Nucleic acid molecule capable of binding to c-Met and use thereof
    2.
    发明授权
    Nucleic acid molecule capable of binding to c-Met and use thereof 有权
    能够结合c-Met的核酸分子及其用途

    公开(公告)号:US08822667B2

    公开(公告)日:2014-09-02

    申请号:US13812190

    申请日:2011-07-26

    IPC分类号: C07H21/04 C07H21/02 A61K48/00

    摘要: The present invention provides a nucleic acid molecule capable of binding to c-Met as a substance that can be used for clarification of the pathogenic mechanism of diseases caused by c-Met, diagnosis and treatment of the diseases, and the like, and also the use thereof. The c-Met binding nucleic acid molecule of the present invention is any one of the following nucleic acid molecules (A1), (A2), (B1), and (B2). (A1) a nucleic acid molecule including the base sequence of any one of SEQ ID NOs: 1 to 38 (A2) a nucleic acid molecule that is capable of binding to c-Met and includes a base sequence obtained by substitution, deletion, addition, and/or insertion of one or more bases in the base sequence of any one of SEQ ID NOs: 1 to 38 (B1) a nucleic acid molecule including the base sequence of any one of SEQ ID NOs: 39 to 76 (B2) a nucleic acid molecule that is capable of binding to c-Met and includes a base sequence obtained by substitution, deletion, addition, and/or insertion of one or more bases in the base sequence of any one of SEQ ID NOs: 39 to 76.

    摘要翻译: 本发明提供能够结合c-Met的核酸分子,作为能够用于澄清由c-Met,疾病的诊断和治疗等引起的疾病的致病机制的物质,以及 使用它。 本发明的c-Met结合核酸分子是以下核酸分子(A1),(A2),(B1)和(B2)中的任一种。 (A1)包含SEQ ID NO:1至38(A2)中任一个的碱基序列的核酸分子,其能够结合c-Met并包含通过取代,缺失,加成获得的碱基序列 ,(SEQ ID NO:39)至(38)中的任何一个的碱基序列的核酸分子,和/或在SEQ ID NO:1至38(B1)中任一个的碱基序列中插入一个或多个碱基, 能够结合c-Met的核酸分子,并且包含通过SEQ ID NO:39至76中任一个的碱基序列中的一个或多个碱基的取代,缺失,添加和/或插入获得的碱基序列 。

    APTAMER THAT RECOGNIZES PEPTIDE
    4.
    发明申请
    APTAMER THAT RECOGNIZES PEPTIDE 有权
    认可肽的APTAMER

    公开(公告)号:US20120129720A1

    公开(公告)日:2012-05-24

    申请号:US13320462

    申请日:2010-05-14

    摘要: An aptamer capable of binding to a histidine peptide is provided. A nucleic acid used as the aptamer capable of binding to a histidine peptide is any of the following nucleic acids (a) to (d): (a) a nucleic acid having a base sequence represented by SEQ ID NO: 17: GGUNnAYUmGGH (SEQ ID NO: 17), where in the nucleic acid (a), N represents A, G, C, U, or T, n of Nn represents the number of Ns and is an integer from 1 to 3, Y represents U, T, or C, m of Um represents the number of Us and is an integer from 1 to 3, and H represents U, T, C, or A; (b) a nucleic acid having a base sequence obtained by substitution, deletion, addition, or insertion of one or more bases in a base sequence of the nucleic acid (a) and being capable of binding to the histidine peptide; (c) a nucleic acid having a base sequence represented by SEQ ID NO: 18: GGCGCCUUCGUGGAAUGUC (SEQ ID NO: 18); and (d) a nucleic acid having a base sequence obtained by substitution, deletion, addition, or insertion of one or more bases in a base sequence of the nucleic acid (c) and being capable of binding to the histidine peptide.

    摘要翻译: 提供了能够结合组氨酸肽的适体。 用作能够结合组氨酸肽的适体的核酸是以下任一核酸(a)至(d):(a)具有由SEQ ID NO:17表示的碱基序列的核酸:GGUNnAYUmGGH(SEQ ID NO: ID号:17),其中在核酸(a)中,N表示A,G,C,U或T,N n表示N的数,为1〜3的整数,Y表示U,T 或C m表示Us的数,是1〜3的整数,H表示U,T,C或A; (b)具有通过在核酸(a)的碱基序列中取代,缺失,添加或插入一个或多个碱基并且能够结合组氨酸肽而获得的碱基序列的核酸; (c)具有由SEQ ID NO:18表示的碱基序列的核酸:GGCGCCUUCGUGGAAUGUC(SEQ ID NO:18); 和(d)具有通过在核酸(c)的碱基序列中取代,缺失,添加或插入一个或多个碱基并且能够结合组氨酸肽而获得的碱基序列的核酸。

    PREDICTION DEVICE, PREDICTION METHOD, PROGRAM, AND RECORDING MEDIUM
    5.
    发明申请
    PREDICTION DEVICE, PREDICTION METHOD, PROGRAM, AND RECORDING MEDIUM 有权
    预测装置,预测方法,程序和记录介质

    公开(公告)号:US20130102480A1

    公开(公告)日:2013-04-25

    申请号:US13807876

    申请日:2011-07-02

    IPC分类号: G06F19/16

    摘要: The present invention provides a prediction device, a prediction method, a program, and a recording medium, with which whether or not desired aptamer sequences are enriched can be predicted easily. The prediction device of the present invention 10 includes an input unit 11, a calculation unit 12, and a prediction unit 13. The input unit 11 is a unit through which sequence information on a target aptamer sequence group including selected aptamers in a target pool and a reference aptamer sequence group including reference aptamer sequences are inputted. The calculation unit 12 calculates the free energy of the target aptamer sequence group and the free energy of the reference aptamer sequence group. The prediction unit 13 compares the free energy of these sequence groups, and predicts that the target pool is an enriched pool when the free energy of the target aptamer sequence group is lower than the free energy of the reference aptamer sequence group. The reference aptamer sequence group is a candidate aptamer sequence group including a plurality of candidate aptamer sequences or a virtual aptamer sequence group that is derived from the target aptamer sequence group and includes virtual aptamer sequences having the same base composition as the target aptamer sequence group.

    摘要翻译: 本发明提供一种预测装置,预测方法,程序和记录介质,可以容易地预测其中是否需要富集需要的适体序列。 本发明的预测装置10包括输入单元11,计算单元12和预测单元13.输入单元11是通过目标池中包括所选择的适配体的目标适体序列组的序列信息和 输入包括参考适体序列的参照适体序列组。 计算单元12计算目标适体序列组的自由能和参考适体序列组的自由能。 预测单元13比较这些序列组的自由能,并且当靶适体序列组的自由能低于参考适体序列组的自由能时,预测目标池是富集池。 参照适体序列组是包含从目标适体序列组得到的多个候选适体序列或虚拟适体序列组的候选适体序列组,并且具有与靶适体序列组相同的基本组成的虚拟适配子序列。

    NUCLEIC ACID MOLECULE CAPABLE OF BINDING TO c-MET AND USE THEREOF
    6.
    发明申请
    NUCLEIC ACID MOLECULE CAPABLE OF BINDING TO c-MET AND USE THEREOF 有权
    可以与C-MET结合的核酸分子和其使用

    公开(公告)号:US20130123350A1

    公开(公告)日:2013-05-16

    申请号:US13812190

    申请日:2011-07-26

    IPC分类号: C07H21/02

    摘要: The present invention provides a nucleic acid molecule capable of binding to c-Met as a substance that can be used for clarification of the pathogenic mechanism of diseases caused by c-Met, diagnosis and treatment of the diseases, and the like, and also the use thereof. The c-Met binding nucleic acid molecule of the present invention is any one of the following nucleic acid molecules (A1), (A2), (B1), and (B2).(A1) a nucleic acid molecule including the base sequence of any one of SEQ ID NOs: 1 to 38 (A2) a nucleic acid molecule that is capable of binding to c-Met and includes a base sequence obtained by substitution, deletion, addition, and/or insertion of one or more bases in the base sequence of any one of SEQ ID NOs: 1 to 38 (B1) a nucleic acid molecule including the base sequence of any one of SEQ ID NOs: 39 to 76 (B2) a nucleic acid molecule that is capable of binding to c-Met and includes a base sequence obtained by substitution, deletion, addition, and/or insertion of one or more bases in the base sequence of any one of SEQ ID NOs: 39 to 76

    摘要翻译: 本发明提供能够结合c-Met的核酸分子,作为能够用于澄清由c-Met,疾病的诊断和治疗等引起的疾病的致病机制的物质,以及 使用它。 本发明的c-Met结合核酸分子是以下核酸分子(A1),(A2),(B1)和(B2)中的任一种。 (A1)包含SEQ ID NO:1至38(A2)中任一个的碱基序列的核酸分子,其能够结合c-Met并包含通过取代,缺失,加成获得的碱基序列 ,(SEQ ID NO:39)至(38)中的任何一个的碱基序列的核酸分子,和/或在SEQ ID NO:1至38(B1)中任一个的碱基序列中插入一个或多个碱基, 能够结合c-Met的核酸分子,并且包含通过SEQ ID NO:39至76中任一个的碱基序列中的一个或多个碱基的取代,缺失,添加和/或插入获得的碱基序列

    Prediction device, prediction method, program, and recording medium
    7.
    发明授权
    Prediction device, prediction method, program, and recording medium 有权
    预测装置,预测方法,程序和记录介质

    公开(公告)号:US09454642B2

    公开(公告)日:2016-09-27

    申请号:US13807876

    申请日:2011-07-02

    摘要: The present invention provides a prediction device, a prediction method, a program, and a recording medium, with which whether or not desired aptamer sequences are enriched can be predicted easily. The prediction device of the present invention 10 includes an input unit 11, a calculation unit 12, and a prediction unit 13. The input unit 11 is a unit through which sequence information on a target aptamer sequence group including selected aptamers in a target pool and a reference aptamer sequence group including reference aptamer sequences are inputted. The calculation unit 12 calculates the free energy of the target aptamer sequence group and the free energy of the reference aptamer sequence group. The prediction unit 13 compares the free energy of these sequence groups, and predicts that the target pool is an enriched pool when the free energy of the target aptamer sequence group is lower than the free energy of the reference aptamer sequence group. The reference aptamer sequence group is a candidate aptamer sequence group including a plurality of candidate aptamer sequences or a virtual aptamer sequence group that is derived from the target aptamer sequence group and includes virtual aptamer sequences having the same base composition as the target aptamer sequence group.

    摘要翻译: 本发明提供一种预测装置,预测方法,程序和记录介质,可以容易地预测其中是否需要富集需要的适体序列。 本发明的预测装置10包括输入单元11,计算单元12和预测单元13.输入单元11是通过目标池中包括所选择的适配体的目标适体序列组的序列信息和 输入包括参考适体序列的参照适体序列组。 计算单元12计算目标适体序列组的自由能和参考适体序列组的自由能。 预测单元13比较这些序列组的自由能,并且当靶适体序列组的自由能低于参考适体序列组的自由能时,预测目标池是富集池。 参照适体序列组是包含从目标适体序列组得到的多个候选适体序列或虚拟适体序列组的候选适体序列组,并且具有与靶适体序列组相同的基本组成的虚拟适配子序列。

    NUCLEIC ACID CONSTRUCT AND COMPLEX FORMATION METHOD AND SCREENING METHOD USING THE SAME
    9.
    发明申请
    NUCLEIC ACID CONSTRUCT AND COMPLEX FORMATION METHOD AND SCREENING METHOD USING THE SAME 审中-公开
    核酸结构和复合形成方法及使用该方法的筛选方法

    公开(公告)号:US20130244239A1

    公开(公告)日:2013-09-19

    申请号:US13638447

    申请日:2011-03-31

    IPC分类号: G01N33/68 C07K19/00

    摘要: The present invention is to provide a new detection method that is superior in detection sensitivity and allows a simple operation. A nucleic acid construct that includes a cloning region, an encoding nucleic acid of a peptide tag, an encoding nucleic acid of an aptamer that is bindable to the peptide tag is used. By inserting the encoding nucleic acid of arbitrary peptide into the cloning region of the nucleic acid construct, the nucleic acid construct is expressed in vivo. Thereby, a complex of a fusion transcript having the base sequence that includes the encoding nucleic acid of arbitrary peptide, the encoding nucleic acid of a peptide tag, and the encoding nucleic acid of the aptamer and a fusion translation that includes the arbitrary peptide and the peptide tag is formed. By bringing the complex into contact with a target and recovering the complex that is bound to the target, the peptide that is bindable to a target and its encoding nucleic acid can be identified from the transcript of the encoding nucleic acid of arbitrary peptide in the complex.

    摘要翻译: 本发明提供一种检测灵敏度优异且能够简单操作的新检测方法。 使用包含克隆区,肽标签的编码核酸,可与肽标签结合的适体的编码核酸的核酸构建体。 通过将任意肽的编码核酸插入到核酸构建体的克隆区中,核酸构建体在体内表达。 由此,具有包含任意肽的编码核酸,肽标签的编码核酸和适配子的编码核酸的碱基序列的融合转录物的复合物和包含任意肽的融合翻译和 形成肽标签。 通过使复合物与靶接触并回收与靶结合的复合物,可以从复合物中任意肽的编码核酸的转录物中鉴定可与靶标结合的肽及其编码核酸 。

    AUDIO-VISUAL SYSTEM, REPRODUCING APPARATUS, AND DISPLAY DEVICE
    10.
    发明申请
    AUDIO-VISUAL SYSTEM, REPRODUCING APPARATUS, AND DISPLAY DEVICE 审中-公开
    视听系统,再现设备和显示设备

    公开(公告)号:US20080284913A1

    公开(公告)日:2008-11-20

    申请号:US12121867

    申请日:2008-05-16

    IPC分类号: H04N5/445

    摘要: The TV receiver as a display device has a drawing generation unit for generating display side drawing data of drawn picture according to a display format for on-screen display, and a reproducing apparatus has a drawing generation unit for generating reproduction side drawing data of drawn picture according to a display format for display on the TV receiver. The drawing generation unit receives the display format information of the drawing generation unit through a connection cable, and generates reproduction side drawing data of display format based on the received display side display format information. The reproducing apparatus supplies the contents data including the generated reproduction side drawing data to the TV receiver through the connection cable, and the TV receiver presents the drawn picture based on the supplied reproduction side drawing data.

    摘要翻译: 作为显示装置的电视接收机具有用于根据用于屏幕显示的显示格式产生绘制图像的显示侧绘图数据的图形生成单元,并且再现装置具有绘制生成单元,用于生成绘制图像的再现侧绘图数据 根据用于在电视接收机上显示的显示格式。 绘图生成单元通过连接电缆接收绘图生成单元的显示格式信息,并且基于接收的显示侧显示格式信息生成显示格式的再现侧绘图数据。 再现装置通过连接电缆向TV接收机提供包括所生成的再现侧绘图数据的内容数据,TV接收机根据所提供的再现侧绘图数据呈现绘制的画面。