号： G01R33/093 ,  B82Y25/00 ,  G01N27/745 ,  G01R33/1269

    摘要： The invention relates to a method and a magnetic sensor device for the determination of the concentration of target particles (2) in a sample fluid, wherein the amount of the target particles (2) in a sensitive region (14) is observed by sampling measurement signals with associated sensor units (10a-10d). The target particles (2) may optionally be bound to binding sites (3) in the sensitive region, and a parametric binding curve, e.g. a Langmuir isotherm, may be fitted to the sampled measurement signals to determine the desired particle concentration in the sample. Moreover, parameters like the sampling rate and the size of the sensitive region (14) can be dynamically fitted during the ongoing sampling process to improve the signal-to-noise ratio. In another embodiment of the invention, single events corresponding to the movement of target particles into, out of, or within the sensitive region are detected and counted.

    摘要翻译： 本发明涉及一种用于确定样品流体中目标颗粒（2）的浓度的方法和磁传感器装置，其中通过采样测量观察敏感区域（14）中的目标颗粒（2）的量 信号与相关联的传感器单元（10a-10d）。 目标颗粒（2）可以任选地结合到敏感区域中的结合位点（3），参与结合曲线，例如， Langmuir等温线可以适应于采样的测量信号，以确定样品中所需的颗粒浓度。 此外，在持续采样过程中，可以动态拟合诸如采样率和敏感区域（14）的尺寸的参数，以提高信噪比。 在本发明的另一个实施例中，检测并计数与目标颗粒移动到敏感区域内部或之内的单个事件。

    MAGNETORESISTIVE SENSOR AS TEMPERATURE SENSOR
    6.
    发明申请
    MAGNETORESISTIVE SENSOR AS TEMPERATURE SENSOR 审中-公开
    磁传感器作为温度传感器

    公开(公告)号：US20100231213A1

    公开(公告)日：2010-09-16

    申请号：US12294479

    申请日：2007-03-23

    申请人： Jeroen Hans Nieuwenhuis ,  Theodorus Petrus Henricus Gerardus Jansen ,  Jeroen Veen ,  Josephus Arnoldus Henricus Maria Kahlman ,  Albert Hendrik Jan Immink

    发明人： Jeroen Hans Nieuwenhuis ,  Theodorus Petrus Henricus Gerardus Jansen ,  Jeroen Veen ,  Josephus Arnoldus Henricus Maria Kahlman ,  Albert Hendrik Jan Immink

    IPC分类号： G01R33/02

    CPC分类号： G01R33/09 ,  B82Y25/00 ,  G01R33/007 ,  G01R33/093 ,  G01R33/12 ,  G01R33/1269

    摘要： A detection system (100, 150) for qualitative or quantitative detection of a magnetic field property of a modulated magnetic field is described. The modulated magnetic field may e.g. stem from an adjacent electrical current (Iadj) or magnetic particles. The detection system (100, 150) comprises at least one magneto resistive sensor element (102), a current controller (104) for providing a sensing current (Isense) flowing through the magnetic sensor element (102) and a controlling means (108). The controlling means (108) is adapted for deriving at a first frequency f1 a temperature-related parameter of the at least one magneto resistive sensor. The controlling means (108) furthermore is adapted for deriving a qualitative or quantitative characteristic of the adjacent electrical current (Iadj) or magnetic particles, taking into account the derived temperature-related parameter. This second frequency (f1) is different from the first frequency (f1}). The invention also relates to a corresponding method.

    摘要翻译： 描述了用于定性或定量检测调制磁场的磁场特性的检测系统（100,150）。 调制磁场可以例如。 来自相邻的电流（Iadj）或磁性颗粒。 检测系统（100,150）包括至少一个磁阻传感器元件（102），用于提供流过磁传感器元件（102）的感测电流（Isense）的电流控制器（104）和控制装置（108） 。 控制装置（108）适于以第一频率f1导出至少一个磁阻传感器的温度相关参数。 此外，控制装置（108）还适于导出相邻电流（Iadj）或磁性颗粒的定性或定量特性，同时考虑导出的温度相关参数。 该第二频率（f1）与第一频率（f1）不同。 本发明还涉及相应的方法。

    MAGNETIC SENSOR DEVICE
    7.
    发明申请
    MAGNETIC SENSOR DEVICE 审中-公开
    磁传感器装置

    公开(公告)号：US20100176807A1

    公开(公告)日：2010-07-15

    申请号：US12377219

    申请日：2007-08-07

    申请人： Haris Duric ,  Josephus Arnoldus Henricus Maria Kahlman ,  Bart Michiel De Boer

    发明人： Haris Duric ,  Josephus Arnoldus Henricus Maria Kahlman ,  Bart Michiel De Boer

    IPC分类号： G01R33/12

    CPC分类号： G01N33/54366 ,  G01N27/745 ,  G01N33/54326 ,  G01N33/54373 ,  G01N35/0098

    摘要： The present invention provides a magnetic sensor device (20) comprising at least one sensor surface lying in a first plane, a first magnetic field generating means (12) for attracting magnetic or magnetizable objects (15) toward a sensor surface (13), the first magnetic field generating means (12) lying in a second plane different from and substantially parallel to the first plane, and a second magnetic field generating means (14) for magnetizing magnetic or magnetizable objects (15) which are bond to the sensor. The spacing between the first magnetic field generating means (12) and the at least one sensor element (11) is smaller than 2 μm down to optionally overlapping. The present invention furthermore provides a method for determining the presence and/or amount of magnetic or magnetizable objects (15) in a sample fluid using the magnetic sensor device (20) according to embodiments of the invention.

    摘要翻译： 本发明提供了一种包括位于第一平面中的至少一个传感器表面的磁传感器装置（20），用于将磁性或可磁化物体（15）吸引到传感器表面（13）的第一磁场产生装置（12） 第一磁场产生装置（12），其位于与第一平面不同并且基本上平行的第二平面中;以及第二磁场产生装置（14），用于磁化磁性或可磁化物体（15），所述第二磁场产生装置结合到传感器。 第一磁场产生装置（12）和至少一个传感器元件（11）之间的间隔小于2μm，直到可选地重叠。 本发明还提供一种用于使用根据本发明的实施例的磁传感器装置（20）来确定样品流体中的磁性或可磁化物体（15）的存在和/或量的方法。

    On-Chip Magnetic Sensor Device with Suppressed Cross-Talk
    8.
    发明申请
    On-Chip Magnetic Sensor Device with Suppressed Cross-Talk 审中-公开
    具有抑制串扰的片上磁传感器装置

    公开(公告)号：US20080309329A1

    公开(公告)日：2008-12-18

    申请号：US10597639

    申请日：2004-07-29

    申请人： Josephus Arnoldus Henricus Maria Kahlman ,  Bart Michiel De Boer ,  Menno Willem Jose Prins

    发明人： Josephus Arnoldus Henricus Maria Kahlman ,  Bart Michiel De Boer ,  Menno Willem Jose Prins

    IPC分类号： G01R33/12

    CPC分类号： G01R33/12 ,  G01N27/745 ,  G01R33/1269

    摘要： A magnetic sensor device is disclosed for the detection or determination of a magnetic field, such as for example, but not limited to, the presence of magnetic particles (15). In particular it relates to an integrated or on-chip magnetic sensor element (11) for the detection of magnetic nano-particles functioning as a label to biological molecules. The device of the present invention offers reduced cross-talk between the magnetic sensor element (11) and a magnetic field generator (12) by compensating capacitive and/or magnetic coupling for instance by using an electrostatic shield and/or modulation and demodulation techniques. The device may be used for magnetic detection of binding of biological molecules on a micro-array or biochip.

    摘要翻译： 公开了用于检测或确定磁场的磁传感器装置，例如但不限于存在磁性颗粒（15）。 特别地，其涉及用于检测用作生物分子的标记的磁性纳米颗粒的集成或片上磁传感器元件（11）。 本发明的装置通过例如通过使用静电屏蔽和/或调制和解调技术来补偿电容和/或磁耦合来减小磁传感器元件（11）和磁场发生器（12）之间的串扰。 该装置可用于磁性检测微阵列或生物芯片上生物分子的结合。

    Magnetic Sensor Device With Different Internal Operating Frequencies
    9.
    发明申请
    Magnetic Sensor Device With Different Internal Operating Frequencies 审中-公开
    具有不同内部工作频率的磁传感器装置

    公开(公告)号：US20080246471A1

    公开(公告)日：2008-10-09

    申请号：US12089947

    申请日：2006-09-29

    申请人： Josephus Arnoldus Henricus Maria Kahlman ,  Jeroen Veen ,  Bart Michiel De Boer ,  Theodorus Petrus Henricus Gerardus Jansen

    发明人： Josephus Arnoldus Henricus Maria Kahlman ,  Jeroen Veen ,  Bart Michiel De Boer ,  Theodorus Petrus Henricus Gerardus Jansen

    IPC分类号： G01N15/06

    CPC分类号： G01R33/09 ,  B82Y25/00 ,  G01N15/0656 ,  G01N27/745 ,  G01R33/093 ,  G01R33/12 ,  G01R33/1269

    摘要： The invention relates to a magnetic sensor device (10) comprising wires (11, 13) for the generation of a magnetic field with a first frequency f1 a GMR sensor (12) operated with an input current of a second frequency f2, and a demodulator (26) operated at a third frequency f3. In order to avoid signal corruption by phase noise and to improve the signal-to-noise ratio, the first, second and third frequencies are derived by a supply unit (121) from a common reference frequency fref. Said derivation may for example be achieved with the help of digital frequency dividers. Furthermore, phase detectors (PD1, PD2) may be used in a feedback control loop to assure predetermined relations between the phases of the three frequencies. In another embodiment of the invention, the phase and/or amplitude of a model signal, which is used to process a desired signal component in the output of the sensor, is tracked by an adaptation algorithm, for example a gradient descent.

    摘要翻译： 本发明涉及一种磁传感器装置（10），其包括用于产生具有第一频率f 1的磁场的导线（11,13），GMR传感器（12）用输入电流 第二频率f 2 2和在第三频率f 3 3处操作的解调器（26）。 为了避免相位噪声的信号损坏并提高信噪比，第一，第二和第三频率由供电单元（121）从公共参考频率f ref 。 所述推导可以例如在数字分频器的帮助下实现。 此外，相位检测器（PD1，PD2）可以用在反馈控制环路中，以确保三个频率的相位之间的预定关系。 在本发明的另一个实施例中，用于处理传感器的输出中的期望信号分量的模型信号的相位和/或幅度由适应算法（例如梯度下降）来跟踪。

    MEANS AND METHOD FOR SENSING A MAGNETIC STRAY FIELD IN BIOSENSORS
    10.
    发明申请
    MEANS AND METHOD FOR SENSING A MAGNETIC STRAY FIELD IN BIOSENSORS 审中-公开
    用于感应生物传感器中磁场的方法和方法

    公开(公告)号：US20090224755A1

    公开(公告)日：2009-09-10

    申请号：US11719953

    申请日：2005-11-28

    申请人： Josephus Arnoldus Henricus Maria Kahlman ,  Bart Michiel De Boer

    发明人： Josephus Arnoldus Henricus Maria Kahlman ,  Bart Michiel De Boer

    IPC分类号： G01R33/09

    CPC分类号： G01R33/093 ,  B82Y25/00 ,  G01R33/1269

    摘要： A magnetic sensor (MS) comprising a magneto-resistive element (GMR) for sensing a magnetic stray field (SF) generated by a magnetizable object (SPB) when magnetized and for generating an electrical object signal (UOB) which depends on the sensed magnetic stray field (SF), the sensor (MS) comprising a magnetic field generator (WR1, WR2) for generating a magnetic field (H, Hext) having a first frequency (ω1) for magnetizing the magnetizable object (SPB), a current source (AC2) for at least generating an AC-current (I2 sin ω2t) having a second frequency (ω2t) through the magneto-resistive element (GMR), and electronic means for generating an electrical output signal (U0) derived from the electrical object signal (UOB), the electronic means comprising stabilization means for stabilizing the amplitude of the electrical output signal (U0), the stabilization means deriving its information which is needed for said stabilization from the amplitude of a signal component, which is present in the object signal (UOB) during operation, which is linearly dependent on the steepness of the magneto-resistive element (GMR), the steepness being defined as the derivative of the resistance of the magneto-resistive element (GMR) as a function of the magnetic field through the magneto-resistive element in a magnetically sensitive direction of the magneto-resistive element (GMR).

    摘要翻译： 一种磁传感器（MS），包括用于感测由磁化物体（SPB）产生的磁性杂散场（SFB）的磁阻元件（GMR），并且用于产生取决于感测的磁性的电物体信号（UOB） 杂散场（SF），包括用于产生具有用于磁化可磁化物体（SPB）的第一频率（ω））的磁场（H，Hext）的磁场发生器（WR1，WR2）的传感器（MS），电流源 （AC2），用于至少通过磁阻元件（GMR）产生具有第二频率（ω）的AC电流（I2sinω2t），以及用于产生从电气对象导出的电输出信号（U0）的电子装置 信号（UOB），所述电子装置包括用于稳定电输出信号（U0）的振幅的稳定装置，稳定装置从信号分量的幅度导出所述稳定所需的信息，该信号是预先 在操作期间发送在对象信号（UOB）中，其与磁阻元件（GMR）的陡度线性相关，陡度被定义为作为功能的磁阻元件（GMR）的电阻的导数 通过磁阻元件在磁阻元件（GMR）的磁敏感方向上的磁场。