SENSOR DEVICE FOR TARGET PARTICLES IN A SAMPLE
    2.
    发明申请
    SENSOR DEVICE FOR TARGET PARTICLES IN A SAMPLE 有权
    传感器装置在样品中的目标颗粒

    公开(公告)号:US20100259254A1

    公开(公告)日:2010-10-14

    申请号:US12738317

    申请日:2008-10-21

    IPC分类号: G01R33/02 G01N33/00 G01N21/55

    摘要: The invention relates to a sensor device (100) and a method for the determination of the amount of target particles (1) at a contact surface (112) adjacent to a sample chamber (2). Target particles (1) in the sample chamber are detected by a sensor element (SE) and at least one corresponding sensor-signal (s, s′) is provided. An evaluation unit (EU) then determines the amount of target particles (1) in a first zone (Z1) immediately at the contracts surface (112) and a second zone (Z2) a distance (z) away from the contact surface based on this sensor-signal. In an optical measurement approach, frustrated total internal reflection taking place under different operating conditions (e.g. wavelength, angle of incidence) may be used to extract information about the first and second zones (Z1, Z2). In a magnetic measurement approach, different magnetic excitation fields may be used to excite magnetic target particles differently in the first and second zone (Z2). Moreover, the temporal course of a sensor-signal (s, s′) can be evaluated, particularly with respect to stochastic movements of the target particles (1).

    摘要翻译: 本发明涉及一种传感器装置(100)和用于确定在与样品室(2)相邻的接触表面(112)处的目标颗粒(1)的量的方法。 通过传感器元件(SE)检测样品室中的目标颗粒(1),并提供至少一个对应的传感器信号(s,s')。 然后,评估单元(EU)基于紧接表面(112)立即确定第一区域(Z1)中的目标颗粒(1)的数量和远离接触表面的距离(z)的第二区域(Z2),基于 这个传感器信号。 在光学测量方法中,可以使用在不同操作条件(例如波长,入射角)下发生的沮丧的全内反射来提取关于第一和第二区(Z1,Z2)的信息。 在磁测量方法中,可以使用不同的磁激励场来在第一和第二区(Z2)中不同地激励磁目标颗粒。 此外,可以评估传感器信号(s,s')的时间过程,特别是关于目标颗粒(1)的随机运动。

    MAGNETORESISTIVE SENSOR AS TEMPERATURE SENSOR
    3.
    发明申请
    MAGNETORESISTIVE SENSOR AS TEMPERATURE SENSOR 审中-公开
    磁传感器作为温度传感器

    公开(公告)号:US20100231213A1

    公开(公告)日:2010-09-16

    申请号:US12294479

    申请日:2007-03-23

    IPC分类号: G01R33/02

    摘要: A detection system (100, 150) for qualitative or quantitative detection of a magnetic field property of a modulated magnetic field is described. The modulated magnetic field may e.g. stem from an adjacent electrical current (Iadj) or magnetic particles. The detection system (100, 150) comprises at least one magneto resistive sensor element (102), a current controller (104) for providing a sensing current (Isense) flowing through the magnetic sensor element (102) and a controlling means (108). The controlling means (108) is adapted for deriving at a first frequency f1 a temperature-related parameter of the at least one magneto resistive sensor. The controlling means (108) furthermore is adapted for deriving a qualitative or quantitative characteristic of the adjacent electrical current (Iadj) or magnetic particles, taking into account the derived temperature-related parameter. This second frequency (f1) is different from the first frequency (f1}). The invention also relates to a corresponding method.

    摘要翻译: 描述了用于定性或定量检测调制磁场的磁场特性的检测系统(100,150)。 调制磁场可以例如。 来自相邻的电流(Iadj)或磁性颗粒。 检测系统(100,150)包括至少一个磁阻传感器元件(102),用于提供流过磁传感器元件(102)的感测电流(Isense)的电流控制器(104)和控制装置(108) 。 控制装置(108)适于以第一频率f1导出至少一个磁阻传感器的温度相关参数。 此外,控制装置(108)还适于导出相邻电流(Iadj)或磁性颗粒的定性或定量特性,同时考虑导出的温度相关参数。 该第二频率(f1)与第一频率(f1)不同。 本发明还涉及相应的方法。

    Microsensor Device
    5.
    发明申请
    Microsensor Device 审中-公开
    微传感器装置

    公开(公告)号:US20080218165A1

    公开(公告)日:2008-09-11

    申请号:US12065612

    申请日:2006-09-07

    IPC分类号: G01N27/72

    CPC分类号: G01N33/54326 G01N27/745

    摘要: The invention relates to a microsensor device like a magnetic biosensor (100). The microsensor device comprises an array of probe-sensors (10.1, 10.2, 10.3) for the measurement of a physical quantity, for example the concentration of molecules labeled with magnetic beads in a sample chamber. The array further comprises a reference-sensor (10.4) that is disposed close to the probe-sensors (10.1, 10.2, 10.3) but shielded from the physical quantity to be measured. The measuring signal of the reference-sensor (10.4) reflects the influence of environmental conditions like temperature and can therefore be used to correct the measuring signals of the probe-sensors (10.1, 10.2, 10.3). The sensors (10.1, 10.2, 10.3, 10.4) are connected via a multiplexer to the same detector unit for further processing in order to minimize variations and to reduce hardware complexity.

    摘要翻译: 本发明涉及一种诸如磁性生物传感器(100)的微传感器装置。 微传感器装置包括用于测量物理量的探针传感器阵列(10.1,10.2,10.3),例如在样品室中用磁珠标记的分子的浓度。 该阵列还包括靠近探头传感器(10.1,10.2,10.3)设置但与被测量的物理量屏蔽的参考传感器(10.4)。 参考传感器(10.4)的测量信号反映了诸如温度等环境条件的影响,因此可用于校正探头传感器(10.1,10.2,10.3)的测量信号。 传感器(10.1,10.2,10.3,10.4)通过多路复用器连接到相同的检测器单元以进行进一步处理,以便最小化变化并降低硬件复杂度。

    Laser driver/method for generating a laser drive signal
    9.
    发明授权
    Laser driver/method for generating a laser drive signal 失效
    用于产生激光驱动信号的激光驱动器/方法

    公开(公告)号:US07362690B2

    公开(公告)日:2008-04-22

    申请号:US10560678

    申请日:2004-06-16

    IPC分类号: G11B7/00

    摘要: A driver for driving a light generator for generating light, comprising a digitalto-analog converter (DAC) having a data input, a data output for generating an analog signal, a first multiplexer (MUX1) for cyclic selection of a number of data levels corresponding to desired intensity levels of the light and for coupling the data levels to the data input; a de multiplexer (DE-MUX) synchronized with the first multiplexer (MUX1) for de-multiplexing the analog signal into a set of analog signals; memory means for temporarily storing the set of analog signals; and a second multiplexer (MUX2) for selection of the stored set of analog signals and for generating a drive signal (IL) for the light generator. The memory means is preferably implemented by a set of capacitors (C1-C8). Usually, for instance in an optical disc drive, the light generator is implemented by a laser (Ls). In this situation the data input of the digital-to-analog converter comprises a threshold data input part; a delta data input part; a threshold gain reference input associated with the threshold data input part; and a delta gain reference input associated with the delta data input part. So in fact the DAC is split into two parts (DAC1 and DAC2) for separate threshold power and delta power control of the laser (LS).

    摘要翻译: 一种用于驱动用于产生光的光发生器的驱动器,包括具有数据输入的数模转换器(DAC),用于产生模拟信号的数据输出端,用于循环选择多个数据电平的第一多路复用器(MUX1) 对应于光的期望强度水平并且用于将数据电平耦合到数据输入; 与多路复用器(DE-MUX)同步的第一多路复用器(MUX1),用于将模拟信号解复用为一组模拟信号; 用于临时存储该组模拟信号的存储装置; 和用于选择存储的模拟信号组并用于产生用于光发生器的驱动信号(IL)的第二多路复用器(MUX2)。 存储装置优选地由一组电容器(C 1 -C 8)实现。 通常,例如在光盘驱动器中,光发生器通过激光(L s)实现。 在这种情况下,数模转换器的数据输入包括阈值数据输入部分; 增量数据输入部分; 与阈值数据输入部分相关联的阈值增益参考输入; 以及与增量数据输入部分相关联的增量增益参考输入。 因此,事实上,DAC分为两部分(DAC 1和DAC 2),用于激光器(LS)的单独阈值功率和Δ功率控制。