公开(公告)号：US20060270709A1

公开(公告)日：2006-11-30

申请号：US11396555

申请日：2006-04-04

申请人： Julian Gray ,  Yoshiharu Yamanishi ,  Nobuyuki Mori ,  Scott Fields

发明人： Julian Gray ,  Yoshiharu Yamanishi ,  Nobuyuki Mori ,  Scott Fields

IPC分类号： A61K31/445 ,  A61K31/444

CPC分类号： A61K31/4412 ,  A61K31/444 ,  A61K31/445 ,  A61K2300/00

摘要： The invention provides methods for treating and/or preventing cognitive impairments, dementia, or neurodegenerative diseases and disorders (e.g., Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis) in patients by administering therapeutically effective amounts of an AMPA receptor antagonist (e.g., 1,2-dihydropyridine compounds) and therapeutically effective amounts of nootropics (e.g., cholinesterase inhibitors) to patients. The invention also provides combinations, commercial packages, and pharmaceutical compositions comprising therapeutically effective amounts of AMPA receptor antagonists (e.g., 1,2-dihydropyridine compounds) and therapeutically effective amounts nootropics (e.g., cholinesterase inhibitors). The 1,2-dihydropyridine compound may be, for example, 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one. The cholinesterase inhibitor may be, for example, donepezil.

摘要翻译： 本发明提供了通过施用治疗有效量的AMPA受体拮抗剂（例如，治疗和/或预防）的方法来治疗和/或预防患者的认知障碍，痴呆或神经变性疾病和障碍（例如，阿尔茨海默氏病，帕金森病，亨廷顿舞蹈病，肌萎缩性侧索硬化） ，1,2-二氢吡啶化合物）和治疗有效量的益智酸（例如胆碱酯酶抑制剂）给患者。 本发明还提供了包含治疗有效量的AMPA受体拮抗剂（例如1,2-二氢吡啶化合物）和治疗有效量的精神病药（例如胆碱酯酶抑制剂）的组合，商业包装和药物组合物。 1,2-二氢吡啶化合物可以是例如3-（2-氰基苯基）-5-（2-吡啶基）-1-苯基-1,2-二氢吡啶-2-酮。 胆碱酯酶抑制剂可以是例如多奈哌齐。

公开(公告)号：US20090131480A1

公开(公告)日：2009-05-21

申请号：US11887729

申请日：2006-04-04

申请人： Julian A. Gray ,  Yoshiharu Yamanishi ,  Julian A. Gray ,  Yoshiharu Yamanishi ,  Nobuyuki Mori ,  Scott Fields

发明人： Julian A. Gray ,  Yoshiharu Yamanishi ,  Julian A. Gray ,  Yoshiharu Yamanishi ,  Nobuyuki Mori ,  Scott Fields

IPC分类号： A61K31/444 ,  A61P25/28

CPC分类号： A61K31/4412 ,  A61K31/444 ,  A61K31/445 ,  A61K2300/00

摘要： The invention provides methods for treating and/or preventing cognitive impairments, dementia, or neurodegenerative diseases and disorders (e.g., Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis) in patients by administering therapeutically effective amounts of an AMPA receptor antagonist (e.g., 1,2-dihydropyridine compounds) and therapeutically effective amounts of nootropics (e.g., cholinesterase inhibitors) to patients. The invention also provides combinations, commercial packages, and pharmaceutical compositions comprising therapeutically effective amounts of AMPA receptor antagonists (e.g., 1,2-dihydropyridine compounds) and therapeutically effective amounts nootropics (e.g., cholinesterase inhibitors). The 1,2-dihydropyridine compound may be, for example, 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one. The cholinesterase inhibitor may be, for example, donepezil.

摘要翻译： 本发明提供了通过施用治疗有效量的AMPA受体拮抗剂（例如，治疗和/或预防）的方法来治疗和/或预防患者的认知障碍，痴呆或神经变性疾病和障碍（例如，阿尔茨海默氏病，帕金森病，亨廷顿舞蹈病，肌萎缩性侧索硬化） ，1,2-二氢吡啶化合物）和治疗有效量的益智酸（例如胆碱酯酶抑制剂）给患者。 本发明还提供了包含治疗有效量的AMPA受体拮抗剂（例如1,2-二氢吡啶化合物）和治疗有效量的精神病药（例如胆碱酯酶抑制剂）的组合，商业包装和药物组合物。 1,2-二氢吡啶化合物可以是例如3-（2-氰基苯基）-5-（2-吡啶基）-1-苯基-1,2-二氢吡啶-2-酮。 胆碱酯酶抑制剂可以是例如多奈哌齐。

公开(公告)号：US20060276510A1

公开(公告)日：2006-12-07

申请号：US11396621

申请日：2006-04-04

申请人： Susan Abu-Shakra ,  Julian Gray ,  Yoshiharu Yamanishi ,  Nobuyuki Mori

发明人： Susan Abu-Shakra ,  Julian Gray ,  Yoshiharu Yamanishi ,  Nobuyuki Mori

IPC分类号： A61K31/444

CPC分类号： A61K31/4412 ,  A61K31/444 ,  A61K31/445 ,  A61K2300/00

摘要： The invention provides methods for treating and/or preventing headaches by administering to patients therapeutically effective amounts of 1,2-dihydropyridine compounds, and, optionally, cholinesterase inhibitors and/or anti-migraine agents. The headaches may be primary headaches, such as migraines, or secondary headaches. The invention also provides combinations, commercial packages, and pharmaceutical compositions comprising therapeutically effective amounts of 1,2-dihydropyridine compounds and, optionally, cholinesterase inhibitors and/or anti-migraine agents. The 1,2-dihydropyridine compound may be, for example, 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one. The cholinesterase inhibitor may be, for example, 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine.

摘要翻译： 本发明提供了通过向患者施用治疗有效量的1,2-二氢吡啶化合物和任选的胆碱酯酶抑制剂和/或抗偏头痛药物来治疗和/或预防头痛的方法。 头痛可能是原发性头痛，如偏头痛或继发性头痛。 本发明还提供了包含治疗有效量的1,2-二氢吡啶化合物和任选的胆碱酯酶抑制剂和/或抗偏头痛药物的组合，商业包装和药物组合物。 1,2-二氢吡啶化合物可以是例如3-（2-氰基苯基）-5-（2-吡啶基）-1-苯基-1,2-二氢吡啶-2-酮。 胆碱酯酶抑制剂可以是例如1-苄基-4 - （（5,6-二甲氧基-1-茚满酮）-2-基）甲基哌啶。

公开(公告)号：US09604267B2

公开(公告)日：2017-03-28

申请号：US13511898

申请日：2010-11-15

申请人： Nobuyuki Mori ,  Yukihiro Oishi

发明人： Nobuyuki Mori ,  Yukihiro Oishi

IPC分类号： B21B3/00 ,  C22C23/00 ,  C22C23/02 ,  B21B38/00

CPC分类号： B21B3/00 ,  B21B38/006 ,  B21B2003/001 ,  B21B2267/12 ,  Y10T428/12333

摘要： There are provided a method for producing a magnesium alloy sheet having good press formability and a magnesium alloy coil stock obtained by coiling the magnesium alloy sheet. After a raw material sheet 1 composed of a magnesium alloy is preheated to 280° C. or less, the heated raw material sheet 1 is rolled with a reduction roll 3 and the obtained long rolled sheet is coiled. The surface temperature of the reduction roll 3 is set to be 230° C. or more and 290° C. or less. The preheating, rolling, and coiling are repeatedly performed in a continuous manner. By setting both the temperatures of the raw material sheet 1 and reduction roll 3 to be certain temperatures, the rolling property of the raw material sheet can be improved and the raw material sheet can be properly rolled in a continuous manner. In addition, a variation in temperature in the width direction of the reduction roll can be suppressed and uniform rolling can be performed, resulting in the production of a long magnesium alloy sheet. In this magnesium alloy sheet, working strain is sufficiently introduced by rolling and an increase in the size of crystal grains is suppressed. Thus, the magnesium alloy sheet has good press formability. Furthermore, a coil stock in which telescoping is not easily caused and that has good appearance is obtained.

公开(公告)号：US20130323523A1

公开(公告)日：2013-12-05

申请号：US13985531

申请日：2012-02-13

申请人： Yukihiro Oishi ,  Nobuyuki Mori ,  Ryuichi Inoue ,  Masaaki Fujii ,  Masahiko Ito ,  Nozomu Kawabe

发明人： Yukihiro Oishi ,  Nobuyuki Mori ,  Ryuichi Inoue ,  Masaaki Fujii ,  Masahiko Ito ,  Nozomu Kawabe

IPC分类号： B21B1/26

CPC分类号： B21B1/26 ,  B21B3/00 ,  C22C23/02 ,  C22F1/06 ,  Y02P70/127 ,  Y10T428/12

摘要： Provided are a rolled Mg alloy material which has a wide width and whose mechanical properties are uniform in a width direction, a Mg alloy structural member produced by plastically working the rolled Mg alloy material, and a method for producing the rolled Mg alloy material. The method for producing a rolled Mg alloy material includes rolling a Mg alloy material with a reduction roll. The Mg alloy material has a width of 1,000 mm or more, and the reduction roll has three or more regions in the width direction. The temperature is controlled in each of the regions so that a difference between a maximum temperature and a minimum temperature is 10° C. or less in the width direction of a surface of the reduction roll. The variation in the rolled state in the width direction can be reduced by reducing a difference in temperature over the width direction of the reduction roll. As a result, it is possible to produce a rolled Mg alloy material whose mechanical properties are substantially uniform in the width direction.

摘要翻译： 本发明提供宽幅宽，机械特性在宽度方向上均匀的轧制Mg合金材料，通过对Mg合金材料进行塑性加工而制造的Mg合金结构体，以及轧制Mg合金材料的制造方法。 轧制Mg合金材料的制造方法包括用还原辊轧制Mg合金材料。 Mg合金材料的宽度为1000mm以上，还原辊在宽度方向上具有3个以上的区域。 在每个区域中控制温度，使得最大温度和最低温度之间的差异在还原辊的表面的宽度方向上为10℃以下。 通过减小压下辊的宽度方向上的温度差，可以减小宽度方向上轧制状态的变化。 结果，可以生产在宽度方向上机械性能基本均匀的轧制Mg合金材料。

公开(公告)号：US08393074B1

公开(公告)日：2013-03-12

申请号：US13267601

申请日：2011-10-06

申请人： Seiichi Takayama ,  Koji Shimazawa ,  Shinji Hara ,  Yasuhiro Ito ,  Nobuyuki Mori ,  Ryo Hosoi ,  Kazuaki Takanuki ,  Youichi Ando ,  Chimoto Sugiyama

发明人： Seiichi Takayama ,  Koji Shimazawa ,  Shinji Hara ,  Yasuhiro Ito ,  Nobuyuki Mori ,  Ryo Hosoi ,  Kazuaki Takanuki ,  Youichi Ando ,  Chimoto Sugiyama

IPC分类号： G11B5/127 ,  H04R31/00

CPC分类号： G11B5/314 ,  G11B5/6088 ,  G11B2005/0021 ,  Y10T29/49025 ,  Y10T29/49041 ,  Y10T29/49043 ,  Y10T29/4905 ,  Y10T29/5313 ,  Y10T29/53165

摘要： A method of manufacturing a thermally-assisted magnetic recording head includes: providing a light source unit including a laser diode; providing a slider having a thermally-assisted magnetic recording head section thereon, the thermally-assisted magnetic recording head section including a magnetic pole, an optical waveguide, and a plasmon generator, the magnetic pole and the optical waveguide both extending toward an air bearing surface, the plasmon generator being located between the magnetic pole and the optical waveguide; driving the laser diode to allow a light beam to be emitted therefrom, the light beam including both a TE polarization component and a TM polarization component; performing an alignment between the light source unit and the thermally-assisted magnetic recording head section, based on a light intensity distribution of the TE polarization component in the light beam which has been emitted from the laser diode and then passed through the optical waveguide; and bonding the light source unit to the slider after the alignment is completed.

摘要翻译： 一种制造热辅助磁记录头的方法包括：提供包括激光二极管的光源单元; 提供一种在其上具有热辅助磁记录头部分的滑块，所述热辅助磁记录头部分包括磁极，光波导和等离子体发生器，所述磁极和光波导均朝空气轴承表面延伸 所述等离子体发生器位于所述磁极和所述光波导之间; 驱动激光二极管以允许从其发射光束，所述光束包括TE偏振分量和TM偏振分量; 基于从激光二极管发射的光束中的TE偏振分量的光强度分布然后通过光波导，执行光源单元和热辅助磁记录头部之间的对准; 并且在对准完成之后将光源单元接合到滑块。

公开(公告)号：US08358252B2

公开(公告)日：2013-01-22

申请号：US12658888

申请日：2010-02-17

申请人： Nobuyuki Mori

发明人： Nobuyuki Mori

IPC分类号： H01Q19/10

CPC分类号： H01Q1/243 ,  H01Q1/36 ,  H01Q9/16 ,  H01Q19/30

摘要： An antenna includes: a dipole antenna; and a parasitic element arranged in parallel to the dipole antenna and having a linear structure and a meander structure, wherein a directivity and a return loss of the dipole antenna are controlled by setting a distance between the dipole antenna and the parasitic element and a shape and size of the meander structure.

摘要翻译： 天线包括：偶极天线; 以及与偶极子天线并联布置并具有线性结构和弯曲结构的寄生元件，其中通过设置偶极天线和寄生元件之间的距离来控制偶极子天线的方向性和回波损耗，并且形状和 蜿蜒结构的大小。

公开(公告)号：US20120244373A1

公开(公告)日：2012-09-27

申请号：US13511898

申请日：2010-11-15

申请人： Nobuyuki Mori ,  Yukihiro Oishi

发明人： Nobuyuki Mori ,  Yukihiro Oishi

IPC分类号： B21B27/06 ,  C22C23/02

CPC分类号： B21B3/00 ,  B21B38/006 ,  B21B2003/001 ,  B21B2267/12 ,  Y10T428/12333

摘要： There are provided a method for producing a magnesium alloy sheet having good press formability and a magnesium alloy coil stock obtained by coiling the magnesium alloy sheet. After a raw material sheet 1 composed of a magnesium alloy is preheated to 280° C. or less, the heated raw material sheet 1 is rolled with a reduction roll 3 and the obtained long rolled sheet is coiled. The surface temperature of the reduction roll 3 is set to be 230° C. or more and 290° C. or less. The preheating, rolling, and coiling are repeatedly performed in a continuous manner. By setting both the temperatures of the raw material sheet 1 and reduction roll 3 to be certain temperatures, the rolling property of the raw material sheet can be improved and the raw material sheet can be properly rolled in a continuous manner. In addition, a variation in temperature in the width direction of the reduction roll can be suppressed and uniform rolling can be performed, resulting in the production of a long magnesium alloy sheet. In this magnesium alloy sheet, working strain is sufficiently introduced by rolling and an increase in the size of crystal grains is suppressed. Thus, the magnesium alloy sheet has good press formability. Furthermore, a coil stock in which telescoping is not easily caused and that has good appearance is obtained.

摘要翻译： 提供了一种制造具有良好压制成形性的镁合金板的方法和通过卷绕镁合金板而获得的镁合金线圈坯料。 将由镁合金构成的原料片1预热至280℃以下后，用还原辊3轧制被加热的原料片1，将所得的长卷材卷成。 还原辊3的表面温度设定为230℃以上290℃以下。 以连续的方式重复进行预热，轧制和卷取。 通过将原料片1和还原辊3的温度均设定为一定温度，能够提高原料片的卷曲性，并且可以连续地适当地卷曲原料片。 此外，可以抑制还原辊的宽度方向的温度变化，并且可以进行均匀的轧制，从而制造长的镁合金板。 在该镁合金板中，通过轧制充分地引入加工应变，并且抑制了晶粒尺寸的增加。 因此，镁合金板具有良好的压制成形性。 此外，获得了不容易引起伸缩并且具有良好外观的线圈架。

公开(公告)号：US08250737B2

公开(公告)日：2012-08-28

申请号：US12904553

申请日：2010-10-14

申请人： Koji Shimazawa ,  Seiichi Takayama ,  Nobuyuki Mori ,  Yoshihiro Tsuchiya ,  Shinji Hara

发明人： Koji Shimazawa ,  Seiichi Takayama ,  Nobuyuki Mori ,  Yoshihiro Tsuchiya ,  Shinji Hara

IPC分类号： G11B5/127 ,  H04R31/00

CPC分类号： G11B5/314 ,  B82Y10/00 ,  B82Y25/00 ,  G11B5/1278 ,  G11B5/3967 ,  G11B5/6088 ,  G11B2005/001 ,  G11B2005/0021 ,  G11B2005/3996 ,  Y10T29/49021 ,  Y10T29/49032 ,  Y10T29/5313 ,  Y10T29/53191

摘要： Provided is a method for manufacturing a thermally-assisted magnetic recording head including a light source unit with a light source and a slider with an optical system. The method comprises steps of: adhering by suction the light source unit with a back holding jig; moving the back holding jig, then aligning a light-emission center of the light source with a light-receiving end surface of the optical system in directions within a slider back surface of the slider; bringing the light source unit into contact with the slider back surface, with a suction surface of the back holding jig tilted from the normal to the slider back surface; applying a load to a load application surface of the unit substrate by a loading means to bring a joining surface of the light source unit into conformity with the slider back surface; and bonding the light source unit and the slider. This method can improve the conformity, thereby achieving adequately strong junction and adequately high accuracy in position.

摘要翻译： 提供一种制造包括具有光源的光源单元和具有光学系统的滑块的热辅助磁记录头的方法。 该方法包括以下步骤：用后保持夹具吸附光源单元; 移动后保持夹具，然后将光源的发光中心与光学系统的光接收端面沿滑块的滑块后表面内的方向对准; 使光源单元与滑块后表面接触，后保持夹具的吸力表面从滑块后表面的法线倾斜; 通过加载装置将负载施加到单元基板的负载施加表面，以使光源单元的接合表面与滑块背面一致; 并且接合光源单元和滑块。 该方法可以改善一致性，从而实现足够强的接合和足够高的位置精度。

公开(公告)号：US08248895B2

公开(公告)日：2012-08-21

申请号：US12726981

申请日：2010-03-18

申请人： Koji Shimazawa ,  Yoshihiro Tsuchiya ,  Seiichi Takayama ,  Nobuyuki Mori ,  Yasuhiro Ito ,  Kosuke Tanaka ,  Osamu Shindo ,  Ryuji Fujii ,  Takashi Honda ,  Yoshitaka Sasaki

发明人： Koji Shimazawa ,  Yoshihiro Tsuchiya ,  Seiichi Takayama ,  Nobuyuki Mori ,  Yasuhiro Ito ,  Kosuke Tanaka ,  Osamu Shindo ,  Ryuji Fujii ,  Takashi Honda ,  Yoshitaka Sasaki

IPC分类号： G11B11/00

CPC分类号： G11B5/314 ,  G11B5/105 ,  G11B5/6088 ,  G11B2005/001 ,  G11B2005/0021

摘要： A method for manufacturing a thermally-assisted magnetic recording head is provided, in which a light source unit including a light source and a slider including an optical system are bonded. A unit substrate is made of a material transmitting light having a predetermined wavelength, and an adhesion material layer is formed on the light source unit and/or the slider. The manufacturing method includes: aligning the light source unit and the slider in such a way that a light from the light source can enter the optical system and the adhesion material layer is sandwiched therebetween; irradiating the adhesion material layer with a light including the predetermined wavelength through the unit substrate; and bonding them. The adhesion material layer melted by the light including the predetermined wavelength and transmitted through the unit substrate can ensure high alignment accuracy as well as higher bonding strength and less change with time.

摘要翻译： 提供了一种用于制造热辅助磁记录头的方法，其中包括光源和包括光学系统的滑块的光源单元被结合。 单位基板由透射具有预定波长的光的材料制成，并且在光源单元和/或滑块上形成粘合材料层。 该制造方法包括：将光源单元和滑块对准，使得来自光源的光能够进入光学系统，并且粘合材料层夹在其间; 用包含所述预定波长的光通过所述单元基板照射所述粘附材料层; 并粘合它们。 由包含预定波长并透过单元基板的光熔化的粘合材料层可以确保高对准精度以及更高的粘接强度和随时间变化的变化。